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Photovoltaic-thermal solar-assisted heat pump systems for building applications:Integration and design methods

Energy and Built Environment 2023年第1期4卷 39-56页

作者： Alessandro Miglioli NiccolòAste claudio del pero Fabrizio Leonforte Architecture Built environment and Construction Engineering DepartmentPolitecnico di MilanoVia Ponzio 3120133 Milan Italy

The photovoltaic-thermal collector is one of the most interesting technology for solar energy conversion,com-bining electric and thermal energy production in a single ***-compression heat pump is already considered the most suitable clean technology for buildings thermal energy *** combination of these two technologies in an integrated“photovoltaic-thermal solar-assisted heat pump”(PVT-SAHP)system allows reaching a high fraction of the building thermal needs covered by renewable energy sources and to improve the performances of both the photovoltaic-thermal collector and the heat *** first is cooled down increasing its energy conversion efficiency,while providing low-temperature thermal energy to the second,which benefits from a higher evaporation *** review study presents the state-of-art of photovoltaic-thermal solar-assisted heat pump systems intended to cover thermal energy needs in buildings,with a particular focus on the integration methodologies,the possible configurations,the use of different sources and the design of sub-system *** issues are addressed by much scientific research,to improve the reliability and applicability of this technology,as an option for the building *** study aims to present PVT-SAHP systems in an organic and critical way to propose a useful tool for future research *** in detail,the work highlights the fact that the integration of photovoltaic-thermal collectors as evaporator of the heat pump in direct-expansion systems allows the highest heat recovery and ***,the distinction of the two circuits lead to more reliable,flexible and robust systems,especially when combined with a second heat source,being able to cover both heating and cooling *** implementation of real-time control strategy,as well as the continuous development of the compressor and refrigerant industries is positively influencing this technology,which is receiving more an

关键词： Solar-assisted heat pump Photovoltaic-thermal collector PVT-SAHP Renewable energy HVAC Technology review

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Interleukin 1βreceptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

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Neural Regeneration Research 2025年第2期20卷 416-423页

作者： Roberto Piacentini claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s ***,the molecular mechanisms underlying this association are not completely *** the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central ***,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.

关键词： herpes simplex virus type 1 interleukin 1β microglia neuroinflammation synaptic dysfunction

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MUF Resins Improved by Citric Acid as Adhesives for Wood Veneer Panels

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Journal of Renewable Materials 2023年第2期11卷 539-553页

作者： claudio del Menezzi Antonio Pizzi Siham Amirou Xuedong Xi Department of Forestry Engineering Faculty of TechnologyUniversity of BrasiliaBrasíliaBrazil LERMAB University of LorraineNancyFrance SeniorPost-Doctoral Internship LERMAB-ENSTIBUniversity of LorraineEpinalFrance Yunnan Key Laboratory of Wood Adhesives and Glue Products College of Material Science and EngineeringSouthwest Forestry UniversityKunmingChina International Joint Research Center for Biomass Materials Southwest Forestry UniversityKunmingChina

This article presents the first applied results of using citric acid in combinations with a melamine-urea-formal-dehyde(MUF)resin for bonding wood *** chemical reactions involved are shown based on a MALDI ToF analysis of the reaction of the MUF resin with citric *** preliminary results of the physical and mechanical properties of the LVL prepared are also *** from Populus sp were used to manufacture 5-layer laminated veneer lumber(LVL)of small *** combinations of the amount of citric acid,MUF spread rate and pressing parameters were *** bonded with 20%of citric acid+100 g/m^(2)of MUF,hot-pressed using a 3-step process with maximum 1.5 MPa of pressure yielded the board with better dimensional stability and mechanical *** could be concluded that citric acid in combination with MUF can be used for bonding wood veneer and the research should be continued to study further the parameters involved and to enhance the results.

