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Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications

World Journal of Stem Cells 2016年第10期8卷 332-341页

作者： Miruna Mihaela Micheu Ana-Maria Rosca Oana-claudia Deleanu Department of Cardiology Clinical Emergency Hospital of Bucharest 014461 Bucharest Romania Department of Regenerative Medicine “Nicolae Simionescu” Institute for Cellular Biology and Pathology 050568 Bucharest Romania “Carol Davila” University of Medicine and Pharmacy 050474 Bucharest Romania “Marius Nasta” Institute of Pneumophtisiology Bucharest 050159 Bucharest Romania

Obstructive sleep apnea syndrome(OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular disease, stroke, metabolic disorders, occupational errors, motor vehicle accidents and even death. Thus, OSAS has severe consequences and represents a significant economic burden. However, some of the consequences, as well as their costs can be reduced with appropriate detection and treatment. In this context, the recent advances that were made in stem cell biology knowledge and stem cell- based technologies hold a great promise for various medical conditions, including respiratory diseases. However, the investigation of the role of stem cells in OSAS is still recent and rather limited, requiring further studies, both in animal models and humans. The goal of this review is to summarize the current state of knowledge regarding both lung resident as well as circulating stem/progenitor cells and discuss existing controversies in the field in order to identify future research directions for clinical applications in OSAS. Also, the paper highlights the requisite for inter-institutional, multi-disciplinary research collaborations in order to achieve breakthrough results in the field.

关键词： Obstructive sleep apnea syndrome Continuous positive airway pressure therapy Lung resident stem/progenitor cells Circulating stem/progenitor cells Lung homeostasis

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Circulating and stool nucleic acid analysis for colorectal cancer diagnosis

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World Journal of Gastroenterology 2014年第4期20卷 957-967页

作者： Giulia De Maio claudia Rengucci Wainer Zoli Daniele Calistri Biosciences Laboratory Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS

In recent years, the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased. Up to now, none of the markers or panels of markers analyzed have met the rigorous standards required of a screening program. The important discovery of circulating nucleic acids in biological fluids has aroused intense scientific interest because of their usefulness in malignant and non malignant diseases. Over time, their yield and stability have been identified and compared with other “standard” biomarkers. The analysis of circulating DNA from blood and stool is a relatively simple and non-invasive procedure, representing a very attractive marker to detect genetic and epigenetic mutations and to monitor disease progression. A correlation between blood and stool biomarkers could also help to enhance currently available diagnostic approaches. However, various processing and analytic problems need to be resolved before such an approach can be applied in clinical practice.

关键词： Colorectal cancer Circulating DNA Circulating RNA Early diagnosis DNA integrity

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Causes and predictors of mortality in South Africans with systemic sclerosis

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Rheumatology & Autoimmunity 2023年第2期3卷 108-114页

作者： Zodwa Dire claudia Ickinger Mohammed Tikly Department of Internal Medicine Faculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Division of Rheumatology Chris Hani Baragwanath Academic HospitalFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa

Background:There is a dearth of mortality data on systemic sclerosis(SSc)in sub-Saharan *** undertook a retrospective study of causes and predictors of death in low-income indigent South Africans with ***:A retrospective records review of clinicodemographic,laboratory,and outcome data of SSc patients attending a state-funded tertiary Rheumatology service in South ***:Most of the 164 patients were Black(92.7%)and female(87.8%).The mean(SD)age at diagnosis and follow-up duration were 42.6(12.9)and 5.5(5.6)years,*** majority(75.6%)had diffuse cutaneous SSc(dcSSc);and digital pits/ulcers,interstitial lung disease(ILD),and pulmonary hypertension(PH)were documented in 73.6%,55.0%,and 38.3%,*** were 56 known deaths and an equal number of patients were lost to *** resulted from ILD complicated by PH(42.9%),infections(8.9%),cardiac disease(7.1%),and malignancies(3.6%).Estimated 5-and 10-year survival rates for patients with known outcomes were 58%and 42%,*** predictors of death were renal dysfunction and cor ***:Most patients in this study of South Africans had dcSSc and poor *** deaths resulted from cardiorespiratory complications of ILD complicated by *** pulmonale and renal dysfunction were independent predictors of death.

