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Abdominal tuberculosis: diagnosis and demographics, a 10-year retrospective review from a single centre

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World Journal of Clinical Cases 2016年第8期4卷 207-212页

作者： Jeremy S Nayagam claire Mullender Catherine Cosgrove Andrew Poullis Gastroenterology St George’s Hospital Clinical Infection Unit St George’s Hospital

AIM: To review all cases of abdominal tuberculosis(ATB) for demographic details, diagnostic work up and evidence of vitamin D ***: This was a retrospective analysis of all patients diagnosed with ATB from June 2003 to August 2013 at St George's Hospital, london. Demographic data was available from the local tuberculosis database. Further clinical information was collected from electronic patient records, including radiology, endoscopy, microbiology, histology, biochemistry and serology. Patients were classified as either confirmed ATB [if mycobacteria tuberculosis(MTB) was cultured from abdominal site] or presumed ATB(if suggestive findings or high clinical suspicion). Subtypes of ATB were classified as tuberculosis(TB) peritonitis, luminal TB, solid organ TB or from a combination of ***: There were a total of 65 cases identified in this time period, with a mean of 6.5 cases per year(range 4-9). Mean age 42 years, 49.2% females. Fifty-two point three percent were South Asian, 38.5% African. Forty-nine point two percent had gastrointestinal endoscopy, 30.8% paracentesis and 24.6% surgery in order to obtain samples. Forty-seven point seven percent were defined as confirmed ATB with positive culture of MTB from abdominal sites, the rest were treated as presumed ATB. Twenty-four point six percent had co-existing sputum culture positive for MTB, and 30.8% had an abnormal chest X-ray. Subtypes of ATB: 35.4% had TB peritonitis; 27.7% luminal TB; 3.1% solid organ TB; and 33.8% TB at a combination of abdominal sites. Thirteen point nine percent were human immunodeficiency virus positive, all with CD4 count less than 300 cells/μl. Seventy point five percent had severe vitamin D deficiency, and 25% were vitamin D ***: ATB mainly affects young South Asian and African patients, with difficulties in confirming diagnosis despite a range of non-invasive and invasive diagnostic tests.

关键词： Abdominal gastrointestinal tuberculosis vitamin D human immunodeficiency virus

医疗状况对于脑膜炎双球菌感染患儿预后的影响:对致死性与非致死性病例进行的病例对照研究

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 6-7页

作者： Ninis N. phillips C. Bailey l. 张振 Department of Paediatrics Faculty of Medicine Imperial College of Science Technology and Medicine London W2 1PG United Kingdom

Objective: To determine whether suboptimal management in hospital could contribute to poor outcome in children admitted with meningococcal disease. Design: Case-control study of childhood deaths from meningococcal disease, comparing hospital care in fatal and non-fatal cases. Setting: National statistics and hospital records. Subjects: All children under 17 years who died from meningococcal disease (cases) matched by age with three survivors (controls) from the same region of the country. Main outcome measures: Predefined criteria defined optimal management. A panel of paediatricians blinded to the outcome assessed case records using a standardised form and scored patients for suboptimal management. Results: We identified 143 cases and 355 controls. Departures from optimal (per protocol) management occurred more frequently in the fatal cases than in the survivors. Multivariate analysis identified three factors independently associated with an increased risk of death: failure to be looked after by a paediatrician, failure of sufficient supervision of junior staff, and failure of staff to administer adequate inotropes. Failure to recognise complications of the disease was a significant risk factor for death, although not independently of absence of paediatric care (P = 0.002). The odds ratio for death was 8.7 (95%confidence interval 2.3 to 33) with two failures, increasing with multiple failures. Conclusions: Suboptimal health care delivery significantly reduces the likelihood of survival in children with meningococcal disease. Improved training of medical and nursing staff, adherence to published protocols, and increased supervision by consultants may improve the outcome for these children and also those with other life threatening illnesses.