关键词： LVL wood adhesives citric acid MUF resins MALDI ToF mechanical performance

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Measuring 3D face deformations from RGB images of expression rehabilitation exercises

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Virtual Reality & Intelligent Hardware 2022年第4期4卷 306-323页

作者： claudio FERRARI Stefano BERRETTI Pietro PALA Alberto del BIMBO Department of Engineering and Architecture University of ParmaParma 43124Italy Department of Information Engineering University of FlorenceFlorence 50139Italy

Background The accurate(quantitative)analysis of 3D face deformation is a problem of increasing interest in many *** particular,defining a 3D model of the face deformation into a 2D target image to capture local and asymmetric deformations remains a challenge in existing literature.A measure of such local deformations may be a relevant index for monitoring the rehabilitation exercises of patients suffering from Par-kinson’s or Alzheimer’s disease or those recovering from a *** In this paper,a complete framework that allows the construction of a 3D morphable shape model(3DMM)of the face is presented for fitting to a target RGB *** model has the specific characteristic of being based on localized components of *** fitting transformation is performed from 3D to 2D and guided by the correspondence between landmarks detected in the target image and those manually annotated on the average *** fitting also has the distinction of being performed in two steps to disentangle face deformations related to the identity of the target subject from those induced by facial *** The method was experimentally validated using the MICC-3D dataset,which includes 11 *** subject was imaged in one neutral pose and while performing 18 facial actions that deform the face in localized and asymmetric *** each acquisition,3DMM was fit to an RGB frame whereby,from the apex facial action and the neutral frame,the extent of the deformation was *** results indicate that the proposed approach can accurately capture face deformation,even localized and asymmetric *** The proposed framework demonstrated that it is possible to measure deformations of a reconstructed 3D face model to monitor facial actions performed in response to a set of ***,these results were obtained using only RGB targets,without the need for 3D scans captured with costly *** paves the way for the use of the

关键词： 3D morphable face model Sparse and locally coherent 3DMM components Local and asymmetric Face deformations Face rehabilitation Face deformation measure

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nZEB:bridging the gap between design forecast and actual performance data

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Energy and Built Environment 2022年第1期3卷 16-29页

作者： N.Aste R.S.Adhikari M.Buzzetti C.del pero H.E.Huerto-Cardenas F.Leonforte A.Miglioli Politecnico di Milano-Dept.of Architecture Built Environment and Construction EngineeringVia Ponzio 3120133 MilanoItaly

The nZEB objectives have raised the standard of building performance and changed the way in which buildings are designed and *** energy dynamic simulation tools are potentially the most suitable way for accurately evaluating and forecasting the thermal performance,they need several data inputs and user’s knowledge that can affect the reliability of the *** is precisely these two aspects that proved to be particularly critical,since the reliability of the ICT calculation tools has been widely proven in recent ***,in order to foster credibility in sustainable architecture,bridging the gap between predicted and measured performance is pivotal to boost the building market towards energy efficiency and provide reliable data to inhabitant,investors and policy *** present research aims to identify and quantify the main factors that affect the energy performance gap through a detailed energy analysis carried out on a case study,which can be considered one of the first nearly zero energy residential complex built in *** on the analysis,the study identifies the main causes of the deviation between the calculated and measured data and demonstrates how it is possible to achieve very reliable models and,therefore,real *** the procedure traces a classic model calibration scheme,actually it consists of a verification of possible downstream errors mainly due to human factors,such as the provision of incorrect technical data or inappropriate *** observations on the technical,management and regulatory gaps that may generate these errors are reported at the end of the study,together with practical suggestions that can provide effective solutions.

关键词： nZEB Energy performance gap Building energy dynamic simulation Post occupancy evaluation Model calibration GIGO

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Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第45期20卷 16841-16857页

作者： Alessandro Federico claudio Zulli Ilario de Sio Anna del Prete Marcello Dallio Mario Masarone Carmela Loguercio Department of Clinical and Experimental Medicine F.Magrassi e A.Lanzara Hepatogastroenterology Division Interuniversity Research Centre on Food Nutrition and the Gastrointestinal Tract (CIRANAD)-Second University of Naples Department of Internal Medicine and Hepatology University of Salerno

