检索结果-南通市图书馆

Dispersion and Filler Network Structure of Fibrillar Silicates in Elastomers

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2016年第7期34卷 858-872页

作者： Zhao li Hai-bin Sun cong-yi li Yong-lai Lu Wang Qiao 宁南英 li-qun Zhang 田明 Aeolus Tyre Co. Ltd State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Petro China Sichuan Petrochemical Co. Ltd Office of Scientific Research and Development Beijing University of Chemical Technology

The dispersion and filler network of fibrillar silicate（FS） in elastomers were studied. The results showed that a good dispersion of FS in matrix during mechanical blending in unvulcanized composites contributed to a strong FS filler network, different from that of traditional reinforcing fillers. Meanwhile, the filler re-aggregation during vulcanization caused by the overlapping and intertwining of FS further strengthened the filler network. The factors including Mooney viscosity and molecular polarity of elastomer, type and amount of silane coupling agents used for filler modification, that may influence the filler network, were studied. Our study helps us to understand the mechanism for the formation of filler network of FS in elastomers and provides guidance for the preparation of high performance FS/elastomer composites.

关键词： Fibrillar silicates Dispersion Filler network Elastomers

Assessment of intraocular pressure measured by Reichert Ocular Response Analyzer,Goldmann Applanation Tonometry,and Dynamic Contour Tonometry in healthy individuals

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2012年第1期5卷 102-107页

作者： Ping-Bo Ouyang cong-yi li Xiao-Hua Zhu and Xuan-Chu Duan Department of Ophthalmology the Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China

AIM: To investigate the accuracy of intraocular pressure (IOP) as measured by a Reichert Ocular Response Analyzer (ORA), as well as the relationship between central corneal thickness (CCT) and IOP as measured by ORA, Goldmann applanation tonometry (GAD, and dynamic contour tonometry (DCT). METHODS: A total of 158 healthy individuals (296 eyes) were chosen randomly for measurement of IOP. After CCT was measured using A-ultrasound (A-US), IOP was measured by ORA, GAT, and DCT devices in a randomized order. The IOP values acquired using each of the three tonometries were compared, and the relationship between CCT and IOP values were analyzed separately. Two IOP values, Goldmann-correlated IOP value (IOPg) and corneal-compensated intraocular pressure (IOPcc), were got using ORA. Three groups were defined according to CCT: 1) thin cornea (CCT580 mu m) groups. RESULTS: In normal subjects, IOP measurements were 14.95 2.99mmHg with ORA (IOPg), 15.21+/- 2.77mmHg with ORA(IOPcc),1522+/- 2.77mmHg with GAT,and 15.49+/- 2.56mmHg with DCT. Mean differences were 0.01+/- 2.29mmHg between IOPcc and GAT (P >0.05) and 0.28+/- 2.20mmHg between IOPcc and DC (P >0.05). There was a greater correlation between IOPcc and DCT (r =0.946, P =0.000) than that between IOPcc and GAT (r=0.845, P=0.000). DCT had a significant correlation with GAT (r=0.854, P=0.000). GAT was moderately correlated with CCT (r=0.296, P580 mu m) showed the least significant correlation between IOPcc and GAT (r=0.859, 0.000); while the thin cornea group (CCT< 520 mu m) had the most significant correlation between IOP

关键词： intraocular pressure tonometry central corneal thickness

Rapid response to lipids profile and leukocyte gene expression after rosuvastatin administration in Chinese healthy volunteers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第13期121卷 1215-1219页

作者： HUA cong-xiao li yi-shi liU Yu-qing liU Hong li Na WU ying XU li HUANG yi-ling Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health Beijing Fuwai Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100037 China

