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Nine-year experience of doxorubicin-eluting beads chemoembolization for hepatocellular carcinoma

Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 493-498页

作者： Alvin Ho-Kwan Cheung colin siu-chi lam Henry Shiu-Cheung Tam Tan-To Cheung Roberta Pang Ronnie Tung-Ping Poon Department of Surgery University of Hong Kong and Queen Mary Hospital

BACKGROUND: Chemoembolization with doxorubucin-eluting beads (DEB) has been used to treat hepatocellular carcinoma (HCC) since 2007. This study compared the efifcacy and sur-vival between transarterial chemoembolization (TACE) with DEB and conventional approach (cTACE) in HCC treatment. METHODS: This retrospective case-control study compared the overall survival and tumor response of HCC patients to cTACE (n=190) and DEB (n=143) by the reassessment of com-puted tomography and serum alpha-fetoprotein (AFP). Mul-tivariate analysis was used to determine the factors affecting tumor response. RESULTS: The median post-treatment to pre-treatment AFP level was 0.8 for a DEB session (n=258) and 1.0 for a cTACE session (n=452), showing a signiifcantly greater decrease in AFP after DEB (Pchieved objective response (complete and partial) compared with those in the cTACE group (Pchieving at least one objective tumor response in a patient when compared to cTACE (P80 months after the ifrst TACE session in the DEB group. CONCLUSION: DEB is a safe alternative to cTACE in HCC pa-tients with better therapeutic efifcacy.

关键词： doxorubicin-eluting beads transarterial chemoembolization hepatocellular carcinoma

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Mismatch repair enzyme expression in primary and castrate resistant prostate cancer

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Asian Journal of Urology 2016年第4期3卷 223-228页

作者： Belinda Nghiem Xiaotun Zhang Hung-Ming lam Lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson colin CPritchard Colm Morrissey Department of Urology University of WashingtonSeattleWAUSA State Key Laboratory of Quality Research in chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao(SAR)China Department of Pathology University of WashingtonSeattleWAUSA Divison of Human Biology Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Medicine University of WashingtonSeattleWAUSA Department of Laboratory Medicine University of WashingtonSeattleWAUSA

Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 ***(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression *** between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were ***:There was no correlation between levels of MMR protein and *** of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,***2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC *** of individual MMR proteins did not correlate with BCR or time from diagnosis to *** absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression *** finding correlated with microsatellite instability previously reported in this CRPC cohort.

关键词： Mismatch repair Castration resistant prostate cancer MLH1 MSH2 MSH6 PMS2

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