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Crucial steps in the natural history of inflammatory bowel disease

World Journal of Gastroenterology 2012年第29期18卷 3790-3799页

作者： Giovanni Latella claudio papi Gastroenterology Unit Department of Internal Medicine and Public HealthUniversity of L'Aquila67100 L'AquilaItaly Gastroenterology and Hepatology Unit S.Filippo Neri Hospital00135 RomeItaly

Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling *** the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of *** identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate *** treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for *** this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical *** methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Natural history Clinical course Complications Therapy Surgery Mortality

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Controlling DNA Bundle Size and Spatial Arrangement in Selfassembled Arrays on Superhydrophobic Surface

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Nano-Micro Letters 2015年第2期7卷 146-151页

作者： Gabriele Ciasca Massimiliano papi Valentina Palmieri Michela Chiarpotto Simone Di claudio Adele De Ninno Ennio Giovine Gaetano Campi Annamaria Gerardino Luca Businaro Marco De Spirito Istituto di Fisica Universitá Cattolica SC L.go Francesco Vito 100168 Rome Italy Istituto di Fotonica e Nanotecnologie-CNR Via Cineto Romano 42 00156 Rome Italy Institute of Crystallography-CNR Via Salaria Km 290016 Monterotondo Rome Italy

The use of superhydrophobic surfaces(SHSs) is now emerging as an attractive platform for the realization of one-dimensional(1D) nanostructures with potential applications in many nanotechnological and biotechnological *** this purpose, a strict control of the nanostructures size and their spatial arrangement is highly required. However, these parameters may be strongly dependent on the complex evaporation dynamics of the sessile droplet on the SHS. In this work, we investigated the effect of the evaporation dynamics on the size and the spatial arrangement of self-assembled 1D DNA bundles. Our results reveal that different arrangements and bundle size distributions may occur depending on droplet evaporation stage. These results contribute to elucidate the formation mechanism of 1D nanostructures on SHSs.

关键词： Superhydrophobicity DNA array Cassie state Wenzel state 1D nanostructures Self-assembly

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