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Intermittent suckling with or without comingling of non-littermate piglets before weaning improves piglet performance in the immediate post-weaning period when compared with conventional weaning

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Journal of Animal Science and Biotechnology 2017年第3期8卷 721-732页

作者： Diana l.Turpin Pieter.l.ngendijk Kate Plush John r.Pluske School of Veterinary and life Sciences Murdoch UniversityMurdochWA 6150Australia Trouw Nutrition Veerstraat 38Boxmeer 5831 iNThe Netherlands South Austr.l.an research and Development Institute Roseworthy CampusJS Davis BuildingRoseworthySA 5371Australia Present address:SunPork Farms 563 Coleman RoadPinkerton PlainsSA 5400Australia

Background： In this experiment, intermittent suckling（IS） with or without the co-mingling（Co M） of piglets was studied as a method to stimulate solid feed intake and reduce post-weaning ***： Three weaning regimes using 30 multiparous sows were compared：（1） conventional weaning（CW）（n = 10 litters）, where piglets had continuous access to the sow until weaning（d 0, farrowing = d-25 r.l.tive to weaning）;（2） intermittent suckling（IS）（n = 10 litters）, where piglets were separated from the sow for 8 h/d starting at d-7（r.l.tive to weaning）; and（3） intermittent suckling with co-mingling（ISCo）（n = 10 litters） where IS started at d-7 and two litters were housed together during separation and then returned to their original sow. Ad libitum creep feed was available from d-17. At weaning pigs were housed in pens of 11 pigs, 27 pens in total. The ISCo treatment was divided in half to examine effects of different mixing strategies after weaning. Half of the ISCo litters were kept in familiar groups（ISCo F, familiar, n = 4） and the other half were mixed within treatment resulting in groups of unfamiliar pigs（ISCo NF, not familiar, n = 5）, the same as IS（n = 9） and CW（n = 9） ***： The ISCo piglets ate more creep feed in the week before weaning（P 〈 0.01）, but also showed more aggressive and manipulative behaviour on first day of Co M compared with CW piglets（P 〈 0.05）. IS with or without Co M increased exploratory and play behaviour on the first day of treatment intervention（P 〈 0.001） and increased sleeping behaviour on the last day of treatment intervention compared with CW（P 〈 0.001）. Mixing strategy at weaning had an effect on performance data with the highest growth and feed intake seen in ISCo F pigs 2 to 8 d after weaning（P 〈0.001）. IS and ISCo NF pigs also grew faster and ate more than CW pigs 2 to 8 d after weaning（P 〈 0.001）. Post-weaning injury scores suggested reduced aggression in ISCo as evidenced by reduced redness（skin irritation）（P 〈 0.05）, a

关键词： Behaviour Co-mingling Intermittent suckling Piglet Weaning

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reproductive potential of field-collected overwintering boll weevils （Coleoptera： Curculionidae） fed on pollen in the laboratory

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Insect Science 2009年第4期16卷 321-327页

作者： S. M. Greenberg G. D. Jones J. J. Adamczyk, Jr. F. Eischen J. S. Armstrong r. J. coleman M. Setamou Tong-Xian liu USDA-ArS-KSArC-BIrU 2413 E. Hwy. 83 Weslaco Texas 78596 APMrU-SPA-ArS-USDA College Station Texas 77845 USDA- ArS-KSA rC-Honey Bee research Unit Texas A&M University Kingsville Citrus Center Weslaco TX 78596 Department of Entomology Texas AgriLife Research Texas A&M University System Weslaco Texas 78596 USA

