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Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia

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Journal of Geriatric Cardiology 2017年第6期14卷 407-415页

作者： Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte clare bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty Department of Rehabilitation Aged and Extended Care Faculty of Medicine Nursing and Health Sciences School of Health Sciences Flinders University Daw Park Australia NHMRC Cognitive Partnership Centre The University of Sydney Sydney NSW Australia Kolling Institute of Medical Research St Leonards NSW Australia and Sydney Medical School University of Sydney Sydney NSW Australia Institute for Choice University of South Australia GPO Box 2471 Adelaide SA Australia Infection & Immunity - Aboriginal Health SAHMRI PO Box 11060 Adelaide SA Australia

Objective To examine associations between cardiovascular system medication use with cognition function and diagnosis of dementia in older adults living in nursing homes in Australia. Methods As part of a cross-sectional study of 17 Australian nursing homes examining quality of life and resource use, we examined the association between cognitive impairment and cardiovascular medication use （identified using the Anatomical Therapeutic Classification System） using general linear regression and logistic regression models. People who were receiving end of life care were excluded. Results Participants included 541 residents with a mean age of 85.5 years （± 8.5）, a mean Psychogeriatric Assessment Scale–Cognitive Impairment （PAS-Cog） score of 13.3 （± 7.7）, a prevalence of cardiovascular diseases of 44% and of hypertension of 47%. Sixty-four percent of participants had been diagnosed with dementia and 72% had received cardiovascular system medications within the previous 12 months. Regression models demonstrated the use of cardiovascular medications was associated with lower （better） PAS-Cog scores [Coefficient （β） = -3.7; 95% CI： -5.2 to -2.2; P 〈 0.0001] and a lower probability of a dementia diagnosis （OR = 0.44; 95% CI： 0.26 to 0.75, P = 0.0022）. Analysis by subgroups of medications showed cardiac therapy medications （C01）, beta blocking agents （C07）, and renin-angiotensin system agents （C09） were associated with lower PAS-Cog scores （better cognition） and lower dementia diagnosis probability. Conclusions This analysis has demonstrated an association between greater cardiovascular system medication use and better cognitive status among older adults living in nursing homes. In this population, there may be differential access to health care and treatment of cardiovascular risk factors. This association warrants further investigation in large cohort studies.

关键词： Cardiovascular agents Cognitive dysfunction Dementia Residential facilities

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Linking uplift and mineralisation at the Mount Novit Zn-Pb-Ag Deposit,Northern Australia:Evidence from geology,U-Pb geochronology and sphalerite geochemistry

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Geoscience Frontiers 2022年第2期13卷 333-350页

作者： bradley Cave William Perkins Richard Lilly Department of Earth Sciences University of AdelaideAdelaideSAAustralia Geological Survey of Queensland BrisbaneQLDAustralia

The subeconomic Mount Novit Zn-Pb-Ag deposit is located approximately 20 km south of Mount Isa,*** contrast to the nearby Mount Isa,Hilton and George Fisher Zn-Pb-Ag deposits,mineralisation at Mount Novit is situated to the west of the regional-scale Mount Isa Fault and is hosted in the Moondarra Siltstone as opposed to the Urquhart ***-grade(10 wt.%Zn+Pb)mineralisation occurs as a matrix supported breccia dominated by sphalerite and pyrrhotite with galena,pyrite,and ***-situ U-Pb geochronology was completed on apatite and two textural varieties of ***-grained(10 ppm),possibly reflecting the leaching of the metals from an underlying basement *** GGIMFis geothermometer(Frenzel et al.,2016)produced a mean formation temperature of 345±52℃.The timing and temperature of Zn-Pb-Ag mineralisation is consistent with the age and cooling temperature of apatite presented in this *** on these correlations,we

关键词： Mount Isa Mount Novit Zn-Pb-Ag mineralisation Monazite Apatite Geochronology

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The silent spermatozoon： are man-made endocrine disruptors killing male fertility？

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Asian Journal of Andrology 2013年第2期15卷 165-168,I0004页

作者： bradley D Anawalt Department of Medicine University of Washington Seattle WA 98195 USA

In 1992, a Danish group led by Skakkebaek , reported in a meta-analysis that global mean sperm counts were fallingandthat testicular cancer, hypospadias and cryptorchidism were increasing. They hypothesized that environmental factors were the cause. Their rectaanalysis was criticized subsequently for many methodological flaws. However, their controversial metamlysls and hypothesis spurred pubfic and scientific interest in the study of male reproductive function and stimulated more rigorous scientific work in the area. Subsequent research has not convincingly supported their hypothesis, However, it is caudal to continue high quality studies of the effects of drugs and manmade pollutants on male eeproductlve function.

