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Eventual Positivity of Hermitian Algebraic Functions and Associated Integral Operators

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Chinese Annals of Mathematics,Series B 2020年第6期41卷 967-988页

作者： colin tan Wing-Keung TO Department of Statistics&Applied Probability National University of Singapore Current address:Science Mat hematics and TechnologySingapore University of Technology and Design8 Somapah RoadSingapore 487372 Department of Mathematics National University of SingaporeBlock S1710 Lower Kent Ridge RoadSingapore 119076

Quillen proved that repeated multiplication of the standard sesquilinear form to a positive Hermitian bihomogeneous polynomial eventually results in a sum of Hermitian squares,which was the first Hermitian analogue of Hilbert s seventeenth problem in the nondegenerate *** Catlin-D’Angelo generalized this positivstellensatz of Quillen to the case of Hermitian algebraic functions on holomorphic line bundles over compact complex manifolds by proving the eventual positivity of an associated integral *** arguments of Catlin-D’Angelo involve subtle asymptotic estimates of the Bergman *** this article,the authors give an elementary and geometric proof of the eventual positivity of this integral operator,thereby yielding another proof of the corresponding positivstellensatz.

关键词： Hermitian algebraic functions Integral operators Positivity

Comment on visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 323-324页

作者： Kelvin Z.Li colin S.tan National Healthcare Group Eye Institute Tan Tock Seng Hospital Fundus Image Reading Center National Healthcare Group Eye Institute

Dear Editor,We read with interest the article by Chen etaitlj on the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery. The authors reported that 93.3% of patients in the study experienced loss of perception of light at least during one of the surgical steps after the contralateral eye was covered intraoperatively. Most of the patients （81%） reported losing light perception between 6min and 30min from the commencement of the surgery.

关键词： LASIK Comment on visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery

Factors affecting visual outcome of myopic choroidal neovascularization treated with verteporfin photodynamic therapy

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 327-330页

作者： colin S. tan Milton C. Chew Kai-Hung Lim Tock-Han Lim National Healthcare Group Eye Institute Tan Tock Seng Hospital Fundus Image Reading Center National Healthcare Group Eye Institute

AIM: To evaluate the visual outcomes of choroidal neovascularization (CNV) secondary to pathological myopia and the impact of novel risk factors affecting the final visual outcome. ·METHODS: Interventional case series of 18 consecutive patients with pathological myopia treated with photodynamic therapy (PDT). Inclusion criteria were spherical equivalent -6D or worse or features of pathological myopia on retinal examination. The main outcome measure was final best -corrected visual acuity (BCVA). ·RESULTS: Of 18 eyes, 13 (72.2%) avoided moderate visual loss (≥3 lines of LogMAR BCVA) and 5 eyes (27.8%) improved by at least 1 line after 1 year. Patients with LogMAR BCVA ≤0.3 (Snellen equivalent 20/40) at one year were younger than those with BCVA >0.3 (mean age 39.0 vs 61.6 years, P =0.001). A higher proportion of eyes with greatest linear dimension (GLD) of ≤1 000μm avoided moderate visual loss (100% vs 50%, P =0.026). Among patients who were treated within 2 weeks of visual symptoms, 88.9% avoided the loss of 3 or more lines compared to 55.6% for those who presented later. The mean improvement in LogMAR BCVA of those with GLD ≤1 000μm was +0.12 compared to a loss of 0.55 LogMAR units for those with GLD >1 000μm (P =0.02). Visual outcomes were not associated with gender or refractive error.·CONCLUSION: Good visual outcome in myopic CNV is associated with younger age, smaller lesion size and earlier initiation of treatment. These factors are relevant for ophthalmologists considering treatment options for myopic CNV.

关键词： myopic choroidal neovascularization pathologic myopia photodynamic therapy

Building a Machine Learning-based Ambulance Dispatch Triage Model for Emergency Medical Services

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Health Data Science 2023年第1期3卷 17-25页

作者： Han Wang Qin Xiang Ng Shalini Arulanandam colin tan Marcus E.H.Ong Mengling Feng Saw Swee Hock School of Public Health National University Health SystemNational University of SingaporeSingapore. Singapore Civil Defence Force Singapore. Health Services Research Centre Singapore Health ServicesSingapore. Health Services and Systems Research Duke-NUS Medical SchoolNational University of SingaporeSingapore. Department of Emergency Medicine Singapore General HospitalSingapore. Institute of Data Science National University of SingaporeSingapore.

Background:In charge of dispatching the ambulances,Emergency Medical Services(EMS)call center specialists often have difficulty deciding the acuity of a case given the information they can gather within a limited *** there are protocols to guide their decision-making,observed performance can still lack sensitivity and *** learning models have been known to capture complex relationships that are subtle,and well-trained data models can yield accurate predictions in a split of a ***:In this study,we proposed a proof-of-concept approach to construct a machine learning model to better predict the acuity of emergency *** used more than 360,000 structured emergency call center records of cases received by the national emergency call center in Singapore from 2018 to *** were created using call records,and multiple machine learning models were ***:A Random Forest model achieved the best performance,reducing the over-triage rate by an absolute margin of 15%compared to the call center specialists while maintaining a similar level of under-triage ***:The model has the potential to be deployed as a decision support tool for dispatchers alongside current protocols to optimize ambulance dispatch triage and the utilization of emergency ambulance resources.

关键词： Services absolute proof

Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy

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Cancer Communications 2020年第4期40卷 135-153页

作者： Wei Chang colin tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim Yong Loo Lin School of Medicine National University of SingaporeSingapore169856Singapore Department of Anatomical Pathology Singapore General HospitalSingapore169856Singapore Institute of Molecular Cell Biology(IMCB) Agency of ScienceTechnology and Research(A*STAR)Singapore169856Singapore Singapore Immunology Network Agency of Science(SIgN)Technology and Research(A*STAR)Singapore169856Singapore Duke-NUS Medical School Singapore169856Singapore

Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue ***,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue *** review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell *** these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly ***/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue *** technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy.

