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Observer-based leader-following tracking control under both fixed and switching topologies

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Control Theory and Technology 2016年第1期14卷 28-38页

作者： Jinhuan WANG Pengxiao ZHANG Zhixin liu Xiaoming hu School of Sciences Hebei University of Technology Tianfin 300130 China .Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Optimization and Systems Theory and ACCESS Linnaeus Center Royal Institute of Technology Stockholm 100 44 Sweden

This paper studies the tracking problem for a class of leader-follower multi-agent systems moving on the plane using observer- based cooperative control strategies. In our set-up, only a subset of the followers can obtain some relative information on the leader. We assume that the control input of the leader is not known to any of the followers while the system matrix is broadcast to all the followers. To track such a leader, an observer-based decentralized feedback controller is designed for each follower and detailed analysis for the convergence is presented for both fixed and switching interaction topologies between agents with the method of common Lyapunov function. We can also generalize the result to the higher dimension case for fixed topology and some special system matrices of the leader for switching topology.

关键词： Multi-agent systems leader-following decentralized control observer

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儿童紫癜性肾炎临床研究结局指标的范围综述

中国全科医学 2024年第29期27卷 3696-3703页

作者：佟静涵吴晓明孙雅欣李姝凝梁琛董恒车刚刘畅胡艳刘雅莉国家儿童医学中心首都医科大学附属北京儿童医院国家儿童医学中心首都医科大学附属北京儿童医院中医科首都医科大学中医药学院甘肃省嘉峪关市第一人民医院国家儿童医学中心首都医科大学附属北京儿童医院临床流行病学与循证医学中心

背景过敏性紫癜是一种好发于儿童期的血管炎性疾病，部分患儿会累及肾脏，临床上称为紫癜性肾炎。目前不同研究建议的干预措施不尽相同，对于相应干预措施所采用的结局指标存在较大差异。目的调查分析我国紫癜性肾炎临床研究结局指标... 详细信息

背景过敏性紫癜是一种好发于儿童期的血管炎性疾病，部分患儿会累及肾脏，临床上称为紫癜性肾炎。目前不同研究建议的干预措施不尽相同，对于相应干预措施所采用的结局指标存在较大差异。目的调查分析我国紫癜性肾炎临床研究结局指标现状，为该领域核心结局指标集的建立提供参考依据。方法系统检索中国知网、中国生物医学文献数据库、维普网、万方数据知识服务平台，PubMed,Cochrane Library,Embase及Web of Science，收集公开发表的紫癜性肾炎相关研究，检索时限均为2010年1月—2021年6月。中文数据库采用题名或关键词结合主题词的检索策略进行检索，英文数据库采用主题词结合自由词的方式进行检索。由两名研究员按照纳入与排除标准独立筛选文献和提取资料，并对结局指标数据进行处理分析。结果共纳入紫癜性肾炎的随机对照研究148篇，紫癜性肾炎研究结局指标以理化指标为主，症状类指标较少。结局指标出现频次依次为临床疗效（121次，81.76%），不良反应（74次，50.00%）,24 h尿蛋白（68次，45.95%），尿红细胞（43次，29.05%），复发率（20次，13.51%）。仅2篇文献明确区分主要和次要结局指标。结论国内紫癜性肾炎研究结局指标种类繁多，以理化指标为主，异质性较大。研究关注疗效指标而对不良反应的关注度不足。因此有必要建立紫癜性肾炎临床干预性研究结局指标集，为同类研究选择结局指标及指导临床决策提供参考依据。

关键词：紫癜性肾炎过敏性紫癜儿童结局指标结局指标集范围综述

来源：博看期刊

Chemical characteristics and Pb isotopic compositions of PM2.5 in Nanchang, China

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Particuology 2017年第3期15卷 95-102页

作者： Yang Zhao Ruilian Yu Gongren hu Xiaohui Lin Xianrong liu College of Chemical Engineering Huoqiao University Xiamen 361021 China Environmental Protection Agency of Nanchang City Nanchang 330038 China

