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disentangling multiple scattering with deep learning:application to strain mapping from electron diffraction patterns

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npj Computational Materials 2022年第1期8卷 2419-2433页

作者： Joydeep Munshi Alexander Rakowski Benjamin H.Savitzky Steven E.Zeltmann Jim Ciston Matthew Henderson Shreyas Cholia Andrew M.Minor Maria K.Y.Chan colin Ophus Center for Nanoscale Materials Argonne National LaboratoryArgonne DrWoodridge60517ILUSA National Center for Electron Microscopy Molecular FoundryLawrence Berkeley National Laboratory1 Cyclotron RoadBerkeley94720CAUSA department of Materials Science and Engineering University of California BerkeleyBerkeley94720CAUSA Scientific data division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeley94720CAUSA

A fast,robust pipeline for strain mapping of crystalline materials is important for many technological *** electron nanodiffraction allows us to calculate strain maps with high accuracy and spatial resolutions,but this technique is limited when the electron beam undergoes multiple ***-learning methods have the potential to invert these complex signals,but require a large number of training *** implement a Fourier space,complex-valued deep-neural network,FCU-Net,to invert highly nonlinear electron diffraction patterns into the corresponding quantitative structure factor ***-Net was trained using over 200,000 unique simulated dynamical diffraction patterns from different combinations of crystal structures,orientations,thicknesses,and microscope parameters,which are augmented with experimental *** evaluated FCU-Net against simulated and experimental datasets,where it substantially outperforms conventional analysis *** code,models,and training library are open-source and may be adapted to different diffraction measurement problems.

关键词： valued adapted crystalline

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五十年来高强度混凝土的发展

世界桥梁 1978年第1期 45-54页

作者： colin d.Johnston ,宁国钧

引言当我们对于有关水泥和集料的各种特征的重要性的理解更加完全时,对于控制混凝土强度的各种因素的知识以及对提高混凝土强度的能力总是随之而不断进步。本文总结了普通波特兰水泥混凝土的现状,并指出仅仅用波特兰

关键词：混凝土强度工作度干硬度硅酸盐水泥波特兰水泥水灰比水泥混凝土集料试验挠曲强度

Key houses of the twentieth century : plans, sections and elevations /

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Real time imaging of two-dimensional iron oxide spherulite nanostructure formation

2006年

作者： davies colin

来源：畅想之星图书光盘版（南... 评论

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Nano Research 2019年第11期12卷 2889-2893页

作者： Wenjing Zheng Matthew R.Hauwiller Wen-I Liang colin Ophus Peter Ercius Emory M.Chan Ying-Hao Chu Mark Asta Xiwen du A.Paul Alivisatos Haimei Zheng Institute of New-Energy Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China Materials Sciences division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA department of Chemistry University of CaliforniaBerkeleyBerkeleyCA94720USA department of Materials Science and Engineering “National Chiao Tung University”Hsinchu30010TaiwanChina The Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720USA department of Materials Science and Engineering University of CaliforniaBerkeleyBerkeleyCA94720USA Kavli Energy NanoScience Institute University of California-Berkeley and Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

The formation of complex hierarchical nanostructures has attracted a lot of attention from both the fundamental science and potential applications point of *** structures with radial fibrillar branches have been found in various solids;however,their growth mechanisms remain poorly ***,we report real time imaging of the formation of two-dimensional(2d)iron oxide spherulite nanostructures in a liquid cell using transmission electron microscopy(TEM).By tracking the growth trajectories,we show the characteristics of the reaction front and growth *** observations reveal that the tip of a growing branch splits as the width exceeds certain sizes(5.5–8.5 nm).The radius of a spherulite nanostructure increases linearly with time at the early stage,transitioning to nonlinear growth at the later ***,a thin layer of solid is accumulated at the tip and nanoparticles from secondary nucleation also appear at the growing front which later develop into fibrillar *** spherulite nanostructure is polycrystalline with the co-existence of ferrihydrite and Fe3O4 through-out the growth.A growth model is further established,which provides rational explanations on the linear growth at the early stage and the nonlinearity at the later stage of growth.

关键词： liquid cell transmission electron microscopy(TEM) in situ TEM iron oxide spherulite nanostructures

Loss of the vitamin d receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling

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Bone Research 2017年第3期5卷 195-206页

作者： Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas colin dunstan Hong Zhou Markus J Seibel Bone Research Program ANZAC Research Institute Asbestos diseases Research Institute Cardiothoracic Genomics School of Medical Sciences University of New South Wales department of Pathology Shihezi University School of Medicine Biomedical Engineering AMME University of Sydney Concord Clinical School The University of Sydney

Vitamin d co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin d, 1,25-dihydroxy-vitamin d [1,25（OH）2d] are mediated through binding to the vitamin d receptor （VdR）. Here, we report on the unexpected finding that stable knockdown of VdR expression in the human breast and prostate cancer cell lines, MdA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VdR knockdown cells into the mammary fat pad （MdA-MB-231）, subcutaneously （PC3） or intra-tibially （both cell lines） in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls. These growth-retarding effects of VdR knockdown occur in the presence and absence of vitamin d and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VdR knockdown and non-target control cell lines demonstrated that loss of the VdR was associated with significant attenuation in the Wnt/0-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin d1, interleukin-6 （IL-6）, and IL-8. Stabilization of 0-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VdR knockdown. Our results indicate that the unliganded VdR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VdR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer.

