检索结果-南通市图书馆

Vismodegib Provides a Novel Treatment for Advanced Basal Cell Carcinoma

Journal of Cancer Therapy 2014年第2期5卷 217-221页

作者： Jennifer l. Kelm Thomas J. Magliaro Matthew l. Anderson claire M. Mach College of Pharmacy University of Houston Houston USA Department of Obstetrics and Gynecology Baylor College of Medicine Houston USA

Objective: To review and evaluate vismodegib, the first US Food and Drug Administration (FDA) approved treatment for locally advanced (laBCC) or metastatic basal cell carcinoma (mBCC) that has recurred after surgery or for patients in which surgery or radiation is not an option. Data Sources: A literature search using PubMed was conducted through January 2013, using the terms vismodegib, GDC-0449, and Erivedge. Additional literature was found through the reference citations of identified articles. Study Selection and Data Extraction: Potential sources were limited to human studies published in English with a priority placed on those focused on laBCC or mBCC. Data Synthesis: Vismodegib is a selective inhibitor of the hedgehog (Hh) pathway approved for the treatment of laBCC or mBCC that has recurred after surgery, or for patients for whom surgery or radiation is contraindicated. Vismodegib inhibits cancer cell growth and survival by binding Smoothened, a transmembrane protein involved in the Hedgehog signal transduction. Vismodegib is administered orally at a dose of 150 mg daily. It is primarily eliminated through the feces unchanged but does have some oxidative metabolites produced from the recombinant cytochrome P450 (CYP) 2C9 and CYP3A4/5. Despite CYP450 involvement, it appears to have very few drug interactions. The most common adverse events reported with vismodegib include muscle spasms, dysgeusia, alopecia, weight loss, fatigue, nausea, anorexia, and diarrhea. FDA approval was based on a single arm phase II study that demonstrated an objective response rate of 30% in mBCC patients and 45% in laBCC patients. Vismodegib was approved by the FDA on January 30, 2012 for use in patients with advanced basal cell carcinoma, and continues to be studied in other patient populations for additional potential uses. Conclusions: Based on a review of current evidence, vismodegib provides an effective and well-tolerated treatment for otherwise untreatable basal cell carcinom

关键词： Vismodegib GDC-0449 Erivedge Basal Cell Carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纳米技术：基于相关指标及统计数据的述评(Ⅱ)

引用

科技导报 2011年第23期29卷 15-22页

作者： Christopher Palmberg Hélène Dernis claire Miguet 张树良经济合作与发展组织(OECD)科学技术及产业理事会

3 纳米技术应用领域及机构分析3．1概述研究及分析人员认为，纳米技术可能发展为下一代通用技术，这意味着纳米技术将很可能迅速发展成为在各应用领域及产业广泛应用的技术㈣。其主要依据是纳米技术使得在基本原子和分子水平更深入地认... 详细信息

3 纳米技术应用领域及机构分析3．1概述研究及分析人员认为，纳米技术可能发展为下一代通用技术，这意味着纳米技术将很可能迅速发展成为在各应用领域及产业广泛应用的技术㈣。其主要依据是纳米技术使得在基本原子和分子水平更深入地认识和控制物质成为可能，从而有助于改进几乎所有产业的制造工艺。

关键词：纳米技术统计数据述评机构分析分子水平制造工艺应用产业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Green tea extract:A potential cause of acute liver failure

引用

World Journal of Gastroenterology 2013年第31期19卷 5174-5177页

作者： Shreena S Patel Stacey Beer Debra l Kearney Garrett phillips Beth A Carter Department of Pediatrics Baylor College of Medicine Houston TX 77030 United States Division of Pediatric Gastroenterology Texas Children’s Hospital Houston TX 77030 United States Department of Pathology and Immunology Baylor College of Medicine Houston TX 77030 United States Division of Pediatric Gastroenterology Baylor College of Medicine Houston TX 77030 United States

The use of herbal products has increased significantly in recent *** these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite ***,their use is generally regarded as safe and natural by the ***,there has been an increase in the number of reported adverse events occurring with the use of herbal *** present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea *** case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract *** the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal ***,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory ***,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products.

关键词： Green tea Plant extract Dietary supplements liver failure liver injury Hepatotoxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于相关指标及统计数据的述评(Ⅰ)

引用

科技导报 2011年第22期29卷 15-24页

作者： CHRISTOPHER Palmberg HlNE Dernis claire Miguet 张树良经济合作与发展组织(OECD)科学技术及产业理事会

0引言＂纳米技术是在纳米尺度范围（典型但非唯一的范围为100毫微米以内的一维或多维空间）对物质及过程的认识和控制,在该尺度范围,一系列尺度依存现象通常使原有物质及过程产生新的应用特性。＂

关键词：统计数据述评多维空间纳米尺度纳米技术毫微米物质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optical Nanoimpacts of Dielectric and Metallic Nanoparticles on Gold Surface by Reflectance Microscopy: Adsorption or Bouncing?