关键词： Africa interstitial lung disease mortality pulmonary hypertension systemic sclerosis

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The carbon fluxes in different successional stages:modelling the dynamics of tropical montane forests in South Ecuador

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Forest Ecosystems 2017年第2期4卷 143-153页

作者： sebastian paulick claudia dislich jürgen homeier rico fischer andreas huth Department of Ecological Modelling Helmholtz Centre for Environmental Research-UFZPermoserstr1504318 LeipzigGermany Georg-August-University Gottingen Plant EcologyUntere KarspOle 237073 GottingenGermany University of Osnabriick Institute of Environmental Systems ResearchBarbarastr1249076 OsnabruckGermany iDiv German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-LeipzigDeutscher Platz 5e04103 LeipzigGermany

Background： Tropical forests play an important role in the global carbon（C） ***, tropical montane forests have been studied less than tropical lowland forests, and their role in carbon storage is not well *** forests are highly endangered due to logging, land-use and climate *** objective was to analyse how the carbon balance changes during forest ***： In this study, we used a method to estimate local carbon balances that combined forest inventory data with process-based forest *** utilised such a forest model to study the carbon balance of a tropical montane forest in South Ecuador, comparing two topographical slope positions（ravines and lower slopes vs upper slopes and ridges）.Results： The simulation results showed that the forest acts as a carbon sink with a maximum net ecosystem exchange（NEE） of 9.3 Mg C？（ha？yr）-1during its early successional stage（0–100 years）.In the late successional stage, the simulated NEE fluctuated around zero and had a variation of 0.77 Mg C？（ha？yr）–*** simulated variability of the NEE was within the range of the field *** discovered several forest attributes（e.g., basal area or the relative amount of pioneer trees） that can serve as predictors for NEE for young forest stands（0–100 years） but not for those in the late successional stage（500–1,000 years）.In case of young forest stands these correlations are high, especially between stand basal area and ***： In this study, we used an Ecuadorian study site as an example of how to successfully link a forest model with forest inventory data, for estimating stem-diameter distributions, biomass and aboveground net primary *** conclude, this study shows that process-based forest models can be used to investigate the carbon balance of tropical montane *** this model it is possible to find hidden relationships between forest attributes and forest carbon *** relationships promote a better understandin

关键词： Forest model Tropical montane forest Forest succession Carbon balance Forest productivity FORMIND

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Optimization of wavelength range and data interval in chemometric analysis of complex pharmaceutical mixtures

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Journal of Pharmaceutical Analysis 2016年第1期6卷 64-69页

作者： Michele De Luca Giuseppina Ioele claudia Spatari Gaetano Ragno Department of Pharmacy Health and Nutritional Sciences University of Calabria

The performance of different chemometric approaches was evaluated in the spectrophotometric determination of pharmaceutical mixtures characterized by having the amount of components with a very high ratio. Principal component regression （PCR）, partial least squares with one dependent variable （PLS1） or multi-dependent variables （PLS2）, and multivariate curve resolution （MCR） were applied to the spectral data of a ternary mixture containing paracetamol, sodium ascorbate and chlorpheniramine （150：140：1, m/m/m）, and a quaternary mixture containing paracetamol, caffeine, phenylephrine and chlorpheniramine （125：6. 25：1.25：1, m/m/m/m）. The UV spectra of the calibration samples in the range of 200-320 nm were pre-treated by removing noise and useless data, and the wavelength regions having the most useful analytical information were selected using the regression coefficients calculated in the multivariate modeling. All the defined chemometric models were validated on external sample sets and then applied to commercial pharmaceutical formulations. Different data intervals, fixed at 0.5, 1.0, and 2.0 point/nm, were tested to optimize the prediction ability of the models. The best results were obtained using the PLSlcalibration models and the quantification of the species of a lower amount was sig- nificantly improved by adopting 0.5 data interval, which showed accuracy between 94.24% and 107.76%.

