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早期乳腺癌保乳术后部分乳腺高剂量率后装加速照射的毒性反应及美容效果

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中华放射肿瘤学杂志 2007年第1期16卷 25-29页

作者：修霞 Tripuraneni prabhakar Giap Huan Lin Ray Chu colin 北京医院放疗科 100730 Tripuraneni prabhakar Giap HuanLin RayChu Colin

目的介绍早期乳腺癌保乳术后单独行局部高剂量率组织间插植加速照射的方法、副作用及美容效果。方法46例Ⅰ、Ⅱ期乳腺癌的47个乳腺在肿瘤局部扩大切除后使用了高剂量率^192Ir组织间插植瘤床区加速照射（ApBI）。符合条件的患者包括年龄... 详细信息

目的介绍早期乳腺癌保乳术后单独行局部高剂量率组织间插植加速照射的方法、副作用及美容效果。方法46例Ⅰ、Ⅱ期乳腺癌的47个乳腺在肿瘤局部扩大切除后使用了高剂量率^192Ir组织间插植瘤床区加速照射（ApBI）。符合条件的患者包括年龄＞40岁、T1～T2n0～n1（≤3阳性淋巴结），手术切缘＞1～2mm，小叶癌和炎性乳腺癌除外。术后接受高剂量率近距离放疗，2次／d，间隔至少6h，总量34Gy分10次5d完成。治疗后1、6、12个月及以上观察毒性反应及美容效果。结果全组患者随访18～46个月（中位随访34个月），治疗期间急性反应包括红斑、水肿、乳腺触痛和感染共21例（46％），均为1～2级，无3～4级发生。晚期毒性包括皮肤纤维化、乳腺触痛、脂肪坏死及毛细血管扩张1＋2级加例（43％），3级2例（4％），其中1例疗后接受6个周期系统化疗。美容效果达到极好和良好的在6、12个月分别为95％、98％，无一局部复发。结论早期乳腺癌保乳术后ApBI后装组织间插植技术具有良好美容功效，急性和晚期毒性作用小，局部控制率有待于长期随访观察。

关键词：乳腺肿瘤/放射疗法近距离疗法毒性反应美容效果

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云南赤麂的亚种分类记述(英文)

兽类学报 1988年第2期 95-104页

作者：马世来,王应祥,colin p.Groves 中国科学院昆明动物研究所中国科学院昆明动物研究所澳大利亚国立大学史前学及人类学系堪培拉

赤麂(Muntiacus muntjak)又名印度麂或吠鹿,广泛分布于亚洲南部的热带和亚热带地区,为麂属中数量最多,分布最广的一种。同时又是具有较高经济价值的毛皮兽。迄今,本种已记载过15个亚种,其中7个分布于中国大陆(Ellerman和Morrison-Scott,... 详细信息

赤麂(Muntiacus muntjak)又名印度麂或吠鹿,广泛分布于亚洲南部的热带和亚热带地区,为麂属中数量最多,分布最广的一种。同时又是具有较高经济价值的毛皮兽。迄今,本种已记载过15个亚种,其中7个分布于中国大陆(Ellerman和Morrison-Scott,1951),8个见于东南亚诸岛(Chasen,1940)。近来,本文作者之一的Groves和他的同事Grubb又将这15个亚种归并为8个(论文已交付出版)。关于云南赤麂的亚种问题以往很少深入研究,仅在部份区系分类报告中有过简要记载。但因各学者所获标本有限(或者仅得少数皮张),而将云南及整个中国大陆的赤麂 (Muntiacus muntjak)统统归入了***亚种。事实上,真正的***仅局限于尼泊尔,锡金,印度东北部,缅甸西部的阿拉刚(Arakan)和中国的西藏东南部(Grubb和Groves,待发表)。笔者查看了采自云南各地的60余号赤麂标本,经与已知亚种的外部形态、头骨特征和主要性状差异系数值的比较(表3)发现:云南的赤麂不仅与***,海南亚种***以及邻国的其它亚种(如***和***等)明显有别,而且与中国的四川、贵州和广西等省的标本差异亦颇大。就说云南南北(约为22°20`n.以南;23°10`n.以北)两地标本的差异也十分显著(两地之间有一狭窄的过渡地带,发