引用

Journal of Analysis and Testing 2019年第2期3卷 175-188页

作者： Jean-François lemineur Talia Jane Stockmann Jérôme Médard claire Smadja Catherine Combellas Frédéric Kanoufi UniversitéSorbonne Paris Cité UniversitéParis DiderotITODYSCNRS UMR 708615 rue J.A.de Baïf75013 ParisFrance Present Address:Memorial University of Newfoundland Chemistry Department283 Prince Philip Dr.St.John’sNL A1B 3X7Canada Faculty of Pharmacy University Paris-SudCNRS UMR 86125 rue J.B.Clément92296 Châtenay-MalabryFrance

Optical modeling coupled to experiments show that a microscope operating in reflection mode allows imaging,through solutions or even a microfluidic cover,various kinds of nanoparticles,NPs,over a(reflecting)sensing surface,here a gold(Au)*** modeling suggests that this configuration enables the interferometric imaging of single NPs which can be characterized individually from local change in the surface *** interferometric detection improves the optical limit of detection compared to classical configurations exploiting only the light scattered by the *** method is then tested experimentally,to monitor in situ and in real time,the collision of single Brownian NPs,or optical nanoimpacts,with an Au-sensing ***,mimicking a microfluidic biosensor platform,the capture of 300 nm FeOx maghemite NPs from a convective flow by a surface-functionalized Au surface is dynamically ***,the adsorption or bouncing of individual dielectric(100 nm polystyrene)or metallic(40 and 60 nm silver)NPs is observed directly through the *** influence of the electrolyte on the ability of NPs to repetitively bounce or irreversibly adsorb onto the Au surface is *** such visualization mode of single-NP optical nanoimpacts is insightful for comprehending single-NP electrochemical studies relying on NP collision on an electrode(electrochemical nanoimpacts).

关键词： Reflection microscopy Single nanoparticle Sensor Adsorption Silver Polystyrene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microfungi on Tamarix

引用

Fungal Diversity 2017年第1期82卷 239-306页

作者： Kasun M.Thambugala Dinushani A.Daranagama Alan J.l.phillips Timur S.Bulgakov Darbhe J.Bhat Erio Camporesi Ali H.Bahkali Prapassorn D.Eungwanichayapant Zuo-Yi liu Kevin D.Hyde Guizhou Key laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand State Key laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don344090 Rostov RegionRussia Formerly Department of Botany Goa UniversityGoaIndia Curca No.128/1–JAzad Housing SocietyGoa VelhaIndia A.M.B.Gruppo Micologico ForliveseBAntonio Cicognani^ Via Roma 18ForlìItaly A.M.B.Circolo Micologico BGiovanni Carini^ C.P.314BresciaItaly Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia

Tamarix species are small trees that grow in various natural habitats and have a wide geographic *** species previously found on Tamarix and recently collected in Italy and Russia were identified based on morphological characters and analyses of gene sequence *** sexual morph of the coelomycetous genus Homortomyces was collected for the first time and is described and illustrated.A new family,Homortomycetaceae(Dothideomycetes,families incertae sedis)is introduced to accommodate *** new genera Neomicrosphaeropsis(Didymellaceae)and Tamaricicola(Pleosporaceae)are introduced in this *** tamaricicola was recollected and is placed in Neomicrosphaeropsis based on morphology and molecular *** new species,Cytospora italica,***,Diaporthe ravennica,Eutypella tamaricis,Neomicrosphaeropsis italica,***,***,Keissleriella tamaricicola,Paracamarosporium tamaricis and Tamaricicola muriformis are introduced,while Alternaria tenuissima,Dothiorella sarmentorum,Neofusicoccum luteum,Paraepicoccum amazonense,Pleospora herbarum and Pseudocamarosporium propinquum are reported for the first time on Tamarix *** descriptions and ***-gene analyses show that Paraepicoccum amazonense should be placed in Pleosporineae,Pleosporales,where it is closely related to Camarosporium sensu *** herbarium specimens were studied to illustrate other fungal species recorded on Tamarix species.A comprehensive account of microfungi on Tamarix is provided,which includes a list with data from the literature,as well as those identified in the present *** taxonomic placement of most taxa discussed in this study is based on a modern taxonomic framework based on analysis of multi-gene sequence data.