The reproductive potential of overwintering boll weevil, Anthonomus grandis grandis （Boheman）, females collected from pheromone traps in September, November and January, fed for 1, 3, and 5 weeks on plant pollens, and then provided cotton squares, was determined in the laboratory at 27 ~ I^C, 65% rH, and a photoperiod 13 ： 11 （l ： D） h. Duration of pollen feeding by overwintering boll weevils did not significantly influence egg and feeding punctures, or puncture ratios （egg to total punctures） for any of the three months of parent weevil collections when provided cotton squares on a daily basis. However, punctures and puncture ratios are significantly different when comparing mean data between months of boll weevil collections. When boll weevils were provided with cotton squares daily, the pre-ovipositional periods of female parents captured in September, November and January were 5, 9 and 14 days, respectively. The rate of eggs by females was significantly lower during November and January than September. Female parents collected in September produced a significantly higher percentage of eggs yielding adult progeny than those collected in November and January. life table parameters indicated that net reproductive rate （ro） of boll weevil females collected in September was 1.2- fold higher than those collected in November and 10.7-fold higher than those collected in January. Except for testes size, no differences in male reproductive parameters were observed during the cotton-free period compared with males captured during mid-cotton （June）. The number of oocytes in the ovarioles and the number of ooeytes containing yolk were significantly lower during September, November and January compared with June. The reproductive potential ofoverwintering boll weevil females collected in different months is an important consideration in determining the success of any contr.l.strategy.

关键词： Anthonomusgrandisgrandis overwintering boll weevil reproductive pollen

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Free bisphenol A(BPA),BPA-Glucuronide(BPA-G),and total BPA concentrations in maternal serum and urine during pregnancy and umbilical cord blood at delivery

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Emerging Contaminants 2019年第1期5卷 279-287页

作者： Warren G.Foster Cariton Kubwabo Ivana Kosarac Sandra Gregorovich Garima Aryal Kaela coleman Department of Obstetrics&Gynaecology McMaster UniversityHamiltonOntarioL8S 4K1Canada Environmental Health Science and research Bureau Health CanadaOttawaOntarioK1A 0K9Canada Tobacco Contr.l.Directorate Health CanadaOttawaOntarioK1A 0K9Canada

While adult exposure to total bisphenol A(BPA)has been well documented,developmental exposure to BPA and fetal exposure to the bioactive form(free BPA)remains poorly ***,pregnant women(n?199)between 28 and 35 weeks of pregnancy were invited to participate in this *** serum free of hemolysis(n?189)and urine(n?112)were collected at third trimester and delivery along with umbilical cord blood(UCB)at *** BPA,BPA mono-glucuronide(BPA-G)and total BPA concentrations were measured using gas chromatography coupled with tandem mass *** concentrations of free BPA were quantifiable above the method detection limit(MDl?0.026 ng/ml)in approximately 34%of serum samples in the third trimester and 21%of samples at delivery whereas BPA-G and total BPA were quantified in 43 and 70%of third trimester and delivery samples,*** geometric mean of free BPA,BPA-G and total BPA concentrations in maternal serum during the third trimester and at delivery were 0.62 ng/l andl,0.09 and 0.28 ng/ml,and 0.24 and 0.31 ng/ml,*** mean urinary concentrations of free BPA,BPA-G,and total BPA(MDl?0.027 ng/ml)in the third trimester and delivery samples were 0.07 and 0.06 ng/ml,0.36 and 0.09 ng/ml,and 0.36 and 0.09 ng/ml,*** the UCB,the geometric means for free BPA,BPA-G,and total BPA concentrations were 0.05,0.08 and 0.10 ng/ml,*** results suggest that,in our study population,free BPA concentrations were low compared to other Canadian cohorts.

关键词： Bisphenol A Free BPA Conjugated BPA Pregnancy Exposure Fetal development Cord blood

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Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

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Translational Neurodegeneration 2023年第1期12卷 70-89页

作者： Car.l.n Tallon Benjamin J.Bell Medhinee M.Malvankar Pragney Deme Carlos Nogueras-Ortiz Erden Eren Ajit G.Thomas Kristen r.Hollinger Arindom Pal Maja Mustapic Meixiang Huang Kaleem coleman Tawnjerae r.Joe rana rais Norman J.Haughey Dimitrios Kapogiannis Barbara S.Slusher Johns Hopkins Drug Discovery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Neur.l.gy Johns Hopkins University School of MedicineBaltimoreMD 21205USA Cell Biology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Oncology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMD 21205USA Psychiatry and Behavior.l.Science Johns Hopkins University School of Medicine855 N.Wolfe StreetRangos 278BaltimoreMD 21205USA Intramur.l.research Program Laboratory of Clinical InvestigationNational Institute on AgingNational Institutes of Health251 Bayview BlvdSte 8C228BaltimoreMD 21224USA Johns Hopkins University School of Medicine 600 N.Wolfe StreetPathology 517BaltimoreMD 21287USA