关键词： Indian muntjac Muntiacus muntjak(赤麂) Classification(分类) new subspecies (新亚种) Yunnan(云南)。

Future for inertial-fusion energy in Europe:a roadmap

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High power Laser Science and Engineering 2023年第6期11卷 162-192页

作者： Dimitri Batani Arnaud Colaitis Fabrizio Consoli colin n.Danson Leonida Antonio Gizzi Javier Honrubia Thomas Kühl Sebastien Le pape Jean-Luc Miquel Jose Manuel perlado R.H.H.Scott Michael Tatarakis Vladimir Tikhonchuk Luca Volpe Centre Lasers Intenses et Applications(CELIA) Universitéde Bordeaux±CNRS±CEATalence cedexFrance EnEA Fusion and Technology for Nuclear Safety and Security DepartmentC.R.FrascatiFrascatiItaly AWE AldermastonReadingUK Centre for Inertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Istituto nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)PisaItaly ETSIAE Universidad politecnica de Madrid MadridSpain GSI-Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Laboratoire pour l’Utilisation des Lasers Intenses(LULI) CNRS±Ecole PolytechniquePalaiseau cedexFrance ALp Le BarpFrance and CEA/DAMÎle de FranceBruyères le ChâtelArpajon cedexFrance Instituto Fusión nuclearªGuillermo Velardeº(IFn-GV) Universidad Politecnica de MadridMadridSpain Central Laser Facility STFC Rutherford Appleton LaboratoryHarwell OxfordOxfordshireUK Institute of plasma physics and Lasers University Research and Innovation CentreHellenic Mediterranean UniversityRethymnoCreteGreece Department of Electronic Engineering School of EngineeringHellenic Mediterranean UniversityChaniaCreteGreece Extreme Light Infrastructure ERIC ELI-Beamlines FacilityDolníBÏrežanyCzech Republic Centro de Laseres pulsados(CLpU) Parque CientificoVillamayorSalamancaSpain

The recent achievement of fusion ignition with laser-driven technologies at the national Ignition Facility sets a historic accomplishment in fusion energy *** accomplishment paves the way for using laser inertial fusion as a viable approach for future energy *** has a unique opportunity to empower research in this field internationally,and the scientific community is eager to engage in this *** propose establishing a European programme on inertial-fusion energy with the mission to demonstrate laser-driven ignition in the direct-drive scheme and to develop pathway technologies for the commercial fusion *** proposed roadmap is based on four complementary axes:(ⅰ)the physics of laser-plasma interaction and burning plasmas;(ⅱ)high-energy high repetition rate laser technology;(ⅲ)fusion reactor technology and materials;and(ⅳ)reinforcement of the laser fusion community by international education and training *** foresee collaboration with universities,research centres and industry and establishing joint activities with the private sector involved in laser *** project aims to stimulate a broad range of high-profile industrial developments in laser,plasma and radiation technologies along with the expected high-level socio-economic impact.

关键词： education and training fusion reactor technology high-energy laser high repetition rate laser inertial confinement fusion laser-plasma interaction public-private partnership radiation resistant materials

A Meta-Analysis of the Genome-Wide Association Studies on Two Genetically Correlated phenotypes Suggests Four new Risk Loci for Headaches

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phenomics 2023年第1期3卷 64-76页

作者： Weihua Meng parminder S.Reel Charvi nangia Aravind Lathika Rajendrakumar Harry L.Hebert Qian Guo Mark J.Adams Hua Zheng Zen Haut Lu Me Research Team Debashree Ray Lesley A.Colvin colin n.A.palmer Andrew M.McIntosh Blair H.Smith nottingham ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100China Division of population Health and Genomics Ninewells Hospital and Medical SchoolUniversity of DundeeDundee DD24BFUK Division of psychiatry Edinburgh Medical SchoolUniversity of EdinburghEdinburgh EH105HFUK Department of Anaesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China pApRSB Institute of Health Sciences Universiti Brunei DarussalamBandar Seri Begawan BE1410Brunei Darussalam andMe Inc.SunnyvaleCA 94086USA Department of Epidemiology Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA Department of Biostatistics Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA

Headache is one of the commonest complaints that doctors need to address in clinical *** genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically *** this study,we performed a meta-analysis of genome-wide association studies(GWAS)on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test(metaUSAT)software for genetically correlated phenotypes(n=397,385).We identified 38 loci for headaches,of which 34 loci have been reported before and four loci were newly *** LDL receptor related protein 1(LRp1)-Signal Transducer and Activator of Transcription 6(STAT6)-Short chain Dehydrogenase/Reductase family 9C member 7(SDR9C7)region in chromosome 12 was the most significantly associated locus with a leading p value of 1.24×10^(-62)of *** One Cut homeobox 2(OnECUT2)gene locus in chromosome 18 was the strongest signal among the four new loci with a p value of 1.29×10^(-9)of *** study demonstrated that the genetically correlated phenotypes of self-reported headache and self-reported migraine can be meta-analysed together in theory and in practice to boost study power to identify more variants for *** study has paved way for a large GWAS meta-analysis involving cohorts of different while genetically correlated headache phenotypes.

关键词： Headache Migraine Unified Score-based Association Test Correlated phenotypes Meta-analysis Genome-wide association study

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基于重、磁异常的西太平洋中段构造特征研究

地球物理学报 2022年第5期65卷 1712-1731页

作者：朱莹洁王万银 J.Kim Welford colin G.Farquharson 杨永罗新刚王丁丁马涛马杰长安大学重磁方法技术研究所长安大学地质工程与测绘学院长安大学西部矿产资源与地质工程教育部重点实验室西安710054 海洋油气勘探国家工程研究中心北京100028 纽芬兰纪念大学地球科学系加拿大圣约翰斯A1B3X5 南方海洋科学与工程广东省实验室(广州) 广州511458 自然资源部海底矿产资源重点实验室广州海洋地质调查局广州510075

西太平洋中段包含发育众多独立海山、海山链及海岭的西太平洋海山省(WpSp)、马里亚纳海沟和马里亚纳岛弧,其形成与演化与构造运动密切相关.研究区金属矿产、尤其是WpSp区域的富钴结壳资源较丰富,具有重要的研究意义.本文采用重、磁异常... 详细信息

西太平洋中段包含发育众多独立海山、海山链及海岭的西太平洋海山省(WpSp)、马里亚纳海沟和马里亚纳岛弧,其形成与演化与构造运动密切相关.研究区金属矿产、尤其是WpSp区域的富钴结壳资源较丰富,具有重要的研究意义.本文采用重、磁异常数据研究了西太平洋中段的构造特征.其中,采用归一化总水平导数垂向导数(nVDR-THDR)方法技术划分区域内的断裂,并采用欧拉反褶积深度反演方法得到断裂的视深度;采用深度约束下的双界面模型快速反演方法得到研究区莫霍面的起伏形态;同样采用nVDR-THDR方法技术识别nE向和nW向磁条带;采用重磁对应分析方法圈定研究区的火成岩,包括独立海山、海山链、海岭、马里亚纳岛弧型火成岩及大洋盆地溢流型玄武岩省.通过对研究区断裂分布、莫霍面深度、磁条带分布及火成岩分布的研究,得到了西太平洋中段的构造单元分布特征.马里亚纳海沟东侧,即WpSp区域内识别的断裂走向主要为nW(WnW)向和nE(EnE)向,而西侧,即马里亚纳岛弧区域识别的断裂与马里亚纳岛弧近n-S向的走向特征一致.研究区的大洋盆地溢流型玄武岩省呈nW向条带状展布、nE向块状分布的特征,并与独立海山、海山链和海岭相间分布.综合对西太平洋中段构造特征的研究,认为断裂对研究区的构造演化起到了重要作用.莫霍面深度在一级深大断裂两侧普遍存在突变;一些磁条带被断裂错断;火成岩的形成与分布也受控于断裂:独立海山、海山链、海岭及马里亚纳岛弧型火成岩位于莫霍面凹陷区,大洋盆地溢流型玄武岩省位于莫霍面隆起区.综合以上研究,划分了西太平洋中段的构造单元.在WpSp的构造单元呈nW向条带状展布、nE向块状分布的特征,而马里亚纳弧沟体系的构造单元呈近n-S向带状展布的特征.