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Utilizing a novel fiber optic technology to capture the axial responses of fully grouted rock bolts

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 222-235页

作者： Nicholas Vlachopoulos Daniel Cruz bradley Forbes Department of Civil Engineering Royal Military College of Canada Department of Geological Sciences and Geological Engineering Queen's UniversityKingston

Rock bolts are one of the primary support systems utilized in underground excavations within the civil and mining engineering industries. Rock bolts support the weakened rock mass adjacent to the opening of an excavation by fastening to the more stable, undisturbed formations further from the excavation. The overall response of such a support element has been determined under varying loading conditions in the laboratory and in situ experiments in the past four decades; however, due to the limitations with conventional monitoring methods of capturing strain, there still exists a gap in knowledge associated with an understanding of the geomechanical responses of rock bolts at the microscale. In this paper, we try to address this current gap in scientific knowledge by utilizing a newly developed distributed optical strain sensing(DOS) technology that provides an exceptional spatial resolution of 0.65 mm to capture the strain along the rock bolt. This DOS technology utilizes Rayleigh optical frequency domain reflectometry(ROFDR) which provides unprecedented insight into various mechanisms associated with axially loaded rebar specimens of different embedment lengths, grouting materials, borehole annulus conditions, and borehole diameters. The embedment length of the specimens was found to be the factor that significantly affected the loading of the rebar. The critical embedment length for the fully grouted rock bolts(FGRBs) was systematically determined to be430 mm. The results herein highlight the effects of the variation of these individual parameters on the geomechanical responses FGRBs.

关键词： Fiber optic technology Fully grouted rock bolts Load transfer Stress distribution

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A Systematic Spectroscopic Study of Four Apollo Lunar Soils

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Journal of Earth Science 2011年第5期22卷 578-585页

作者：凌宗成 Alian Wang bradley L Jolliff School of Space Science and Physics & Shandong Provincial Key Laboratory of Optical Astronomy & Solar-Terrestrial Environment Shandong University Weihai 264209 China Department of Earth & Planetary Sciences and McDonnell Center for the Space Sciences Washington University St. Louis MO 63130 United States National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

A systematic spectroscopic study including Raman, Mid-IR, N1R, and VIS-NIR, is used to investigate four endmember lunar soils. Apollo soils （〈45 μm） 14163, 15271, 67511, and 71501 were selected as endmembers to study, based on their soil chemistry, maturity against space weathering, and the sampling locations. These endmembers include an anorthositic highlands soil （67511）, a low-Ti basaltic soil （15271）, a high-Ti basaltic soil （71501）, and a mafic, KREEPy, impact-melt-rich soil （14163）. We used a laser Raman point-counting procedure to derive mineral modes of the soils and the compositional distributions of major mineral phases, which in turn reflect characteristics of the main source materials for these soils. The Mid-IR, NIR, and VIS-NIR spectroscopic properties also yield distinct information on mineralogy, geochemistry, and maturity among the four soils. Knowledge of the mineralogy resulting from the Raman point-counting procedure corresponds well with bulk mineralogy and soil properties based on Mid-IR, NIR, and VIS-NIR spectroscopy. The future synergistic application of these spectroscopy methods on the Moon will provide a linkage between the results from in situ surface exploration and those from orbital remotesensing observations.

关键词： geochemistry mineralogy planetary structural geology.

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Variant selection in stationary shoulder friction stir welded Ti-6Al-4V alloy

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Journal of Materials Science & Technology 2018年第1期34卷 198-208页

作者： Xiaoqing Jiang bradley P.Wynne Jonathan Martin Engineering Research Center of Advanced Manufacturing Technology for Automotive Structural Parts Ministry of Education College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Department of Materials Science and Engineering The University of Sheffield The Welding Institute Granta Park

Stationary shoulder friction stir welding of Ti-6Al-4V of 7 mm thickness was conducted with varying welding speeds and rotation speeds. Variant selection analysis was carried out based on the inherited α phase texture and the reconstructed 13 phase texture. The weld surfaces became significantly smoother with increasing welding speed and decreasing rotation speed. Heat input decreased greatly with increased welding speed and it decreased slightly with decreased rotation speed. The orientation relationship between the prior 13 grains was measured based on the reconstructed electron backscattered diffraction （EBSD） data. Weak Variant selection has occurred in all the welds because most of the prior 13 grains did not share { 110} poles. Strong links between crystal orientation of the prior 13 grains and hardness have been found.

