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International Journal of Ophthalmology(English edition) 2019年第3期12卷 363-368页

作者： Ya-Ru Dong claire E Gustafson Jun Wang Ji-Zhe Cui Takeshi Yoshitomi Department of Ophthalmology the Second Hospital of Jilin University Department of Ophthalmology Akita University School of Medicine Division of Immunology and Rheumatology Department of Medicine Stanford University

AIM: To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery(OCA) in spontaneously hypertensive rat(SHR).METHODS: In this experiment, 20-week-old male SHR and Wistar Kyoto rat(WKY) were studied. The heart rate(HR), the blood pressure(BP; the systolic BP and the diastolic BP) of rats with an electronic sphygmomanometer were measured. Vascular morphometry and isometric tension measurement were used to investigate the alterations in structure and contractility of ***: A general narrowing of OCAs was observed in SHR compared to the control WYK. In SHR, the media of OCAs were thicker, the luminal diameters were smaller, and the media-to-lumen ratios were higher when compared with WKY(P0.05). Indomethacin(10 μmol/L) decreased the contractions induced by norepinephrine in OCAs from WKY(P0.05).CONCLUSION: Our results demonstrate that the structure and function of OCAs are altered in hypertension. OCAs from SHR are remodeled with decreased lumen diameter and increased media-to-lumen ratio. Moreover, the contractile responsiveness of OCAs from SHR is diminished due to the disruption of vasoconstrictive effect of prostaglandins.

关键词： remodeled structure contractile responsiveness ocular ciliary artery hypertension spontaneously hypertensive rat

The IgH 3′ regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage

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Cellular & Molecular Immunology 2018年第3期15卷 289-291页

作者： Hussein Issaoui Nour Ghazzaui Alexis Saintamand claire Carrion Christelle Oblet Yves Denizot CNRS UMR 7276 CRIBLUniversitéde LimogesLimogesFrance INSERM U1236 UniversitéRennes 1RennesFrance

The bone marrow-derived B2 population represents the vast majority of bone marrow,blood,lymph node and splenic *** B1 B-cells mostly originate during embryonic life in the liver and represent the main B-cell population in the pleural and peritoneal cavities.1,2,3,4,5 B1 and B2 B-cells differ in their origin,antigen specificity,cell surface markers,tissue distribution and capacity for class switch recombination(CSR).Schematically,B1 B-cells appear earlier than B2 B-cells during fetal development and maintain their self-renewal ability throughout their life.

关键词： maintain specificity mostly

Connections Between Insomnia and Cognitive Aging

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Neuroscience Bulletin 2020年第1期36卷 77-84页

作者： claire E.Sexton Konstantina Sykara Elissaios Karageorgiou Jenny Zitser Talita Rosa Kristine Yaffe Yue Leng Global Brain Health Institute Memory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoCAUSA Department of Psychiatry University of OxfordOxfordUK Neurological Institute of Athens AthensGreece Department of Psychiatry Neurology and EpidemiologyUniversity of CaliforniaSan FranciscoCAUSA

Insomnia is a common sleep disorder among older adults,and a risk factor for poor physical and mental ***,the relationship between insomnia and cognitive health is not well ***,we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia,magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure,and interventional studies that have explored whether the treatment of insomnia can improve cognitive *** are inconsistent findings regarding impaired performance in objective cognitive tests and reduced grey matter volumes,and limited,emerging,evidence that suggests that insomnia is associated with an increased risk of dementia and reduced white matter *** the interventional literature is still in its infancy,there is some indication that treatment may have an impact on ***-powered studies examining sources of heterogeneity are warranted.

关键词： Insomnia Sleep Dementia Cognition

Contemporary review of the 532 nm laser for treatment of benign prostatic hyperplasia

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Asian Journal of Urology 2015年第2期2卷 102-106页

作者： Bilal Chughtai Leanna Laor claire Dunphy Alexis Te Department of Urology Weill Cornell Medical CollegeNew York Presbyterian HospitalNew YorkNYUSA

Benign prostatic hyperplasia(BPH)is a condition that occurs increasingly with *** established gold standard treatment for BPH has been the electrocautery-based transurethral resection of the prostate(TURP).TURP,however,is associated with several complications and side ***,there is an increasing interest in a number of emerging minimally invasive therapies as alterative treatment *** therapy using the Greenlight laser is a promising alternative to the traditional *** absorption by hemoglobin allows rapid,hemostatic vaporization of prostate *** advantages include avoidance or minimization of complications such as intraoperative fluid absorption,and bleeding,retrograde ejaculation,impotence,and incontinence,as well as its use in treating high volume *** review the use of the Greenlight laser in the treatment of BPH,when comparing complications and advantages in relation to TURP.