Background Cognitive decline in Alzheimer’s disease(AD)is associated with hyperphosphor.l.ted tau(pTau)propagation between neurons along synaptically connected networks,in part via extracellular vesicles(EVs).EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutr.l.sphingomyelinase2(nSMase2)-mediated cleavage of *** report,for the first time,that human tau expression elevates brain ceramides and nSMase2 *** To determine the therapeutic benefit of inhibiting this elevation,we evaluated PDDC,the first potent,selective,or.l.y bioavailable,and brain-penetrable nSMase2 inhibitor in the transgenic PS19 AD mouse ***,we directly evaluated the effect of PDDC on tau propagation in a mouse model where an adeno-associated virus(AAV)encoding P301l/S320F double mutant human tau was stereotaxically-injected unilater.l.y into the *** contr.l.ter.l.transfer of the double mutant human tau to the dentate gyrus was *** examined ceramide levels,histopathological changes,and pTau content within EVs isolated from the mouse *** Similar to human AD,the PS19 mice exhibited increased brain ceramide levels and nSMase2 activity;both were completely normalized by PDDC *** PS19 mice also exhibited elevated tau immunostaining,thinning of hippocampal neuronal cell layers,increased mossy fiber synaptophysin immunostaining,and glial activation,all of which were pathologic features of human *** treatment reduced these *** plasma of PDDC-treated PS19 mice had reduced levels of neuronal-and microglial-derived EVs,the former carrying lower pTau levels,compared to untreated *** the tau propagation model,PDDC normalized the tau-induced increase in brain ceramides and significantly reduced the amount of tau propagation to the contr.l.ter.l.*** PDDC is a first-in-class therapeutic candidate that normalizes elevated brain ceramides and nSMase2 activity,leading to the slo

关键词： Alzheimer’s disease Extracellular vesicles Neutr.l.sphingomyelinase 2 Tau Ceramide

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基于遗传算法的多光谱影像非监督训练分类系统(英文)

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遥感学报 2007年第5期11卷 702-709页

作者： HUNG Chih-Cheng XIANG Mei Minh Pham KUO Bor-Chen Tommy l. coleman 南方技术州立大学计算与软件学院乔治亚州30067美国阿拉巴马农工大学农业与环境科学学院阿拉巴马州35762美国国立台中大学教育管理与统计研究所台中中国台湾

本文将遗传算法(GA)应用于非监督训练,提高了遥感数据的分类精度。遗传竞争学习算法(GA-Cl)综合了遗传算法和简单的竞争学习算法,可用于改进非监督训练的结果。遗传算法在典型样本聚类的过程中可以避免得到局部最优值。Jeffries-Matusit... 详细信息

本文将遗传算法(GA)应用于非监督训练,提高了遥感数据的分类精度。遗传竞争学习算法(GA-Cl)综合了遗传算法和简单的竞争学习算法,可用于改进非监督训练的结果。遗传算法在典型样本聚类的过程中可以避免得到局部最优值。Jeffries-Matusita(J-M)距离法是通过统计测量两个训练类别之间的分离度,可用于评价这种算法。将此算法应用于TM数据的结果显示,遗传算法改进了简单的竞争学习算法,与其他非监督训练算法相比,其提供了K-均值,GA-K-均值和简单的竞争学习算法。

关键词：非监督训练聚类算法人工神经网络竞争学习算法遗传算法

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A Graduated Nonconvex regularization for Sparse High Dimensional Model Estimation

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Journal of Computer and Communications 2014年第11期2卷 1-14页

作者： Thomas F. coleman Yuying li 不详

Many high dimensional data mining problems can be formulated as minimizing an empirical loss function with a penalty proportional to the number of variables required to describe a model. We propose a graduated non-convexification method to facilitate tracking of a global minimizer of this problem. We prove that under some conditions the proposed regularization problem using the continuous piecewise linear approximation is equivalent to the original 0 l regularization problem. In addition, a family of graduated nonconvex approximations are proposed to approximate its 1 l continuous approximation. Computational results are presented to illustrate the performance.

