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Intestinal inflammation and colorectal cancer:A doubleedged sword?

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World Journal of Gastroenterology 2011年第26期17卷 3092-3100页

作者： Angelamaria Rizzo Francesco Pallone Giovanni Monteleone Massimo claudio Fantini Department of Internal Medicine University of Rome "Tor Vergata"

Chronic inflammation is thought to be the leading cause of many human cancers including colorectal cancer(CRC).Accordingly,epidemiologic and clinical studies indicate that patients affected by ulcerative colitis and Crohn's disease,the two major forms of inflammatory bowel disease,have an increased risk of developing *** recent years,the role of immune cells and their products have been shown to be pivotal in initiation and progression of colitis-associated *** the other hand,activation of the immune system has been shown to cause dysplastic cell elimination and cancer suppression in other *** and experimental data herein reviewed,while confirming chronic inflammation as a risk factor for colon carcinogenesis,do not completely rule out the possibility that under certain conditions the chronic activation of the mucosal immune system might protect from colonic dysplasia.

关键词： Colorectal cancer Inflammation T cells Cytokines Immunosurveillance

MUF Resins Improved by Citric Acid as Adhesives for Wood Veneer Panels

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Journal of Renewable Materials 2023年第2期11卷 539-553页

作者： claudio Del Menezzi Antonio Pizzi Siham Amirou Xuedong Xi Department of Forestry Engineering Faculty of TechnologyUniversity of BrasiliaBrasíliaBrazil LERMAB University of LorraineNancyFrance SeniorPost-Doctoral Internship LERMAB-ENSTIBUniversity of LorraineEpinalFrance Yunnan Key Laboratory of Wood Adhesives and Glue Products College of Material Science and EngineeringSouthwest Forestry UniversityKunmingChina International Joint Research Center for Biomass Materials Southwest Forestry UniversityKunmingChina

This article presents the first applied results of using citric acid in combinations with a melamine-urea-formal-dehyde(MUF)resin for bonding wood *** chemical reactions involved are shown based on a MALDI ToF analysis of the reaction of the MUF resin with citric *** preliminary results of the physical and mechanical properties of the LVL prepared are also *** from Populus sp were used to manufacture 5-layer laminated veneer lumber(LVL)of small *** combinations of the amount of citric acid,MUF spread rate and pressing parameters were *** bonded with 20%of citric acid+100 g/m^(2)of MUF,hot-pressed using a 3-step process with maximum 1.5 MPa of pressure yielded the board with better dimensional stability and mechanical *** could be concluded that citric acid in combination with MUF can be used for bonding wood veneer and the research should be continued to study further the parameters involved and to enhance the results.

关键词： LVL wood adhesives citric acid MUF resins MALDI ToF mechanical performance

Single-photon avalanche diode imagers in biophotonics:review and outlook

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Light(Science & Applications) 2019年第1期8卷 409-436页

作者： claudio Bruschini Harald Homulle Ivan Michel Antolovic Samuel Burri Edoardo Charbon AQUA EPFLNeuchatelSwitzerland AQUA TU DelftDelftThe Netherlands

Single-photon avalanche diode(SPAD)arrays are solid-state detectors that offer imaging capabilities at the level of individual photons,with unparalleled photon counting and time-resolved *** fascinating technology has progressed at a very fast pace in the past 15 years,since its inception in standard CMOS technology in 2003.A host of architectures have been investigated,ranging from simpler implementations,based solely on off-chip data processing,to progressively“smarter”sensors including on-chip,or even pixel level,time-stamping and processing *** the technology has matured,a range of biophotonics applications have been explored,including(endoscopic)FLIM,(multibeam multiphoton)FLIM-FRET,SPIM-FCS,super-resolution microscopy,time-resolved Raman spectroscopy,NIROT and *** will review some representative sensors and their corresponding applications,including the most relevant challenges faced by chip designers and ***,we will provide an outlook on the future of this fascinating technology.

关键词： image photon simpler

Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin,a synthetic analogue of the tripeptide hemiasterlin

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World Journal of Gastroenterology 2006年第42期12卷 6771-6778页

作者： Yogesh K Vashist Celine Tiffon Christoforos Stoupis claudio A Redaelli Department of General Visceral and Thoracic Surgery University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Visceral and Transplantation Surgery University Clinic Bern Switzerland Department of Clinical Research University of Bern Switzerland Institute of Clinical Radiology University of Bern Switzerland Gastrozentrum Hirslanden-Viszeralchirurgie Hirslanden Klinik Zurich Switzerland Department of Visceral and Transplantation Surgery and Department of Clinical Research University of Bern Switzerland

AIM： To investigate the inhibitory effects of taltobulin （HTI-286）, a synthetic analogue of natural hemiasterlin derived from marine sponges, on hepatic tumor growth in vitro and in vivo. METHODS： The potential anti-proliferative effects of HTI-286 on different hepatic tumor cell lines in vitro and in vivo were examined. RESULTS： HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines （mean IC50 = 2 nmol/L ±1 nmol/L） in vitro. Interestingly, no decrease in viable primary human hepatocytes （PHH） was detected under HTI-286 exposure. Moreover, intravenous administration of HTI-286 significantly inhibited tumor growth in vivo （rat allograft model）. CONCLUSION： HFI-286 might be considered a potent promising drug in treatment of liver malignancies. HTI-286 is currently undergoing clinical evaluation in cancer patients.

关键词： Hepatocellular carcinoma Antimicrotubuleagent HTI-286

New insights for the catalytic oxidation of cyclohexane to K-A oil

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Journal of Energy Chemistry 2022年第7期31卷 45-51,I0002页

作者： Alessandro Vomeri Marta Stucchi Alberto Villa claudio Evangelisti rea Beck Laura Prati Dipartimento di Chimica Universitàdegli Studi di MilanoVia Golgi 1920133MilanoItaly CNR-ICCOM-Istituto di Chimica dei Composti Organo Metallici Via G.Moruzzi 1I-56124 PisaItaly Centre for Energy Research Surface Chemistry and Catalysis DepartmentP.O.Box 49H-1525 BudapestHungary

Au-based catalysts have been reported to be active in the cyclohexane oxidation to K-A oil, but they showed some limitiations in terms of productivity, selectivity and required reaction conditions. The possibility to overcome some of these limits has been explored coupling Au with Cu, which can be suitable for undergoing the electron-switch in the initial step of the cyclohexane oxidation. Hence, a bimetallic 2 wt% Au Cu/Al_(2)O_(3) catalyst was tested in the oxidation of cyclohexane, working at mild conditions of 120 ℃ and 4 bar of O_(2). The combination of the catalyst with a very small amount of benzaldehyde used as cheaper and non-toxic radical initiator allowed to obtain a very high productivity of cyclohexanol and cyclohexanone(45 mmol*m L/mgmet*h) with a selectivity of 94%. Moreover, comparing the catalysed reaction with the non-catalysed one, the role of the catalyst has been disclosed.

关键词： K-A oil Cyclohexane oxidation Benzaldehyde Radical initiator Heterogeneous catalysis Radical mechanism AuCu bimetallic catalyst

Psychophysics in the ophthalmological practice—*** acuity

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Annals of Eye Science 2022年第4期7卷 50-64页

作者： Carlo Aleci claudio Rosa Department of Ophthalmology University of TurinMolinette HospitalTurinItaly

Perception is the ability to see,hear,or become aware of external stimuli through the *** stimuli are electromagnetic waves that interact with the eye and elicit a ***,indeed,imply the detection,resolution,and recognition of objects and images,and their accuracy depends on the integrity of the visual *** clinical practice,evaluating the integrity of the visual system relies greatly on the assessment of visual acuity,that is to say on the capacity to identify a *** acuity,indeed,is of utmost importance for diagnosing and monitoring ophthalmological *** acuity is a function that detects the presence of a stimulation(a signal)and resolves its detail(s).This is the case of a symbol like“E”:the stimulus is detected,then it is resolved as three horizontal bars and a vertical *** fact,within the clinical setting visual acuity is usually measured with alphanumeric symbols and is a three-step process that involves not only detection and resolution,but,due to the semantic content of letters and numbers,their *** with subjective(psychophysical)procedures,objective methods that do not require the active participation of the observer have been proposed to estimate visual acuity in non-collaborating subjects,malingerers,or *** paper aims to explain the psychophysical rationale underlying the measurement of visual acuity and revise the most common procedures used for its assessment.

关键词： Visual acuity(VA) Landolt ETDRS preferential looking Oktotype

TRANSFORMATION BETWEEN TWO KINDS OF EXPANSION COEFFICIENTS OF SYMMETRIC FUNCTIONS BASED ON MAPPING METHOD

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Journal of Electronics(China) 1996年第4期13卷 366-372页

作者： claudio Moraga Dortmund University

This paper discusses the definitions and properties of two kinds of fundamental symmetric functions, which are based on AND-OR-NOT algebraic system and AND-Exclusive OR algebraic system, respectively. Based upon it, some mapping transformation methods between two kinds of expansion coefficients of an arbitrary symmetric, function in the complete set of two fundamental symmetric functions.

关键词： Reed-Muller expansion Symmetric function bj maps Exclusive OR logic

Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults:A case report and review of the literature

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World Journal of Gastroenterology 2008年第6期14卷 960-965页

作者： Cosimo Sperti Mattia Berselli claudio Pasquali Davide Pastorelli Sergio Pedrazzoli Department of Medical and Surgical Sciences Clinica Chirurgica Ⅳ University of Padua Padua 35128 Italy Department of Oncology Istituto Oncologico Veneto Padua Italy

Solid-pseudopapillary tumor (SPT) is a rare neoplasm of the pancreas that usually occurs in young females. It is generally considered a low-grade malignant tumor that can remain asymptomatic for several years. The occurrence of infiltrating varieties of SPT is around 10%-15%. Between 1986 and 2006, 282 cystic tumors of the pancreas were observed. Among them a SPT was diagnosed in 8 patients (2.8%) with only one infiltrating variety. This was diagnosed in a 49-year-old female 13 years after the sonographic evidence of a small pancreatic cystic lesion interpreted as a pseudocyst. The tumor invaded a long segment of the portal- mesenteric vein confluence, and was removed with a total pancreatectomy, resection of the portal vein and reconstruction with the internal jugular vein. Histological examination confirmed the R-0 resection of the primary SPT, although a vascular invasion was demonstrated. The postoperative course was uneventful, but 32 mo after surgery the patient experienced diffuse liver metastases. Chemotherapy with different drugs was started. The patient is alive and symptom-free, with stable disease, 75 mo after surgery. Twenty-five patients with invasion of the portal vein and/or of mesenteric vessels were retrieved from the literature, 16 recent patients with tumor relapse after potentially curative resection were also retrieved. The best treatment remains a radical resection whenever possible, even in locally advanced or metastatic disease. The role of chemotherapy, and/or radiotherapy, is still to be defined.

关键词： Solid-pseudopapillary tumor Pancreatectomy Vascular resection Liver metastases Follow-up

Feeding of yeast(Candida spp.) improves in vitro ruminal fermentation of fibrous substrates

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Journal of Integrative Agriculture 2015年第3期14卷 514-519页

作者： Yoandra Marrero Yamicela Castillo Oscar Ruiz Eduviges Burrola claudio Angulo Department of Physiology Animal Science Institute Multidisciplinary Division Autonomous University of Juárez Faculty of Animal Science and Ecology Autonomous University of Chihuahua

In vitro gas production technique（IVGPT） was used with the objective of determining the inclusion effect of live cells of two strains of Candida yeast on in vitro ruminal fermentation of two fibrous substrates. In order to achieve this, two experiments were performed： A） using oat straw（Avena sativa） as substrate; B） using alfalfa hay（Medicabo sativa） as substrate, comparing the effect of two different strains of Candida genre, both isolated from the rumen, on the mentioned substrates. Levica 25（Candida tropicalis） yeast belongs to the culture collection of the Institute of Animal Science, Cuba, and Levazoot 15（Candida norvegensis） yeast is part of the collection of the Faculty of Zootechnology and Ecology of the Autonomous University of Chihuahua, Mexico. Both strains demonstrated their potential in activating the ruminal fermentation. They stimulated（P〈0.0001） the ruminal fermentation of the substrates under study. However, the Levazoot strain stimulated the dry matter（DM） fermentation of alfalfa in 21.43%, more than Levica 25. It is concluded that there is an influence of yeast strain and diet on the rumen environment and, therefore, it is important to select the appropriate strain in every production condition.

关键词： rumen yeast gas production fermentation product microbial additive