关键词： MdA Loss of the vitamin d receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt catenin signaling VdR Wnt

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Non-thermal plasma for exhaust gases treatment

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Frontiers of Mechanical Engineering 2015年第3期10卷 301-305页

作者： Elvia ALVA R. Marquidia PACHECO P.l Fernando GOMEZ B. Joel PACHECO P. Arturo colin C Victor SANCHEZ-MENdIETA Ricardo VALdIVIA B Alfredo SANTANA d. Jose HUERTAS C Hilda FRIAS P. Instituto Nacional de Investigaciones Nucleates Ocoyoacac 52750Mexico Universidad Autonoma del Estado de Mexico Toluca 50000 Mexico Instituto Tecnologico y de Estudios Superiores de Monterrey CampusToluca 50110 Mexico

This article describes a study on a non-thermal plasma device to treat exhaust gases in an internal combustion engine. Several tests using a plasma device to treat exhaust gases are conducted on a Honda GX200- 196 cm3 engine at different rotational speeds. A plasma reactor could be efficient in degrading nitrogen oxides and particulate matter. Monoxide and carbon dioxide treatment is minimal. However, achieving 1%-3% degradation may be interesting to reduce the emission of greenhouse gases.

关键词： plasma treatment NOx CO CO2 particulatematter vehicle

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KEY HOUSES OF THE TWENTIETH CENTURY by colin davies.

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Geographically distributed hybrid testing & collaboration between geotechnical centrifuge and structures laboratories

2006年

作者： by colin davies.

来源：畅想之星图书光盘版（南... 评论

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Earthquake Engineering and Engineering Vibration 2018年第1期17卷 53-71页

作者： Mobin Ojaghi Ignacio Lamata Martínez Matt S.dietz Martin S.Williams Anthony Blakeborough Adam J.Crewe colin A.Taylor S.P.Gopal Madabhushi Stuart K.Haigh department of Engineering Science University of Oxford department of Civil Engineering University of Bristol department of Engineering University of Cambridge

distributed Hybrid Testing（dHT） is an experimental technique designed to capitalise on advances in modern networking infrastructure to overcome traditional laboratory capacity limitations. By coupling the heterogeneous test apparatus and computational resources of geographically distributed laboratories, dHT provides the means to take on complex, multi-disciplinary challenges with new forms of communication and collaboration. To introduce the opportunity and practicability afforded by dHT, here an exemplar multi-site test is addressed in which a dedicated fibre network and suite of custom software is used to connect the geotechnical centrifuge at the University of Cambridge with a variety of structural dynamics loading apparatus at the University of Oxford and the University of Bristol. While centrifuge time-scaling prevents real-time rates of loading in this test, such experiments may be used to gain valuable insights into physical phenomena, test procedure and accuracy. These and other related experiments have led to the development of the real-time dHT technique and the creation of a flexible framework that aims to facilitate future distributed tests within the UK and beyond. As a further example, a real-time dHT experiment between structural labs using this framework for testing across the Internet is also presented.

关键词： centrifuge distributed dynamics geotechnical hardware-in-the-loop real-time hybrid testing

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Osteogenesis of MC3T3 Preosteoblasts on 3d Bioactive Peptide Modified Nano-Macroporous Bioactive Glass Scaffolds

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Journal of Biomaterials and Nanobiotechnology 2015年第3期6卷 146-159页

作者： colin Przybylowski Mohamed Ammar Courtney LeBlon Sabrina S. Jedlicka Integrated degree in Engineering Arts & Sciences (IDEAS) Program Lehigh University Bethlehem PA USA Bioengineering Program Lehigh University Bethlehem PA USA department of Materials Science & Engineering Lehigh University Bethlehem PA USA department of Mechanical Engineering & Mechanics Lehigh University Bethlehem PA USA Center for Advanced Materials & Nanotechnology Lehigh University Bethlehem PA USA

Biointerface design that targets osteogenesis is a growing area of research with significant implications in biomedicine. Materials known to either support or stimulate osteogenesis are composed of a biomimetic ceramic material, such as bioactive glass. Bioactive glass is osteoproductive, and the potential for osteoproductivity can be enhanced by the addition of proteins or other additives designed to alter functionality. In addition, soluble growth factors are often added to osteogenic culture on bioactive glasses, further intensifying the effects of the material. In this paper, synthetic peptide combinations, covalently bound to a three-dimensional bioactive glass network, are used to mimic the effects of the whole fibronectin and bone morphogenetic proteins (BMP) 2 and 9. Peptide-silanes possessing critical binding sequences from each of these proteins are synthesized and used to decorate the surface of three-dimensional (3d) nano-macroporous bioactive glass. MC3T3 preosteoblast cells are then assessed for differentiation on the materials in the absence of soluble differentiation cues. MC3T3 preosteoblasts undergo enhanced differentiation on the peptide-silane samples over the standard nano-macroporous bioactive glass, and the differentiation capacity of the cells exposes only to peptide-silane surfaces approaches that of cells grown in chemical differentiation induction media.

关键词： Bioactive Glass Bioactive Peptide MC3T3 Osteogenesis