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Syn3,a newly developed cyclic peptide and BDNF signaling enhancer,ameliorates retinal ganglion cell degeneration in diabetic retinopathy

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Protein & Cell 2024年第11期15卷 858-865页

作者： Ke-ran Li Meng-Jia Huan Jin Yao Jia-jun Li Yuan cao Suyu Wang Mandar TNaik Yuan Fang John Marshall Chang-gong Lan cong cao The Affiliated Eye Hospital Nanjing Medical UniversityNanjing 210029China Department of Ophthalmology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Molecular Pharmacology Physiology and BiotechnologyBrown UniversityProvidenceRI 02912United States Department of Ophthalmology&Vision Science Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200433China Department of Joint Surgery and Geriatric Orthopedics Affiliated Hospital of YouJiang Medical University for NationalitiesGuangxi Key Laboratory of Basic and Translational Research of Bone and Joint Degenerative DiseasesGuangxi Biomedical Materials Engineering Research Center for Bone and Joint Degenerative DiseasesBaise 533000China Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversityInstitution of NeuroscienceSoochow UniversitySuzhou 215031China

Dear Editor,Diabetic retinopathy(DR)remains a leading cause of irreversible blindness in adults worldwide(Sabanayagam et al.,2019).Increasing evidence suggests that visual deficits are closely associated with neurodegeneration,especially the synaptic loss and degeneration of retinal ganglion cells(RGCs)(Kern and Barber,2008).Neurotrophic factors play a key role in supporting the survival of RGCs(Kimura et al.,2016)and brain-derived neurotrophic factor(BDNF)stands out as a crucial neurotrophin vital for RGCs(Kimura et al.,2016).In vivo studies have demonstrated that intravitreal administration of BDNF enhances the survival of axotomized RGCs in rats,and astrocytes designed to secrete BDNF promote RGC survival in vitro(Castillo et al.,1994).

关键词： degeneration retinopathy

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Scientific Value Weights more than Being Open or Toll Access:An analysis of the OA advantage in Nature and Science

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Journal of Data and Information Science 2021年第4期6卷 62-75页

作者： Howell Y.Wang Shelia X.Wei cong cao Xianwen Wang Fred Y.Ye International Joint Informatics Laboratory&Jiangsu Key Laboratory of Data Engineering and Knowledge Service School of Information ManagementNanjing UniversityNanjing 210023China Nottingham University Business School China University of Nottingham Ningbo ChinaNingbo315100China WISE Lab. Dalian University of TechnologyDalian 116024China

Purpose:We attempt to find out whether OA or TA really affects the dissemination of scientific ***/methodology/approach:We design the indicators,hot-degree,and R-index to indicate a topic OA or TA ***,according to the OA classification of the Web of Science(WoS),we collect data from the WoS by downloading OA and TA articles,letters,and reviews published in Nature and Science during 2010–*** papers are divided into three broad disciplines,namely biomedicine,physics,and ***,taking a discipline in a journal and using the classical Latent Dirichlet Allocation(LDA)to cluster 100 topics of OA and TA papers respectively,we apply the Pearson correlation coefficient to match the topics of OA and TA,and calculate the hot-degree and R-index of every OA-TA topic ***,characteristics of the discipline can be *** qualitative comparison,we choose some high-quality papers which belong to Nature remarkable papers or Science breakthroughs,and analyze the relations between OA/TA and citation ***:The result shows that OA hot-degree in biomedicine is significantly greater than that of TA,but significantly less than that of TA in *** on the R-index,it is found that OA advantages exist in biomedicine and TA advantages do in ***,the dissemination of average scientific discoveries in all fields is not necessarily affected by OA or ***,OA promotes the spread of important scientific discoveries in high-quality *** limitations:We lost some citations by ignoring other open sources such as arXiv and *** limitation came from that Nature employs some strong measures for access-promoting subscription-based articles,on which the boundary between OA and TA became *** implications:It is useful to select hot topics in a set of publications by the hotdegree *** finding comprehensively reflects the differences of OA and TA in different disciplines,which is a u

关键词： Open access Toll access Scientific discovery Academic dissemination Data analysis

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Chemical characteristics of haze particles in Xi＇an during Chinese Spring Festival： Impact of fireworks burning

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Journal of Environmental Sciences 2018年第9期30卷 179-187页

作者： Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang cong cao Jin Li Shuagshuang Ge Yuning Xie Xinpei Wang Guoyan Xue State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and Physics Institute of Earth Environment Chinese Academy of Sciences Xi' an 710061 China Key Laboratory of Geographic Information Science of the Ministry of Education School of Geographic Sciences East China Normal University Shanghai 210062 China Center for Excellence in Regional Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China University of Chinese Academy of Sciences Beijin9 100049 China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China

Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year （LNY） period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM2.5 samples in Xi＇an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content （LWC） of the fine aerosols. PM2.5 during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard （75 μg/m^3）. K^＋（28 wt.% of the total ion mass） was the most abundant ion in the LNY period, followed by SO^2-4 （25 wt.%） and C1^- （18 wt.%）. In contrast, NO^-3 （34 wt.%） was the most abundant species in the haze periods （hourly PM2.5 〉 75 μg/m^3）, followed by SO^2-4 （29.2 wt.%） and NH^＋4 （16.3 wt.%）, while SC94 （35 wt.%） was the most abundant species in the clean periods （hourly PM2.5 〈 75 μg/m^3）, followed by NO^-3 （23.1 wt.%） and NH^＋4 （11 wt.%）. Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K2SO4 and KC1, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO^-3/SO^2-4 and NH^＋4/SO^2-4 indicated that heterogeneous reaction of HNO3 with NH3 was an important formation pathway of particulate nitrate and ammonium during the LNY period.

关键词： Inorganic ions Aerosol acidity Liquid water content Composition and source Nitrate formation

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Gap induced mode evolution under the asymmetric structure in a plasmonic resonator system

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Photonics Research 2017年第2期5卷 113-118页

作者： YONG-PAN GAO TIE-JUN WANG cong cao CHUAN WANG State Key Laboratory of Information Photonics and Optical Communications and School of Science Beijing University of Posts and Telecommunications School of Ethnic Minority Education Beijing University of Posts and Telecommunications

The modulation of resonance features in microcavities is important to applications in *** on the asymmetric whispering-gallery modes(WGMs)in a plasmonic resonator,we theoretically studied the mode evolution in an asymmetric WGM plasmonic *** the gap or nano-scatter in the plasmonic ring cavity,the symmetry of the system will be broken and the standing wave in the cavity will be *** on this asymmetric structure,the output coupling rate between the two cavity modes can also be ***,the proposed method could further be applied for sensing and detecting the position of defects in a WGM system.

关键词： mode Gap induced mode evolution under the asymmetric structure in a plasmonic resonator system

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《巴门尼德》与前苏格拉底的“存在之战”

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现代哲学 2020年第6期 90-95页

作者：曹聪西安交通大学人文与社会科学学院哲学系西安710049

本文以柏拉图的埃利亚对话关于前苏格拉底哲学“存在之战”讨论为切入点,考察《巴门尼德》中少年苏格拉底引入形相的背景———前苏格拉底哲学和智术师运动,同时结合文本辨析柏拉图对存在派与流变派的不同态度及其原因。本文认为,为应... 详细信息

本文以柏拉图的埃利亚对话关于前苏格拉底哲学“存在之战”讨论为切入点,考察《巴门尼德》中少年苏格拉底引入形相的背景———前苏格拉底哲学和智术师运动,同时结合文本辨析柏拉图对存在派与流变派的不同态度及其原因。本文认为,为应对前苏格拉底哲学的“存在之战”,柏拉图接受并改造了埃利亚哲学,尤其是巴门尼德对“非存在”和“意见”的基本判断,试图通过形相论拯救“真意见”。与此同时,柏拉图借《巴门尼德》传达出一种对存在论探究路向的态度,形相论最终仍难以克服前苏格拉底哲学引发的困难。

关键词：《巴门尼德》前苏格拉底形相存在流变

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Gai1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis

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Protein & Cell 2023年第3期14卷 217-222页

作者： Gang Xu Li-na Qi Mei-qing Zhang Xue-yun Li Jin-long Chai Zhi-qing Zhang Xia Chen Qian Wang Ke-ran Li cong cao Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhou 215004China Department of Orthopedics The Affliated Lianyungang Hospital of Xuzhou Medical UniversityThe First Affliated Hospital of Kangda College of Nanjing Medical UniversityLianyungang 222002China Department of Anesthesiology Children's Hospital of Soochow UniversitySuzhou215025China The Affliated Eye Hospital Nanjing Medical UniversityNanjing210029China

Dear Editor,R-spondin3(RSPO3)is essential for vascular development and *** RSPO3-knockout embryos revealed severe vascular defects in the placenta(Aoki et al.2007).In both Xenopus and murine embryos,RSPO3 KO led to significant vascular defects(Kazanskaya et al.2008)and embryonic death(Kazanskaya et al.2008).In the placenta,RSPO3 could promote vascular endothelial growth factor(VEGF)expression(Kazanskaya et al.2008).RSPO3 is a ligand of low-density lipoprotein receptor-related protein 6(LRP6)and leucine-rich repeat G protein-coupled receptor 4(LGR4)to form a multiple ligands-receptors-cluster with Wnt and frizzled(FzD),thereby activating and amplifying downstreamβ-catenin signaling(in and Yoon 2012;Tocci et al.2020).