关键词： immunofluorescence immunohistochemistry immunotherapy multiplex overview

Nearest Neighbor Sampling of Point Sets Using Rays

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1131-1174页

作者： Liangchen Liu Louis Ly colin B.Macdonald Richard Tsai Department of Mathematics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computational Engineering and Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Department of Mathematics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a new framework for the sampling,compression,and analysis of distributions of point sets and other geometric objects embedded in Euclidean *** approach involves constructing a tensor called the RaySense sketch,which captures nearest neighbors from the underlying geometry of points along a set of *** explore various operations that can be performed on the RaySense sketch,leading to different properties and potential *** information about the data set can be extracted from the sketch,independent of the ray *** integrals on point sets can be efficiently computed using the *** also present several examples illustrating applications of the proposed strategy in practical scenarios.

关键词： Point clouds Sampling Classification Registration Deep learning Voronoi cell analysis

Recent Progress of the Solar Wind Magnetosphere Ionosphere Link Explorer (SMILE) Mission

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空间科学学报 2024年第4期44卷 692-698页

作者： WANG Chi ESCOUBET Philippe FORSYTH colin LI Jing AGNOLON David State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 European Space Agency/European Space Research and Technology Centre Noordwijk 2201 AZ Mullard Space Science Laboratory University College LondonLondon RH56 NT

The SMILE(Solar wind Magnetosphere Ionosphere Link Explorer)mission is a joint space science mission between the Chinese Academy of Sciences(CAS)and the European Space Agency(ESA),aiming to understand the interaction of the solar wind with the Earth’s magnetosphere in a global *** of May 2024,the SMILE mission is in phase-D with an expected launch date of September *** report summarizes developments in the mission during the past two years.

关键词： SMILE Soft X-ray Imager Ultra-Violet Imager Light Ion Analyzer Magnetometer

Thin-film flow technology in controlling the organization of materials and their properties Special Collection:Distinguished Australian Researchers

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Aggregate

Aggregate 2024年第1期5卷 115-129页

作者： Clarence Chuah Xuan Luo Javad Tavakoli Youhong tang colin L.Raston Flinders Institute for Nanoscale Science and Technology College of Science and EngineeringFlinders UniversityAdelaideSouth AustraliaAustralia Centre for Health Technologies School of Biomedical EngineeringFaculty of Engineering and Information TechnologyUniversity of Technology SydneySydneyNew South WalesAustralia

Centrifugal and shear forces are produced when solids or liquids *** systems and devices that use these forces,such as dynamic thin-film flow technology,are evolving continuously,improve material structure-property relationships at the nanoscale,representing a rapidly thriving and expanding field of research high with green chemistry metrics,consolidated at the inception of *** vortex fluidic device(VFD)provides many advantages over conventional batch processing,with fluidic waves causing high shear and producing large surface areas for micro-mixing as well as rapid mass and heat transfer,enabling reactions beyond diffusion *** these abilities allows for a green and innovative approach to altering materials for various research and industry applications by controlling small-scale flows and regulating molecular and macromolecular chemical reactivity,self-organization phenomena,and the synthesis of novel *** review highlights the aptitude of the VFD as clean technology,with an increase in efficiency for a diversity of top-down,bottom-up,and novel material transformations which benefit from effective vortex-based processing to control material structure-property relationships.

关键词： material nanoscale structure-property relationship thin film flow technology vortex fluidic device

Chemical-assisted MMP reduction on methane-oil systems:Implications for natural gas injection to enhanced oil recovery

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Petroleum 2024年第1期10卷 101-108页

作者： Mohamed Almobarak Matthew B.Myers colin D.Wood Yongbing Liu Ali Saeedi Quan Xie Discipline of Petroleum Engineering WA School of Mines:MineralsEnergy and Chemical EngineeringCurtin UniversityWestern AustraliaAustralia Commonwealth Scientific and Industrial Research Organization Kensington6151Australia Curtin University Oil and Gas Innovation Centre Management Kensington6151Australia State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation No.8 Xindu AvenueXindu DistrictChengdu 610500PR China

***,the main challenge in this process is the high minimum miscibility pressure(MMP)between natural gas and crude oil,which limits its application and recovery factor,especially in hightemperature ***,we present a novel investigation to quantify the effect of chemicalassisted MMP reduction on the oil recovery ***,we measured the interfacial tension(IFT)of the methane-oil system in the presence of chemical or CO_(2) to calculate the MMP reduction at a constant temperature(373K)using the vanishing interfacial tension(VIT)***,we performed three coreflooding experiments to quantify the effect of MMP reduction on the oil recovery factor under different injection *** interfacial tension measurements show that adding a small fraction(1.5 wt%)of the tested surfactant(SOLOTERRA ME-6)achieved 9%of MMP reduction,while adding 20 wt%of CO_(2) to the methane yields 13%of MMP ***,the coreflooding results highlight the significance of achieving miscibility during gas injection,as the ultimate recovery factor increased from 65.5%under immiscible conditions to 77.2%using chemical-assisted methane,and to 79%using gas mixture after achieving near miscible *** results demonstrate the promising potential of the MMP reduction to signifi-cantly increase the oil recovery factor during gas ***,these results will likely expand the application envelop of the miscible gas injection,in addition to the environmental benefits of utilizing the produced gas by re-injection/recycling instead of flaring which contributes to reducing the greenhouse gas emissions.

关键词： Gas injection Enhanced oil recovery Miscibility Coreflooding