In mid-September 2013, PM2.5 samples were collected at six sites in Nanchang, Jiangxi Province, China, to quantify nine water-soluble ions （Ca2＋, Mg2＋, K＋, Na＋, NH4＋, SO42-, Cl-, F , NO3 ）, 29 trace elements （Ba, Zn, Pb, Ni, Mo, Cr, Cu, Sr, Sb, Rb, Cd, Bi, Zr, V, Ga, Li, Y, Nb, W, Cs, Tl, Sc, Co, U, Hf, In, Re, Be, and Ta）, and to characterize Pb isotopic ratios （^207pb/^206pb, ^208pb/^206pb, and ^207pb/^204pb） for identifying the main source（s） of Pb. The results showed that the average daily PM2.5 concentration （53.16 ± 24.17） Dg/m3 was within the secondary level of the Chinese ambient air quality standard. The combined concentrations of SO42-, NH4＋, and NO3- to total measured water-soluble ion concentrations in PM2.5 ranged from 79.40% to 95.18%, indicating that anthropogenic sources were significant. Coal combustion and vehicle emissions were both contributors to PM2.5 based on the NO3-/SO4^2- ratios. Wushu School experienced the lowest concentrations of PM2.s and most trace elements among the six sampling sites. Enrichment factor results showed that TI, Cr, In, Cu, Zn, Pb, Bi, Ni, Sb, and Cd in PM2.5 were affected by anthropogenic activities. Cluster analysis suggested that Cd, Sb, Pb, Re, Zn, Bi, Cs, Tl, Ga, and In were possibly related to coal combustion and vehicle exhaust, while Ni, Nb, Cr, and Mo may have originated from metal smelting. Pb isotopic tracing showed that coal dust, cement dust, road dust and construction dust were the major Pb sources in PM2.5 in Nanchang. Combined, these sources contributed an average of 72.51% of the Pb measured, while vehicle exhaust accounted for 27.49% of Pb based on results from a binary Pb isotope mixed model,

关键词： PMzs Water-soluble ions Trace elements Pb isotopic composition Nanchang

Multimodal bioimaging based on gold nanorod and carbon dot nanohybrids as a novel tool for atherosclerosis detection

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Nano Research 2018年第3期11卷 1262-1273页

作者： Xiaojing liu Luting liu Xiujie hu Shuyun Zhou Rinat Ankri Dror Fixler Zheng Xie Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Faculty of Engineering and Institute of Nanotechnology and Advanced Materials Bar-Ilan University Ramat-Gan 52900 Israel

Advanced biocompatible and robust platforms equipped with diverse properties are highly required in biomedical imaging applications for the early detection of atherosclerotic vascular disease and cancers. Designing nanohybrids composed of noble metals and fluorescent materials is a new way to perform multimodal imaging to overcome the limitations of single-modality counterparts. Herein, we propose the novel design of a multimodal contrast agent; namely, an enhanced nanohybrid comprising gold nanorods （GNRs） and carbon dots （CDs） with silica （SiO2） as a bridge. The nanohybrid （GNR@SiO2@CD） construction is based on covalent bonding between SiO2 and the silane-functionalized CDs, which links the GNRs with the CDs to form typical core-shell units. The novel structure not only retains and even highly improves the optical properties of the GNRs and CDs, but also possesses superior imaging performance in both diffusion reflection （DR） and fluorescence lifetime imaging microscopy （FLIM） measurements compared with bare GNRs or fluorescence dyes and CDs. The superior bioimaging properties of the GNR@SiOa@CD nanohybrids were successfully exploited for in vitro DR and FLIM measurements of macrophages within tissue-like phantoms, paving the way toward a theranostic contrast agent for atherosclerosis and cancer.

关键词： nanohybrids multimodal imagingcontrast agent diffusion reflection fluorescence lifetimeimaging atherosclerosis macrophages

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齐聪运用祛瘀生新理论辨治癥瘕不孕经验

中医文献杂志 2024年第1期42卷 56-58页

作者：高晓晴胡攀伟杨红齐聪章晓乐上海中医药大学附属曙光医院上海201203 上海中医药大学附属市中医医院上海200071

上海市名中医齐聪教授擅长孕前祛瘀消癥养卵、孕后补肾养血安胎原则辨治子宫腺肌症不孕,以及以活血药治疗早孕合并绒毛膜下出血,总结齐师临床应用祛瘀生新理论辨治的有效案例以供借鉴。

关键词：子宫腺肌症不孕祛瘀生新名医经验中医药疗法

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糖代谢异常对血清激活素A水平的影响

实用老年医学 2024年第5期38卷 495-499页

作者：刘童君赵雅洁胡洁玲胡洋梁伟上海交通大学医学院附属瑞金医院老年科上海市200025 山东大学齐鲁医院(青岛)放射科山东省青岛市266034

目的探讨老年人群血清激活素A(ACT-A)的表达情况及其在不同血糖状态病人中的影响因素。方法纳入2022年7月至2023年2月期间瑞金医院特需病房体检人群293例,检测其血清ACT-A水平,分析不同临床特征病人ACT-A的表达差异及不同血糖状态病人... 详细信息

