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Prevention of hepatitis B reactivation in patients with hematologic malignancies treated with novel systemic therapies:Who and Why?

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World Journal of Gastroenterology 2024年第5期30卷 509-511页

作者： Matteo Tonnini clara Solera Horna Luca Ielasi Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Infectious Disease Unit Azienda USL-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Department of Internal Medicine Ospedale degli Infermi di FaenzaFaenza 48018Italy

The risk of reactivation in patients with chronic or past/resolved hepatitis B virus(HBV)infection receiving chemotherapy or immunosuppressive drugs is a wellknown *** indication of antiviral prophylaxis with nucleo(t)side analogue is given according to the risk of HBV reactivation of the prescribed *** the advent of new drugs is occurring in all the field of medicine,in the setting of hematologic malignancies the last few years have been characterized by several drug classes and innovative cellular *** novel therapies,there are few data about the rate of HBV reactivation and the decision of starting or not an antiviral prophylaxis could be ***,patients are often treated with a combination of different drugs,so evaluating the actual role of these new therapies in increasing the risk of HBV reactivation is *** results are now available,but further studies are still *** with chronic HBV infection[hepatitis B surface antigen(HBsAg)positive]are reasonably all ***/resolved HBV patients(HBsAg negative)are the actual area of uncertainty where it could be difficult choosing between prophylaxis and pre-emptive strategy.

关键词： Hepatitis B reactivation Hepatitis B virus Antiviral prophylaxis Hematologic malignancies Chimeric antigens receptor-T cell therapy Immune checkpoint inhibitors

Thermal and Mechanical Properties of Thermoplastic Starch and Poly(Vinyl Alcohol-Co-Ethylene)Blends

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Journal of Renewable Materials 2019年第3期7卷 245-252页

作者： Ana clara Lancarovici Alves Rafael Grande Antonio José Felix Carvalho Department of Materials Engineering Sao Carlos School of EngineeringUniversity of Sao PauloAv.Joao Dagnone110013563-120Sao Carlos-SP-Brazil

The interest in thermoplastic starch(TPS)as a substitute material to replace conventional thermoplastics continues especially due its biodegradability,availability,low cost and because it is obtained from renewable ***,its poor mechanical properties and its high sensitivity to humidity have limited its use in several ***,the copolymer poly(ethylene-co-vinyl alcohol)(EVOH),with two different ethylene contents,27 and 44 mol%were blended with TPS by extrusion in order to overcome these *** obtained blends were characterized by thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),mechanical tensile testing,Scanning Electron Microscopy(SEM)and moisture absorption *** addition of EVOH copolymer did not significantly changed the thermal stability of TPS,however it increased the tensile strength in 65%when compared to *** morphology of the blends did not showed two distinct phases,an indication of miscibility or partial miscibility of the components.A decrease of moisture absorption was obtained by the addition of EVOH and is more pronounced for the EVOH with 44% of ethylene.

关键词： Thermoplastic starch EVOH polymer blends thermal properties of polymers mechanical properties of polymers

The Use of Zinc Oxide Nanoparticles in Eva to Obtain Food Packing Films

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Advances in Nanoparticles 2020年第3期9卷 59-80页

作者： clara Teixeira de Oliveira Jorge pereira Chimanowsky Junior Maria Inês Bruno Tavares Instituto de Macromoléculas Professora Eloisa Universidade Federal do Rio de Janeiro Centro de Tecnologia Bloco J Ilha do Fund&atilde o CP Rio de Janeiro RJ Brazil

The increasing demand for new packages with increased shelf life properties has stimulated the increase of research in the active packaging sector. The use of antimicrobial agents requires an in-depth study of their properties to avoid loss of efficiency of the polymer processing. In this context, the objective of this work was to evaluate the preparation of an 18% ethylene vinyl acetate copolymer (EVA) nanocomposite and zinc oxide (ZnO) as microbicidal nanoparticle, prepared in a monosulfon extruder. The nanoparticle was modified with octadecylamine and EVA 18 nanocomposite films were prepared and compared to the systems containing modified nanoparticle. These new materials were characterized by thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Dynamic Mechanical Analysis (DMA), Time Domain Nuclear Magnetic Resonance (NMR) to investigate the effect of zinc oxide nanoparticles on thermal properties, EVA crystallinity and antimicrobial effect. The TGA showed a tendency of increase of the thermal stability in different proportions of ZnO. DSC results did not show significant changes in thermal parameters. The XRD analysis showed an increase in the degree of crystallinity of the nanocomposites in relation to the EVA matrix and change in the crystallinity with the increase of ZnO percentages. DMA analysis indicates change in structural organization through the variation of storage modulus, loss, and tan delta. Time domain NMR data corroborate with XRD data through the change in molecular mobility.

