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Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo Yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RCTs were *** binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

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绿色生活,从小开始

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初中生 2024年第29期 42-46页

作者： claire Daniel 晏晖霞(编译) 不详

被送去外婆家度夏的萨曼莎,跟着外婆一起制作堆肥,种植蔬菜和花草,并在自家车道尽头搭建了一个摊位,向过往的行人出售自家种植的蔬菜。她见证了堆肥是如何使土壤变得肥沃、帮助植物生长的。更令人感动的是,面对摊位收款箱里的钱不翼而飞... 详细信息

被送去外婆家度夏的萨曼莎,跟着外婆一起制作堆肥,种植蔬菜和花草,并在自家车道尽头搭建了一个摊位,向过往的行人出售自家种植的蔬菜。她见证了堆肥是如何使土壤变得肥沃、帮助植物生长的。更令人感动的是,面对摊位收款箱里的钱不翼而飞时,外婆选择了信任和理解他人,而不是愤怒和指责。

关键词：外婆家萨曼莎植物生长堆肥

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Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates

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Pediatric Investigation 2024年第2期8卷 135-138页

作者： Samantha Gilg Sebastian Acosta Rohit S.Loomba claire Rizk Gary E.Stapleton David Faraoni Fabio Savorgnan Department of Pediatrics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of Pediatrics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of Pediatrics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA Department of Anesthesiology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The standard of care in the management of d-transposition of the great arteries(TGA)includes the arterial switch operation(ASO).1,2 Although some institutions have begun to publish the results of performing the ASO within the first few hours of life,most centers continue to"electively"delay ASO for several days to allow for a reduction in pulmonary vascular resistance and the stabilization of renal and liver function.1,2 The early initiation of prostaglandin E1(PGE)infusion to maintain ductal patency is a nearly universal component of therapy in order to maintain adequate arterial oxygen saturation and systemic oxygen delivery during the pre-operative period via intercirculatory mixing at the atrial septal and patent ductus arteriosus levels1,3.

关键词： balloon maintain stabilization

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Circadian Clock Genes Universally Control Key Agricultural Traits

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Molecular Plant 2015年第8期8卷 1135-1152页

作者： claire Bendix Plant Gene Expression Center USDA-ARS Albany CA 94710 USA Department of Plant & Microbial Biology University of California Berkeley CA 94720 USA

Circadian clocks are endogenous timers that enable plants to synchronize biological processes with daily and seasonal environmental conditions in order to allocate resources during the most beneficial times of day and year. The circadian clock regulates a number of central plant activities, including growth, develop- ment, and reproduction, primarily through controlling a substantial proportion of transcriptional activity and protein function. This review examines the roles that alleles of circadian clock genes have played in domestication and improvement of crop plants. The focus here is on three groups of circadian clock genes essential to clock function in Arabidopsis thaliana： PSEUDO-RESPONSE REGULATORs, GIGANTEA, and the evening complex genes EARL Y FLOWERING 3, EARLY FLOWERING 4, and LUX ARRHYTHMO. Homol- ogous genes from each group underlie quantitative trait loci that have beneficial influences on key agricul- tural traits, especially flowering time but also yield, biomass, and biennial growth habit. Emerging insights into circadian clock regulation of other fundamental plant processes, including responses to abiotic and biotic stresses, are discussed to highlight promising avenues for further crop improvement.

关键词： circadian clock PSEUDO-RESPONSE REGULATORs GIGANTEA evening complex genes quantitative trait loci flowering time

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澳大利亚国家美术馆唐逊现代中国木刻版画收藏初探

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美术学报 2024年第3期 4-10页

作者： [澳]罗清奇贺旺(译) 墨尔本大学中央美术学院人文学院

唐逊(Peter Townsend)是20世纪下半叶英国艺术界的重要人物之一,但鲜为人知的是,他于1941年至1951年间在中国生活与工作。期间他受周恩来的影响,对中国木刻艺术产生了兴趣,随之收藏了逾250件木刻版画作品,这些作品现收藏于澳大利亚国家... 详细信息

唐逊(Peter Townsend)是20世纪下半叶英国艺术界的重要人物之一,但鲜为人知的是,他于1941年至1951年间在中国生活与工作。期间他受周恩来的影响,对中国木刻艺术产生了兴趣,随之收藏了逾250件木刻版画作品,这些作品现收藏于澳大利亚国家美术馆。本文通过研究唐逊在中国的收藏历程以及唐逊与澳大利亚的关系,不仅揭示了唐逊木刻版画收藏的多重重要性,还为中国木刻艺术研究提供了一个海外视角。

关键词：唐逊木刻版画澳大利亚国家美术馆

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Quantifying Environmental Impacts of Temporary Housing at the Urban Scale: Intersection of Vulnerability and PostHurricane Relief in New Orleans

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International Journal of Disaster Risk Science 2019年第4期10卷 478-492页

作者： claire McConnell Chiara Bertolin Department of Architecture and Technology Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of Mechanical and Industrial Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

The increasing risk and exposure of people and assets to natural hazards and disasters suggests an increasing need for temporary housing following *** to natural hazards is dependent on the resources available to families or communities to prepare for and mitigate risk,influenced by social *** study seeks to quantify the total environmental impact of temporary housing deployment in New Orleans,using the catastrophic impact of Hurricane Katrina in southern Louisiana in August 2005 as a case *** employ a novel approach to estimate displacement period and take into account social vulnerability across New Orleans neighborhoods to better understand the scale of post-disaster relief and its global warming *** methodology implemented in this study comprises three steps:a risk assessment,a life cycle assessment,and a resulting total impact *** demonstrate the considerable risk of greenhouse gas emissions and energy impacts from temporary housing deployment linked to hurricane ***,we show that environmental impact is highly sensitive to displacement period and find the current methodology of anticipating temporary housing use by hazard alone to be ***,the approach presented in this article provides tools to politicians and disaster risk professionals that allow for resource investment planning to decrease social vulnerability,thus enhancing resilience and adaptive capacity in a more homogeneous way at the urban scale.

