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Advances in Manufacturing 2024年第1期12卷 185-206页

作者： Lin Ling Zhe-Ming Song Xi Zhang Peng-Zhou Cao Xiao-Qiao Wang cong-hu liu Ming-Zhou liu School of Mechanical Engineering Hefei University of TechnologyHefei230009People’s Republic of China Guobo Electronics Co.Ltd. Nanjing211111People’s Republic of China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou234000AnhuiPeople’s Republic of China Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai200030People’s Republic of China

Production logistics(PL)is considered as a critical factor that affects the efficiency and cost of production operations in discrete manufacturing *** effectively utilize manufacturing big data to improve PL efficiency and promote job shop floor economic benefits,this study proposes a PL trajectory analysis and optimization decision making method driven by a manufacturing task data chain(MTDC).First,the manufacturing task chain(MTC)is defined to characterize the discrete production process of a *** handle manufacturing big data,the MTC data paradigm is designed,and the MTDC is ***,the logistics trajectory model is presented,where the various types of logistics trajectories are extracted using the MTC as the search engine for the *** on this,a logistics efficiency evaluation indicator system is proposed to support the optimization decision making for the ***,a case study is applied to verify the proposed method,and the method determines the PL optimization decisions for PL efficiency without changing the layout and workshop equipment,which can assist managers in implementing the optimization decisions.

关键词： Production logistics(PL) Logistics trajectory analysis Logistics optimization Data driven Manufacturing task data chain(MTDC)

Micro-mechanism Study on the Different Antioxidants Protective Effect of Vegetable Oil by ReaxFF Molecular Dynamics

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1269-1279页

作者： Haoxi cong Xuefeng hu Hao Pan Qingmin Li State Key Laboratory of Alternate Electrical Power System With Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

The aging problem of vegetable oil has severely restricted the popularization and application of vegetable oil *** antioxidants is the most recommended *** present,there is insufficient research on the micromechanism application of the protective effect of antioxidants on vegetable *** this paper,multiple vegetable oil models with different types and concentrations of antioxidants are *** the molecular dynamics simulation based on ReaxFF is carried out at different temperatures and oxygen *** show that the protective mechanism of antioxidants is to release H and combine this with free radicals generated by the decomposition of unsaturated fatty acids(UFA)in the *** addition,the protective effects of four antioxidants show different *** stronger ones are tert-butyl hydroquinone(TBHQ)and butylated hydroxytoluene(BHT),while the weaker ones are butylated hydroxyanisole(BHA)and propyl gallate(PG).TBHQ has a better protective effect at lower concentrations,but the decomposition of UFA is promoted at higher *** the temperature rises,the decomposition of UFA is *** the addition of oxygen,smaller molecular compounds are easily oxidized,and the decomposition of UFA is *** above research could reveal the microscopic mechanism of antioxidant protection on vegetable oil,providing theoretical references for further exploration of effective vegetable oil aging protection technology.

关键词： Antioxidant molecular dynamics transformer vegetable oil

Crossroads:Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

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BIOCELL 2024年第1期48卷 9-19页

作者： YANG LI JIAN liu YUEDI hu CHENGZHI cong YIMING CHEN QIAO ZHOU Department of Rheumatology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230031China First Clinical Medical School Anhui University of Chinese MedicineHefei230031China Institute of Rheumatology Anhui Academy of Chinese MedicineHefei230031China

Rheumatoid arthritis(RA)is a prevalent autoimmune disease whose main features include chronic synovial inflammation,bone destruction,and joint *** are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of *** extracellular traps(NETs),a meshwork of DNA-histone complexes and proteins released by activated neutrophils,are widely involved in the pathophysiology of autoimmune diseases,especially RA,in addition to playing a key role in the neutrophil innate immune *** have been found to be an important source of citrullinated autoantigen antibodies and inflammatory factor release,which can activate RA synovial fibroblasts(FLS)and cause joint *** article reviews the role of NETs in the pathophysiology of RA,demonstrating the application of multiple molecules with various therapies,with a view to informing the discovery and development of novel biomarkers and therapeutic targets for RA.

关键词： Rheumatoid arthritis Neutrophil extracellular traps Review

Dynamical pattern recognition for univariate time series and its application to an axial compressor

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Control Theory and Technology 2024年第1期22卷 39-55页

作者： Jingtao hu Weiming Wu Zejian Zhu cong Wang Center for Intelligent Medical Engineering School of Control Science and TechnologyShandong UniversityJinan250061ShandongChina School of Automation Science and Engineering South China University of TechnologyGuangzhou510641GuangdongChina

In this paper, a learning and recognition approach is proposed for univariate time series composed of output measurements of general nonlinear dynamical systems. Firstly, a class of dynamical systems in the canonical form is derived to describe the univariate time series by introducing coordinate transformation. An observer-based deterministic learning technique is then adopted to achieve dynamical modeling of the associated transformed systems of the training univariate time series, and the modeling results in the form of radial basis function network (RBFN) models are stored in a pattern library. Subsequently, multiple observer-based dynamical estimators containing the RBFN models in the pattern library are constructed for a test univariate time series, and a recognition decision scheme is proposed by the derived recognition indicator. On this basis, more concise recognition conditions are provided, which is beneficial for verifying the recognition results. Finally, simulation studies on the Rossler system and aero-engine stall warning verify the effectiveness of the proposed approach.