关键词： Food Packaging Ethylene Vinyl Acetate Copolymer Antimicrobial ZnO

Managing Brands Over Time:The Valentino Case

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Managing Brands Over Time:The Valentino Case

作者： clara Ellena 复旦大学

学位级别：硕士

过去几年奢侈品市场正在发生巨变。技术革新以及“平易近人的奢侈”概念的兴起深刻地影响着诸多奢侈品牌。品牌专卖店正逐渐成为消费者体验品牌的场所。本研究将探索华伦天奴应该如何继承其品牌内涵,同时适应新的市场变化。一直以来华... 详细信息

过去几年奢侈品市场正在发生巨变。技术革新以及“平易近人的奢侈”概念的兴起深刻地影响着诸多奢侈品牌。品牌专卖店正逐渐成为消费者体验品牌的场所。本研究将探索华伦天奴应该如何继承其品牌内涵,同时适应新的市场变化。一直以来华伦天奴的主要客户群是成熟而优雅的中年女性,为他们出席高端活动,如鸡尾酒会,晚宴等提供相应的服饰。现如今,这是相对小众的一个市场。本研究的第一个假设是华伦天奴只专注于高端服饰的作风可能成为其在新环境下进一步发展的障碍。华伦天奴也应该照顾到女性在其他各种场合的着装需求,并着眼于为客服提供整体穿衣方案。对过去5年公司产品手册的深人研究将帮助理解公司在迎合用户多种需求和产品设计方面是否有所改变。同时,对不同品类产品销售数据的分析将帮助理解它们各自的销售表现

关键词：品牌专卖店客户体验产品设计市场销售数据分析

Impact of tropospheric modelling on GNSS vertical precision:an empirical analysis based on a local active network

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International Journal of Digital Earth 2018年第9期11卷 880-896页

作者： MªSelmira Garrido Mªclara de Lacy Ana MªRojas Department of Cartographic Geodetic and Photogrammetric EngineeringUniversity of JaénJaenSpain Center for Advanced Studies in Earth Sciences University of JaénJaenSpain Research group RNM282–Microgeodesia Jaén University of JaénJaenSpain

The troposphere affects Global Navigation Satellite System(GNSS)signals due to the variability of the refractive *** delay is a function of the satellite elevation angle and the altitude of the GNSS receiver and depends on the atmospheric *** the residual tropospheric delay is not modelled carefully a bias error will occur in the vertical *** order to analyse the precise altimetric positioning based on a local active network,four scenarios in Southern Spain with different topographical,environmental,and meteorological conditions are presented,considering both favourable and non-favourable *** use of surface meteorological observations allows us to take into account the tropospheric conditions instead of a standard atmosphere,but introduces a residual tropospheric bias which reduces the accuracy of precise GNSS ***,with short observation times it is recommended not to estimate troposphere parameters,but to use an a priori model together with the standard *** results confirm that it is possible to achieve centimetre-scale vertical accuracy and precision with real time kinematic positioning even with large elevation differences with respect to the nearest reference *** numerical results may be taken into consideration for improving the altimetric configuration of the local active network.

关键词： Altimetry GNSS meteorological data active network tropospheric refraction

History of pseudomyxoma peritonei from its origin to the first decades of the twenty-first century

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World Journal of Gastrointestinal Surgery 2019年第9期11卷 358-364页

作者： Francisco J Morera-Ocon clara Navarro-Campoy Department of General Surgery Hospital General de RequenaValencia 46340Spain Department of Gynecology and Obstetrics Hospital 9 OctubreValencia 46340Spain

Pseudomyxoma peritonei(PMP)is a disease surrounded by misunderstanding and *** about the etymology of pseudomyxoma is useful to remove the ambiguity around that *** word pseudomyxoma derives from pseudomucin,a type of *** was first described in a case of a woman alleged to have a ruptured pseudomucinous cystadenoma of the ovary,a term that has disappeared from today’s classifications of cystic ovarian *** is known today that in the majority of cases,the origin for PMP is an appendiceal neoplasm,often of low histological ***,ovarian tumors are wrongly being considered a significant recognized etiology of *** classification continues to be under discussion,and experts’panels strive for *** is also under discussion,and it is shown in this review that there is a long-standing historical reason for *** is the main tool in the treatment armamentarium for PMP,and the only therapy with potential curative option.

