检索结果-南通市图书馆

International Journal of Geosciences 2024年第8期15卷 632-666页

作者： colin michael jones Retired Cambridge UK

The Roaches Grit in the UK Pennine Basin was a complex deep water deltaic sequence deposited during the Late Carboniferous glacial period. The channels of the upper part of the Roaches Grit, deposited towards the end of the cyclothem after the eustatic minimum, contain evidence for very high seasonal discharges related to strong monsoon rainfall in the catchment areas. In some channels, intense turbulence near the delta front, led to knick point recession and deep incision. These channels were filled with sediments during reduced discharge, including very large sets of cross-bedding up to 16 m thick. Channels were short-lived with frequent avulsions. Over time slightly lower discharges formed laterally migrating channels dominated by bar forms. Different discharge-controlled processes operated on the reactivated delta slope. Incised channels generated turbidity currents during floods which transported sediments directly into the basin far from the delta. Migrating channels built mouth bars;resedimentation during floods formed density currents which then deposited sediment on the lower parts of the slope.

关键词： Carboniferous Delta Climate Monsoon Rainfall ITCZ Precession

Climatic Influences on Upper Carboniferous (Serpukhovian to Mid-Bashkirian) Sedimentary Sequences in the UK Pennine and Other European Basins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Geosciences 2022年第8期13卷 715-778页

作者： colin michael jones Cambridge UK

Upper Carboniferous successions in European sedimentary basins contain cyclothems related to glacial cycles of approximately 100 Ky duration. Within the UK Pennine Basin both simple and complex cyclothems are recognized. In the latter, mid-cycle deltas were flooded by sea-level rises, possibly related to short period orbital forcing events. They were followed by late cycle forced regression delta channels and then by incised coarse-grained channels active after the glacial maximum. Other European successions commonly contain coarse incised channel fills in the same cyclothems;these were deposited during colder glacial periods. Simple cyclothems formed during warmer periods contain only lobate mid-cycle deltas. The distribution of different cyclothem types is not random. Correlation with the eastern Australian succession using revised published radiometric dates from Eastern Europe suggests that the early Namurian C1 glaciation in Australia correlates with a group of Pennine complex cycles of late Pendleian to early Arnsbergian age. The C2 glaciation began just prior to the late Kinderscoutian and possibly lasted into the early Langsettian;the Pennine succession shows evidence for a number of colder periods with complex cycles, especially in the late Kinderscoutian and mid Marsdenian. The intervening period, particularly from Alportian to mid Kinderscoutian was warmer.

关键词： Carboniferous Climate Glacial Cyclicity Pennines Europe

Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 9031-9043页

作者： Narsimha Mamidi michael Poellmann Kaila Javius-jones KiChang Nam Seungpyo Hong Wisconsin Center for NanoBioSystems University of Wisconsin-MadisonMadisonWI 53705USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Department of Medical Engineering College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Pharmacy Yonsei UniversityIncheon 21983Republic of Korea Lachman Institute for Pharmaceutical Development University of Wisconsin-MadisonMadisonWI 53705USA

Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical ***,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a major *** response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side *** address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target *** review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response ***,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are *** also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关键词： cancer immunotherapy drug delivery hydrogels immunotherapeutic agents immune modulation clinical outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sanya Beyond the Sea

China Weekly 2024年第7期 60-61页

作者： michael jones 不详

Sanya,the tropical paradise on the southern tip of the island province of Hainan,has long been a destination for those in China seeking rest,relaxation and *** miles of quiet beaches,golden sands,and magnificent palm ... 详细信息

关键词： seeking island relaxation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lost Horizons

China Weekly 2024年第4期 60-61页

作者： michael jones 不详

A trip off the beaten track in Xizang Autonomous Region will reward with stunning sights and isolated monasteries in the Tibetan grasslands and mountains.