Background Statins are potent lipid-lowering agents widely used in medical practice. There has been growing evidence suggesting the pleiotropic effects of statins in addition to the lipid-lowering effect. However, it is still unclear how rapidly the beneficial effects of statins occur. The transcriptome of peripheral blood cells can be used as a sensor to drug therapy. The purpose of the study was to investigate the acute effects of rosuvastatin both on lipids profile and gene expression of peripheral leukocytes following therapy with a single dose of rosuvastatin. Methods Thirty healthy Chinese male volunteers were enrolled. The serum lipids, high-sensitivity C-reactive protein, and plasma fibrinogen were determined before and 72 hours after administration of 20 mg of rosuvastatin. The differentially expressed genes of peripheral leukocytes after administration of rosuvastatin were screened using human oligonucleotide microarray gene expression chips. Then four of the differentially expressed genes including ATM, CASP8 IL8RB and SIOOB were verified by real-time polymerase chain reaction （PCR）. Results Rosuvastatin decreased both serum total cholesterol and low-density lipoprotein cholesterol significantly 72 hours after administration of a single dose of 20 mg rosuvastatin. However, no significant changes occurred in blood high-density lipoprotein cholesterol, triglycerides, C-reactive protein and fibrinogen after the treatment. A total of 24 genes were differentially expressed after the treatment. They were involved in important cell biological processes such as cytokine-cytokine receptor interaction, apoptosis signaling, etc. Conclusions Rosuvastatin rapidly modulates the serum lipids and affects the gene expression of peripheral leukocytes in healthy volunteers. This finding provides some new clues for further studies on its potential pleiotrooic effects.

关键词： rosuvastatin leukocytes microarray analysis gene expression

High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai yi li Yabo Xie Qiancheng Chen Xin Zhang Jian-Rong li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen li Leilei liang Baoshan Zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Malicious Document Detection Based on GGE Visualization

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 1233-1254页

作者： Youhe Wang yi Sun Yujie li Chuanqi Zhou Henan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

With the development of anti-virus technology,malicious documents have gradually become the main pathway of Advanced Persistent Threat(APT)attacks,therefore,the development of effective malicious document classifiers has become particularly ***,detection methods based on document structure and behavioral features encounter challenges in feature engineering,these methods not only have limited accuracy,but also consume large resources,and usually can only detect documents in specific formats,which lacks versatility and *** address such problems,this paper proposes a novel malicious document detection method-visualizing documents as GGE images(Grayscale,Grayscale matrix,Entropy).The GGE method visualizes the original byte sequence of the malicious document as a grayscale image,the information entropy sequence of the document as an entropy image,and at the same time,the grayscale level co-occurrence matrix and the texture and spatial information stored in it are converted into grayscale matrix image,and fuses the three types of images to get the GGE color *** Convolutional Block Attention Module-EfficientNet-B0(CBAM-EfficientNet-B0)model is then used for classification,combining transfer learning and applying the pre-trained model on the ImageNet dataset to the feature extraction process of GGE *** shown in the experimental results,the GGE method has superior performance compared with other methods,which is suitable for detecting malicious documents in different formats,and achieves an accuracy of 99.44%and 97.39%on Portable Document Format(PDF)and office datasets,respectively,and consumes less time during the detection process,which can be effectively applied to the task of detecting malicious documents in real-time.

关键词： Malicious document visualization EfficientNet-B0 convolutional block attention module GGE image

Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China life Sciences 2025年

作者： cong Zhou Tingting Gong Shuhang li li Jin Shaohua Fan State Key Laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we construct an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ORA眼反应分析仪的临床应用价值

国际眼科杂志 2009年第5期9卷 934-937页

作者：李从谊段宣初中南大学湘雅二医院眼科中国湖南省长沙市410011

眼反应分析仪(reichert ocular response analyzer,ORA)是一种新型非接触喷气式眼压计。它利用一种动态双向压平过程测量眼压,不仅使测得的眼压值真实可靠,免受中央角膜厚度和硬度的影响,而且可得到反应角膜生物力学特性的新指标:角膜... 详细信息

眼反应分析仪(reichert ocular response analyzer,ORA)是一种新型非接触喷气式眼压计。它利用一种动态双向压平过程测量眼压,不仅使测得的眼压值真实可靠,免受中央角膜厚度和硬度的影响,而且可得到反应角膜生物力学特性的新指标:角膜滞后量和角膜阻力因素。其操作简单,能自动显示眼压读数及角膜生物力学特性。该仪器精确度高,可重复性好,非接触特性,因此可广泛用于临床监测眼压,尤其适用于已行准分子激光角膜屈光手术后的患者,但仍需进一步明确其对青光眼诊断和治疗的指导作用。

关键词：眼反应分析仪眼压中央角膜厚度角膜滞后量

Overview of in-situ oxygen production technologies for lunar resources

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei cong Guoyu Qian Dong Wang Laishi li Yusheng Wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis