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Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis

World Journal of Gastroenterology 2019年第41期25卷 6238-6247页

作者： Colin Markus Kruger Ulrich Adam Thomas Adam Axel Kramer claus d heidecke Frank Makowiec Hartwig Riediger department of Surgery Immanuel Hospital RüdersdorfBerlin 15562Germany department of General Surgery Vivantes-Humboldt hospitalBerlin 13503Germany department of Microbiology Labor Berlin GmbHBerlin 13353Germany Institute of Hygiene and Environmental Medicine University Medicine GreifswaldGreifswald 17495Mecklenburg VorpommernGermany department of Surgery Clinic of GeneralVisceralVascular and Thoracic SurgeryUniversity Medicine GreifswaldGreifswald 17475Mecklenburg VorpommernGermany Section of clinical risk assessment University hospital of FreiburgFreiburg 79106Baden-WürttembergGermany

BACKGROUNd Jaundice or preoperative cholestasis(PC)are typical symptoms of pancreatic *** 50%of patients undergo preoperative biliary drainage(PBd)*** is a common cause of bacterobilia(BB)and is a known surgical site infection risk *** adjustment of preoperative antibiotic prophylaxis(PAP)may be reasonable according to the profile of *** this,we examined the microbiological findings in routine series of *** To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head *** In the period from January 2009 to december 2015,285 consecutive pancreatic head resections were *** for surgery were malignancy(71%),chronic pancreatitis(18%),and others(11%).A PBd was in 51%and PC was in 42%.The standard PAP was ampicillin/***,a smear was taken from the hepatic *** analysis of the isolated species and resistograms was *** were categorized according to the presence or absence of PC(PC+/PC-)and PBd(PBd+/PBd-)into four *** efficiency was analyzed for standard PAP and possible *** BB was present in 150 patients(53%).BB was significantly more frequent in PBd+(n=120)than in PBd-(n=30),Pd without PC:(PBd-/PC-:18%,PBd-/PC+:30%,PBd+/PC-:88%,PBd+/PC+:80%).BB was more frequent in malignancy(56%)than in chronic pancreatitis(45%).PBd,however,was the only independent risk factor in multivariate *** total,357 pathogens(342 bacteria and 15 fungi)were *** five most common groups(n=256,74.8%)were Enterococcus spp.(28.4%),Streptococcus spp.(16.9%),Klebsiella spp.(12.6%),Escherichia coli(10.5%),and Enterobacter spp.(6.4%).A polymicrobial BB(PBd+:77% vs PBd-:40%,Pd a more frequent detection of Enterococcus(Pd with PBd+.In PBd+,the efficiency of imipenem and piperacillin/tazobactam was significantl

关键词： Pancreatic surgery Bacteriobilia Antibiotic prophylaxis Cholestasis Cholangiopancreatography Endoscopic retrograde

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A Prospective Study Comparing Quality of Life and Cosmetic Results between Single-Port and Conventional Laparoscopic Cholecystectomy

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Surgical Science 2016年第2期7卷 114-125页

作者： Olaf Teubner claus d. heidecke Thomas Kohlmann Kaja Ludwig Maciej Patrzyk department of Surgery Clinic of General Surgery Visceral Thoracic and Vascular Surgery Ernst-Moritz-Arndt-University Hospital Greifswald Germany Institute for Community Medicine Ernst-Moritz-Arndt-University Greifswald Germany department of Surgery Südstadt Hospital Rostock Germany

Background: Multiple studies from the last five years have demonstrated that single-incision laparoscopic surgery cholecystectomy (SILS) is not only feasible but also produces a result comparable with that of conventional laparoscopic cholecystectomy (CLC). Methods and results: In this bicentric study, we used the Short Form (36) (SF-36) and Nottingham Health Profile (NHP) surveys to estimate and compare the post-operative quality of life up to the 28th post-operative day for 66 patients who had undergone either CLC (n = 32) or SILS (n = 34). Additionally, we investigated patient satisfaction with the cosmetic results after one year. The curves summarizing the eight sections in the physical sum scale and in the mental sum scale (SF-36) were the same within the confidence interval with a confidence level of 95%. Thus, post-operative quality of life could be assumed to be equivalent for the two groups. Evaluation of the NHP survey produced similar results. The perceived cosmetic results were significantly better for the SILS group (1.3 on a scale of 1 - 5 with 1 being the best) than for the CLC group (1.9) (p = 0.016). Conclusions: This study did not demonstrate better quality of life for the single-port procedure as it had been expected. Instead, the single-port procedure produced subjectively better cosmetic results.

关键词： Single-Port Laparoscopic Cholecystectomy Conventional Laparoscopic Cholecystectomy Quality of Live Cosmetic

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determination of sex by jasmonate^FA

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Journal of Integrative Plant Biology 2020年第2期62卷 162-164页

作者： claus Wasternack department of Molecular Signal Processing Leibniz Institute of Plant BiochemistryHalle(Saale)D‐06120Germany Laboratory of Growth Regulators Institute of Experimental Botany AS CR&Palacky UniversityOlomoucCZ‐78371Czech Republic

Jasmonic acid (JA) and some of its derivatives are important signals in plant stress responses such as biotic or abiotic stresses during alteration of the environment and are signals in several developmental processes such as trichome development, growth/defense balance, root growth, senescence, or light signaling (Wasternack and Hause 2013).

关键词： determination sex jasmonate

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Representation theory of dynkin quivers. Three contributions

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Frontiers of Mathematics in China 2016年第4期11卷 765-814页

作者： claus Michael RINGEL Fakultat fiir Mathematik Universitat Bielefeld P. O. Box 100 131 D-33501 Bielefeld Germany department of Mathematics Shanghai Jiao Tong University Shanghai 200240 China

The representations of the dynkin quivers and the corresponding Euclidean quivers are treated in many books. These notes provide three building blocks for dealing with representations of dynkin （and Euclidean） quivers. They should be helpful as part of a direct approach to study representations of quivers, and they shed some new light on properties of dynkin and Euclidean quivers.

关键词： Quiver dynkin quiver Euclidean quiver the exceptional vertices of a dynkin quiver representations of quivers thin representations filtrations of vector spaces conical representations of star quivers Auslander- Reiten quiver thick subcategories perpendicular subcategories one-point extension antichains of a poset antichains of an additive category simplifi- cation hammocks the 2-4-8 property the magic Freudenthal-Tits square

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Liver fat content determined by magnetic resonance imaging and spectroscopy

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World Journal of Gastroenterology 2010年第13期16卷 1560-1566页

作者： Fabian Springer Jürgen Machann claus d claussen Fritz Schick Nina F Schwenzer Section on Experimental Radiology Department of Diagnostic and Interventional Radiology University Hospital Tübingen department of diagnostic and Intervent ional Radiology University Hospital Tübingen

Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALd) or non-alcoholic fatty liver disease (NAFLd). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALd, NAFLd is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations.

关键词： Hepatic steatosis Magnetic resonance imaging Proton magnetic resonance spectroscopy Lipids

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THE REGULAR COMPONENTS OF THE AUSLANdER-REITEN QUIVER OF A TILTEd ALGEBRA

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Chinese Annals of Mathematics,Series B 1988年第1期9卷 1-18页

作者： claus MICHAEL RLNGEL Fakultt Fr Mathematik Universitt d-4800 Bielefeld 1 West-Germany

Let B be a connected finite-dimensional hereditary algebra of infinite *** is shown that there exists a regular tilting B-module if and only if B is wild andhas at least three simple *** this way,the author determines the possible form ofregular components which arise as a connecting component of the Auslander-Reitenquiver Γ(A)of a tilted algebra *** second result asserts that for a tilted algebra A,any regular component of Γ(A)which is not a connecting component,is quasi-serial.

