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Otilonium bromide in irritable bowel syndrome:A dose-ranging randomized double-blind placebo-controlled trial

World Journal of Gastroenterology 2014年第34期20卷 12283-12291页

作者： Danuta Chmielewska-Wilkoń Giorgio Reggiardo colin gerard egan Department of Gastrointestinal Endoscopy Gabinet Endoskopii Przewodu PokarmowegoSzewska31-009 KrakowPoland Medi Service World Trade Center16149 GenoaItaly Primula Multimedia SRL 56121 PisaItaly

AIM: To examine the efficacy and safety of otilonium bromide (OB) in treatment-sensitive functional irritable bowel syndrome (IBS) clinical parameters.

关键词： Otilonium bromide Irritable bowel syndrome Spasmolytic Acute treatment

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Intraocular lens power calculation following laser refractive surgery

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Eye and Vision 2015年第1期2卷 63-70页

作者： Christopher Hodge Colm McAlinden Michael Lawless colin Chan gerard Sutton Aifric Martin Vision Eye Institute Level 3270 Avenue ChatwoodVictoriaNSWAustralia Save Sight Institute University of SydneySydneyNSWAustralia Flinders University Bedford ParkAdelaideSouth AustraliaAustralia Wenzhou Medical College WenzhouZhejiangChina School of Optometry and Vision Science University of New South WalesSydneyAustralia University College Dublin MontroseDublinIreland

Refractive outcomes following cataract surgery in patients that have previously undergone laser refractive surgery have traditionally been *** is related to several key issues including the preoperative assessment(keratometry)and intraocular lens power ***-reviewed literature is overwhelmed by the influx of methodology to manipulate the corneal or intraocular lens(IOL)powers following refractive *** would suggest that the optimal derivative formula has yet been *** review discusses the problems facing surgeons approaching IOL calculations in these post-refractive laser patients,the existing formulae and programs to address these *** published outcomes will be reviewed.

关键词： Cataract Laser refractive surgery Intraocular lens calculations

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400 TW operation of Orion at ultra-high contrast

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High Power Laser Science and Engineering 2018年第3期6卷 79-84页

作者： Stefan Parker colin Danson David egan Stephen Elsmere Mark Girling Ewan Harvey David Hillier Dianne Hussey Stephen Masoero James McLoughlin Rory Penman Paul Treadwell David Winter Nicholas Hopps AWE plc Aldermaston Reading RG7 4PR UK

The Orion facility at the Atomic Weapons Establishment in the United Kingdom has the capability to operate one of its two 500 J, 500 fs short-pulse petawatt beams at the second harmonic, the principal reason being to increase the temporal contrast of the pulse on target. This is achieved post-compression, using 3 mrn thick type-1 potassium dihydrogen phosphate crystals. Since the beam diameter of the compressed pulse is ~600 mm, it is impractical to achieve this over the full aperture due to the unavailability of the large aperture crystals. Frequency doubling was originally achieved on Orion using a circular sub-aperture of 300 mm diameter. The reduction in aperture limited the output energy to 100 J. The second-harmonic capability has been upgraded by taking two square 300 mmx 300 mm sub-apertures from the beam and combining them at focus using a single paraboloidal mirror, thus creating a 200 J, 500 fs, i.e., 400 TW facility at the second harmonic.

关键词： contrast frequency conversion ultra-high intensity

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Petawatt and exawatt class lasers worldwide

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High Power Laser Science and Engineering 2019年第3期7卷 168-221页

作者： colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel AWE AldermastonReadingUK OxCHEDS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxfordUK CIFS Blackett LaboratoryImperial CollegeLondonUK NIF&Photon Science Directorate Lawrence Livermore National LaboratoryLivermoreUSA Fraunhofer Institute for Laser Technology(ILT) AachenGermany Chair for Laser Technology LLT RWTH Aachen UniversityAachenGermany University of Rochester Laboratory for Laser EnergeticsRochesterUSA Central Laser Facility STFC Rutherford Appleton LaboratoryChiltonDidcotUK LULI CNRSCEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance Department of Physics The Ohio State UniversityColumbusUSA Centre for Ultrafast Optical Science University of MichiganAnn ArborUSA Intense Laser Irradiation Laboratory Istituto Nazionale di Ottica(INO)CNRPisaItaly Institute of Optics and Quantum Electronics Friedrich-Schiller-University Jena and Helmholtz InstituteJenaGermany The Graduate School for the Creation of New Photonics Industries NishikuHamamatsuJapan Institute of Applied Physics Russian Academy of SciencesNizhny NovgorodRussia Institute of Laser Engineering Osaka UniversitySuitaOsakaJapan ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Applied Physics(IAP)at Friedrich-Schiller-University Jena JenaGermany Helmholtz Institute Jena JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering(IOF) JenaGermany Key Laboratory for Laser Plasma(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Centre for Relativistic Laser Science(CoReLS) Institute for Basic ScienceDepartment of Physics and Photon ScienceGwangju Institute of Science and Techno

In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was *** was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has *** are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under *** addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR *** apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.

关键词： exawatt lasers high-power lasers petawatt lasers ultra-high intensity

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