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Quantifying Environmental Impacts of Temporary Housing at the Urban Scale: Intersection of Vulnerability and PostHurricane Relief in New Orleans

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International Journal of Disaster Risk Science 2019年第4期10卷 478-492页

作者： claire McConnell Chiara Bertolin Department of Architecture and Technology Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of Mechanical and Industrial Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

The increasing risk and exposure of people and assets to natural hazards and disasters suggests an increasing need for temporary housing following *** to natural hazards is dependent on the resources available to families or communities to prepare for and mitigate risk,influenced by social *** study seeks to quantify the total environmental impact of temporary housing deployment in New Orleans,using the catastrophic impact of Hurricane Katrina in southern Louisiana in August 2005 as a case *** employ a novel approach to estimate displacement period and take into account social vulnerability across New Orleans neighborhoods to better understand the scale of post-disaster relief and its global warming *** methodology implemented in this study comprises three steps:a risk assessment,a life cycle assessment,and a resulting total impact *** demonstrate the considerable risk of greenhouse gas emissions and energy impacts from temporary housing deployment linked to hurricane ***,we show that environmental impact is highly sensitive to displacement period and find the current methodology of anticipating temporary housing use by hazard alone to be ***,the approach presented in this article provides tools to politicians and disaster risk professionals that allow for resource investment planning to decrease social vulnerability,thus enhancing resilience and adaptive capacity in a more homogeneous way at the urban scale.

关键词： Disaster risk Global warming potential Hurricane Katrina Life cycle assessment New Orleans Social vulnerability Temporary housing

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A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

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Cellular & Molecular Immunology 2023年第10期20卷 1114-1126页

作者： Morgane Thomas Charlotte Bruzeau Ophélie Alyssa Martin Justine Pollet Sébastien Bender claire Carrion Sandrine Le Noir Eric Pinaud Laboratoire Contrôle de la Réponse Immune B et des Lymphoproliférations(CRIBL) Universitéde LimogesCNRS UnitéMixte de Recherche 7276Inserm Unité1262LimogesFrance Centre Hospitalier Universitaire Dupuytren Service d’ImmunopathologieLimogesFrance Centre Hospitalier Universitaire de Limoges Centre National de l’Amylose AL et Autres Maladies par Dépôt d’Immunoglobulines MonoclonalesLimogesFrance Laboratoire Suivi des Therapies Innovantes Institut de Genetique HumaineUMR 9002 CNRS-UMMontpellierFrance

SATB1(Special A-T rich Binding protein 1)is a cell type-specific factor that regulates the genetic network in developing T cells and *** T cells,SATB1 is required for lineage commitment,VDJ recombination,development and *** that its expression varies during B-cell differentiation,the involvement of SATB1 needs to be clarified in this *** a KO mouse model in which SATB1 was deleted from the pro-B-cell stage,we examined the consequences of SATB1 deletion in naive and activated B-cell *** model indicates first,unlike its essential function in T cells,that SATB1 is dispensable for B-cell development and the establishment of a broad IgH ***,we show that SATB1 exhibits an ambivalent function in mature B cells,acting sequentially as a positive and negative regulator of Ig gene transcription in naive and activated cells,***,our study indicates that the negative regulatory function of SATB1 in B cells extends to the germinal center response,in which this factor limits somatic hypermutation of Ig genes.

关键词： B cells Nuclear factor Ambivalent Somatic hypermutation

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Health problems among street children seeking care in the Center for Social and Preventive Medicine in Egypt

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World Journal of Pediatrics 2017年第5期13卷 503-507页

作者： Hoda Ibrahim rizk Nihal Mohamed El Rifai Hana Mohamed Aboulghar Public Health and Community Medicine Department Faculty of MedicineCairo UniversityCairoEgypt Pediatrics Department Faculty of MedicineCairo UniversityCairoEgypt

Background:In Egypt,around 1 million children are on the *** children's health is an issue that is not well *** objective of the current study was to determine the health problems of a targeted group of street children seeking medical care and to generate a hypothesis about the positive/negative role of street children care ***:A cross-sectional study was done on 2169 street children who sought medical care at El-Basma clinic at the Center for Social and Preventive Medicine in Cairo University Children Hospital from January 2011 to July ***:Respiratory illnesses and skin problems were the most prevalent conditions,affecting 485 (22.4%) and 359 (16.6%) of the patients,*** issues and trauma were significantly higher among the adolescent *** and gastrointestinal problems were significantly higher among children aged less than 2 *** and cardiac problems were significantly higher among those referred from organizations whereas trauma was significantly higher among those coming directly from the streets.A significant proportion of children at the extremes of the studied age spectrum were coming directly from the *** transmitted infections were rare ***:Respiratory and skin diseases were the major morbidity problems among street children,especially adolescent *** afforded opportunities for access to different health care services.