关键词： Th THE REGULAR COMPONENTS OF THE AUSLANdER-REITEN QUIVER OF A TILTEd ALGEBRA

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A High Order Sharp-Interface Method with Local Time Stepping for Compressible Multiphase Flows

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Communications in Computational Physics 2011年第1期9卷 205-230页

作者： Angela Ferrari claus-dieter Munz Bernhard Weigand Institute of Aerodynamics and Gasdynamics University of StuttgartPfaffenwaldring 21D-70569 StuttgartGermany Institute of Aerospace Thermodynamics University of StuttgartPfaffenwaldring 31D-70569 StuttgartGermany

In this paper,a new sharp-interface approach to simulate compressible multiphase flows is *** new scheme consists of a high order WENO finite volume scheme for solving the Euler equations coupled with a high order pathconservative discontinuous Galerkin finite element scheme to evolve an indicator function that tracks the material *** the interface our method applies ghost cells to compute the numerical flux,as the ghost fluid ***,unlike the original ghost fluid scheme of Fedkiw et al.[15],the state of the ghost fluid is derived from an approximate-state Riemann solver,similar to the approach proposed in[25],but based on a much simpler *** formulation leads only to one single scalar nonlinear algebraic equation that has to be solved at the interface,instead of the system used in[25].Away from the interface,we use the new general Osher-type flux recently proposed by dumbser and Toro[13],which is a simple but complete Riemann solver,applicable to general hyperbolic conservation *** time integration is performed using a fully-discrete one-step scheme,based on the approaches recently proposed in[5,7].This allows us to evolve the system also with time-accurate local time *** to the sub-cell resolution and the subsequent more restrictive time-step constraint of the dG scheme,a local evolution for the indicator function is applied,which is matched with the finite volume scheme for the solution of the Euler equations that runs with a larger time *** use of a locally optimal time step avoids the introduction of excessive numerical diffusion in the finite volume *** different fluids have been used,namely an ideal gas and a weakly compressible fluid modeled by the Tait *** tests have been computed to assess the accuracy and the performance of the new high order scheme.A verification of our algorithm has been carefully carried out using exact solutions as well as a comparison with other numerical re

关键词： Sharp interface capturing compressible multiphase flows one-step time-integration time-accurate local time stepping modified ghost fluid method WENO schemes discontinuous Galerkin methods

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degradation of 3d-printed magnesium phosphate ceramics in vitro and a prognosis on their bone regeneration potential

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Bioactive Materials 2023年第1期19卷 376-391页

作者： Gefel Eugen Moseke claus Schmitt Anna-Maria dümmler Niklas Stahlhut Philipp Ewald Andrea Meyer-Lindenberg Andrea Vorndran Elke Institute and department for Functional Materials in Medicine and dentistry University Clinic WuerzburgWuerzburgGermany Institute for Biomedical Engineering(IBMT) University of Applied Sciences Mittelhessen(THM)Wiesenstraße 14GießenGermany Clinic for Small Animal Surgery and Reproduction Ludwig-Maximilians-UniversitätMunichGermany

Regenerative bone implants promote new bone formation and ideally degrade simultaneously to *** clinically established calcium phosphate bone grafts provide excellent osseointegration and osteoconductive efficacy,they are limited in terms of *** phosphate(MP)based ceramics are a promising alternative,because they are biocompatible,mechanically extremely stable,and degrade much faster than calcium phosphates under physiological *** of an implant material can include both chemical dissolution as well as cellular *** investigated the bioresorption of 3d powder printed struvite and newberyite based MP ceramics in vitro by a direct human osteoclast culture *** osteoclast response and cellular resorption was evaluated by means of fluorescence and TRAP staining,determination of osteoclast activities(CA II and TRAP),SEM imaging as well as by quantification of the ion release during cell ***,the bioactivity of the materials was investigated via SBF immersion,whereas hydroxyapatite precipitates were analyzed by SEM and EdX *** bioactive coating was resorbed by *** contrast,only chemical dissolution contributed to bioresorption of MP,while no cellular resorption of the materials was *** on our results,we expect an increased bone regeneration effect of MP compared to calcium phosphate based bone grafts and complete chemical degradation within a maximum of 1.5-3.1 years.