关键词： Benign prostatic hyperplasia Laser prostatectomy 532 nm prostatectomy

Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model

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Nano Research 2020年第2期13卷 467-476页

作者： Aurore Van de Walle Alexandre Fromain Anouchka Plan Sangnier Alberto Curcio Luc Lenglet Laurence Motte Yoann Lalatonne claire Wilhelm Laboratoire Matière et Systèmes Complexes MSCUMR 7057CNRS&University of Paris75205Paris Cedex 13France Inserm U1148Laboratory for Vascular Translational ScienceSorbonne Paris NordSorbonne Paris CitéF-93017 BobignyFranc Normafin Sàrl 8 rue Mathilde Girault92300 Levallois-PerretFrance Services de Biochimie et Médecine Nucléaire Hópital Avicenne Assistance Publique-Hôpitaux de ParisF-93009 BobignyFrance

The use of magnetic nanoparticles in nanomedicine keeps expanding and,for most applications,the nanoparticles are internalized in cells then left within,bringing the need for accurate,fast,and easy to handle methodologies to assess their behavior in the cellular ***,a benchtop-size magnetic sensor is introduced to provide real-time precise measurement of nanoparticle magnetism within living *** values obtained with the sensor,of cells loaded with different doses of magnetic nanoparticles,are first compared to conventional vibrating sample magnetometry(VSM),and a strong correlation remarkably validates the use of the magnetic sensor as magnetometer to determine the nanoparticle cellular *** sensor is then used to monitor the progressive intracellular degradation of the nanoparticles,over ***,this real-time in situ measure is performed on a stem cell-spheroid tissue model and can run continuously on a same spheroid,with cells kept alive ***,such continuous magnetic measurement of cell magnetism at the tissue scale does not impact either tissue formation,vibility,or stem cell function,including differentiation and extracellular matrix production.

关键词： magnetic nanoparticles magnetometry real-time in operando measures biodegradation stem cells

A Novel Multi-Channel Dispersion Slope Compensator Using Sampled FBG

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光学学报 2003年第S1期23卷 -页

作者： J. J. Pan claire Gu Albert Li Lightwaves 2020 Inc. 1323 Great Mall Drive Milpitas CA 95035 USADepartment of Electrical Engineering University of California at Santa Cruz Santa Cruz CA 95064 USALightwaves 2020 Inc. 1323 Great Mall Drive Milpitas CA 95035 USA

A novel dispersion slope compensator is proposed and fabricated using a sampled fiber grating. The dispersion slope of this compensator is demonstrated to match that of Coming LS fiber for a multi-channel 50GHz WDM sy... 详细信息

关键词： A Novel Multi-Channel Dispersion Slope Compensator Using Sampled FBG in for as WDM with GHz

Bubbles and incentives:an experiment on asset markets

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Economic and Political Studies 2021年第1期9卷 68-89页

作者： Stéphane Robin Katerina Stráznická Marie claire Villeval Grenoble INP Institute of Engineering and Management Grenoble Applied Economics Laboratory(GAEL)University of Grenoble AlpesGrenobleFrance French National Centre for Scientific Research(CNRS) ParisFrance National Institute for Agricultural Research(INRA) ParisFrance Clermont Research Management(CleRMA) University of Clermont AuvergneClermont-FerrandFrance University of Lyon LyonFrance Group of Economic Analysis and Theory(GATE) French National Centre for Scientific Research(CNRS)EcullyFrance Institute of Labour Economics(IZA) BonnGermany

We explore the effects of competitive incentives and of their time horizon on the evolution of both asset prices and trading activity in experimental asset *** compare(i)a no-bonus treatment;(ii)a short-term bonus treatment in which bonuses are assigned to the best performers at the end of each trading period;(iii)a long-term bonus treatment in which bonuses are assigned to the best performers at the end of the 15 periods of the *** find that the existence of bonus contracts does not increase the likelihood of bubbles but it affects their severity,depending on the time horizon of *** with longterm bonus contracts experience lower price deviations and a lower turnover of assets than markets with either no bonuses or long-term bonus ***-term bonus contracts increase price deviations but only when markets include a higher share of male *** the individual level,the introduction of bonus contracts increases the trading activity of males,probably due to their higher competitiveness.

关键词： Asset market bubbles incentives bonuses risk attitudes experiment

Brain-derived neurotrophic factor rs6265(Val66Met)single nucleotide polymorphism as a master modifier of human pathophysiology

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Neural Regeneration Research 2023年第1期18卷 102-106页

作者： Van Thuan Nguyen Braxton Hill Naiya Sims Aaron Heck Marcus Negron claire Lusk Cristi LGalindo Department of Biology Western Kentucky UniversityBowling GreenKYUSA

Brain-derived neurotrophic factor is the most prevalent member of the nerve growth factor *** its discovery in 1978,this enigmatic molecule has spawned more than 27,000 publications,most of which are focused on neurological ***-derived neurotrophic factor is indispensable during embryogenesis and postnatally for the normal development and function of both the central and peripheral nervous *** is becoming increasingly clear,however,that brain-derived neurotrophic factor likewise plays crucial roles in a variety of other biological functions independently of sympathetic or parasympathetic ***-derived neurotrophic factor is also increasingly recognized as a sophisticated environmental sensor and master coordinator of whole organismal *** that point,we recently found that a common nonsynonymous(Val66→Met)single nucleotide polymorphism in the brain-derived neurotrophic factor gene(rs6265)not only substantially alters basal cardiac transcriptomics in mice but subtly influences heart gene expression and function differentially in males and *** addition to a short description of recent results from associative neuropsychiatric studies,this review provides an eclectic assortment of research reports that support a modulatory role for rs6265 including and beyond the central nervous system.

