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Adverse Events following AstraZeneca COVId-19 Vaccination: A Case Study in Abidjan, Côte d’Ivoire

Open Journal of Immunology 2024年第2期14卷 11-15页

作者： Chiayé claire Antoinette Yapo-Crezoit Samuel Boahene Mireille dosso Immunity Biology Unit Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire

Introduction: Pharmaceutical companies have boosted vaccine production following the global COVId-19 pandemic. In Côte d’Ivoire, the first vaccination campaign with the AstraZeneca vaccine began on March 1, 2021, as part of the Covax program. despite the positive benefit/risk balance, the adverse effects of vaccination should not be minimized. Objective: To identify adverse events of AstraZeneca’s COVId-19 vaccination for better management. Materials and Methods: This is a case of a 57-year-old obese (BMI = 39 kg/m2) female health care worker who experienced adverse events in March 2021 after the second dose of AstraZeneca vaccine administered 4 weeks apart. These were subject to mandatory case reporting. Results: Major post-vaccination events occurred in a noisy systemic picture with parameters showing significant disturbances. Biological surveillance remains costly and makes the accountability of the vaccine complex. Conclusion: Vaccination remains the ultimate weapon in the fight against endemic diseases but should not overshadow the reporting of adverse events.

关键词： Adverse Events Post-Second Immunization AstraZeneca Vaccine Abidjan

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新型脱甲基酶抑制剂氯氟醚菌唑对水稻恶苗病致病菌藤仓镰孢菌的抑菌活性

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农药学学报 2024年第1期26卷 69-76,35页

作者：陈星杨家伟 KOKLANNOU damalk Saint claire Senakpon 孙扬陈雨安徽农业大学植物保护学院合肥230036 作物有害生物综合治理安徽省重点实验室合肥230036

水稻恶苗病是水稻生产中的重要种传真菌病害,其在我国的主要致病菌为藤仓镰孢菌Fusarium fujikuroi。本研究采用菌丝生长速率法和孢子萌发法,测定了102株藤仓镰孢菌对新型脱甲基酶抑制剂氯氟醚菌唑的敏感性,明确了其敏感性分布,同时测... 详细信息

水稻恶苗病是水稻生产中的重要种传真菌病害,其在我国的主要致病菌为藤仓镰孢菌Fusarium fujikuroi。本研究采用菌丝生长速率法和孢子萌发法,测定了102株藤仓镰孢菌对新型脱甲基酶抑制剂氯氟醚菌唑的敏感性,明确了其敏感性分布,同时测定了氯氟醚菌唑对藤仓镰孢菌菌丝和孢子形态、细胞膜通透性、细胞壁和细胞膜完整性、麦角甾醇和毒素合成的影响。结果表明:氯氟醚菌唑对藤仓镰孢菌菌丝生长和孢子萌发的EC50值范围分别在0.0305~0.7579μg/mL和0.1091~1.6870μg/mL,平均EC50值分别为(0.2469±0.0167)μg/mL和(0.6397±0.0324)μg/mL。此外,用EC50浓度的氯氟醚菌唑处理,可使藤仓镰孢菌菌丝扭曲破裂、孢子皱缩扁平,可破坏菌丝细胞壁和细胞膜完整性,显著降低了麦角甾醇含量,影响毒素合成。研究结果证实了氯氟醚菌唑对藤仓镰孢菌的生物活性,可为水稻恶苗病的田间防治以及氯氟醚菌唑的科学合理使用提供依据。

关键词：脱甲基酶抑制剂氯氟醚菌唑水稻恶苗病藤仓镰孢菌抑菌活性

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Establishment of a system for screening and identification of novel bactericide targets in the plant pathogenic bacterium Xanthomonas oryzae pv. oryzae using Tn-seq and SPR

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Journal of Integrative Agriculture 2024年第5期23卷 1580-1592页

作者： Chaoyue Pang Ling Jin Haoyu Zang damalk Saint-claire SKoklannou Jiazhi Sun Jiawei Yang Yongxing Wang Liang Xu Chunyan Gu Yang Sun Xing Chen Yu Chen School of Plant Protection Anhui Agricultural UniversityHefei 230036China Institute of Plant Protection and Agro-Products Safety Anhui Academy of Agricultural SciencesHefei 230031China Anhui Province Laboratory for Green Pesticide development and Application School of Plant ProtectionAnhui Agricultural UniversityHefei230036China Hefei Research Center State Key Laboratory for Biology of Plant Diseases and Insect PestsHefei 230036China Key Laboratory of Integrated Crop Pest Management of Anhui Province School of Plant ProtectionAnhui Agricultural University Hefei230036China Shandong Vicome Greenland Chemical Co. Ltd.Jinan 250204China

Xanthomonas spp. cause severe bacterial diseases. However, effective strategies for prevention and management of these diseases are scarce. Thus, it is necessary to improve the efficiency of control of diseases caused by Xanthomonas. In this study, Xanthomonas oryzae pv. oryzae(Xoo), which causes rice bacterial leaf blight, has been studied as a representative. A transposon insertion library of Xoo, comprising approximately 200,000 individual insertion mutants, was generated. Transposon sequencing data indicated that the mariner C9 transposase mapped at 35.7–36.4% of all potential insertion sites, revealing 491 essential genes required for the growth of Xoo in rich media. The results show that, compared to the functions of essential genes of other bacteria, the functions of some essential genes of Xoo are unknown, 25 genes might be dangerous for the Xanthomonas group, and 3 are specific to Xanthomonas. High-priority candidates for developing broad-spectrum, Xanthomonas-specific, and environment-friendly bactericides were identified in this study. In addition, this study revealed the possible targets of dioctyldiethylenetriamine using surface plasmon resonance(SPR) in combination with high performance liquid chromatography–mass spectrometry(HPLC–MS). The study also provided references for the research of some certain bactericides with unknown anti-bacterial mode of action. In conclusion, this study urged a better understanding of Xanthomonas,provided meaningful data for the management of bacterial leaf blight, and disclosed selected targets of a novel bactericide.

关键词： rice bacterial leaf blight Xanthomonas essential genes Tn-seq dioctyldiethylenetriamine

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