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International Journal of Sediment Research 2021年第2期36卷 279-290页

作者： Xiaohui Yan colin david rennie Abdolmajid Mohammadian Department of Civil Engineering University of Ottawa

This paper presents a model for local scour at submerged weirs with downstream slopes that uses a coupled moving-mesh and masked-element approach. In the developed model, the fluid-sediment interface is tracked using a moving-mesh technique, and the effects of the structure on the hydrodynamics and bed morphology are resolved using a masked-element technique. Compared to traditional sediment scour models, based on the moving-mesh technique, the present model has the advantage of allowing for a simpler setup of the computational grids and a larger-amplitude deformation. Laboratory experiments on local scour at a submerged weir with a downstream slope were conducted, which provided bed profiles at different time instants. The results obtained by the present model are compared to the experimental data. The comparisons demonstrate the performance of the model in satisfactorily predicting local scour at a submerged weir with a downstream slope. The model was further modified and employed to carry out additional computations to investigate the influence of various parameters and sub-models.

关键词： Numerical modeling Bed morphology Submerged weir Downstream slope Moving-mesh and masked-element OpenFOAM

Improved bridge pier collar for reducing scour

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International Journal of Sediment Research 2022年第1期37卷 37-46页

作者： Christopher Valela colin david rennie Ioan Nistor Department of Civil Engineering University of Ottawa

This study performed a bridge pier collar comparison for the purpose of reducing scour,while introducing a new collar *** new collar,referred to as Collar Prototype Number 3,was designed based on an equilibrium scour hole and provides a method of controlling the horseshoe *** modelling was utilized to show the flow field and bed shear stress as a result of using Collar Prototype Number 3.A prototype model of Collar Prototype Number 3 and a flat plate collar were constructed for the purpose of comparing both experimentally under different flow *** Prototype Number 3 proved to be an effective device as it reduced scour in terms of the maximum depth downstream of the pier and overall volume,in some instances,by up to 69.7%and 75.7%,***,Collar Prototype Number 3 outperformed the flat plate collar,especially because,unlike the flat plate collar,Collar Prototype Number 3 did not experience undermining.

关键词： Bridge pier Scour Horseshoe vortex Pier collar Scour countermeasure

Recent Progress of the Solar Wind Magnetosphere Ionosphere Link Explorer (SMILE) Mission

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空间科学学报 2024年第4期44卷 692-698页

作者： WANG Chi ESCOUBET Philippe FORSYTH colin LI Jing AGNOLON david State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 European Space Agency/European Space Research and Technology Centre Noordwijk 2201 AZ Mullard Space Science Laboratory University College LondonLondon RH56 NT

The SMILE(Solar wind Magnetosphere Ionosphere Link Explorer)mission is a joint space science mission between the Chinese Academy of Sciences(CAS)and the European Space Agency(ESA),aiming to understand the interaction of the solar wind with the Earth’s magnetosphere in a global *** of May 2024,the SMILE mission is in phase-D with an expected launch date of September *** report summarizes developments in the mission during the past two years.

关键词： SMILE Soft X-ray Imager Ultra-Violet Imager Light Ion Analyzer Magnetometer

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman david Han colin Hanna david Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino Drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

Petawatt class lasers worldwide

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High Power Laser Science and Engineering 2015年第1期3卷 5-18页

作者： colin Danson david Hillier Nicholas Hopps david Neely AWE STFC Rutherford Appleton Laboratory

The use of ultra-high intensity laser beams to achieve extreme material states in the laboratory has become almost routine with the development of the petawatt laser. Petawatt class lasers have been constructed for specific research activities,including particle acceleration, inertial confinement fusion and radiation therapy, and for secondary source generation(x-rays, electrons, protons, neutrons and ions). They are also now routinely coupled, and synchronized, to other large scale facilities including megajoule scale lasers, ion and electron accelerators, x-ray sources and z-pinches. The authors of this paper have tried to compile a comprehensive overview of the current status of petawatt class lasers *** definition of ‘petawatt class' in this context is a laser that delivers >200 TW.

关键词： diode pumped high intensity high power lasers megajoule petawatt lasers

Pulse fidelity in ultra-high-power(petawatt class)laser systems

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High Power Laser Science and Engineering 2014年第4期2卷 5-16页

作者： colin Danson david Neely david Hillier Centre for Inertial Fusion Studies (CIFS) Imperial College London AWE plc Aldermaston UK Central Laser Facility STFC Rutherford Appleton Laboratory

There are several petawatt-scale laser facilities around the world and the fidelity of the pulses to target is critical in achieving the highest focused intensities and the highest possible contrast. The United Kingdom has three such laser facilities which are currently open for access to the academic community: Orion at AWE, Aldermaston and Vulcan & Astra-Gemini at the Central Laser Facility(CLF), STFC(Science and Technology Facilities Council)Rutherford Appleton Laboratory(RAL). These facilities represent the two main classes of petawatt facilities: the mixed OPCPA/Nd:glass high-energy systems of Orion and Vulcan and the ultra-short-pulse Ti:Sapphire system of AstraGemini. Many of the techniques used to enhance and control the pulse generation and delivery to target have been pioneered on these facilities. In this paper, we present the system designs which make this possible and discuss the contrast enhancement schemes that have been implemented.