关键词： Sparse Model Estimation Variable Selection τ0 regularization

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Predicting outcome after early brain insult

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中华物理医学与康复杂志 2014年第5期36卷 385-385页

作者： Anderson VA Spencer-Smith MM coleman l

BACKGrOUND AND OBJECTIVE recent advances in neuroscience demonstrate that brain plasticity can facilitate changes in the brain in response to environment and *** study was designed to further understand the impact of age at the time of brain insult,as well as the influence of insult and environmental factors on cognitive and behavior.l.outcomes.

关键词：脑损伤预测预后早期环境因素神经科学可塑性大脑

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天然气脱硫的进展

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低碳化学与化工 1979年第6期 113-118页

作者： B.W.Bur.l.w r.l.coleman 黄家鹄

改进了的分析仪器正开始有助于对使用钴钼触媒一氧化锌系统运转特性的监测多年来,氨、甲博及氢气生产单元的天然气原料的脱硫系通过将硫化物吸附在由金属浸渍过的活性炭（处理过的）上来实现的。只要被脱除的硫化物是H2S和/或低级硫醇... 详细信息

改进了的分析仪器正开始有助于对使用钴钼触媒一氧化锌系统运转特性的监测多年来,氨、甲博及氢气生产单元的天然气原料的脱硫系通过将硫化物吸附在由金属浸渍过的活性炭（处理过的）上来实现的。只要被脱除的硫化物是H2S和/或低级硫醇而天然气又不含有明显量的较重烃类,则该项技术就工作得很好。较重烃优先被炭吸附将大大降低其吸附硫化物的能力,而H2S和硫醇以外的其它硫化物往往会导致两种情况:要么操作周期极短,要么穿透活性炭。硫氧化碳

关键词：脱硫系统高分子硫化物硫化合物天然气脱硫脱除催化剂活性炭吸附剂 ZnO 空速

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消极的和积极的实证主义

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法理学论丛 2014年第1期 109-132页

作者： [美]Jules l.coleman 王琦(译) 耶鲁大学法学院柏林自由大学法学院

任何一种关于法律的性质或者本质的理论都宣称提供一种标准(standard),以用来确定(determine)某一社会中的哪些规范构成该社会的法律,这些标准通常采取充分且必要条件的陈述形式。举例而言,法律现实主义的一种幼稚版本坚持认为一个社会... 详细信息

任何一种关于法律的性质或者本质的理论都宣称提供一种标准(standard),以用来确定(determine)某一社会中的哪些规范构成该社会的法律,这些标准通常采取充分且必要条件的陈述形式。举例而言,法律现实主义的一种幼稚版本坚持认为一个社会的法律是由法官们的判决所构成。在奥斯丁这类早期的实证主义者看来,法律由所谓的主权者的命令构成。

关键词：理论法律主权者社会举例实证主义现实主义标准

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用锌还原水作氢的同位素分析

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地球与环境 1983年第3期 55-57页

作者： M.l.coleman ,何禄卿中南矿冶学院中心实验室

本文制定了一种使用金属锌从毫克量水制备氢气的新方法。对小量样品而言,该方法具有比常用的方法更精确和制备时间更短的优点。本设计方案起源下***的设想,并且最初是为了作天然和人工合成晶体中流体包裹体中极小量水的同位素分析而设... 详细信息

本文制定了一种使用金属锌从毫克量水制备氢气的新方法。对小量样品而言,该方法具有比常用的方法更精确和制备时间更短的优点。本设计方案起源下***的设想,并且最初是为了作天然和人工合成晶体中流体包裹体中极小量水的同位素分析而设计的。通常采用的方法(1,2)需要将水样引入到高真

关键词：同位素分析氢气水样工业气体反应管矿物包体流体包裹体样品管真空系统质谱计锌粒

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