关键词： Pseudomyxoma peritonei Pseudomucin Appendiceal neoplasm Hyperthermic intraperitoneal chemotherapy

Urine-derived stem/progenitor cells:A focus on their characterization and potential

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World Journal of Stem Cells 2020年第10期12卷 1080-1096页

作者： Perrine Burdeyron Sébastien Giraud Thierry Hauet clara Steichen INSERM U1082 IRTOMIT CHU de PoitiersPoitiers 86021France Facultéde Médecine et Pharmacie Universite de PoitiersPoitiers 86021France

Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized *** the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(USCs)have aroused interest in the past *** display classical features of mesenchymal stem cells such as differentiation capacity and ***,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive ***,USCs can be differentiated into renal cell *** is of high interest for renal cell therapy-based regenerative *** review will firstly describe the isolation and characterization of *** will specifically present USC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation *** the second part of this review,we will present and discuss the main applications of *** include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or ***,we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes,which is a strategy being increasingly *** the last section,we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine.

关键词： Urine-derived stem cells Urine progenitor cells Exosomes Cell therapy Kidney injury and repair Regenerative medicine

Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus

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Neural Regeneration Research 2022年第3期17卷 649-654页

作者： Agnes Magyar Eva Racz clara Matesz Ervin Wolf Peter Kiss Botond Gaal Pediatrics Clinic Faculty of MedicineUniversity of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Division of Oral Anatomy Faculty of DentistryUniversity of DebrecenDebrecenHungary MTA-DE Neuroscience Research Group DebrecenHungary

Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements,posture and vegetative *** a shorter or longer period of time,the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic *** the plasticity of adult central nervous system is associated with the alteration of extracellular matrix,including its condensed form,the perineuronal net,we studied the changes of brevican expression in the perineuronal nets of the superior vestibular nucleus after unilateral labyrinth *** results demonstrated that the unilateral labyrinth lesion and subsequent compensation are accompanied by the changing of brevican staining pattern in the perineuronal nets of superior vestibular nucleus of the *** reduction of brevican in the perineuronal nets of superior vestibular nucleus may contribute to the vestibular plasticity by suspending the non-permissive role of brevican in the restoration of perineuronal net *** a transitory decrease,the brevican expression restored to the control level parallel to the partial restoration of impaired vestibular *** bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular *** experimental procedures were approved by the 'University of Debrecen–Committee of Animal Welfare'(approval No.6/2017/DEMAB) and the 'Scientific Ethics Committee of Animal Experimentation'(approval ***/06/éLB/2270-10/2017;approved on June 6,2017).

关键词： brainstem brevican chondroitin sulfate proteoglycan extracellular matrix labyrinth lesion neural plasticity perineuronal net perisynaptic matrix vestibular compensation vestibular system

Enhancement of THz generation in LiNbO_(3) waveguides via multi-bounce velocity matching

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Light(Science & Applications) 2022年第12期11卷 2994-3001页

作者： Blake S.Dastrup Eric R.Sung Frank Wulf clara Saraceno Keith A.Nelson Department of Chemistry Massachusetts Institute of TechnologyCambridgeMA 02139USA Faculty of Electrical Engineering and Information Technology Ruhr University BochumBochum 44801Germany

To realize the full promise of terahertz polaritonics(waveguide-based terahertz field generation,interaction,and readout)as a viable spectroscopy platform,much stronger terahertz fields are needed to enable nonlinear and even robust linear terahertz *** use a novel geometric approach in which the optical pump is totally internally reflected to increase the distance over which optical rectification *** matching is achieved by tuning the angle of internal *** doing this,we are able to enhance terahertz spectral amplitude by over 10x compared to conventional single-pass terahertz *** analysis of the depletion mechanisms reveals that 3-photon absorption and divergence of the pump beam are the primary limiters of further *** level of enhancement is promising for enabling routine spectroscopic measurements in an integrated fashion and is made more encouraging by the prospect of further enhancement by using longer pump wavelengths.

关键词： pump waveguide tuning