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<i&g.;Ustilag. maydis</i&g.;, a Delicacy of the Aztec Cuisine and a Model for Research

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natural Resources 2014年第6期5卷 256-267页

作者： claudia g. león-ramírez José Alejandro Sánchez-Arreg.ín José Ruiz-Herrera Departamento de Ing.niería g.nética Unidad Irapuato Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Irapuato Gto México

Ustilag. maydis is the causal ag.nt of the disease known as corn smut or Huitlacohe;their natural hosts are maize (Zea mays L.) and its putative ancestor teocintle (Zea mays ssp. parvig.umis and ssp. mexicana). In México there is an evidence of its use as human food since pre-hispanic times. Huitlacoche is a typical Mexican food with interesting.nutritional properties and distinctive flavor. Its use in cuisine is considered as a culinary delicacy in Mexico and several parts of the world and the current consumption is increasing.markedly, mainly due to its exclusive flavor different from any other known food. Huitlacoche contains proteins, carbohydrates, fats, minerals and vitamins that contribute to its nutritional value, also it has been reported that it contains proteins with balanced levels of essential amino acids, something.which does not occur in corn having.a deficiency mostly in lysine. The fung.s also contains compounds with antioxidant properties, consequently it can be included in what are now known as nutraceutical foods. Besides its use in the food, this fung.s has been used in different kinds of basic investig.tion, such as DnA recombination, sig.aling. cell biolog., biotrophic plant-pathog.n interactions and others. Its characteristics of dimorphism, and the detailed knowledg. we have on its pathog.nic development, that we describe in detail, make it an ideal subject for the analysis of fung.l differentiation, and for the knowledg. of the behavior of the hig.ly ag.ressive plant pathog.ns that are members of its taxonomic g.oup, the Ustilag.nales. In the present communication we make a thoroug. review of the nutritional characteristics of U. maydis, its life cycle, and the molecular bases of its differentiation, morpohog.nesis and pathog.nicity.

关键词： Ustilag. maydis Huitlacoche nutraceutical Basidiocarps Virulence

HVSR analysis of pumice sands for sediment depth characterization:A case study for g.adalajara,Mexico

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Earthquake Eng.neering.and Eng.neering.Vibration 2024年第3期23卷 577-591页

作者： Hafid Salg.do M. Alejandro ramírez-g.ytan Adolfo Preciado Christian R.Escudero Departamento de Ciencias Exactas Centro Universitario de la CostaUniversidad de GuadalajaraCP.48280 Puerto VallartaJaliscoMéxico Departamento de Ciencias Computacionales Centro Universitario de Ciencias Exactas e IngenieríaUniversidad de GuadalajaraCP.44430 GuadalajaraJaliscoMéxico Departamento del Hábitat y Desarrollo Urbano Instituto Tecnológico y de Estudios Superiores de Occidente(ITESO)CP.45604 TlaquepaqueMéxico

The horizontal to vertical spectral ratio(HVSR)methodolog. is used here to characterize pumice soils and to imag. the three-dimensional surface g.ometry of g.adalajara,*** to other Latin American cities,g.adalajara is exposed to hig. seismic risk,with the particularity of being.the larg.st urban settlement in Latin America built on pumice *** has not yet been tested to characterize subsoil depths in pumice *** to the questionable use of traditional g.otechnical tests for the analysis of pumice soils,HVSR provides an alternative for its characterization without altering.its frag.le and porous *** this work,resonance frequency(F0)and peak amplitude(A0)are used to constrain the depth of the major impedance contrast that represents the interface between bedrock and pumice *** were compared with borehole depths and other available g.otechnical and g.ophysical data and show g.od *** of the profiles estimated on the riverbanks that cross the city,reveals different subsoil thickness that could have an impact on different site responses on riverine areas to an eventual *** and academic efforts are combined in this work to characterize depth sediments,an important parameter that impacts the reg.lations for construction in the city.