关键词： Egypt health problems street children

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LncRNA H19 mediates BMP9-induced angiogenesis in mesenchymal stem cells by promoting the p53-Notch1 angiogenic signaling axis

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Genes & Diseases 2023年第3期10卷 1040-1054页

作者： Chengcheng Du Qiang Cheng Piao Zhao claire Wang Zhenglin Zhu Xiangdong Wu Shengqiang Gao Bowen Chen Jing Zou Wei Huang Junyi Liao Department of Orthopedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Orthopedic Laboratory of Chongqing Medical University Chongqing 400016China Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Computational and Applied Mathematics Rice UniversityHoustonTX 77005USA Department of Orthopedic Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BMP9 mediated osteogenic differentiation mechanisms of MSCs were widely explored, however, mechanisms of BMP9-induced angiogenesis still need to be clarified. We previously characterized that Notch1 promoted BMP9-induced osteogenesis–angiogenesis coupling process in mesenchymal stem cells (MSCs). Here, we explored the underlying mechanisms of lncRNA H19 (H19) mediated regulation of BMP9-induced angiogenesis through activating Notch1 signaling. We demonstrated that basal expression level of H19 was high in MSCs, and silencing H19 attenuates BMP9-induced osteogenesis and angiogenesis of MSCs both in vitro and in vivo. Meanwhile, we identified that BMP9-induced production of CD31+ cells was indispensable for BMP9-induced bone formation, and silencing H19 dramatically blocked BMP9-induced production of CD31^(+) cells. In addition, we found that down-regulation of H19 inhibited BMP9 mediated blood vessel formation and followed subsequent bone formation in vivo. Mechanistically, we clarified that H19 promoted p53 phosphorylation by direct interacting and phosphorylating binding, and phosphorylated p53 potentiated Notch1 expression and activation of Notch1 targeting genes by binding on the promoter area of Notch1 gene. These findings suggested that H19 regulated BMP9-induced angiogenesis of MSCs by promoting the p53-Notch1 angiogenic signaling axis.

关键词： Angiogenesis BMP9 Bone tissue engineering LncRNA H19 Mesenchymal stem cells

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Medium-term clinical efficacy and safety of single incision and modified trans-obturator mid-urethral slings for female stress urinary incontinence

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 57-62页

作者： Jerome Melon Paivi K.Karjalainen claire McGannon Joseph K.Lee Anna Rosamilia Pelvic Floor Unit Monash Medical CentreMelbourneVICAustralia Central Finland Central Hospital JyvaskylaFinland Department of Obstetrics and Gynaecology Monash Medical CentreMelbourneVICAustralia University of New South Wales KensingtonNSWAustralia Cabrini Hospital Malvern MelbourneVICAustralia

Aims:To evaluate the medium term efficacy and safety of Altis and Solyx single incision slings(SIS)compared with tension-free vaginal tape(TVT)Abbrevo trans-obturator *** hypothesize that both SIS show little difference in efficacy and safety and perform similarly to TVT ***:We conducted an ambispective comparative cohort study of women with stress urinary incontinence who received a SIS in comparison to matched TVT Abbrevo subjects from a concurrent randomized controlled trial(RCT).Subjects were identified retrospectively,and prospectively invited for examination and questionnaires>12 months *** included intrinsic sphincter deficiency,previous sling surgery,and *** outcome was subjective cure[negative response to International Consultation Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-UI SF)question 6,leakage during coughing/activity].Secondary outcomes include objective cure(negative cough stress test),functional outcomes,and adverse ***:Between 2012 and 2018,a total of 113 women received one of two SIS surgeries;Solyx(n=50)followed by the Altis(n=63);104 were available for final efficacy *** follow-up was 21.7(Altis),46.0(Solyx),and 29.0(Abbrevo)*** characteristics were comparable between the *** was no significant differences in the subjective or objective cure rates between the groups,and no differences in functional outcomes such as patient global impression of improvement,and post-operative ICIQ-UI SF *** was a low rate of mesh related complications and no differences seen between the ***:Despite being an underpowered study,Altis and Solyx SIS have favourable efficacy and safety profiles which are comparable to an established trans-obturator mid-urethral slings(MUS).

关键词： Efficacy Mini-sling Safety Single incision sling Stress urinary incontinence

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The crosstalk between autophagy and apoptosis: where does this lead?

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Protein & Cell 2012年第1期3卷 17-27页

作者： claire Gordy You-Wen He Department of Immunology Duke University Medical CenterDurhamNC 27710USA

Recent advances in the understanding of the molecular processes contributing to autophagy have provided insight into the relationship between autophagy and *** contrast to the concept of“autophagic cell death,”accumulating evidence suggests that autophagy serves a largely cytoprotective role in physiologically relevant *** cytoprotective function of autophagy is mediated in many circumstances by negative modulation of *** signaling,in turn,serves to inhibit *** the mechanisms mediating the complex counter-regulation of apoptosis and autophagy are not yet fully understood,important points of crosstalk include the interactions between Beclin-1 and Bcl-2/Bcl-xL and between FADD and Atg5,caspase-and calpain-mediated cleavage of autophagy-related proteins,and autophagic degradation of *** investigation of these and other means of crosstalk between apoptosis and autophagy is necessary to elucidate the mechanisms controlling the balance between survival and death both under normal conditions and in diseases including cancer.

