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Hemorrhagic fever with renal syndrome complicated with aortic dissection:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5795-5801页

作者： Feng-Qi Qiu cong-cong li Jian-Ya Zhou Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Critical Care Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Hemorrhagic fever with renal syndrome is caused by hantaviruses presenting with high fever,hemorrhage,and acute kidney *** injury and hemorrhage in mucus were often observed in patients with hantavirus *** with bacterial and virus related aortic aneurysm or dissection occurs ***,we report a previously unreported case of hemorrhagic fever with concurrent aortic *** SUMMARY A 56-year-old man complained of high fever and generalized body ache,with decreased platelet counts of 10×10^9/L and acute kidney *** enzymelinked immunosorbent assays test for immunoglobulin M and immunoglobulin G hantavirus-specific antibodies were both *** the convalescent period,he complained sudden onset acute chest pain radiating to the back,and the computed tomography angiography revealed an aortic dissection of the descending aorta extending to iliac *** was diagnosed with hemorrhagic fever with renal syndrome and Stanford B aortic *** patient recovered completely after surgery with other support *** Hemorrhagic fever with renal syndrome complicated with aortic dissection is rare and a difficult clinical *** infection not only causes microvascular damage presenting with hemorrhage but may be risk factor for acute macrovascular detriment.A causal relationship has yet to be confirmed.

关键词： Hantavirus Hemorrhagic fever with renal syndrome Aortic dissection Infection Acute kidney injury Case report

A Bright Single-Photon Source from Nitrogen-Vacancy Centers in Diamond Nanowires

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Chinese Physics Letters 2017年第9期34卷 70-73页

作者： Shen li Cui-Hong li Bo-Wen Zhao Yang Dong cong-cong li Xiang-Dong Chen Ya-Song Ge Fang-Wen Sun Key Lab of Quantum Information Chinese Academy of Sciences University of Science and Technology of China Hefei 230026 Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 University of Chinese Academy of Sciences Beijing 100049

Single-photon flux is one of the crucial properties of nitrogen vacancy （NV） centers in diamond for its application in quantum information techniques. Here we fabricate diamond conical nanowires to enhance the single-photon count rate. Through the interaction between tightly confined optical mode in nanowires and NV centers, the single-photon lifetime is much shortened and the collection efficiency is enhanced. As a result, the detected single-photon rate can be at 564 kcps, and the total detection coefficient can be 0.8%, which is much higher than that in bulk diamond. Such a nanowire single-photon device with high photon flux can be applied to improve the fidelity of quantum computation and the precision of quantum sensors.

关键词： A Bright Single-Photon Source from Nitrogen-Vacancy Centers in Diamond Nanowires

Opinion dynamics in finance and business: a literature review and research opportunities

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Financial Innovation 2020年第1期6卷 971-992页

作者： Quanbo Zha Gang Kou Hengjie Zhang Haiming liang Xia Chen cong‑cong li Yucheng Dong School of Management Science and Real Estate Chongqing UniversityChongqing 400045China School of Business Administration Southwestern University of Finance and EconomicsChengdu 611130China Business School Hohai UniversityNanjing 211100China Center for Network Big Data and Decision-Making Business SchoolSichuan UniversityChengdu 610065China School of Economics and Management Southwest Jiaotong UniversityChengdu 610031China

Opinion dynamics is an opinion evolution process of a group of agents,where the final opinion distribution tends to three stable states:consensus,polarization,and *** present,the opinion dynamics models have been extensively studied in differrent *** paper provides a review of opinion dynamics in finance and business,such as,finance,marketing,e-commerce,politics,and group decision ***,identified research challenges have been proposed to promote the future research of this topic.

关键词： Opinion dynamics Financial market Business

Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury

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Chinese Medical Journal 2019年第11期132卷 1298-1304页

作者： Wei liu cong-cong li Xi Lu li-Yan Bo Fa-Guang Jin Departm ent of Respiratory The Second Affiliated Hospital The Air Force Military Medical University Xi'an Shaanxi 710038 China Department of Respiratory The General Hospital of Northern Theater Shenyang Liaoning 110000 China

Background:Acute lung injury (Ali) is characterized by an acute inflammatory process, and oxidative stress in the lung tissue leads to a lack of effective therapeutics. This study aimed to identify whether the overexpression of transcription factor EB (TFEB) regulates mitophagy to protect against lipopolysaccharide (LPS)-induced Ali. Methods: We detected the expression of inflammatory factors, cytochrome c (Cyt.c) and nicotinamide adenine dinucleotide phosphate (NADPH), and autophagy-related proteins and observed the changes in lung histopathology induced by Ali in rats and the changes in the cell ultrastructure of primary alveolar type II epithelial cells induced by changing the expression of TFEB in the context of Ali. Results: The overexpression of TFEB could reduce the expression of proinflammatory factors, such as IL-1 and IL-6, and increase the expression of anti-inflammatory factors, such as IL-10, both in vitro and in vivo. In addition, the overexpression of TFEB could reduce the Cyt.c and NADPH levels both in vivo and in vitro. The overexpression of TFEB could upregulate the expression of autophagy-related proteins, such as lysosomal-associated membrane protein 1 (LAMP1), microtubule-associated protein light chain 3B (LC3B), and Beclin both in vivo and in vitro^ and promote mitochondrial autophagy. The overexpression of TFEB significantly improved the histopathologic changes induced by LPS-induced Ali in rats. However, low TFEB expression produced the opposite results. Conclusion: TFEB overexpression can decrease inflammation and mitochondrial damage in the lung tissue and alveolar epithelial cells through regulating mitochondrial autophagy to protect against LPS-induced Ali. Therefore, TFEB is likely a potential therapeutic target in LPS-induced Ali.

关键词： Transcription factor EB Mitochondrial autophagy Acute lung injury Inflammation Mitochondrial damage

Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

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Science China life Sciences 2025年

作者： cong Zhou Tingting Gong Shuhang li li Jin Shaohua Fan State Key Laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we construct an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

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Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei cong Guoyu Qian Dong Wang Laishi li Yusheng Wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期7卷 50-70页

作者： Yi li Bei-Qi Wang Xin-Yin Zhang Shi-Jie Wang cong-Yi li Hui-Long Yang Ran-Ran Su Tong liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

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改进的自适应Canny边缘检测算法

计算机工程与设计 2018年第6期39卷 1645-1652页

作者：段锁林殷聪聪李大伟常州大学机器人研究所江苏常州213164

针对传统Canny算法需要设定滤波参数且对椒盐噪声滤波效果不佳,以及需要预先设定高、低阈值等问题,提出一种改进的自适应Canny边缘检测算法。利用分治法思想和相邻窗口排序信息相关性的原理,改进自适应中值滤波器,以此来替代高斯滤波器... 详细信息

针对传统Canny算法需要设定滤波参数且对椒盐噪声滤波效果不佳,以及需要预先设定高、低阈值等问题,提出一种改进的自适应Canny边缘检测算法。利用分治法思想和相邻窗口排序信息相关性的原理,改进自适应中值滤波器,以此来替代高斯滤波器;增加45°和135°方向的梯度模板计算像素梯度;利用二分法查找原理改进Otsu算法计算梯度幅值的高、低阈值。Matlab仿真结果表明,该算法在椒盐噪声和高斯噪声环境下都有较好的边缘检测效果,具有自适应性强、抗噪性好、计算机耗时少等优点。

关键词：边缘检测 Canny算法中值滤波 Otsu算法二分法