关键词： Chemometrics'Spectrophotometry'Principal component analysis'Partial least squares'Multivariate curve resolution

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Living on the edge: morphological and behavioral adaptations to a marginal high-elevation habitat in an arboreal mammal

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Integrative Zoology 2023年第4期18卷 746-761页

作者： claudia TRANQUILLO Lucas Armand WAUTERS Francesca SANTICCHIA Damiano PREATONI Adriano MARTINOLI Environment Analysis and Management Unit-Guido Tosi Research Group-Department of Theoretical and Applied Sciences Universitàdegli Studi dell’InsubriaVareseItaly Evolutionary Ecology Group Department of BiologyUniversity of AntwerpWilrijkBelgium

Habitats are characterized by different local environmental conditions that inﬂuence both behavior and morphology of species,which can result in habitat-dependent phenotypic differences among animals living in heterogeneous *** studied 3 alpine populations of Eurasian red squirrels(Sciurus vulgaris),1 living in a marginal high-elevation habitat at the edge of the species’altitudinal distribution,and 2 occurring in higher-quality ***,we investigated whether squirrels living in the marginal area differed in 2 morphological parameters(body size and body mass)and/or in the expression of 4 personality traits estimated with an openﬁeld test and a mirror image stimulation test(activity,exploration,activity-exploration,and social tendency).Furthermore,we tested whether within-individual variance of the traits(behavioral plasticity)was higher in the edge *** squirrels in the edge habitat were smaller and weighed less than in the other study areas,while among females,size–habitat relationships were less *** sex-speciﬁc patterns were explained by a strong association between body mass and reproductive success in female *** in the marginal habitat were more active,explorative,and had a more social personality than in the other ***,in contrast to our predictions,behavioral plasticity was smaller in the marginal habitat,but only for the trait *** results suggest that animals choose the habitat that bestﬁts their personality,and that habitat-related differences in selective pressures may shape animals’morphology.

关键词： behavioral plasticity marginal edge-habitat morphology personality Sciurus vulgaris

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Bats and marsupials as indicators of endemism in the Yungas forest of Argentina

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Zoological Research 2010年第6期31卷 633-644页

作者： María L Sandoval claudia A Szumik Rubén M Barquez PIDBA (Research Program of Argentinean Biodiversity) Natural Sciences Faculty and Miguel Lillo Institute National University of Tucuman Miguel Lillo 205 San Miguel de Tucumán CP 4000 Tucumán Argentina CONICET (National Council of Scientific and Technical Researches) Argentina INSUE (Superior Institute of Entomology "Dr. Abraham Willink") Natural Sciences Faculty and Miguel Lillo Institute National University of Tucuman Miguel Lillo 205 San Miguel de Tucumán CP 4000 Tucumán Argentina

Several studies have characterized the Yungas as a separate biogeographic unit, mainly based in floristic components. However, these characterizations were mainly qualitative and did not include faunal groups. The Yungas have been assumed as a region with rich floral and faunal diversity, but without testing how well they are described by animal distributions. Our study consists of a formal analysis of endemism based on distribution of small mammals in the southernmost portion of the Yungas. This area is biogeographically very interesting because the Yungas are comprised of discontinuous fragments of forests that extend into temperate arid and semiarid habitats. As a first approximation, we contrasted a group of volant species （bats） versus a group of non-volant species （marsupials）. Our results show that small mammals are efficient indicators of endemism in Yungas. Eighty percent of the species of small marsupials included in the analysis supported the identified areas as being zones of endemism. Regarding bats, almost 55 percent of the species supported a designation of endemism. The results also show that the areas we considered are congruent with the botanical definition of the Yungas of northwestern Argentina and their subdivisions, an assumption that had not been previously tested with a formal quantitative method. We also found that non-volant species are better indicators of endemism than volant ones at regional scales, but volant species are better indicators than was previously thought.