关键词： autophagy apoptosis Beclin-1 lymphocytes

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First Report of a Successful Development of Yam Hybrids(Dioscorea alata L.)from Lyophilized and Long-Term Stored Pollens

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国际实验植物学杂志(英文) 2023年第10期92卷 2861-2874页

作者： Erick Malédon Elie Nudol Christophe Perrot Marie-claire Gravillon Ronan Rivallan Denis Cornet Hâna Chair Komivi Dossa CIRAD UMR AGAP InstitutPetit BourgGuadeloupe97170France UMR AGAP Institut Univ MontpellierCIRADINRAEInstitut AgroMontpellierF-34398France CIRAD UMR AGAP InstitutMontpellierF-34398France

Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding ***,pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic *** 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam *** pollens were collected from two Dioscorea alata males,then lyophilized(two lyophilization treatments were applied),followed by storage at room temperature(24℃–25℃)for 12 ***,the lyophilized and stored pollens were tested for viability by crossing with four female *** results showed that lyophilization is effective for achieving viable pollens after 12 months of *** 1(48 h drying)showed higher pollen germination and fertility rates than Treatment 2(72 h drying).Although we observed a reduction in viability of lyophilized pollens after 12 months of storage,we generated hybrid seedlings with success rates from 12%to 21%compared to 21%–31%when using fresh *** testing based on molecular genotyping confirmed the hybrid status of the obtained seedlings,which grew well in a *** is a practical approach for a long-term storage of greater yam pollen *** protocol will positively impact yam breeding programs particularly in developing countries.

关键词： Yam freeze-drying pollen conservation genetic gain

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Evolution of fruit types and seed dispersal： A phylogenetic and ecological snapshot

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植物分类学报 2008年第3期46卷 396-404页

作者： claire M. LORTS Trevor BRIGGEMAN Tao SANG Department of Plant Biology Michigan State University East Lansing MI 48824 USA

Success of flowering plants is greatly dependent on effective seed dispersal. Specific fruit types aid different mechanisms of seed dispersal. However, little is known about what evolutionary forces have driven the diversification of fruit types and whether there were phylogenetic constraints on fruit evolution among angio-sperm lineages. To address these questions, we first surveyed the orders and families of angiosperms for fruit types and found no clear association between fruit types and major angiosperm lineages, suggesting there was little phylogenetic constraint on fruit evolution at this level. We then surveyed fruit types found in two contrasting habitats: an open habitat including the Indian desert and North American plains and prairies, and a closed forest habitat of Australian tropical forest. The majority of genera in the survey of tropical forests in Australia were fleshy fruit trees, whereas the majority of genera in the survey of prairies and plains in central North America were herbs with capsules and achenes. Both capsules and achenes are frequently dispersed by wind in the open, arid habitat, whereas fleshy fruits are generally dispersed by animals. Since desert and plains tend to provide continuous wind to aid dispersal and there are more abundant mammal and bird dispersers in the closed forest, this survey suggests that fruit evolution was driven at least in part by dispersal agents abundant in particular habitats.

关键词：果实种子进化历史系统演化生态学

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Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1193-1208页

作者： Brigkita Venardou John VO’Doherty Shane Maher Marion TRyan Vivian Gath Rajeev Ravindran claire Kiely Gaurav Rajauria Marco Garcia-Vaquero Torres Sweeney School of Veterinary Medicine University College DublinBelfield Dublin 4Ireland School of Agriculture and Food Science University College DublinBelfield Dublin 4Ireland.

Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in *** objectives of this study were to:1)evaluate the *** activity of ANE(containing 46.6%fucoidan,18.6%laminarin,10.7%mannitol,4.6%alginate)in vitro,and;2)compare the effects of dietary supplementation with ANE and Zinc oxide(ZnO)on growth performance,Salmonella shedding and selected gut parameters in naturally infected *** was established post-weaning(newly weaned pig experiment)and following regrouping of post-weaned pigs and experimental re-infection with ***(challenge experiment).Results:In the in vitro assay,increasing ANE concentrations led to a linear reduction in *** counts(P0.05).ANE supplementation decreased the Enterobacteriaceae counts compared to the *** counts were also reduced in the ZnO-residual group compared to the control(P<0.05).ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control(P<0.05).Conclusions:ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,Salmonella sh

关键词： Ascophyllum nodosum Gastrointestinal microbiota Inflammation Pig Salmonella Seaweed extract Zinc oxide

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Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

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Nano Research 2020年第4期13卷 989-998页

作者： Natasha Logan claire McVey Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

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