关键词： mountains Tibetan sights

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arches to the Past

China Weekly 2024年第2期 60-61页

作者： michael jones 不详

Visiting Zhujiajiao ancient water town,reachable by metro,provides a perfect place to get a taste for Qing-era history,as well as temples,museums and the post office。I't is strange how the most alien of places can sometimes feel the most like *** is exactly how I felt when I first visited Zhujiajiao,and it is what has kept me revisiting year after year ever *** is a classic Chinese water town located in the Qingpu District of *** was founded over 1,700 years ago and developed as a trading center for businesses specializing in rice and ***,the small town has a population of less than 100,000 people,who are often dwarfed by the number of visiting tourists,especially on public holidays.

关键词： trading visiting founded

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gants of the Past

China Weekly 2024年第1期 60-61页

作者： michael jones 不详

The ancient statues of southwestern China are an authentic reminder of the pinnacle of Buddhist rock carving.

关键词： authentic southwestern ancient

Sun Yat-sen Sites:Revolutionary Roads

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Weekly 2024年第8期 60-61页

作者： michael jones 不详

Dr Sun Yat-sen(1866-1925)is a monumental figure in Chinese *** is held in high esteem by Chinese people across the Chinese mainland and many other regions and countries,as well as among Chinese *** is regarded as a revolutionary,a visionary and a *** might explain why so many cities in China promote tourist attractions connected to Sun's life and *** story of Sun's life is not only historically important,it is also fascinating,especially for those who are interested in the Chinese revolution of 1911 and the foundation of the Republic of China.

关键词： evolutionary mainland attraction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laid-back Lamma

China Weekly 2024年第9期 60-61页

作者： michael jones 不详

Away from the frenetic pace of Hong Kong,no-car Lamma lsland is an oasis of calm with great food options,treks,beaches and a walk on the wild side Hong Kong is a dynamic and creative city,centered around a vibrant and bustling *** times,the city can provide a unique rush of *** can be empowering,exciting and ***,the dense city center also has the ability to drain you of all your energy,especially on an oppressively hot summer's day.

关键词： energy. island beach

Subsequent total joint arthroplasty: Are we learning from the first stage?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第3期15卷 230-237页

作者： Christine Jiang Wu colin Penrose Sean Patrick Ryan michael Paul Bolognesi Thorsten Markus Seyler Samuel Secord Wellman Department of Orthopaedic Surgery Duke University HospitalDurhamNC 27710United States Department of Orthopaedic Surgery Midwest Center for Joint ReplacementIndianapolisIN 46241United States

BACKGROUND With the increasing incidence of total joint arthroplasty(TJA),there is a desire to reduce peri-operative complications and resource *** degenerative conditions progress in multiple joints,many patients undergo multiple *** To determine if both physicians and patients learn from the patient’s initial arth-roplasty,resulting in improved outcomes following the second *** The institutional database was retrospectively queried for primary total hip arth-roplasty(THA)and total knee arthroplasty(TKA).Patients with only unilateral THA or TKA,and patients undergoing same-day bilateral TJA,were *** demographics,comorbidities,and implant sizes were collected at the time of each procedure and patients were stratified by first vs second *** metrics evaluated included operative time,length of stay(LOS),disposition,90-d readmissions and emergency department(ED)*** A total of 642 patients,including 364 undergoing staged bilateral TKA and 278 undergoing bilateral THA,were *** was no significant difference in demographics or comorbidities between the first and second procedure,which were separated by a mean of 285 *** THA and TKA,LOS was significantly less for the second surgery,with 66%of patients having a shorter hospitalization(P<0.001).THA patients had significantly decreased operative time only when the same sized implant was utilized(P=0.025).The vast majority(93.3%)of patients were discharged to the same type of location following their second ***,when a change in disposition was present from the first surgery,patients were significantly more likely to be discharged to home after the second procedure(P=0.033).There was no difference between procedures for post-operative readmissions(P=0.438)or ED visits(P=0.915).CONCLUSION After gaining valuable experience recovering from the initial surgery,a patient’s perioperative outcomes are improved for their second *** may

关键词： Staged total joint arthroplasty Asynchronous total joint arthroplasty Subsequent total joint arthroplasty Contralateral total joint arthroplasty Perioperative outcomes