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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 23-24页

作者： Van Coevorden A.M. coenraads p.j. Svensson A. 田中伟 Dermatology Department Groningen UniversityHospital Groningen Netherlands

Background: Hand eczema is a major cause of morbidity and lost earnings. Many interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain. Objectives: As part of a long-term project to improve standards of design and reporting in hand eczema trials, we sought to describe the prevalent study designs and comment on the quality of reporting of such studies. Methods and data sources: Electronic databases (Cochrane, Medline, Embase, pascal, jicst-Eplus, Amed) were searched from january 1977 to April 2003 using all possible variants of the terms hand and eczema/dermatitis. In addition, four general medical and 17 specialist dermatology journals were hand-searched by pairs of researchers for all possible therapeutic studies. Study selection: Studies were eligible for inclusion if they dealt with hand eczema as diagnosed by a physician irrespective of the aetiology, and if they described the results of a study of a therapeutic intervention in humans. Single case reports and reviews were excluded, but case series and non-randomized studies were considered alongside randomized studies. Data selection: For each study, two researchers independently assessed the type of study, outcome measures, enrolment criteria, randomization, masking of interventions and how losses to follow-up were dealt with. Main outcome measures: proportion of studies according to type of intervention and study type. proportion of randomized controlled trials (RCTs) that adequately reported eligibility criteria, randomization generation and concealment,masking and intention-to-treat analysis. Results: A total of 90 studies reported in 87 papers dealt with 11 different classes of interventions. Around 80%of the studies dealt with just four interventions: ultraviolet light, topical steroids, radiation and systemic immunosuppressives. Of the 90 studies, 44 were case series, 15 were nonrandomized controlled trial

关键词：手部湿疹 EDEN 随机对照试验最佳治疗方法随机化方法环孢素类固醇激素内科医师综合性期刊 Cochrane

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用于评估慢性手部皮炎严重性图片的收集

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 8-9页

作者： coenraads p.j. Van Der Walle H. Thestrup-pedersen K. C.De La Loge 罗素菊冯义国 MApI Values 27 rue de la Villette 69003 Lyon France

Background: A standardized instrument is needed to rate the overall severity of chronic hand dermatitis (CHD), in particular during clinical trials. Objectives: To design and validate a photographic guide. Methods: Initially, five experts were asked to grade 50 photographs of CHD, first individually, then as a consensus-building group, in order to select the photographs included in the guide. Then, a validation session with 11 different dermatologists evaluating 28 patients was conducted to assess the interrater reliability and test-retest reproducibility of the assessment of disease severity, relying on the photographic guide, on two consecutive days. patient order was randomized, and only diseased hands were visible to prevent any bias in evaluation. Results: The experts reached a consensus for development of a photographic guide composed of five severity levels and four photographs per severity level. Results of the validation session showed a high level of interrater reliability and test- retest reproducibility. Conclusions: The photographic guide is a reliable tool for assessing the morphological severity of hand dermatitis, and can be used as part of a comprehensive evaluation of disease in international multicentre clinical trials.

关键词：皮肤科医生临床试验评分者

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职业接触二(口恶)英对男工血浆中氧化应激指标的影响

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中华劳动卫生职业病杂志 2006年第7期24卷 419-422页

作者：耿广华董丽杜宝宏张春梅马世伟汤乃军韩伟张芃 p.j.coenraads 天津大沽化工投资发展公司职工医院 300455 天津医科大学劳动卫生教研室 Occupational & Environmental Dermatology Unit University Medical Center Groningen Netherlands.

目的探讨职业接触二(口恶)英对男工血浆中氧化应激指标的影响。方法以职业接触二(口恶)英的作业男工为暴露组和没有该职业接触史的人群为对照组,分别测定血浆中丙二醛(MDA)含量,谷胱甘肽过氧化酶(GSH-px)和超氧化物歧化酶(SOD)活力。结... 详细信息

目的探讨职业接触二(口恶)英对男工血浆中氧化应激指标的影响。方法以职业接触二(口恶)英的作业男工为暴露组和没有该职业接触史的人群为对照组,分别测定血浆中丙二醛(MDA)含量,谷胱甘肽过氧化酶(GSH-px)和超氧化物歧化酶(SOD)活力。结果与对照组相比,暴露组血浆中MDA含量明显增高,差异有统计学意义(p＜0．01),提示工人体内可能发生了脂质过氧化；同时抗氧化系统中SOD和GSH-px活力均出现下降趋势,但仅有后者的下降差异有统计学意义(p＜0．05)。结论职业性接触二(口恶)英对男工血浆中氧化应激指标具有一定的干扰作用。

关键词：二噁英丙二醛谷胱甘肽过氧化酶超氧化物歧化酶

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职业接触二噁英对男工血浆中氧化应激指标的影响

职业接触二噁英对男工血浆中氧化应激指标的影响

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中华预防医学会第二届学术年会暨全球华人公共卫生协会第二届年会

作者：耿广华董丽杜宝宏张春梅马世伟汤乃军韩伟张芃 p.j.coenraads 天津市大华医院天津医科大学劳动卫生教研室 Occupational & Environmental Dermatology Unit University Medical Center Groningen．NL

二噁英(dioxins),是由75种多氯代二苯并二噁英(pCDDs)和135种多氯代二苯并呋喃(pCDFs)组成的化合物的总称。动物实验和流行病学调查均证明其极强的毒性,主要表现为皮肤、肝脏、肾脏、免疫以及生殖发育等多个系统的损伤。对于二噁英毒作...

二噁英(dioxins),是由75种多氯代二苯并二噁英(pCDDs)和135种多氯代二苯并呋喃(pCDFs)组成的化合物的总称。动物实验和流行病学调查均证明其极强的毒性,主要表现为皮肤、肝脏、肾脏、免疫以及生殖发育等多个系统的损伤。对于二噁英毒作用机制的研究众多学者也做出了不懈的努力,其中氧化应激被认为其中主要的作用机制之一。

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海洛因(二酯吗啡)引起的接触性变态反应及呼吸道/黏膜症状

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 44-44页

作者： Hogen Esch A.j. Van Der Heide S. Van Den Brink W. p.j. coenraads 罗素菊 Dermatology UMCG POBox 30001 9700 RB Groningen Netherlands

After the start of heroin (diacetylmorphine)-assisted treatment to a selected group of chronic treatment-resistant heroin-dependent patients in the Netherlands,we reported about work-related eczema and positive patch tests to heroin in some nurses and nasal and respiratory complaints. To investigate the prevalence of heroin contact allergy,we started a questionnaire-based study with follow-up by allergological examinations. Of 120 questionnaires sent, 101 (84% ) was returned: 67 from nurses and 34 from other employees. Of 101 workers, 38 (38% ) had reported work-related complaints: 33 of 67 (49% ) nurses and 5 of 34 (15% ) other employees. patch tests to heroin were performed in 24 nurses and were positive in 8 (33% ). All the 8 had eyelid or facial eczema and, in 6, accompanied by mucosal or respiratory complaints. The prevalence of heroin contact allergy in this study was 8% (8/101) among all employees and 12% (8/67) among nurses. Respiratory and mucosal complaints could not be ascribed to a contact allergy, and in these cases, serum was analysed for specific immunoglobulin E to heroin. A type 1 allergy to heroin could not be shown. These complaints are possibly due to the histamine-liberating effect of heroin, to atopic constitution, to a combination of these factors or less likely to other non-allergic factors.

关键词：接触性变态反应海洛因依赖斑贴试验二酯过敏性体质敏学组胺释放 Ⅰ型变态反应特异性

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