关键词： Stationary shoulder friction stir welding Texture Variant selection Hardness

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THE OPTIMIZATION OF BUILDING DECONSTRUCTION FOR DEPARTMENT OF DEFENSE FACILITIES:*** DECONSTRUCTION PROJECT

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Journal of Green Building 2006年第1期1卷 102-122页

作者： bradley Guy Hamer Center for Community Design The Pennsylvania State University

Deconstruction is the selective dismantling of building structures to recover the maximum amount of primarily reusable and secondarily recyclable materials in a safe and cost-effective *** is a labor intensive process and can be difficult to achieve in a time-efficient and economical manner for light wood-framed *** techniques that balance hand and mechanical labor must be developed to maintain the integrity of materials for reuse and obtain maximum salvage value per unit of cost and *** project entailed the removal of three identical WWII-era two-story wood-framed barracks buildings at *** Army Base,Anniston,AL,using hand deconstruction,combined mechanical and hand deconstruction techniques,and a traditional demolition method,i.e.,mechanical reduction and disposal,in order to determine“optimal”deconstruction techniques based on salvage value per unit of *** maximum practical materials salvage from the study buildings using 100%hand deconstruction techniques was 39%of the mass by weight.A combination of hand and mechanical techniques was discovered to have approximately the same economic efficiency as 100%hand deconstruction,measured as a ratio of gross cost per salvage value,with a 44.6%reduction in total labor-hours,and a reduction of only 7%of salvage materials by *** findings indicate the potential for greatly increasing wood-framed building deconstruction practice relative to the additional time-on-site and labor that is required,compared to demolition,while optimizing economic *** paper describes the research methods and deconstruction techniques employed,and lessons learned to advance the practice of deconstruction to be more economically competitive and time-efficient.

关键词： demolition deconstruction building materials reuse building salvage building dismantling

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The Silk Road and Sources of Chinese Medicine Expansion:Part 2-Formularies

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Chinese Medicine and Culture 2018年第2期1卷 68-70页

作者： Sean bradley Department of Asian Languages and Literature University of WashingtonSeattleWAUSA

Medicines have been traded along the Silk Road from antiquity until modern *** products and their associated knowledge have been transferred over the land and sea between Asia,Europe,and *** texts that contain formulas and treatments passed along the Silk *** of these formulas and treatment methods called formularies contain unique information that informs this transfer of *** texts and information flowed in both directions along these routes and while Chinese medicine influenced foreign medical practices both in history,and today,the incorporation of non-Chinese medicine and information also continues to influence Chinese medicine.

关键词： Chinese medicine formulary history Materia medica Silk Road

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The Silk Road and Sources of Chinese Medicine Expansion: Part 1 – Materia Medica

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Chinese Medicine and Culture 2018年第1期1卷 29-31页

作者： Sean bradley Deaprtment of Asian Languages and Literature University of WashingtonWashingtonUSA

The Silk Road stretched over land and across seas connecting Europe,Africa,and *** trade of medicine along these routes has had profound impacts on the populations and traditions they have come into contact *** Medicine is no exception as it has taken numerous nonnative products and incorporated them into the unique philosophical construct of systematic correspondences that govern its *** looking at the four categories of primary source materials and studying the history of medical exchange along the Silk Road,we can determine how and where this information is used in Chinese *** Materia Medica(ben cao本草)texts are the first source of information for this study that will explore multiple sources to better understand the development of Chinese Medicine in relation to the rest of the world.

关键词： Chinese Medicine Materia Medica medical exchange Silk Road

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Sinology in Seattle: The University of Washington and its Influence on the Study of Chinese Medicine

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Chinese Medicine and Culture 2021年第3期4卷 176-180页

作者： Sean bradley Department of Asian Languages and Literature University of WashingtonSeattleWA 98195USA

The University of Washington has played a pivotal role in the field of sinology with faculty and alumni producing major publications in Chinese history,literature,phonetics,and *** contributions have been instrumental in the development of sinology as a field and have both directly and indirectly influenced the study of Chinese *** tracing the history of the Department of Asian Languages and Literature and examining several major figures,we can better understand how these individuals shaped the development of Chinese Medicine and contributed to its spread worldwide.

关键词： Chinese medicine history influence Seattle sinology

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