关键词： Andean rainforests Chiroptera Didelphimorphia Optimality criterion Small mammals

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Diabetic kidney disease in pediatric patients: A current review

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World Journal of Diabetes 2022年第8期13卷 587-599页

作者： Carmen Muntean Iuliana Magdalena Starcea claudia Banescu Department of Pediatrics I “George Emil Palade”University of MedicinePharmacySciences and Technology of Târgu MuresTârgu Mures 540142Romania Department of IVth Pediatrics University of Medicine and Pharmacy“Grigore T.Popa”Iasi 700115Romania Center for Advanced Medical and Pharmaceutical Research University of MedicinePharmacySciences and Technology of Târgu MureșMureșTârgu Mures 540142Romania

In the last decades,a significant increase in the incidence of diabetic kidney disease(DKD)was observed concomitant with rising diabetes mellitus(DM)*** disease associated with DM in children and adolescents is represented by persistent albuminuria,arterial hypertension,progressive decline in estimated glomerular filtration rate to end-stage renal disease and increased cardiovascular and all-cause morbidity and mortality of these *** medical practice,the common and still the“gold standard”marker for prediction and detection of diabetic kidney involvement in pediatric diabetes is represented by microalbuminuria screening even if it has low specificity to detect early stages of *** are some known limitations in albuminuria value as a predictor biomarker for DKD,as not all diabetic children with microalbuminuria or macroalbuminuria will develop end-stage renal *** tubular damage occurs before the glomerular injury,tubular biomarkers are superior to the glomerular ***,they may serve for early detection of DKD in both type 1 DM and type 2 *** and new biomarkers to identify diabetic children and adolescents at risk of renal complications at an early stage as well as renoprotective strategies are necessary to delay the progression of kidney disease to end-stage kidney *** biomarkers and therapeutic strategies are discussed as timely diagnosis and therapy are critical in the pediatric diabetic population.

关键词： Diabetes Kidney disease Biomarkers Microalbuminuria Therapy Children

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Reproducible Research Publication Workflow:A Canonical Workflow Framework and FAIR Digital Object Approach to Quality Research Output

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Data Intelligence 2022年第2期4卷 306-319页

作者： Limor Peer claudia Biniossek Dirk Betz Thu-Mai Christian Institution for Social and Policy Studies Yale UniversityConnecticut 06520USA Center for Empirical Research in Economics and Behavioral Sciences(CEREB) University of ErfurtThuringen 99089Germany Odum Institute for Research in Social Science University of North Carolina SystemNorth Carolina 27514-3916USA

In this paper we present the Reproducible Research Publication Workflow(RRPW)as an example of how generic canonical workflows can be applied to a specific *** RRPW includes essential steps between submission and final publication of the manuscript and the research artefacts(i.e.,data,code,etc.)that underlie the scholarly claims in the manuscript.A key aspect of the RRPW is the inclusion of artefact review and metadata creation as part of the publication *** paper discusses a formalized technical structure around a set of canonical steps which helps codify and standardize the process for researchers,curators,and *** proposed application of canonical workflows can help achieve the goals of improved transparency and reproducibility,increase FAIR compliance of all research artefacts at all steps,and facilitate better exchange of annotated and machine-readable metadata.

关键词： FAIR research output FAIR Digital Objects Reproducible research Research compendium Compendium publication workflow Data quality review

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Topographic effects observed at Amatrice hill during the 2016-2017 Central Italy seismic sequence

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 63-78页

作者： Gerardo Grelle Laura Bonito Maresca Rosalba Silvia Iacurto claudia Madiai Paola Revellino Giuseppe Sappa Department of Civil Building and Environmental EngineeringSapienza University of RomeItaly Department of Sciences and Technologies University of SannioItaly Department of Civil and Environmental Engineering University of FlorenceItaly

The estimate of seismic site effects by experimental approaches is based on different assumptions aimed at simplifying the complex actual site conditions and related ***,the reliability of the results can increase if the experimental data is focused on quite strong seismic sequences and the on-site acquisition of a large number of signals is deemed strategic for the assessment of the expected *** on these considerations,the ground motion at the Red Zone sector of Amatrice hill,violently struck by the 2016-2017 Central Italy seismic sequence,was analyzed via an observational approach.A large set of weak motions(moment magnitude Mw 2.5-3.9)was analyzed in this study by means of standard(SSR)and horizontal to vertical(HVSR)spectral ratio *** results from the experimental analysis of the site effects by using weak motion and noise signals show a significant amplification at the top of Amatrice hill with a remarkable polarization of the motion and changes in spectral shapes according to the topographic setting of the relief.

关键词： topographic effects standard spectra ratio(SSR) horizontal and vertical spectral ratio(HVSR) directional effects

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