关键词： Newberyite Struvite Bioresorption Ceramic bone implants Human osteoclasts Bioactivity

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Effects of temperature,pH and O_(2) on the removal of hydrogen sulfide from biogas by external biological desulfurization in a full scale fixed-bed trickling bioreactor(FBTB)

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International Journal of Agricultural and Biological Engineering 2013年第1期6卷 69-81页

作者： Hans-Joachim Naegele Jonas Lindner Wolfgang Merkle Andreas Lemmer Thomas Jungbluth claus Bogenrieder University of Hohenheim State Institute for Agricultural Engineering and BioenergyGarbenstraße 9 StuttgartBaden-WürttembergDE 70599 Germany Züblin Umwelttechnik GmbH UmwelttechnikOtto-Dürr-Straße 1StuttgartBaden-WürttembergDE 70435 Germany

Hydrogen sulfide(H_(2)S)is a critical component of biogas formed under anaerobic conditions by sulfur and sulfate reducing bacteria from animal manure and renewable energy crops.H_(2)S causes high corrosion in equipment,has a negative environmental impact,inhibits the biogas formation process and is furthermore odorous and *** several methods for internal and external desulfurization found their way into practice and had been explored at laboratory scale,no data were available on the performance of such methods in full scale practice,especially for an external fixed-bed trickling bioreactor(FBTB).The effects of temperature,pH and air ratio on H_(2)S removal efficiency(RE)were *** study was conducted at a research biogas plant with a given output of 96 m^(3) biogas per hour,and an H_(2)S concentration ranging between 500 ppm and 600 ppm(1 ppm=1 cm^(3)/m^(3))on *** FBTB column has been designed to hold a packing volume of 2.21 m^(3) at a gas retention time of 84 seconds being loaded at an average of 32.88 g H_(2)S/(m^(3)·h).The highest H_(2)S RE of 98% was found at temperatures between 30℃ and 40℃.A major decline in RE to 21%-45%was observed at temperatures from 5℃ to 25℃.The results clearly showed a temperature optimum range for sulfate reducing *** results reveal that RE is little affected by different pH values and air *** the experimental period,the practical suitability of the FBTB system could be proved while avoiding the disadvantages of internal biological desulfurization methods.

关键词： external biological desulfurization fixed-bed trickling bioreactor(FBTB) H_(2)S removal efficiency(RE) hydrogen sulfide biogas full scale biogas research plant

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Postnatal germ cell development in cryptorchid boys

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Asian Journal of Andrology 2020年第3期22卷 258-264页

作者： Li-Hua dong Simone HildorF Erik Clasen-Linde Kolja Kvist dina Cortes Jorgen Thorup claus Yding Andersen Laboratory of Reproductive Biology Copen hagen University Hospital RigshospitaletCopenhage n 2100Den mark Faculty of Health and Medical Scie nces University of CopenhagenCopenhagen 2200Denmark department of Pathology Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark department of Pediatric Surgery Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark department of Pediatrics Copenhagen University Hospital HvidovreCopenhagen 2650Denmark.

Cryptorchidism is associated with infertility in *** orchiopexy is suggested to reduce the *** is lacking on the potential link between infant germ cell maturation and the risk of future *** objective of the study was to evaluate age-related germ cell development in *** for markers of germ cell development(octamerbinding transcription factor 3/4[0CT3/4],placental alkaline phosphatase[PLAP],KIT proto-oncogene[C-KIT],podoplanin[d2-40],Lin-28 homolog A[LIN28],and G antigen 7[GAGE-7])was performed in testicular biopsies from 40 cryptorchid boys aged 4-35 mon *** cell nu mbers and distributi ons were evaluated in cross sectio ns of semi niferous tubules,with and without immuno staini ***3/4,d2-40,and LIN 28 were gen erally expressed in the early stages of germ cell development,as show n by positive expression in germ cells in the central region of seminiferous tubules・In contrast,PLAP and GAGE-7 were expressed in both central and peripheral parts of the tubules in the early stages of development and expressed mainly in a peripheral position with advancing *** cell maturation was delayed in this study population as compared with that observed in our previous study on germ cell markers in a healthy *** number of GAGE-7-positive germ cells per tubular cross section obtained by immunostaining was significantly higher than that obtained by standard hematoxylin and eosin *** immunostaining revealed heterogeneity in germ cell development in cryptorchid *** results shed light on the pathophysiology of germ cell development in boys with cryptorchidism.

关键词： cryptorchidism germ cells immunostaining male fertility preservation reproductive index testis

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