关键词：非致死性脑膜炎双球菌医疗状况病例对照研究感染性疾病医疗情况儿科治疗儿科医师疾病患儿病例记录

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lQR and lQG based optimal switching techniques for PSS and UPFC in power systems

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Control Theory and Technology 2018年第1期16卷 25-37页

作者： l. YATHISHA S. PATIlKUlKARNI E & C Department ATME College of Engineering VTU Karnataka India E & C Department Sri Jayachamarajendra College of Engineering (JSSSTU) Karnataka India

Selection of better optimized unified power flow controller （UPFC） control inputs along with simultaneous coordinated design of power system stabilizer （PSS） is a challenge in the present scenario of power systems. Hence, in this paper, four sets of experiments performed are presented. First set of experiments are without disturbance scenario where switching is done using linear quadratic regulators （lQR＇s）. Second set is for power systems with disturbances using linear quadratic gaussian （lQG）. Switching control algorithms presented here are tested on the single machine infinite bus （SMIB） linearised phillips Heffron model of power system using MATlAB/SIMUlINK~ platform.

关键词： lQR lQG UPFC PSS power system & SMIB

Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature

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World Journal of Clinical Oncology 2014年第2期5卷 177-190页

作者： Claudio l Battaglini Robert C Mills Brett l.phillips Jordan T lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney Department of Exercise and Sport Science Christina StoryChapel Hill NC 27599 United States lineberger Comprehensive Cancer Center Chapel Hill NC 27599 United States Exercise Oncology Research laboratory University of North CarolinaChapel Hill NC 27599 United States Centro Universitario de Brasilia (UniCeub) SEPN 707/907-Campus do UniCEUB-Asa Norte-Brasília-DF-70790-075Brazil Department of Nutrition University of North Carolina at Chapel HillChapel Hill NC 27599 United States

AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient ***:Pub Med, Medline Plus, the Cochrane library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all ***:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of ***:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise.

关键词： Breast cancer Exercise training Complementary Alternative Medicine Oncology VO2peak Patients reported outcomes

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玉米组织培养诱导的染色体组重组

园艺与种苗 1988年第4期 1-4页

作者： M.lee R.l.phillips 舒庆尧

已经充分证明植物组织在离体培养过程中染色体的不稳定性。基因型、培养基成分、外植体类型和培养生理龄都会影响细胞学畸变的发生。培养过程中染色体的变异分数目的改变和结构的变化两种,但对可能导致变异的机理了解甚少。一些尽可能... 详细信息

已经充分证明植物组织在离体培养过程中染色体的不稳定性。基因型、培养基成分、外植体类型和培养生理龄都会影响细胞学畸变的发生。培养过程中染色体的变异分数目的改变和结构的变化两种,但对可能导致变异的机理了解甚少。一些尽可能详细的分析查明,染色体结构的畸变常常多于数目的变化。

关键词：玉米培养物断裂点着丝点再生株杂合体染色体畸变愈伤组织创伤组织减数分裂成熟分裂再生植株染色体组基因组

Acute and Prolonged Effects of a Polyherbal Formulation on Blood Glucose, lipid Profile and liver Function in Normal and Streptozotocin-Induced Diabetic Rats

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Journal of Biosciences and Medicines 2023年第11期11卷 277-302页