关键词： petawatt laser contrast wavefront correction plasma mirror

Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion

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Journal of Genetics and Genomics 2014年第5期41卷 251-259页

作者： Jolene S.Y.Tan colin J.P.Seow Vera J.Goh david L.Silver Signature Research Program in Cardiovascular & Metabolic Disorders Duke-NUS Graduate Medical School Singapore

Lipid droplets （LDs） were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation, expansion, and morphology. The related proteins are summarized such as the fat-specific protein （Fsp27）, fat storage-inducing trans- membrane （FIT） proteins, seipin and ADP-ribosylation factor 1-coat protein complex I （Arf-COPI）. Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved.

关键词： Lipid droplets LD-associated proteins Perilipin Phospholipids

Rudolph's pediatrics / 22th ed

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Intrinsic subtypes and bladder cancer metastasis

2011年

作者： Rudolph, colin david,

ISBN: (纸本)9780071497237

Summary: Publisher Summary 1 The landmark pediatrics reference -- now extensively updated in full color and more clinically relevant than everA Doody's Core Title ESSENTIAL PURCHASE for 2011!Rudolph's Pediatricshas virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. The 22nd edition of Rudolph's Pediatricscontinues a long tradition of adapting its content to changes in our understanding of children's health and disease, providing an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses; and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease *** TO THIS EDITION: New four-color design adds depth and clarity to the book's content Over 900 full-color, high-quality images and illustrations A reorganized, reader-friendly format broken down into sections and chapters for easier navigation and referenceNew emphasis on the clinical management of the patient makes this the most practical edition to dateNew sections provide a timely overview of pediatric care fundamentals and an entirely revised discussion of health promotion and disease preventionSubstantially revised sections cover key areas of pediatric study and practice, including infectious diseases, immunology, allergy, neoplastic disorders, the cardiovascular system, urinary complications, and more Greater use of tables and lists conveniently summarize need-to-know diagnostic and therapeutic informationNe

关键词： Pediatrics.

来源：畅想之星图书光盘版（南... 评论

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Asian Journal of Urology 2016年第4期3卷 260-267页

作者： david J.McConkey Woonyoung Choi Andrea Ochoa colin P.N.Dinney Johns Hopkins Greenberg Bladder Cancer Institute BaltimoreMDUSA Department of Urology Brady Urological InstituteJohns Hopkins UniversityBaltimoreMDUSA Department of Urology U.T.M.D.Anderson Cancer CenterHoustonTXUSA

Recent studies demonstrated that bladder cancers can be grouped into basal and luminal molecular subtypes that possess distinct biological and clinical *** bladder cancers express biomarkers characteristic of cancer stem cells and epithelial-tomesenchymal transition(EMT).Patients with basal cancers tend have more advanced stage and metastatic disease at *** preclinical models basal human orthotopic xenografts are also more metastatic than luminal xenografts are,and they metastasize via an EMT-dependent ***,preclinical and clinical data suggest that basal cancers are also more sensitive to neoadjuvant chemotherapy(NAC),such that most patients with basal cancers who are aggressively managed with NAC have excellent ***,luminal bladder cancers can also progress to become invasive and metastatic,but they appear to do so via mechanisms that are much less dependent on EMT and may involve help from stromal cells,particularly cancer-associated fibroblasts(CAFs).Although patients with luminal cancers do not appear to derive much clinical benefit from NAC,the luminal tumors that are infiltrated with stromal cells appear to be sensitive to anti-PDL1 antibodies and possibly other immune checkpoint ***,neoadjuvant and/or adjuvant immunotherapy may be the most effective approach in treating patients with advanced or metastatic infiltrated luminal bladder cancers.

关键词： Bladder cancer Metastasis Basal subtypes Luminal subtypes Epithelial-tomesenchymal transition

Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis

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Stroke & Vascular Neurology 2019年第4期4卷 189-197页

作者： Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa david M Hasan colin Derdeyn Biyue Dai Harold Adams Enrique Leira Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology and Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Radiology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Biostatistics and Public Health University of Iowa Hospitals and ClinicsIowa CityIowaUSA

background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain *** We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral *** mechanism,collateral circulation,and degree and length of stenosis were *** primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or *** outcome variables included modified Rankin Scale(mRS)score on discharge and last *** Of 6369 patients with AIS/TIA,91(1.43%)had ***-three(80.2%)patients presented with AIS and 18(19.8%)with ***-nine(31.9%)were women and the median age was 66.8±13.6 *** mean follow-up time was 2.7 *** most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral *** 13% of patients with ISBAS presented with complete BA *** ISBAS is an uncommon(1.43%)cause of TIA and *** in their 60s are mostly affected,and artery-to artery embolism is the most common stroke ***-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis.

关键词： stenosis basilar artery