目的探讨老年人群血清激活素A(ACT-A)的表达情况及其在不同血糖状态病人中的影响因素。方法纳入2022年7月至2023年2月期间瑞金医院特需病房体检人群293例,检测其血清ACT-A水平,分析不同临床特征病人ACT-A的表达差异及不同血糖状态病人中ACT-A的影响因素。结果 ACT-A水平随着年龄的增长和糖尿病病情进展均升高(P55 mmHg及脉压指数>0.45的老年糖尿病病人ACT-A水平更高。糖尿病人群中,Pearson相关分析及线性回归均证实ACT-A水平与年龄、HbA1c及胰岛素抵抗指数(HOMA-IR)呈正相关(P均<0.05),与空腹胰岛素水平呈负相关(P<0.05)。结论衰老个体体内ACT-A水平增加,且与年龄呈正相关;ACT-A水平在糖尿病前期即可升高,在糖尿病阶段进一步升高;年龄、HbA1c、空腹胰岛素及HOMA-IR与糖尿病病人ACT-A水平独立相关。

关键词：激活素A 衰老糖尿病糖尿病前期

Effect of Support Height on Microstructure and Mechanical Properties of Selective Laser Melting Ti-15Mo Alloy

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Acta Metallurgica Sinica(English Letters) 2023年第12期36卷 1947-1960页

作者： Libo Zhou Xisheng Bi Jinshan Sun Zhiming hu cong Li Jian Chen Yanjie Ren Yan Niu Wei Qiu Wei Chen Institute of Energy and Power Engineering Changsha University of Science and TechnologyChangsha410114China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

In this research,for the first time,the Ti-15Mo alloy generated via selective laser melting(SLM)with many different support heights was *** the increase of the support height,the risks of forming microcracks and small holes increase while the ductility of the sample *** grain sizes of the samples decrease with an increase in support height because of the more efficient heat dissipation rate during the SLM *** average grain sizes of the samples are 36.95±0.7μm(5 mm-sample I),35.24±0.7μm(10 mm-sample II)and 33.91±0.7μm(15 mm-sample III),*** the support height increases,the intensity of(111)texture increases and the misorientation angles gradually *** ultimate tensile strength,yield strength and ductility of the three samples are 970±13 MPa,769±12 MPa and 9.78%±1.5%(sample I),1051±11 MPa,932±11 MPa and 7.17%±2%(sample II),1123±14 MPa,1089±9 MPa and 5.4%±1.4%(sample III),*** decrease in grain size,increase in dislocation density and enhancement of the(111)texture are all conducive to achieving the higher strength.

关键词： Selective laser melting Titanium alloy Support height Microstructure

HIV-1 Protein Tat_(1–72) Impairs Neuronal Dendrites via Activation of PP1 and Regulation of the CREB/BDNF Pathway

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Virologica Sinica 2018年第3期33卷 261-269页

作者： Yu liu Deyu Zhou Jiabin Feng Zhou liu Yue hu Chang liu Xiaohong Kong Laboratory of Medical Molecular Virology School of Medicine Nankai University

Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus(HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the healthrelated quality of their lives. Although neurons cannot be infected by HIV-1, shed viral proteins such as transactivator of transcription(Tat) can cause dendritic damage. However, the detailed molecular mechanism of Tat-induced neuronal impairment remains unknown. In this study, we first showed that recombinant Tat(1–72 aa) induced neurotoxicity in primary cultured mouse neurons. Second, exposure to Tat_(1–72) was shown to reduce the length and number of dendrites in cultured neurons. Third, Tat_(1–72)(0–6 h) modulates protein phosphatase 1(PP1) expression and enhances its activity by decreasing the phosphorylation level of PP1 at Thr320. Finally, Tat_(1–72)(24 h) downregulates CREB activity and CREBmediated gene(BDNF, c-fos, Egr-1) expression. Together, these findings suggest that Tat_(1–72) might impair cognitive function by regulating the activity of PP1 and the CREB/BDNF pathway.

关键词： Recombinant tat HIV-associated neurocognitive disorders (HAND) - Dendrite impairment - Proteinphosphatase 1 (PP1) CREB/BDNF

THE　KINETIC　RESOLUTION　OF　1，1＇－BINAPHTHYL－2，2＇－DIYLPHOSPHORYL　CHLORIDE　WITH　OPTICALLY　PURE　AMINES

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Chinese Chemical Letters 1995年第11期6卷 959-960页

作者： Wang, M liu, SZ liu, J hu, BF Beijing Agr Univ Dept Appl Chem Beijing 100094 Peoples R China

The reactions of 1.1'-binaphthyl-2,2'-diylphosphoryl chloride with optically pure amines give diastereoselective products with the de% from20% to 82%.

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