关键词：西太平洋海山省马里亚纳重、磁异常断裂莫霍面深度磁条带火成岩

preparation of nanoporous Carbonaceous promoters for Enhanced CO2 Absorption in Tertiary Amines

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Engineering 2020年第12期6卷 1381-1394页

作者： Masood S.Alivand Omid Mazaheri Yue Wu Geoffrey W.Stevens colin A.Scholes Kathryn A.Mumford Department of Chemical Engineering The University of MelbourneParkvilleVIC 3010Australia peter Cook Centre for CCS Research The University of MelbourneParkvilleVIC 3010Australia School of Agriculture and Food Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkvilleVIC 3010Australia

Aqueous solutions of tertiary amines are promising absorbents for CO2 capture,as they are typically characterized by a high absorption capacity,low heat of reaction,and low ***,tertiary amines also exhibit very low kinetics of CO2 absorption,which has made them unattractive options for large-scale ***,a series of novel nanoporous carbonaceous promoters(nCps)with different properties were synthesized,characterized,and used as rate promoters for CO2 absorption in aqueous n,n-diethylethanolamine(DEEA)*** prepare a DEEA–nCp nanofluid,nCps were dispersed into aqueous 3 mol∙L1 DEEA solution using *** results revealed that among microporous(GC)and mesoporous(GS)carbonaceous structures functionalized with ethylenediamine(EDA)and polyethyleneimine(pEI)molecules,the GC–EDA promoter exhibited the best performance.A comparison between DEEA–GC–EDA nanofluid and typical aqueous DEEA solutions highlighted that the GC-EDA promoter enhances the rate of CO2 absorption at 40C by 38.6%(36.8–50.7 kpamin1)and improves the equilibrium CO2 absorption capacity(15 kpa;40C)by 13.2%(0.69–0.78 mol of CO2 per mole of DEEA).Moreover,the recyclability of DEEA–GC–EDA nanofluid was determined and a promotion mechanism is *** outcomes demonstrate that nCp–GC–EDA in tertiary amines is a promising strategy to enhance the rate of CO2 absorption and facilitate their large-scale deployment.

关键词： CO2 absorption nanofluid n,n-diethylethanolamine nanoporous carbonaceous promoters polyamine functionalization

Steroidal plant Growth promoters vs. phytopathogens, via Enzymatic Regulation;An in <i>Silico</i>Approach

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Advances in Enzyme Research 2021年第4期9卷 55-71页

作者： Alan Carrasco-Carballo Emiliano Marín-Merino penélope Merino-Montiel Blanca colin-Lozano Sandra Luz Cabrera Hilerio Jazmin Ciciolil Hilario-Martínez Jesús Sandoval-Ramírez Laboratorio de Elucidación y Síntesis en Química Orgánica Facultad de Ciencias Químicas Benemérita Universidad Autónoma de Puebla Puebla México Laboratorio de Síntesis y Modificación de productos naturales Facultad de Ciencias Químicas Benemérita Universidad Autónoma de Puebla Puebla México Laboratorio de Bromatología Facultad de Ciencias Químicas Benemérita Universidad Autónoma de Puebla Puebla México 4Facultad de Estudios Superiores-Zaragoza UNAM CDMX México Facultad de Estudios Superiores-Zaragoza UNAM CDMX México

Steroidal plant growth promoters (SpGp) have been continuously studied due to their high activity increasing biomass and resistance to diverse stress factors. In our hands, a new SpGp family of 22-oxocholestanic comp... 详细信息

p style="margin-left:10.0pt;"> Steroidal plant growth promoters (SPGP) have been continuously studied due to their high activity increasing biomass and resistance to diverse stress factors. In our hands, a new SPGP family of 22-oxocholestanic compounds stands out at a comparative level to brassinosteroids (BSs). The potential activity of new SPGP against phytopathogens was studied through in silico molecular docking, these assays were performed with relevant ensymes of phytopatogens Chitinase B and 1,3-pan>β-Glucanase. Nine Chitinase B inhibitors and two 1,3-β-Glucanase inhibitors were proposed. The launched study analyzed the interactional and spatial level, determining the presence of interactions with key amino acids in receptors in comparison to reference inhibitors. Even more, the AVR4 and ECP6 effectors were also examined. No compound that blocks ECP6 was found;due to, probably, the influence of its highly hydrophilic environment. In the case of AVR4, two SPGP showed a better docking score (DS) than a chitin fragment (endogenous ligand);this fact demonstrates the latent potential of the 22-oxocholestanic derivatives against phytopathogens, with a specific regulation via proliferation inhibition. Moreover, this SPGP does not affect the symbiotic fungi that are beneficial for the natural plant system. p>

