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Genetic regulators of cytokine responses upon BCG vaccination in children from West Africa

Journal of Genetics and Genomics 2023年第6期50卷 434-446页

作者： collins k.boahen S.J.C.F.M.Moorlag kristoffer Jarlov Jensen Vasiliki Matzaraki Stephanie Fanucchi Ivan Monteiro Charlotte de Bree Ezio T.Fok Musa Mhlanga Leo A.B.Joosten Peter Aaby Christine Stabell Benn Mihai G.Netea Vinod kumar Department of Internal Medicine and Radboud Institute of Molecular Life Sciences(RIMLS) Radboud University Medical CenterNjmegen6525 HPthe Netherlands Department of Internal Medicine and Radboud Center for Infectious Diseases(RCI) Radboud University Medical CenterNjmegen6525 HPthe Netherlands Odense Patient Data Explorative Network University of Southern Denmark/Odense University HospitalOdenseDK-5000Denmark Center for Clinical Research and Prevention Frederiksberg and Bispebjerg HospitalDK-2000FrederiksbergDenmark Lemba Therapeutics Nijmegen6525 GAthe Netherlands Bandim Health Project Indepth NetworkBissaucodex 1004Guinea-Bissau Epigenomics&Single Cell Biophysics Group Department of Cell Biology FNWIRadboud Institute for Molecular Life Sciences(RIMLS)Njmegen6525 HPtheNetherlands Department of Human Genetics Radboud University Medical Center6525 HPthe Netherlands Bandim Health Project Statens Serum InstitutCopenhagen SDK-2300Denmark Danish Institute for Advanced Study University of Southern DenmarkOdenseDK-5000Denmark Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical CenterNijmegen6525 HPthe Netherlands Department for Immunology and Metabolism Life and Medical Sciences Institute(LIMES)University of BonnGermany University of Groningen University Medical Center GroningenDepartment of GeneticsGroningen970o0 RBthe Netherlands Nitte(Deemed to be University) Nitte University Centre for Science Education and Research(NUCSER)Medical Sciences ComplexDeralakatteMangalore575018India

Genetic variation is a key factor influencing cytokine production capacity,but which genetic loci regulate cytokine production before and after vaccination,particularly in African population is ***,we aimed to identify single-nucleotide polymorphisms(SNPs)controlling cytokine responses after microbial stimulation in infants of West-African ancestry,comprising of low-birth-weight neonates randomized to bacillus Calmette-Gue rin(BCG)vaccine-at-birth or to the usual delayed ***-wide cytokine cytokine quantitative trait loci(cQTL)mapping revealed 12 independent loci,of which the LINC01082-LINC00917 locus influenced more than half of the cytokine-stimulation pairs ***,nine distinct cQTLs were found among infants randomized to *** validation confirmed that several complement genes affect cytokine response after BCG *** observed a limited overlap of common cQTLs between the West-African infants and cohorts of Western European *** data reveal strong population-specific genetic effects on cytokine production and may indicate new opportunities for therapeutic intervention and vaccine development in African populations.

关键词： Cytokines Geneticvariation West Africa Immunogenomics QTL BCG

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Spatial analysis of synergies and trade-offs between the Sustainable Development Goals (SDGs) in Africa

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Geography and Sustainability 2022年第3期3卷 220-231页

作者： Adams Osman Emmanuel Abeashi Mensah collins Adjei Mensah Yaw Asamoah Suleman Dauda kofi Adu-boahen Charles Atanga Adongo Department of Geography Education Faculty of Social Sciences EducationUniversity of EducationWinnebaP.O.Box 25WinnebaGhana Department of Geography and Regional Planning Faculty of Social SciencesUniversity of Cape CoastPrivate Mail BagCape CoastGhana Department of Tourism and Hospitality Management Faculty of Social SciencesUniversity of Cape CoastPrivate Mail BagCape CoastGhana Schools of Tourism and Hospitality University of JohannesburgP.O.Box 524Auckland Park 2006South Africa Emperiks Research Limited Cape Coast Stadium AvenueCape CoastGhana

Challenges faced by African countries in achieving the goals of sustainable development are similar and trans-boundary. Previous analysis of Africa’s progress on the Sustainable Development Goals (SDGs) has largely beennon-spatial, reducing the ability to find spatial relationships between countries and SDGs to help cooperationand proffer country-specific interventions. This study adopted techniques of exploratory and inferential spatialstatistics to assess the successes of African countries from 2016 to 2020 in achieving the goals of sustainable de-velopment. Also, the study sought to understand how the spatial synergies and trade-offs between SDGs vary percountry and time. The results revealed that spatial hotspots of countries with high SDGs scores were mostly con-fined to northern African countries with significant coldspots within central and eastern Africa and few patchesin western and southern Africa for 2016. In 2020, the number of countries forming hotspots reduced, with Cen-tral African countries as significant cold spots. Five main spatial relationships: positive linear, negative linear,concave, convex and undefined complex, were found among countries and the SDGs. However, these spatialrelationships were fluid as they changed over time and with different levels of influence from 2016 to *** study concludes that generic solutions and policies by development agencies, governments, developmentfinance instiutions and other impact investors will not be enough in achieving the SDGs because of the spatialheterogeneity of the continent. Tailored and country-specific policies based on results of spatial statistics matter.

关键词： Africa Development Sustainable development Spatial analysis Hotspots Random forest

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