关键词： Dynamical pattern recognition Deterministic learning Stall warning Radial basis function network Sampled-data observer

Effects of vibration conditions,spatial confinement and friction on mixing and segregation characteristics of mixed pebble beds for CFETR WCCB blanket

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Particuology 2024年第2期85卷 268-279页

作者： Yong liu Chongyang He cong Wang Lei Chen Songlin liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230027China Chengdu University Chengdu610106China Zhejiang Lab Hangzhou310000China

This paper presents the study of the dynamic characteristics of confined mixed pebble beds with different friction under different vibration conditions using the discrete element ***λsegre-gation index is used to quantify the degree of particle mixing or *** percolation,convection and diffusion mechanisms are responsible for the segregation patterns of the mixed *** results show the degree of segregation can be suppressed by decreasing the vibration acceleration or free space height below a *** simulation reveals the threshold of vibration acceleration or free space height both are related to the bed height increment which determines the strength of the percolation *** addition,the strength of percolation and convection becomes weaker by decreasing the friction of particles and walls,which makes the pebbled bed remains in a mixed state under *** findings are significant to clarify the main factors behind the three segregation mechanisms and hence provide solutions to retaining the mixed state of the Li2TiO3&Be12Ti mixed pebble bed.

关键词： Vibration Segregation Binary pebble bed Discrete element method

Brain Cognition Mechanism-Inspired Hierarchical Navigation Method for Mobile Robots

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Journal of Bionic Engineering 2024年第2期21卷 852-865页

作者： Qiang Zou Chengdong Wu Ming cong Dong liu Faculty of Robot Science and Engineering Northeastern UniversityShenyang110819China School of Mechanical Engineering Dalian University of TechnologyDalian116024China

Autonomous navigation is a fundamental problem in *** methods generally build point cloud map or dense feature map in perceptual space;due to lack of cognition and memory formation mechanism,traditional methods exist poor robustness and low cognitive *** a new navigation technology that draws inspiration from mammal’s navigation,bionic navigation method can map perceptual information into cognitive space,and have strong autonomy and environment *** improve the robot’s autonomous navigation ability,this paper proposes a cognitive map-based hierarchical navigation ***,the mammals’navigation-related grid cells and head direction cells are modeled to provide the robots with location *** then a global path planning strategy based on cognitive map is proposed,which can anticipate one preferred global path to the target with high efficiency and short ***,a hierarchical motion controlling method is proposed,with which the target navigation can be divided into several sub-target navigation,and the mobile robot can reach to these sub-targets with high confidence ***,some experiments are implemented,the results show that the proposed path planning method can avoid passing through obstacles and obtain one preferred global path to the target with high efficiency,and the time cost does not increase extremely with the increase of experience nodes *** motion controlling results show that the mobile robot can arrive at the target successfully only depending on its self-motion information,which is an effective attempt and reflects strong bionic properties.

关键词： Bionic navigation Spatial localization cells Global path planning Hierarchical motion controlling

Quasi-2D weak lensing cosmological constraints using the PDF-SYM method

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 44-58页

作者： Zhenjie liu Jun Zhang Hekun Li Zhi Shen cong liu Department of Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai 200240China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

Cosmic shear statistics,such as the two-point correlation function(2PCF),can be evaluated with the PDF-SYM method instead of the traditional weighted-sum *** makes use of the full PDF information of the shear estimators,and does not require weightings on the shear estimators,which can in principle introduce additional systematic *** work presents our constraints on S8and?mfrom the shear-shear correlations using the PDF-SYM *** data we use is from the z-band images of the Dark Energy Camera Legacy Survey(DECa LS),which covers about 10000 deg2with more than 100 million *** shear catalog is produced by the Fourier Quad method,and well tested on the real data itself with the field-distortion *** main approach is called quasi-2D as we do use the photo-z information of each individual galaxy,but without dividing the galaxies into redshift *** mainly use galaxy pairs within the redshift interval between 0.2 and 1.3,and the angular range from 4.7 to 180 *** analysis yields S8=0.762±0.026 and?m=0.234±0.075,with the baryon effects and the intrinsic alignments *** results are robust against redshift *** check the consistency of our results by deriving the cosmological constraints from auto-correlations ofγ1andγ2separately,and find that they are consistent with each other,but the constraints from theγ1component are much weaker than that fromγ*** implies a much worse data quality ofγ1,which is likely due to additional shear uncertainties caused by CCD electronics(according to the survey strategy of DECa LS).We also perform a pure 2D analysis,which gives S8=0.81_(-0.04)^(+0.03)and?m=0.25_(-0.05)^(+0.06).Our findings demonstrate the potential of the PDF-SYM method for precision cosmology.