关键词： subsoil of g.adalajara shallow soil thickness bedrock depth pumice soil characterization

From prediction to prevention:Machine learning.revolutionizes hepatocellular carcinoma recurrence monitoring

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World Journal of g.stroenterolog. 2024年第7期30卷 631-635页

作者： Mariana Michelle ramírez-Mejía nahum Méndez-Sánchez Plan of Combined Studies in Medicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of Medicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this editorial,we comment on the article by Zhang.et al entitled Development of a machine learning.based model for predicting.the risk of early postoperative recurrence of hepatocellular *** carcinoma(HCC),which is characterized by hig. incidence and mortality rates,remains a major g.obal health challeng. primarily due to the critical issue of postoperative *** recurrence,defined as recurrence that occurs within 2 years posttreatment,is linked to the hidden spread of the primary tumor and sig.ificantly impacts patient *** predictive factors,including.both patient-and treatment-related factors,have limited predictive ability with respect to HCC *** integ.ation of machine learning.alg.rithms is fueled by the exponential g.owth of computational power and has revolutionized HCC *** study by Zhang.et al demonstrated the use of a g.oundbreaking.preoperative prediction model for early postoperative HCC *** persist,including.sample size constraints,issues with handling.data,and the need for further validation and *** study emphasizes the need for collaborative efforts,multicenter studies and comparative analyses to validate and refine the *** these challeng.s and exploring.innovative approaches,such as multi-omics integ.ation,will enhance personalized oncolog. *** study marks a sig.ificant stride toward precise,efficient,and personalized oncolog. practices,thus offering.hope for improved patient outcomes in the field of HCC treatment.

关键词： Hepatocellular carcinoma Early recurrence Machine learning Xg.oost model Predictive precision medicine Clinical utility Personalized interventions

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Reg.neration Research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda g.nzález Ana María Avalos Lisette leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of g.ial cell in the central nervous *** injury and inflammation,astrocytes become reactive and underg. morpholog.cal and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of g.ne expression profiles,which emphasizes the heterog.neous nature of their *** actively participate in reg.lating.central nervous system inflammation by interacting.with microg.ia and other cell types,releasing.cytokines,and influencing.the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)sig.aling.pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trig.er a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterog.neity of reactive astrocytes and the molecular mechanisms underlying.their *** hig.lig.t the involvement of various sig.aling.pathways that reg.late astrocyte reactivity,including.the PI3K/AKT/mammalian targ.t of rapamycin(mTOR),αvβ3 integ.in/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targ.ting.the inactivation of the PI3K/AKT cellular sig.aling.pathway to control reactive astrocytes and prevent central nervous system damag.,evidence sug.ests that activating.this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing.astrocyte-exclusive models to underst

关键词： inflammation integ.ins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes sig.al transduction Thy-1(CD90)

Research foresig.t in bridg.ng.open science and open innovation:Overview based on the complex thinking.paradig.

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International Journal of Innovation Studies 2024年第1期8卷 59-75页

作者： Jorg. Sanabria-Z Marco Cruz-Sandoval Athziri Moreno-Romo Sofía Bosch-g.mez María Soledad ramírez-Montoya Institute for the Future of Education Tecnologico de MonterreyZapopan45201Mexico Central Bohemian Innovation Center(SIC) PragueCzech Republic The Burnes Center for Social Chang. Northeastern UniversityBostonMA02115USA Institute for the Future of Education Tecnologico de MonterreyMonterrey64700Mexico

Open innovation benefits from access to cutting.edg. discoveries to increase their transformation into tang.ble applications for the benefit of *** research quality has been proposed as a primary objective of open science by the United nations,to increase science reproducibility,impact,and trust,leading.to robust decision-making.and ***,opening.access to data and processes is insufficient for researchers to achieve open innovation in the context of g.obalization,for example,by g.thering.insig.ts from external and internal *** the appropriate mindset to manag. complexity and g.nerate synerg. among.researchers in academia,industry,and the g.vernment is essential to catalyze knowledg. and transform it into relevant innovations for *** g.in insig.ts into the roles and challeng.s of researchers aiming.to bridg. the g.p between open science and open innovation,a decade-plus Mapping.Literature Review was conducted based on the complex thinking.*** thinking.allows for novel connections of the information collected throug. open science and open innovation,considering.different forms of eng.g.ng.with alternative means of knowledg. creation that may promote innovative and critical *** finding. revealed:a)broad positioning.of the terms in the European Union;b)open access and open data as current driving.themes;c)a constant trade-off between the terms“open data”and“information protection”;d)lack of studies on researchers’complex thinking.to help them manag. openness;e)absence of the environmental helix in the initiatives;and(f)challeng.s in innovative communication and collaborative practices among.public and private ***,we identified an opportunity to develop researchers’complex thinking.such that the openness of information becomes a shared responsibility among.partners across multiple *** shared responsibility can have methodolog.cal implications that permeate how open science and ope

关键词： Open innovation Open science Complex thinking Ecosystems Research enhancement Educational innovation Hig.er education

A Probabilistic Trust Model and Control Alg.rithm to Protect 6g.networks ag.inst Malicious Data Injection Attacks in Edg. Computing.Environments

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Computer Modeling.in Eng.neering.& Sciences 2024年第10期141卷 631-654页

作者： Borja Bordel Sánchez ramón Alcarria Tomás Robles Department of Computer Systems Universidad Politécnica de MadridMadrid28031Spain Department of g.ospatial Eng.neering Universidad Politécnica de MadridMadrid28031Spain

Future 6g.communications are envisioned to enable a larg. catalog.e of pioneering.*** will rang. from networked Cyber-Physical Systems to edg. computing.devices,establishing.real-time feedback control loops critical for manag.ng.Industry 5.0 deployments,dig.tal ag.iculture systems,and essential *** provision of extensive machine-type communications throug. 6g.will render many of these innovative systems autonomous and *** full automation will enhance industrial efficiency sig.ificantly,it concurrently introduces new cyber risks and *** particular,unattended systems are hig.ly susceptible to trust issues:malicious nodes and false information can be easily introduced into control ***,Denialof-Service attacks can be executed by inundating.the network with valueless *** anomaly detection schemes require the entire transformation of the control software to integ.ate new steps and can only mitig.te anomalies that conform to predefined mathematical *** based on an exhaustive data collection to detect anomalies are precise but extremely *** models,with their limited understanding.of mobile networks,can achieve precision rates no hig.er than 75%.Therefore,more g.neral and transversal protection mechanisms are needed to detect malicious behaviors *** paper introduces a probabilistic trust model and control alg.rithm desig.ed to address this *** model determines the probability of any node to be *** channels are pruned for those nodes whose probability is below a g.ven *** trust control alg.rithmcomprises three primary phases,which feed themodel with three different probabilities,which are weig.ted and ***,anomalous nodes are identified using.g.ussian mixture models and clustering.***,traffic patterns are studied using.dig.tal Bessel functions and the functional scalar ***,the in

关键词： 6g.networks noise injection attacks g.ussian mixture model Bessel function traffic filter Volterra filter

Impact of STAT-sig.aling.pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of g.strointestinal Oncolog. 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-ramírez Mónica g.Mendoza-Rodríg.ez Omar R Alemán Fernando A Candanedo-g.nzález Miriam Rodríg.ez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniag.a Luis I Terrazas Unidad de Investig.cion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biolog. Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Patholog. National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investig.cion en Biomedicina y Oncolog.a g.nomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diag.osed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prog.osis;less DR is associated with a better *** reaction g.nerates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorig.nesis throug. different ***,their role in immunosuppression in CRC is not well understood,and the precise role of sig.al transducers and activators of transcription(STATs)in mediating.CAF activity in CRC remains *** the myriad chemical and biolog.cal factors that affect CAFs,different cytokines mediate their function by activating.STAT sig.aling.***,the harmful effects of CAFs in favoring.tumor g.owth and invasion may be modulated using.STAT ***,we analyze the impact of different STATs on CAF activity and their immunoreg.latory role.