Non-alcoholic fatty liver disease(NAFLD)has become the most common liver disorder in Western countries and is increasingly being recognized in developing *** liver disease encompasses a spectrum of hepatic pathology,ranging from simple steatosis to non-alcoholic steatohepatitis,cirrhosis,hepatocellular carcinoma and end-stage liver ***,NAFLD is often associated with other metabolic conditions,such as diabetes mellitus type 2,dyslipidemia and visceral *** most recent guidelines suggest the management and treatment of patients with NAFLD considering both the liver disease and the associated metabolic *** and physical exercise are considered the first line of treatment for patients with NAFLD,but their results on therapeutic efficacy are often *** therapy is necessary most of the time to achieve a sufficient *** therapy includes a wide variety of classes of molecules with different therapeutic targets and,often,little evidence supporting the real *** the abundance of clinical trials,NAFLD therapy remains a challenge for the scientific community,and there are no licensed therapies for ***,new pharmacological approaches are ***,we will focus on the challenges facing actual therapeutic strategies and the most recent investigated molecules.

关键词： Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Fatty liver Steatosis Emerging drugs

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Unusual case of B cell lymphoma after immunosuppressive treatment for psoriasis

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World Journal of Hepatology 2015年第5期7卷 814-818页

作者： Lorenzo Nosotti Andrea Baiocchini claudio Bonifati Ubaldo Visco-Comandini Concetta Mirisola Franca del Nonno Gastrointestinal and Liver Department National Institute for HealthMigration and Poverty00153 RomeItaly Infectious Diseases Department National Institute for Infectious Diseases "L.Spallanzani" Department of Inflammatory Skin Diseases San Gallicano Dermatologic Institute (IRCCS)

Lymphomas may be induced by the systemic immunosuppressive therapies used to treat psoriasis,such as ciclosporin,methotrexate and tumour necrosis factor(TNF)-α *** biologic agents currently used in psoriasis include alefacept,efalizumab,and the TNF-α antagonists etanercept,infliximab,and *** and cancer are the main possible consequences of intended or unexpected *** report a 59-year-old man with a history of severe psoriasis vulgaris treated with traditional immunosuppressant drugs followed by anti-TNF-α therapy;the patient was firstly hospitalized for an acute cholestatic toxic hepatitis,which we supposed to be related to *** first liver biopsy showed active disease with severe hepatocellular damage caused by heavy lymphocytes infiltrate in portal tracts at in the interface with a not conclusive diagnosis of lymphoproliferative *** correct diagnosis of T cell/histiocyte-rich large B cell lymphoma(T/HRBCL) was only reached through a gastric biopsy and a second liver biopsy.T/HRBCL is an uncommon morphologic variant of diffuse large B-cell lymphoma not described until now in psoriatic patients receiving immunosuppressive biologic *** psoriatic patients,treated with biologic immunosuppressive agents,the suspect of abdominal lymphoma should always be included as differential *** ultrasound evaluation need therefore to be included in the pretreatment screening as in the follow-up surveillance.

关键词： Psoriasis Tumor necrosis factor-α blocker Immunosuppressant Diffuse large B-cell lymphoma Lymphoma

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Marine propellers performance and flow-field prediction by a free-wake panel method

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Journal of Hydrodynamics 2014年第5期26卷 780-795页

作者： GRECO Luca MUSCARI Roberto TESTA claudio DI MASCIO Andrea CNR-INSEAN Italian Ship Model BasinRomeItaly CNR-IAC Istituto per le Applicazioni del Calcolo "M. Picone"RomeItaly

A Boundary Element Method （BEM） hydrodynamics combined with a flow-alignment technique to evaluate blades shed vorticity is presented and applied to a marine propeller in open water. Potentialities and drawbacks of this approach in capturing propeller performance, slipstream velocities, blade pressure distribution and pressure disturbance in the flow-field are highlighted by comparisons with available experiments and RANSE results. In particular, correlations between the shape of the convected vortex- sheet and the accuracy of BEM results are discussed throughout the paper. To this aim, the analysis of propeller thrust and torque is the starting point towards a detailed discussion on the capability of a 3-D free-wake BEM hydrodynamic approach to describe the local features of the flow-field behind the propeller disk, in view of applications to propulsive configurations where the shed wake plays a dominant role.