关键词： 22-Oxocholestanes Brassinosteroids Chitinase B 1 3-β-Glucanase ARV4 ECp6

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城市生态网络功能性连接辨识方法

生态学报 2015年第19期35卷 6414-6424页

作者：陈春娣 Meurk D. colin Ignatieva E. Maria Stewart H. Glenn 吴胜军中国科学院水库水环境重点实验室、中国科学院重庆绿色智能技术研究院重庆400714 新西兰皇家科学院土地保护研究所新西兰基督城7608 林肯大学新西兰基督城7674

城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以... 详细信息

城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以新西兰基督城为案例,分别利用景观发展强度指数建立阻力面,新西兰鸡毛松(Dacrycarpus dacrydioides)种子最大传播距离作为连接阈值来模拟、评价网络连接。结果表明:在1200 m距离阈值下,共有408条连接,其重要性分为10类。其中Richmond—petrie公园,Hansons—Auburn保护地,Centaurus公园—King George保护地是整个生态网络的关键连接;若去除,景观整体连接度将下降31.73%。此外,研究发现连接重要值与两端的源面积之和没有显著相关性,即面积大的源斑块之间的连接不一定对网络构建起关键作用,这一结论还有待进一步证明。针对缺少动物迁移资料的城市环境,改进最小费用模型和网络连接分析的部分参数;可操作性与实用性强,对中国城市区域生态恢复建设、栖息地选择具有借鉴意义。

关键词：城市生态网络功能性连接乡土栖息地最小费用模型图论乡土树种子传播

Extremely low-volume, high-intensity interval training improves exercise capacity and increases mitochondrial protein content in human skeletal muscle

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Open Journal of Molecular and Integrative physiology 2013年第4期3卷 202-210页

作者： Jasmin K. Ma Trisha D. Scribbans Brittany A. Edgett J. colin Boyd Craig A. Simpson Jonathan p. Little Brendon J. Gurd Department of Emergency Medicine Kingston General Hospital Kingston Canada Department of Health and Social Development University of British Columbia Okanagan Kelowna Canada Department of Kinesiology Queen’s University Kingston Canada

purpose: The purpose of the present study was to evaluate whole-muscle content of several proteins involved in the regulation of skeletal muscle mitochondrial protein content and anaerobic capacity following 4 weeks of extremely low-volume high-intensity interval training (HIT). Methods: Young, healthy, recreationally active adult males (n = 8) trained 4 times a week for 4 weeks on a cycle ergometer. Each session involved 4 min of total exercise comprised of eight 20 s intervals at ~170% of peak aerobic power separated by 10 s rest. Muscle biopsies were taken prior to (pre) and ~72 hrs post-training (post). par- ticipants completed an incremental peak oxygen up- take (VO2peak) test and a Wingate test pre-, mid-, and post-training. Results: VO2peak was elevated (p p nd post-training (pre: 40.5 ± 3.8 ml·kg-1·min-1, mid: 43.4 ± 2.5 ml·kg-1·min-1, post-: 47.2 ± 2.9 ml·kg-1·min-1). Wingate mean power also increased with training (pre-: 701.0 ± 73.0 W, mid-: 745.5 ± 73.3 W, post-: 786.8 ± 80.0 W). While maximal citrate synthase activity was unchanged, protein expression of the mitochondrial protein cytochrome c oxidase (COX) subunit I (+27%;p p p = 0.08) increased. Increases (p α (+19%), and nuclear pGC-1α (+46%) were also observed after 4 weeks of HIT. no changes were observed in the whole-muscle contents of pDHe1a, pDK4, SIRT1, mTOR, S6K1, MCT1, or pFK protein. Conclusions: These results demonstrate that several mitochondrial protein (but not citrate synthase activity), pGC-1α protein content, and exercise capacity can be improved in only 4 min of total training time per day, 4 days per wk using HIT cycle training.

关键词： pGC-1α Mitochondrial Biogenesis High-Intensity Interval Training SIRT1 Aerobic Fitness