作者： Marie claire Tchamadeu Hélène Elena Ndame Calvin Zangueu Bogning Modeste Wankeu-Nya Patience Emambo Olga Sol Fonga Christian Takoukam Tenezogang Alain Bertrand Dongmo Siméon Pierre Choukem Department of Biology and Physiology of Animal Organisms Faculty of Science University of Douala Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Background: Few studies have often focused on medicinal plant mixtures, yet the most used in low-and middle-income areas as alternative drug to treat diseases. Objective: To evaluate the antidiabetic effects of Emilia coccinea (Ec) (Asteraceae), Scoparia dulcis (Sd) (Plantaginaceae) and Tetracarpidium conophorum (Tc) (Euphorbiaceae) aqueous extracts mixture (EcSdTc) in rats. Methodology: Single plant aqueous extracts (Ec, Sd and Tc) and their mixtures (EcSd, EcTc, SdTc and EcSdTc) (each at the doses of 125 and 250 mg/kg body weight respectively) were evaluated in acute administration on blood glucose in normal, glucose-overloaded and diabetic rats;then EcSdTc mixture was assessed in prolonged administration (21 days) on blood glucose, body weight, serum biochemical and antioxidant parameters in diabetic rats. Diabetes was induced by single intraperitoneal administration of streptozotocin (STZ;50 mg/kg), and glibenclamide (10 mg/kg) was used as standard drug. Results: In acute administration, EcTc250, EcSdTc125, SdTc250, SdTc125, EcSd250, and EcSdTc250 extracts mixtures reduced (p Conclusion: EcSdTc aqueous extracts mixture has potent hypoglycemic and antidiabetic effects, probably due to their bioactive compounds synergistic and/or additive actions, justifying its traditional use as alternative remedies.

关键词： Emilia coccinea Scoparia dulcis Tetracarpidium conophorum Traditional Medicinal Potion Diabetes Mellitus Streptozotocin

A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

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Cellular & Molecular Immunology 2023年第12期20卷 1499-1512页

作者： leticia Martín-Cruz Marcos Viñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-phillips Irene Real-Arévalo Francisco Javier Cañada JoséIgnacio Tudela luis Moltó Jesús Moreno-Sierra Joséluis Subiza Oscar Palomares Department of Biochemistry and Molecular Biology School of ChemistryComplutense University of MadridMadridSpain Inmunotek Alcaláde HenaresMadridSpain Fundación Investigación Hospital Clínico San Carlos Martin Lagos s/n28040MadridSpain Centro de Investigaciones Biológicas Margarita Salas CSICRamiro de Maetzu 928040MadridSpain CIBER de Enfermedades Respiratorias(CIBERES)Avda Monforte de Lemos3-528029MadridSpain Servicio de Urología Hospital Clínico San CarlosUniversidad Complutense de MadridMartín Lagos s/n28040MadridSpain

Functional Tregs play a key role in tumor development and progression,representing a major barrier to anticancer *** mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely ***,by using NMR,chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses,we demonstrate that the tumoral carbohydrate A10(Ca10),a cell-surface carbohydrate derived from Ehrlich’s tumor(ET)cells,is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human ***10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming,PD-l1,Il-10,and ***10 also reprograms the differentiation of human monocytes into DCs with tolerogenic *** solid ET-bearing mice,we found positive correlations between Ca10 serum levels,tumor size and splenic Treg *** of isolated Ca10 also increases the proportion of splenic Tregs in tumor-free ***,we provide evidence supporting the presence of a circulating human Ca10 counterpart(Ca10H)and show,for the first time,that serum levels of Ca10H are increased in patients suffering from different cancer types compared to healthy *** note,these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without ***,we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in *** discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.

关键词： Tumoral carbohydrate A10 Heparan sulfate-related proteoglycan Cancer immunology Dendritic cell Regulatory T cell

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亲密伴侣暴力相关的影像表现

国际医学放射学杂志 2019年第3期 361-362页

作者：景瑞 E.George C.H.phillips N.Shah A.l.Connor B.Rosner H.M.Stoklosa Departments of Radiology Brigham and Women's Hospital

摘要目的评估与亲密伴侣暴力(IPV)相关的影像表现。材料与方法回顾性分析了2015年1月—2016年10月期间从急诊科(ED)转诊到IPV支持计划的185例病人的电

关键词：亲密伴侣暴力影像检查影像表现

Coherent Splitting of Bose-Einstein Condensed Atoms with Optically Induced Bragg Diffraction

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Coherent Splitting of Bose-Einstein Condensed Atoms with Opt...