关键词： weak lensing shear-shear correlations cosmological parameters observations analysis

Ferrite features in simulated transition zone of EH36 shipbuilding steel submerged arc welded by CaF_(2)-SiO_(2)-MnO fluxes

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Journal of Iron and Steel Research International 2024年第4期31卷 790-796页

作者： Ming Zhong Dong hu Da-ming Guo Somnath Basu cong Wang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076MaharashtraIndia

Ferrite features in the simulated transition zone welded with CaF_(2)-SiO_(2)-MnO fluxes containing various MnO contents have been *** laser scanning microscopy has been applied to simulate the thermal cycling of the transition zone and the phase transformations during cooling have been in-situ *** has been found that the appearance temperature for ferrite side plate decreases with increasing Mn content in the weld metals caused by MnO content ***,growth rates for both ferrite side plate and acicular ferrite are significantly enhanced with a higher Mn content of weld ***,from the statistical fractions of salient microstructures,for all samples,the acicular ferrite,grain boundary ferrite,and polygonal ferrite take over more than 90%.It has also been demonstrated that with the increase in Mn content,the ferrite side plate fraction increases slightly from 5%to 10%and the acicular ferrite fraction shows a tendency of first increasing and then decreasing,which experiences the maximum with the flux containing 30 wt.%*** phenomenon is believed to be controlled by the O and Mn contents in weld metals synergistically.

关键词： Submerged arc welding Transition zone Phase transformation Microstructure

The Largest Chinese Cohort Study Indicates Homologous Recombination Pathway Gene Mutations as Another Major Genetic Risk Factor for Colorectal Cancer with Heterogeneous Clinical Phenotypes

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Research 2024年第3期6卷 191-203页

作者： Yun Xu Kai liu cong Li Minghan Li Fangqi liu Xiaoyan Zhou Menghong Sun Megha Ranganathan Liying Zhang Sheng Wang Xin hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Tissue BankFudan University Shanghai Cancer CenterShanghaiP.R.China Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Precision Cancer Medical Center Fudan University Shanghai Cancer CenterShanghaiP.R.China

While genetic factors were associated with over 30% of colorectal cancer (CRC) patients, mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients. Besides, previous studies on hereditary CRC were largely designed to analyze germline mutations in patients with single genetic high-risk factor, which limited understanding of the association between genotype and phenotypes. From January 2015 to December 2018, we retrospectively enrolled 2,181 patients from 8,270 consecutive CRC cases, covering 5 categories of genetic high-risk factors. Leukocyte genomic DNA was analyzed for germline mutations in cancer predisposition genes. The germline mutations under each category were detected and analyzed in association with CRC susceptibility, clinical phenotypes, and prognoses. A total of 462 pathogenic variants were detected in 19.3% of enrolled CRC patients. Mismatch repair gene mutation was identified in 9.1% of patients, most prevalent across all high-risk groups. Homologous recombination (HR) gene mutations were detected in 6.5% of cases, penetrated in early-onset and extra-colonic cancer risk groups. Mutations in HR genes, including BARD1, RAD50, and ATM, were found to increase CRC risk with odds ratios of 2.8-, 3.1-, and 3.1-fold, respectively. CRC patients with distinct germline mutations manifested heterogeneous phenotypes in clinicopathology and long-term prognoses. Thus, germline mutation screenings should be performed for CRC patients with any of those genetic risk factors. This study also reveals that HR gene mutations may be another major driver for increased CRC risk.

关键词： susceptibility category Major

Anti-saturation fault-tolerant adaptive torsional vibration control with fixed-time prescribed performance for rolling mill main drive system

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Journal of Iron and Steel Research International 2024年第3期31卷 660-669页

作者： Shuang liu Chen Du cong Zhang Zhen-hua Bai Key Lab of Industrial Computer Control Engineering of Hebei Province Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina

An anti-saturation fault-tolerant adaptive torsional vibration control method with fixed-time prescribed performance for the rolling mill main drive system(RMMDS)was investigated,which is affected by control input saturation,actuator faults,sensor measurement errors,and parameter ***,we gave a continuously differentiable saturation function to approximate the control input saturation characteristic of the RMMDS,translating the saturation characteristic into the matched uncertainty and unknown time-varying gain in the ***,an RMMDS mathematical model with unmatched uncertainty and unknown time-varying gain was developed,taking into account the presence of control input saturation,actuator faults,sensor measurement errors,and parameter *** on the established mathematical model,an error transformation model of the roll speed tracking was constructed by the equivalent error transformation *** to the error transformation model,a barrier Lyapunov function and a novel adaptive controller were studied to ensure that the roll speed tracking error always evolves inside a fixed-time asymmetric ***,numerical simulations were performed in Matlab/Simulink to verify the effectiveness and superiority of the proposed control method in suppressing the RMMDS torsional vibration.

关键词： Fixed-time prescribed performance Control input saturation Actuator fault Unknown time-varying gain Adaptive control Asymmetric constraint