关键词： Disaster risk Global warming potential Hurricane Katrina Life cycle assessment New Orleans Social vulnerability Temporary housing

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Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease

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Neural Regeneration Research 2023年第9期18卷 1931-1939页

作者： Nadège Hertzog claire Jacob Faculty of Biology Institute of Developmental Biology and NeurobiologyJohannes Gutenberg University MainzHanns-Dieter-Hüsch-WegMainzGermany

Schwann cells,the myelinating glia of the peripheral nervous system,wrap axons multiple times to build their myelin *** is of paramount importance for axonal integrity and fast axon potential ***,myelin is lacking or dysfunctional in several neuropathies including demyelinating and dysmyelinating Charcot-M arie-To oth ***-Marie-To oth disease represents the most prevalent inherited neuropathy in humans and is classified either as axonal,demyelinating or dysmyelinating,or as *** demyelinating or dysmyelinating forms of Charcot-Marie-Tooth disease constitute the majority of the disease cases and are most frequently due to mutations in the three following myelin genes:peripheral myelin protein 22,myelin protein ze ro and gap junction beta 1(coding for Connexin 32) causing Charcot-M arie-Tooth disease type 1A,Charcot-Marie-Tooth disease type 1B,and X-linked Charcot-M arie-Tooth disease type 1,*** resulting perturbation of myelin structure and function leads to axonal demyelination or dysmyelination and causes severe disabilities in affected *** treatment to cure or slow down the disease progression is currently available on the market,howeve r,scientific discoveries led to a better understanding of the pathomechanisms of the disease and to potential treatment *** this review,we describe the features and molecular mechanisms of the three main demyelinating or dysmyelinating forms of Charcot-Marie-Tooth disease,the rodent models used in research,and the emerging therapeutic approaches to cure or counteract the progression of the disease.

关键词： Charcot-Marie-Tooth disease rodent models emerging treatments demyelination and dysmyelination endoplasmic reticulum stress gene therapy myelin repair Schwann cells unfolded protein response

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The crosstalk between autophagy and apoptosis: where does this lead?

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Protein & Cell 2012年第1期3卷 17-27页

作者： claire Gordy You-Wen He Department of Immunology Duke University Medical CenterDurhamNC 27710USA

Recent advances in the understanding of the molecular processes contributing to autophagy have provided insight into the relationship between autophagy and *** contrast to the concept of“autophagic cell death,”accumulating evidence suggests that autophagy serves a largely cytoprotective role in physiologically relevant *** cytoprotective function of autophagy is mediated in many circumstances by negative modulation of *** signaling,in turn,serves to inhibit *** the mechanisms mediating the complex counter-regulation of apoptosis and autophagy are not yet fully understood,important points of crosstalk include the interactions between Beclin-1 and Bcl-2/Bcl-xL and between FADD and Atg5,caspase-and calpain-mediated cleavage of autophagy-related proteins,and autophagic degradation of *** investigation of these and other means of crosstalk between apoptosis and autophagy is necessary to elucidate the mechanisms controlling the balance between survival and death both under normal conditions and in diseases including cancer.

关键词： autophagy apoptosis Beclin-1 lymphocytes

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Contributions of Trimorphic Life Cycles to Dispersal and Evolutionary Trends in Large Benthic Foraminifers

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Journal of Earth Science 2022年第6期33卷 1425-1433页

作者： Pamela Hallock claire E.Reymond College of Marine Science University of South FloridaSt.PetersburgFL33701USA School of Earth Sciences China University of GeosciencesWuhan430074China School of Geosciences The University of SydneySydneyNSW2006Australia

The basic life cycle of Foraminifera has long been recognized as alternation between sexual and asexual generations;a common modification is several successive asexual *** and release of flagellated gametes also has been documented as the basic sexual-reproductive mode in extant *** on population dynamics,local spatial distributions,and biogeography of Amphistegina *** Heterostegina depressa have been augmented by culture studies over the past 50years,providing insights that have been widely used in paleoecological and paleoenvironmental *** are proposed suggesting how stages in the life cycle might contribute to understanding biogeographic and evolutionary trends commonly observed in large benthic *** of sexually-produced cryptobiotic propagules,followed by successive asexual generations(schizogeny),can potentially establish viable,locally-adapted populations within literally years,consistent with the concepts of both allopatric speciation and reticulate evolution associated with isolation and reconnection of local *** review concludes with the recommendation that future studies utilizing genomics,proteonomics,geochemistries,scanning technologies,and other approaches can promote greater understanding of both modern and fossil larger benthic foraminiferal lineages.

关键词： Amphistegina coiling ratio diatom symbionts Heterostegina depressa propagule schizogeny life cycle

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Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

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Nano Research 2020年第4期13卷 989-998页

作者： Natasha Logan claire McVey Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

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