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Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study

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Journal of Geriatric Cardiology 2024年第3期21卷 340-348页

作者： Jia-Yin CAI Xin WANG cong-Yi ZHENG Xue CAO Zhen HU Run-Qing GU Yi-Xin TIAN ye TIAN Lan SHAO Lin-Feng ZHANG Zeng-Wu WANG Division of Prevention and Community Health National Center for Cardiovascular DiseaseNational Clinical Research Center of Cardiovascular DiseaseState Key Laboratory of Cardiovascular DiseaseFuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijingChina

BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally *** conducted a Mendelian Randomization(MR)study to explore causal relationships between loneliness and isolation and multiple *** Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide association study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS *** data for 15 CVDs were also obtained from the IEU GWAS *** used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on ***'s Q test and MR-Egger intercept test were used to evaluate the heterogeneity and *** MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR=1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR=1.04;95%CI:1.02-1.06),myocardial infarction(OR=1.02;95%CI:1-1.04)and angina(OR=1.04;95%CI=1.02-1.06).No heterogeneity and pleiotropy effects were found in this *** Causal relationship of loneliness and isolation with CVDs were found in this study.

关键词： diseases cardiovascular angina

Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis

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Engineered Regeneration 2024年第1期5卷 1-10页

作者： Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng Xupeng Chai cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru Gou Zhaoming ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000PR China Orthopedics Research Institute of Zhejiang University Hangzhou 310000PR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou 310000PR China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang-California International Nanosystem InstituteZhejiang UniversityHangzhou 310058PR China Department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003PR China

Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone *** we combine β-TCP with 6 mol%magnesium-doped calcium silicate(Mg6)at three different ratios(TCP,TCP+15%Mg6,TCP+85%Mg6)to find an appropriate ratio which can exert considerable influence on bone *** this study,the bioceramic scaffolds were assessed for mechanical strength,bioactive ion release,biocompatibility,and osteogenic capacity through in vitro ***,the potential for promoting bone regeneration was investigated through in vivo implantation of porous tube-like *** results showed that the compressive strength increased with the augmentation of Mg6 *** the compressive strength of the TCP+85%Mg6 group reached 38.1±3.8 MPa,three times that of the other two ***,extensive in vivo investigations revealed that the TCP+85%Mg6 bioceramic scaffolds were particularly beneficial for the osteogenic capacity of critical-sized femoral defects(20 mm in length).Altogether,magnesium doping in bioceramic implants is a promising strategy to provide stronger mechanical support and enhance osteogenesis to accelerate the repair of large defects.

关键词： Bioceramic tubes Mg-doped calcium silicate Porous structural stability Large segmental bone defects Digital light processing

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国内首型全通透载客潜水器的设计与研制

中国造船 2019年第3期60卷 113-120页

作者：刘帅叶聪汤国伟程斐姜磊中国船舶科学研究中心无锡214082 深海载人装备国家重点实验室无锡214082

为促进我国深海载人潜水器成果转化,填补国内水下高端旅游装备的空白,设计和研制了国内首型全通透载客潜水器。该潜水器由总体结构、电气控制、压载、环控等几大系统组成。总体布局设计以乘客观察视野最大化为目标。通过深入研究大尺寸... 详细信息

为促进我国深海载人潜水器成果转化,填补国内水下高端旅游装备的空白,设计和研制了国内首型全通透载客潜水器。该潜水器由总体结构、电气控制、压载、环控等几大系统组成。总体布局设计以乘客观察视野最大化为目标。通过深入研究大尺寸有机玻璃观察窗与金属窗座之间的变形协调规律,攻克了多段柱形有机玻璃观察窗连接设计及装配等技术难点。为确保电气、控制系统的安全性,充分采用冗余设计理念,广泛应用状态及故障监测、隔离技术。为有效确保乘员安全,设计研制了多种高可靠性和安全性的应急自救装置。水池试验和海上试验充分验证了该潜水器优异的总体性能。论文总结了该全通透载客潜水器各系统主要设计理念,对主要研制过程及意义进行了简要的说明,旨在为今后类似潜水器的研制提供借鉴。

关键词：潜水器全通透海洋旅游

模块化DF_(10DDA)型机车车体的设计

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内燃机车 2008年第11期 6-7,11页

作者：丛茂野大连机车车辆有限公司辽宁大连116022

介绍了DF10DDA型调车机车车体的设计,主要包括其总体布局、性能参数、结构特点等。

关键词： DF10DDA型机车车体底架司机室模块化

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载人潜水器舱室设备智能布局设计方法研究

中国造船 2013年第3期54卷 147-154页

作者：宗立成叶聪余隋怀陈登凯西北工业大学机电学院工业设计研究所西安710072 中船重工702研究所无锡214082

载人潜水器舱室设备智能布局是一种基于知识的智能化过程,以往的载人潜水器舱室CAD系统通常采用交互式输入和修改,不能从全局最优化的思想支持载人潜水器舱室设计全过程。将智能技术引入系统载人潜水器舱室布局设计方法中,可以推动船舶... 详细信息