关键词： brain-derived neurotrophic factor neuropsychiatric disorders rs6265 Val66Met

Perceptions of telemedicine at a pediatric otolaryngology-head and neck surgery program

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World Journal of Pediatric Surgery 2022年第4期5卷 282-288页

作者： claire Gwilt Gregory Metzger Kris Jatana Tran Bourgeois Patrick Walz The Ohio State University College of Medicine ColumbusOhioUSA Department of Surgery The Ohio State University Wexner Medical CenterColumbusOhioUSA Department of Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA Department of Pediatric Otolaryngology Nationwide Children's HospitalColumbusOhioUSA Center for Surgical Outcomes Research Nationwide Children's HospitalColumbusOhioUSA Department of Otolaryngology The Ohio State University Wexner Medical CenterColumbusOhioUSA

Objective With few studies investigating the effectiveness of telemedicine(TM)in pediatric otolaryngology(ear,nose,and throat;ENT),its role in clinical practice is *** objective of this study was to investigate provider perspectives regarding utility of TM in pediatric ENT *** A survey gauging the relative merits of TM visits for common pediatric ENT chief complaints and postoperative visits was distributed to all pediatric ENT providers at a tertiary care,free-standing children’s *** were asked to assess the effectiveness of TM visits compared with in-person visits for completing the following tasks:history collection,physical examination,medical decision-making,and patient *** Providers rated TM visits as less useful than in-person visits for completing the most predefined tasks but did identify advantages in history taking via TM for the majority of *** with providers with≥10 years of experience,those with<10 years of experience found TM to be more effective than the in-person appointment for making clinical decisions for patients presenting with recurrent/chronic pharyngitis,neck masses,and stridor/noisy *** regarding the utility of TM for postoperative visits were mixed,with adenoidectomy,tonsillectomy and superficial procedures being most frequently deemed appropriate for *** The introduction of TM to pediatric ENT faces limitations in detailed examination of areas not accessible without specialized *** to its strength in history taking,results suggest an asynchronous,‘store and forward’encounter followed by an in-person physical examination to confirm the diagnosis and treatment plan could be beneficial.

关键词： pediatric superficial diagnosis

Local Persistence of Large Benthic Foraminifera(LBF)under Increasing Urban Development:A Case Study from Zanzibar(Unguja),East Africa

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Journal of Earth Science 2022年第6期33卷 1434-1450页

作者： Gita R.Narayan Natalia Herrán claire E.Reymond Yohanna W.Shaghude Hildegard Westphal Leibniz Centre for Tropical Marine Research(ZMT) BremenGermany Department of Geosciences Bremen UniversityBremenGermany Leibniz Institute for Baltic Sea Research(IOW) 18119RostockGermany School of Earth Sciences China University of GeosciencesWuhan430074China School of Geosciences The University of SydneySydneyNSW2006Australia Institute of Marine Sciences(IMS) The University of Dar es SalaamZanzibarTanzania King Abdullah University of Science and Technology(KAUST) ThuwalKingdom of Saudi Arabia

Coastal marine management is vital for socio-ecological sustainability of developing,tropical ecosystems,which calls for diverse tools to monitor and assess water *** carbonatedominated habitats off Zanzibar were chosen for study due to potential water quality degradation in a rapidly developing tourist destination heavily reliant on its coral *** reefs are largely unmonitored and subject to local and global stressors.A widely used method for assessing reef health,as an early detection method of ecological changes,is the application of large benthic foraminiferal bioindicators,i.e.,the Fo RAM *** expected to find poor water quality conditions in the unmanaged reefs supported by stress-toelerant(opportunistic)foraminiferal *** dissolved inorganic nitrogen and phosphate values derived from untreated sewage effluent from Stone Town were highly variable(ranging 0.05–3.77 and 0.05–1.45μM,respectively),moderate,and occasionally approached or exceeded critical threshold values for oligotrophic *** analysis of total assemblages indicated an abundance of symbiont-bearing large benthic foraminifera,dominated by prolific Amphistegina species,comparatively low-moderate diversity,high FI values(7.6 on average),and high coral cover.A water quality gradient was reflected by subtle assemblage differences,suggesting that LBF can provide early warning signals of benthic changes,indicating the importance of long-term monitoring programs in vulnerable,rapidly developing coastal ecosystems exposed to increasing pressures.

关键词： carbonate coral reef bioindicator Fo RAM Index nutrients sewage effluent Western Indian Ocean coastal development coastal marine management