关键词： Dothideomycetes Homortomycetaceae Incertae sedis New species Phylogeny Pleosporales Sordariomycetes Tamaricaceae Taxonomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HPlC Quantification of Dexamethasone Palmitate in Bronchoalveolar lavage Fluid of Rat after lung Delivery with large Porous Particles

引用

American Journal of Analytical Chemistry 2019年第9期10卷 404-414页

作者： Alain N’Guessan Armand Koffi Isma&euml l l. Dally Christophe N’Cho Amin claire Gueutin Nicolas Tsapis Elias Fattal Institute Galien Paris-Sud Paris-Sud University Orsay France School of Pharmacy University Félix Houphouet-Boigny Abidjan C&ocirc te d’Ivoire

A high-performance liquid chromatography (HPlC) method has been developed and validated for the determination of dexamethasone palmitate (DXP) in bronchoalveolar fluid lavage samples (BAlF). DXP in rat BAlFs containing the internal standard (IS), testosterone decanoate (TD), was extracted using a mixture of chloroform and methanol (9:1, v/v). Extracts were then centrifuged, dried and dissolved in acetonitrile. A chromatographic separation based on an isocratic elution was done using acetonitrile and water (85:15, v/v) as a mobile phase at a flow rate of 1.2 ml/min. The graph of the developed method was linear within the tested calibration range of 0.5 - 40 μg/ml. The overall extraction recovery of DXP from BAlF samples was 84.3% ± 1.6%. The accuracy (relative error) and precision (coefficient of variation) values were within the pre-defined limits of ≤15% at all concentrations. This methodology has been applied to determine levels of DXP in BAlF samples collected from rats treated with DXP large porous particles. The measured concentrations were successfully evaluated using a non-compartment pharmacokinetic model. Since the developed method requires only a microvolume (100 μl) of BAlF sample for analysis, it is therefore particularly suitable for the evaluation of drug biodistribution in lung.

关键词： Dexamethasone Palmitate Bronchoalveolar lavage Fluid HPlC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human small intestine is capable of restoring barrier function after short ischemic periods

引用

World Journal of Gastroenterology 2017年第48期23卷 8452-8464页

作者： Dirk HSM Schellekens Inca HR Hundscheid claire AJI leenarts Joep Grootjans Kaatje lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx Department of Surgery Maastricht University Medical Center NUTRIM School for Nutrition and Translational Research in MetabolismMaastricht University Department of Gastroenterology Academic Medical Center MHeNs School of Mental Health and Neuroscience Maastricht University Medical Center Pediatric Surgical Center of Amsterdam Emma Children’s Hospital Academic Medical Center and VU University Medical Center

AIM To assess intestinal barrier function during human intestinal ischemia and reperfusion(IR).METHODS In a human experimental model,6 cm of jejunum was selectively exposed to 30 min of ischemia(I) followed by 30 and 120 min of reperfusion(R). A sham procedure was also performed. Blood and tissue was sampled at all-time points. Functional barrier function was assessed using dual-sugar absorption tests with lactulose(l) and rhamnose(R). Plasma concentrations of citrulline,an amino acid described as marker for enterocyte function were measured as marker of metabolic enterocytes restoration. Damage to the epithelial lining was assessed by immunohistochemistry for tight junctions( TJs),by plasma marker for enterocytes damage(I-FABP) and analyzed by electron microscopy(EM) using lanthanum nitrate as an electrondense *** Plasma l/R ratio's were significantly increased after 30 min of ischemia(30 I) followed by 30 min of reperfusion(30 R) compared to control(0.75 ± 0.10 vs 0.20 ± 0.09,P lized(0.17 ± 0.06) and were not significantly different from control. Plasma levels of I-FABP correlated with plasma l/R ratios measured at the same time points(correlation: 0.467,P lining of TJs was again observed at 30 I120 R. Electron microscopy analysis revealed disrupted TJs after 30 I with paracellular leakage of lanthanum nitrate,which restored after 30 I120 R. Furthermore,citrulline concentrations closely paralleled the histological perturbations during intestinal *** This study directly correlates histological data with intestinal permeability tests,revealing that the human gut has the ability of to withstand short episodes of ischemia,with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion.