关键词： al. angiogenesis lipoprotein

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《巴门尼德》与柏拉图式辩证术

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世界哲学 2020年第1期 45-54,160页

作者：曹聪扬州大学社会发展学院

《巴门尼德》的主题是形相论(理念论)与辩证术,柏拉图式辩证术问题与他应对智术师运动及其背后的前苏格拉底“存在之战”直接相关。本文考察柏拉图改造修辞术为辩证术的过程和哲学意义,以此定位形相与辩证术的位置。《巴门尼德》的形相... 详细信息

《巴门尼德》的主题是形相论(理念论)与辩证术,柏拉图式辩证术问题与他应对智术师运动及其背后的前苏格拉底“存在之战”直接相关。本文考察柏拉图改造修辞术为辩证术的过程和哲学意义,以此定位形相与辩证术的位置。《巴门尼德》的形相论批判和辩证术展示指向共同的目的,即呈现逻辑推理与范畴描述对于人类认识存在的作用及限度,并由此凸显辩证术对于哲学探究新路彳圣的意义,这篇对话传达了柏拉图对人类认识与存在之问的深刻反思。

关键词：柏拉图《巴门尼德》形相(理念) 辩证术

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自然教育与人为技艺——卢梭《爱弥儿》教育方案的困境

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全球教育展望 2020年第9期49卷 55-65页

作者：曹聪西安交通大学人文与社会科学学院西安710049

卢梭在《爱弥儿》中呈现了一种反对柏拉图式古典教育传统的自然教育,这种教育思想对现代教育理论影响深远。自然教育是卢梭政治设计的重要部分,目的是通过教育新人解决个人与社会的冲突,其具体教育目标是把普通儿童塑造为既是自然人又... 详细信息

卢梭在《爱弥儿》中呈现了一种反对柏拉图式古典教育传统的自然教育,这种教育思想对现代教育理论影响深远。自然教育是卢梭政治设计的重要部分,目的是通过教育新人解决个人与社会的冲突,其具体教育目标是把普通儿童塑造为既是自然人又是好公民的独立个体。本文通过细致分析《爱弥儿》各卷论证的关键点,剖析这一教育方案的诸多矛盾与困境,试图揭示这些困境的根源是卢梭思想的内在矛盾。

关键词：卢梭《爱弥儿》自然教育

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Coordinated multi-sectoral efforts needed to address the COVID-19 pandemic:lessons from China and the United States

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Global Health Research and Policy 2020年第1期5卷 235-237页

作者： Zhuo Chen cong cao Gonghuan Yang College of Public Health University of GeorgiaAthensGAUSA University of Nottingham Ningbo China NingboZhejiangChina Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina

The COVID-19 pandemic has caused staggering human and economic *** outline four key lessons learned from efforts to address the pandemic in China and the ***,effective surveillance,reporting,and contact tracing are needed to contain an epidemic at its emergence and to mitigate its impact at a later ***,multi-sectoral efforts to offer incentives for those with no or minor symptoms to seek care and to quarantine themselves are critical,which would need concerted efforts from payers,providers,and public ***,sustained and routine prevention efforts involving both the public and the health systems will prove to be useful in times of a ***,a strong public health system is essential and will be appreciated at times of *** multi-sectoral efforts are required to address COVID-19 pandemic with strong leadership from the public health sector.

关键词： COVID-19 Public health system Public health surveillance Multi-sectoral efforts

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下降到城邦的哲学——柏拉图《帕默尼德》的开篇

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兰州大学学报（社会科学版） 2012年第2期40卷 33-37页

作者：曹聪中山大学哲学系广东广州510275

《帕默尼德》被称做柏拉图最难解的对话之一,前后两个部分在形式与内容上看似极不平衡,纯哲学的逻辑讨论包裹在戏剧情节下,开篇的情节看似离题,实则是理解第二部分的钥匙。开篇戏剧场景的设置包含了柏拉图对哲学基本处境的深刻洞察。在... 详细信息

《帕默尼德》被称做柏拉图最难解的对话之一,前后两个部分在形式与内容上看似极不平衡,纯哲学的逻辑讨论包裹在戏剧情节下,开篇的情节看似离题,实则是理解第二部分的钥匙。开篇戏剧场景的设置包含了柏拉图对哲学基本处境的深刻洞察。在《帕默尼德》的开场,克拉佐枚奈的爱智者与埃利亚的爱智者都被置于雅典城邦的政治中心,哲学的探问处于宗教节庆的背景之下。

关键词：柏拉图《帕默尼德》苏格拉底逻各斯爱欲城邦宗教

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