载人潜水器舱室设备智能布局是一种基于知识的智能化过程,以往的载人潜水器舱室CAD系统通常采用交互式输入和修改,不能从全局最优化的思想支持载人潜水器舱室设计全过程。将智能技术引入系统载人潜水器舱室布局设计方法中,可以推动船舶智能设计、智能制造、智能工程的全面发展。论文在研究遗传算法的基础上,提出了基于Pareto的PGA算法进行多目标优化计算,建立载人潜水器舱室布局优化数学模型,并使用PGA进行求解。经设计委托方评审,获得的计算结果符合设计要求,该方法使整个项目的设计效率明显提高。

关键词：载人潜水器舱室布局优化智能设计 PGA

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei ye cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

Cosmetics use-related adverse events

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Chinese Medical Journal 2019年第17期132卷 2135-2136页

作者： Su-Lian Yang Yue Zheng Yun-Qing Zhang cong-Xiu ye Jin-Ling Yi Yu-Fang Liu Wei Lai Department of Dermatology and Venereology The Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

To the Editor: Cosmetics (non-prescription skin care products) use-induced adverse events could present as skin erythema, papules, pruritus, dryness, desquamation, and abnormal discoloration. Non-medicated cosmetics use is more and more common in the China, but little is known about the characteristics of cosmetic-related adverse events.

关键词： pruritus desquamation erythema

2019年—2020年秋、冬季淮南市灰霾过程拉曼-米气溶胶雷达观测研究

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光谱学与光谱分析 2021年第8期41卷 2484-2490页

作者：张帅王明施奇兵叶丛雷刘东合肥中科光博量子科技有限公司安徽合肥230088 中国科学院安徽光学精密机械研究所中国科学院大气光学重点实验室安徽合肥230031

拉曼-米气溶胶激光雷达因无需假设雷达比,而在准确测量气溶胶消光系数方面较传统米散射雷达更具优势。在合肥市的外场探空比对实验结果表明,2.5 km以下拉曼-米激光雷达反演的消光系数更为准确,相差可达0.04 km^(-1),且获取的水汽混合比... 详细信息

拉曼-米气溶胶激光雷达因无需假设雷达比,而在准确测量气溶胶消光系数方面较传统米散射雷达更具优势。在合肥市的外场探空比对实验结果表明,2.5 km以下拉曼-米激光雷达反演的消光系数更为准确,相差可达0.04 km^(-1),且获取的水汽混合比廓线与探空数据一致性良好。利用该技术获得了2019年—2020年秋、冬季期间淮南市的气溶胶消光系数廓线和边界层高度等数据,进而对空气质量污染期间的污染类型(本地污染排放、传输型污染、传输型污染叠加本地污染累积)和颗粒物的时空演变特征进行了统计分析。结果显示该市在此期间受到20次细颗粒传输和8次沙尘传输影响。其中沙尘传输主要来自西北方向,由高空沉降至近地面(厚度达2 km以上),平均大气边界层高度达1.23 km以上。在典型细颗粒传输过程中,边界层高度基本维持在1.1~1.2 km左右,近地面风向以西北风为主,少量东南风主导。在细颗粒传输叠加本地累积的复合污染过程中,边界层高度略低(平均高度在1.0 km左右),近地面风向以偏北风为主,污染气团自低空出现后,其下沿高度持续降低并最终与近地面污染耦合。在细颗粒导致的重污染过程中,近地面水汽混合比及相对湿度数据与PM_(2.5)的浓度变化趋势一致性良好,说明颗粒物的吸湿性增长和气态污染物二次转化过程可能助推了PM_(2.5)的生成,加重污染形势。对边界层的统计结果表明,其高度变化对污染气团的沉降和近地面污染累积有十分明显的正相关性。秋冬季期间,该市的小时边界层高度大部分分布在1.6 km以下,平均为1.0 km左右,小时空气质量达重度污染期间,边界层高度普遍不足0.6 km。从气团后向轨迹模拟结果来看,该市空气质量为中度及以上污染期间的气流主要来自偏北方向,少量来自东南沿线,因而污染期间需要加强市区偏北方向污染源的管控,防止叠加影响。

关键词：拉曼-米气溶胶激光雷达灰霾沙尘气溶胶淮南大气探测

Optimization Algorithm and Simulation Analysis of Feedback Control Parameters of Equilibrium Point about Linear Spring-connected Double Inverted Pendulum

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Optimization Algorithm and Simulation Analysis of Feedback C...