关键词： Intestinal ischemia-reperfusion Intestinal barrier function Intestinal permeability Human Dualsugar absorption test Tight Junctions Citrulline

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Histological grades and prognostic markers of well-differentiated pancreatic neuroendocrine tumor(WDPNET)

引用

Journal of Pancreatology 2020年第4期3卷 188-194页

作者： Yongchao li Daniel Rowan claire P.Williamson Meiyun Fan Ali G.Saad lizhi Zhang Department of Pathology University of Tennessee Health Science CenterMemphisTN Division of Anatomic Pathology Mayo ClinicRochesterMN Department of Pathology University of Miami Miller School of MedicineMiamiFLUSA

Pancreatic neuroendocrine tumors(PNETs)are the second most common neoplasm of the pancreas after ductal *** clinical behavior of PNETs is very difficult to predict,especially for well-differentiated *** classification systems have been developed to differentiate benign from malignant *** current 5th edition WHO(2019)updated the grading system of PNETs which is now entirely based on proliferative rate(either mitotic count or Ki-67 index).In this article,we systemically reviewed the evolution of the histologic classification and grading systems for well-differentiated ***,we also report a comprehensive summary of immunohistochemical and molecular prognostic factors for PNETs patients,including CK19,KIT,PDl1/PD-l1,UCH-l1 and *** believe that more reliable grading systems and prognostic markers are emerging and will change the landscape of treatment for well-differentiated PNETs.

关键词： Grading Ki-67 PNETs Prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Forecasting the number of species of asexually reproducing fungi(Ascomycota and Basidiomycota)

引用

Fungal Diversity 2022年第3期114卷 463-490页

作者： Nalin N.Wijayawardene Alan J.l.phillips Diana Santos Pereira Dong-Qin Dai AndréAptroot Josiane S.Monteiro Irina S.Druzhinina Feng Cai Xinlei Fan laura Selbmann Claudia Coleine Rafael F.Castañeda-Ruiz Martin Kukwa Adam Flakus Patricia Oliveira Fiuza Paul M.Kirk Kunhiraman C.Rajesh Kumar Ilesha S.leperuma Arachchi Nakarin Suwannarach li-Zhou Tang Teun Boekhout Chen Shuhui Tan R.P.Prabath K.Jayasinghe Marco Thines Centre for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Section of Genetics Institute for Research and Development in Health and Social CareNo:393/3Lily AvenueOff Robert Gunawardane MawathaBattaramulla 10120Sri Lanka Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal laboratório de Botânica/liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMS CEP 79070-900Brazil Coordination of Botany Museu Paraense Emílio GoeldiBelémPA 66077830Brazil Fungal Genomics laboratory(FungiG) College of Resources and Environmental SciencesNanjing Agricultural UniversityWeigang 1Nanjing 210095JiangsuPeople’s Republic of China The Key laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Ecological and Biological Sciences University of TusciaViterboItaly Italian National Antarctic Museum(MNA) Mycological SectionGenoaItaly Alejandro de Humboldt’(INIFAT) Instituto de Investigaciones Fundamentales en AgriculturaTropicalSantiago de Las VegasHavanaCuba Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of GdańskWita Stwosza 5980-308 GdańskPoland W.Szafer Institute of Botany Polish Academy of SciencesLubicz 4631-512 KrakowPoland Universidade Federal do Rio Grande do Norte(UFRN) Programa de Pós-Graduação em Sistemática e EvoluçãoCentro de BiociênciasCampus UniversitárioAv.Senador Salgado Filho3000Lagoa NovaNatalRN 59078-970Brazil Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic GardensKewRichmond TW93DSSurreyUK National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.

Asexually reproducing fungi play a significant role in essential processes in managed and wild ecosystems such as nutrients cycling and multitrophic interactions.A large number of such taxa are among the most notorious plant and animal *** addition,they have a key role in food production,biotechnology and *** without or rare sexual reproduction are distinguished based on their sporulating structures and conidiomata in traditional morphology-based *** number,variation and diversity of asexually reproducing taxa are insufficiently known,even though fungi capable of asexual reproduction may provide an untapped,rich biological resource for future ***,ca.30,000 asexual species belonging to ca.3800 genera have been reported(including 1388 coelomycetous and 2265 hyphomycetous genera).Recent reports(2017–2020)reiterate that the number of asexually producing fungi is higher than the number of frequently sexually-reproducing *** the advent of molecular tools and the abandonment of the dual nomenclature system for pleomorphic fungi,priority criteria were established and revisited in the latest outline of fungi and fungus-like ***,species numbers and taxonomic boundaries of pleomorphic taxa and their synanamorphs or synasexual morphs have yet to be *** number of species of speciose genera(***,Aspergillus,Cercospora,Fusarium,Phoma and Pseudocercospora),cryptic species,species of pleomorphic genera,less studied life modes(such as lichenicolous taxa,taxa from extreme environments)and species from biodiversity-rich areas still need evaluation to achieve more reliable estimates of their *** paper discusses the current knowledge on the matter,with diversity estimates,and potential obstacles in several chapters on(1)speciose genera;(2)pleomorphic genera;(3)cryptic species;(4)well-studied but insufficiently resolved taxa,*** inhabiting species,marine fungi,(5)less studied life modes,e.g.

关键词： Cryptic species DNA sequences Morphology Pleomorphism Speciose genera Species identificat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：