关键词： BEM hydrodynamics free-wake analysis BEM-RANSE comparison

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Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules

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Translational Neurodegeneration 2022年第1期11卷 161-177页

作者： Francesca Natale Salvatore Fusco claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro Cuore00168 RomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS 00168 RomeItaly.

Neurodegenerative disorders are one of the most common causes of disability and represent 6.3%of the global burden of *** them,Alzheimer’s,Parkinson’s,and Huntington’s diseases cause cognitive decline,representing the most disabling symptom on both personal and social *** molecular mechanisms underlying the onset and progression of dementia are still poorly understood,and include secretory factors potentially affecting differentiated neurons,glial cells and neural stem cell *** the last decade,much attention has been devoted to exosomes as novel carriers of information exchanged among both neighbouring and distant *** vesicles can be generated and internalized by different brain cells including neurons,neural stem cells,astrocytes,and microglia,thereby affecting neural plasticity and cognitive functions in physiological and pathological ***,we review data on the roles of exosomes as carriers of bioactive molecules potentially involved in the pathogenesis of neurodegenerative disorders and detectable in biological fluids as biomarkers of *** also discuss the experimental evidence of the therapeutic potential of stem cell-derived vesicles in experimental models of neurodegeneration-dependent cognitive decline.

关键词： Extracellular vesicles Neurodegenerative diseases Stem cells Biomarkers Cognitive decline

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Tissue microarray-chip featuring computerized immunophenotypical characterization more accurately subtypes ampullary adenocarcinoma than routine histology

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World Journal of Gastroenterology 2020年第43期26卷 6822-6836页

作者： Matteo Palmeri Niccola Funel Gregorio Di Franco Niccolo Furbetta Desiree Gianardi Simone Guadagni Matteo Bianchini Luca E Pollina claudio Ricci Marco del Chiaro Giulio Di Candio Luca Morelli General Surgery Unit Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Division of Surgical Pathology University-Hospital of PisaPisa 56124Italy Department of Surgical MedicalMolecular Pathology and Critical AreaUniversity of PisaPisa 56124Italy Department of Surgery University of ColoradoDenverCO 80045United States

BACKGROUND Ampullary adenocarcinomas(AACs)are heterogeneous tumors currently classified into three important sub-classes(SC):Intestinal(INT),Pancreato-Biliary(PB)and Mixed-Type(MT).The different subgroups have similar clinical presentation and are treated by pancreatoduodenectomy with curative ***,they respond differently to chemotherapy and have different prognostic *** SC are often difficult to identify with conventional histology *** clinical outcome of all three remains unclear,particularly for *** To identify two main subtypes of AACs,using an immunohistochemical(IHC)score based on CDX2,CK7 and *** Tissue samples from 21 patients who had undergone resection of AAC were classified by HE histology and IHC expression of CDX2,CK7 and CK *** IHC score was obtained for each marker by counting the number of positive cells(0=no stained cells;150%)and their intensity(1=weak;2=moderate and 3=strong).A global score(GS)was then obtained by summation of the IHC scores of each *** MT tumors were grouped either with the INT or PB group based on the predominant immuno-molecular phenotype,obtaining only two AACs *** overall survival in INT and PB patients was obtained by Kaplan-Meier *** Histological parameters defined the AACs subtypes as follows:15%INT,45%PB and 40%*** IHC expression and the GS,75%and 25%of MT samples were assigned to either the INT or the PB *** mean value of the GS was 9.5(range 4-16).All INT samples had a GS above the average,distinct from the PB samples which had a GS score significantly below the average(P=0.0011).The INT samples were identified by high expression of CDX2 and CK20,whereas PB samples exhibited high expression of CK7 and no expression of CK20(P=0.0008).The INT group had a statistically significant higher overall survival than in the PB group(85.7 mo vs 20.3 mo,HR:8.39;95%CI:1.38 to 18.90;P=0.0152).CONCLUSION The combination of histopathological a

关键词： Ampullary adenocarcinoma Histo-molecular phenotype Prognostic CK7 CK20 CDX2

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