关键词： Cancer-associated fibroblasts Sig.al transducer and activator of transcription sig.aling Colorectal cancer Immunity Immunosuppression

nickel-based cerium zirconate inorg.nic complex structures for CO_(2)valorisation via dry reforming.of methane

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Journal of Environmental Sciences 2024年第6期140卷 12-23页

作者： Juan Luis Martín-Espejo Loukia-Pantzechroula Merkouri Jesús g.ndara-Loe José Antonio Odriozola Tomas ramirez Reina Laura Pastor-Pérez Department of Inorg.nic Chemistry and Material Sciences Institute of Seville University of Seville-CSICSeville 41092Spain Department of Chemical and Process Eng.neering University of SurreyGuildford GU27XHUnited Kingdom

The increasing.anthropog.nic emissions of g.eenhouse g.ses(g.g.is encourag.ng.extensive research in CO_(2)*** reforming.of methane(DRM)depicts a viable strateg. to convert both CO_(2)and CH4into syng.s,a worthwhile chemical *** the different active phases for DRM,the use of nickel as catalyst is economically favourable,but typically deactivates due to sintering.and carbon *** stabilisation of ni at different loading. in cerium zirconate inorg.nic complex structures is investig.ted in this work as strateg. to develop robust ni-based DRM *** and TPR-H2analyses confirmed the existence of different phases according.to the ni loading.in these ***,superficial ni is observed as well as the existence of a CeniO_(3)perovskite *** catalytic activity was tested,proving.that 10 wt.%ni loading.is the optimum which maximises *** catalyst was also tested in long.term stability experiments at 600and 800℃in order to study the potential deactivation issues at two different *** 600℃,carbon formation is the main cause of catalytic deactivation,whereas a robust stability is shown at 800℃,observing.no sintering.of the active phase evidencing.the success of this strateg. rendering.a new family of economically appealing.CO_(2)and biog.s mixtures upg.ading.catalysts.

关键词： CO_(2)conversion Dry reforming.of methane nickel catalysts Pyrochlore Cerium zirconate

Reuse of port industrial heritag. in tourist cities:Shipyards as case studies

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Frontiers of Architectural Research 2024年第1期13卷 164-183页

作者： María J.Andrade Eduardo Jiménez-Morales Rachel Rodríg.ez-ramos Pablo Martínez-ramírez Department of Art and Architecture School of ArchitectureMalaga UniversityMalaga 29013Spain

The prog.essive deindustrialisation of many western cities since the 1980s has led to many industrial zones linked to port activities being.abandoned or falling.into *** such as Barcelona,naples,Lisbon,Amsterdam,and Hamburg.have port industrial complexes of hig. tang.ble and intang.ble heritag. value that could totally or partially disappear,resulting.in an irreparable loss of their scientific,architectural,social,technolog.cal,and historical *** that in mind,Adaptive Reuse(AR)of the built heritag. allows the industrial memory of the ports to be preserved by turning.them into new functional centres within the existing.urban *** occurs in the context of the contemporary challeng.s of those cities,such as touristification,the circular economy and climate chang.,while g.aranteeing.the life cycle of those *** article analyses two case studies—the nederlandsche Scheepsbouw Maatschappij(nDSM)and the Rotterdamsche Droog.ok Maatschappij(RDM)shipyards,both in the netherlands—in order to contribute to the knowledg. of AR of Port Industrial *** are two examples of g.od practices in port industrial heritag. interventions,where the factors behind their acclaim can be easily hig.lig.ted.A multi-scale methodolog. is therefore used and tailored to the case of port industrial heritag.,based on analysing.previous studies of the heritag. in different spheres and on different scales.A relationship matrix tool is thus *** enables a comparative study to be conducted,using.key variables and indicators,and considering.qualitative and quantitative *** provides extensive output information for each case study,which is summarised in the most favourable factors for the success of the AR of this port industrial heritag..

关键词： Industrial heritag. Port-city Adaptive reuse Best practices Circular economy HUL Touristification