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A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model

World Journal of Gastroenterology 2006年第42期12卷 6779-6785页

作者： claudia esther carrasco-legleu Yesennia Sánchez-Pérez Lucrecia Márquez-Rosado Samia Fattel-Fazenda Evelia Arce-Popoca Sergio Hernández-García Saúl Villa-Trevio Departamento de Biología Celular Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav). Ave. IPN #2508. Col. San Pedro Zacatenco C.P. 07360 México D.F. México Instituto Nacional de Cancerología San Fernando No. 22 C.P.14080 México D.F. México

AIM： To study of the effect of caffeic acid phenethyl ester （CAPE） on the initiation period in a medium-term assay of hepatocarcinogenesis. METHODS： Male Wistar rats were subjected to a carcinogenic treatment （CT） and sacrificed at 25^th d; altered hepatic foci （AHF） were generated efficiently. To a second group of rats a single 20 mg/kg doses of CAPE was given 12 h before initiation with CT and were sacrificed at 25^th d. We evaluated the expression of preneoplastic markers as Y-glutamyltranspeptidase （GGT） and glutathione S-transferase type pi protein （GSTp） by histochemistry, RT-PCR and Western blot analyses, respectively. We measured thiobarbituric acid reactive substances （TBARS） in homogenates of liver and used Unscheduled DNA Synthesis （UDS） assay by incorporation of [^3H] thymidine （^3HdT） in primary hepatocyte cultures （PHC）. RESULTS： At 25^th d after CT CAPE reduced the observed increase of GGT^＋AHF by 84% and liver expression ofggt mRNA by 100%. In case of the GSTp protein, the level was reduced by 90%. As indicative of oxidative stress generated by diethylnitrosamine （DEN） 12 h after its administration, we detected a 68% increase of TBARS. When CAPE was administered before DEN, it completely protected from liver TBARS induction. To have an indication of the sole effect of CAPE on initiation, two carcinogens were tested in a UDS assay in PHC, we used methyl-n-nitrosoguanidine as a direct carcinogen and DEN, as indirect carcinogen. In this assay, genotoxic damage caused by carcinogens was abolished at 5μM CAPE concentration. CONCLUSION： Our results demonstrated that CAPE possesses anti-genotoxic and antineoplastic capabilities, by an anti-oxidative and free-radical scavenging mechanism.

关键词： Caffeic acid phenethyl ester Antioxidant Hepatocarcinogenesis Initiation

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Advances and Practices on the Research, Prevention and Control of Land Subsidence in Coastal Cities

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Acta Geologica Sinica(English Edition) 2020年第1期94卷 162-175页

作者： YAN Xuexin YANG Tianliang XU Yan Luigi TOSI esther STOUTHAMER Heri ANDREAS Philip MINDERHOUD Anirut LADAWADEE Ramon HANSSEN Gilles ERKENS Pietro TEATINI LIN Jinxin Roberta BONì Jarinya CHIMPALEE HUANG Xinlei Cristina Da LIO claudia MEISINA Francesco ZUCCA Key Laboratory of Land Subsidence Monitoring and Prevention Ministry of Nature Resources of ChinaShanghai 200072China Shanghai Institute of Geological Survey Shanghai 200072China Shanghai Engineering Research Center of Land Subsidence Shanghai 200072China Center for Land Subsidence of China Geological Survey Shanghai 200072China Institute of Geosciences and Earth Resources National Research CouncilVia G.Gradenigo 6Padova 35131Italy Land Subsidence International Initiative(LASII) UNESCOParisFrance Department of Physical Geography Faculty of GeosciencesUtrecht UniversityPrincetonlaan 8A3584 CSUtrechtThe Netherlands Geodesy Research Division Institute of Technology BandungBandung 40132Indonesia Deltares Research Institute Daltonlaan 6003584 BK UtrechtThe Netherlands Department of Groundwater Resources Ministry of Natural Resources and EnvironmentLatyaoChatuchak Bangkok 10900Thailand Delft University of Technology Faculty of Civil Engineering and GeosciencesStevinweg 12628 CNDelftThe Netherlands Department of Civil Environmental and Architectural EngineeringUniversity of PadovaVia Marzolo 9Padova 35131Italy Earth&Environmental Sciences Dept.University of Pavia Pavia 27100Italy Institute of Marine Sciences National Research CouncilArsenale Tesa104-Castello 2737/FVenice 30122Italy

Land subsidence severely threatens most of the coastal plains around the world where high productive industrial and agricultural activities and urban centers are concentrated. Coastal subsidence damages infrastructures and exacerbates the effect of the sea-level rise at regional scale. Although it is a well-known process, there is still much more to be improved on the monitoring, mapping and modeling of ground movements, as well as the understanding of controlling mechanisms. The International Geoscience Programme recently approved an international project(IGCP 663) aiming to bring together worldwide researchers to share expertise on subsidence processes typically occurring in coastal areas and cities, including basic research, monitoring and observation, modelling and management. In this paper, we provide the research communities and potential stakeholders with the basic information to join the participating teams in developing this project. Specifically, major advances on coastal subsidence studies and information on well-known and new case studies of land subsidence in China, Italy, The Netherlands, Indonesia, Vietnam and Thailand are highlighted and summarized. Meanwhile, the networking, dissemination, annual meeting and field trip are briefly introduced.

关键词： land subsidence coastal cities case studies International Geoscience Programme

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