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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas cláudia p oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNpq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(ppared to RIF(ppatic expression of Mmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(ppression of p62/SQSTM1 protein was lower in the RIF-group compared to the control(p=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and Mmp2(p>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(ppared to RIF,and the inverse was observed for miR-224(pps regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(p>0.05).CONclUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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Direct-acting antivirals for chronic hepatitis C treatment: The experience of two tertiary university centers in Brazil

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World Journal of Hepatology 2022年第1期14卷 195-208页

作者： Mariana Sandoval Lourenço patricia Momoyo Y Zitelli Marlone Cunha-Silva Arthur Ivan N oliveira cláudia p oliveira Tiago Sevá-pereira Flair JoséCarrilho Mario G pessoa Daniel F Mazo Division of Gastroenterology Department of Internal MedicineSchool of Medical SciencesUniversity of CampinasSao Paulo 13083-878Brazil Division of clinical Gastroenterology and Hepatology Department of GastroenterologyUniversity of São Paulo School of MedicineSao Paulo 05403-900Brazil

BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent *** interferon-based therapies have been replaced by oral direct-acting antivirals(DAA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of DAAs for HCV treatment in subjects from two tertiary university centers in *** This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November *** therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of ***,anthropometric,clinical,and laboratory variables were *** were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)*** and serious adverse events(SAEs)were *** the statistical analysis,a p value ofpe 1,followed by genotype 3(20.1%).Moreover,306(57.5%)subjects had cirrhosis,and a third of them had decompensated ***(SOF)plus daclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,p=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,p=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,p=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,p=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,p=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,p=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,p=0.0009).AEs were reported

关键词： Chronic hepatitis C Antiviral agents Hepatitis C virus Sustained virologic response Liver cirrhosis Safety

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Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis

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World Journal of Hepatology 2021年第12期13卷 2052-2070页

作者： Larisse Longo pabulo Henrique Rampelotto Eduardo Filippi-Chiela Valessa Emanoele Gabriel de Souza Fernando Salvati Carlos Thadeu Cerski Themis Reverbel da Silveira cláudia p oliveira Carolina Uribe-Cruz Mário ReisÁlvares-da-Silva Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Graduate program in Genetics and Molecular Biology Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Rio Grande do SulBrazil Experimental Research Center Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil School of Medicine Instituto Meridional de Educação-IMEDPasso Fundo 99070-220Rio Grande do SulBrazil Unit of Surgical pathology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Cardiovascular disease is the main cause of death in metabolic-associated fatty liver disease,and gut microbiota dysbiosis is associated with both of *** To assess the relationship between gut dysbiosis and cardiovascular risk(CVR)in an experimental model of *** Adult male Sprague-Dawley rats were randomized to a control group(n=10)fed a standard diet and an intervention group(n=10)fed a high-fat choline-deficient diet for 16 ***,molecular,hepatic,and cardiac *** microbiota variables were *** The intervention group had a significantly higher atherogenic coefficient,Castelli’s risk index(CRI)-I and CRI-II,interleukin-1β,tissue inhibitor of metalloproteinase-1(all pprotein-1(p=0.005),and plasminogen activator inhibitor-1(p=0.037)than the control *** expression of miR-33a increased(p=0.001)and miR-126(pp,and heart computerized histological imaging analysis showed a significant decrease in the percentage of cardiomyocytes with a normal morphometric appearance(p=0.007),reduction in the mean area of cardiomyocytes(p=0.037),and an increase of atrophic cardiomyocytes(p=0.007).There were significant correlations between the cardiomyocyte morphometry markers and those of progression and severity of liver disease and *** intervention group had a lower Shannon diversity index and fewer changes in the structural pattern of gut microbiota(both ppid metabolism were differentially abundant in intervention group and were significantly correlated with markers of liver injury and *** The study found a link between gut dysbiosis and significant cardiomyocyte abnormalities in animals with steatohepatitis.

关键词： Animal model Cardiovascular diseases Gut microbiota Metabolic-associated fatty liver disease predicted lipid metabolism Risk cardiovascular Steatohepatitis

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Testicular prostheses-impact on quality of life and sexual function

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Asian Journal of Andrology 2024年第2期26卷 160-164页

作者： Ana Sofia Araujo Sara Anacleto Ricardo Rodrigues Catarina Tinoco Andreia Cardoso Carlos oliveira Ricardo Leao Department of Urology Braga's HospitalBraga 4710Portugal Faculty of Medicine Coimbra UniversityCoimbra 3000Portugal

Orchiectomy is the recommended treatment for many testicular ***,testicular prosthesis placement is not always performed for different *** this study,we aimed to evaluate patients'opinions and the impact on sexual function and quality of *** retrospective observational single-center study included patients who underwent orchiectomy between January 2014 and December 2020 at the Department of Urology,Braga's Hospital(Braga,portugal),where testicular implants were always available and the decision to undergo the procedure was made fully independent of *** completed four questionnaires that assessed demographic data,satisfaction,self-esteem,and sexual *** the 96 patients who underwent orchidectomy,59 replied to the questionnaires,and of these patients,86.4%decided to undergo silicone-based testicular prostheses *** remaining 13.6%refused the implant based on concerns about complications(37.5%),because they felt that it was unnecessary(37.5%),or because it was not offered by the doctor(25.0%).Overall,96.1%of these patients were satisfied with the implant;however,25.5%classified it as"too firm".No statistically significant differences were found in sexual function(all p>0.05).However,it can be observed that there are more patients with prostheses presenting normal sexual activity compared to patients without prostheses(74.0%vs 50.0%),and none of them reported severe erectile dysfunction(0 vs 16.7%).Regarding self-esteem,both patients with and without prostheses present very similar average scores with no statistically significant *** present study highlights the highest level of satisfaction among patients who received testicular *** prostheses implantation is a safe procedure that does not hamper sexual function after orchiectomy.

关键词： orchiectomy patient satisfaction quality of life sexual dysfunction sexual health testicular prostheses

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prostate cancer temporal and regional trends in Brazil

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Oncology Research 2024年第10期32卷 1565-1573页

作者： MEHRSA JALALIZADEH HEVELINE RAYANE MOURA ROESCH FERNANDO KORKES QUOC DIEN-TRINH LEONARDO oliveira REIS UroScience School of Medical SciencesState University of CampinasCampinas13083-872Brazil Division of Urology Faculdade de Medicina do ABCSão Paulo09051-040Brazil Division of Urological Surgery and Center for Surgery and public Health Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinas13087-571Brazil

Objectives:The Brazilian Unified Health System(SistemaÚnico de Saúde−SUS)is the universal public healthcare system of Brazil that maintains a nationwide database of its *** primary objective was to analyze regional and temporal trends,while our secondary goal was to establish correlations between states’health economy status and their prostate cancer(pCa)***:We analyzed Brazil’s nationwide data on prostate cancer(pCa)incidence,mortality,and care gathered between 2013 and 2021 by the Information Technology Department of SUS(DATA-SUS),updated monthly using the International classification of Diseases(ICD-10)***:In the period,273,933 new cases of pCa and 135,336 pCa deaths were reported in men aged 50 years or over in *** median annual pCa-specific incidence rate(pCSIR)ranged from 14.7 in the Southeast to 6.9 in the North region and the median annual pCa-specific mortality rate(pCSMR)ranged from 7.7 in the Northeast to 6.0 in the South region(per 10,000 men>50).The median annual mortality to incidence ratio(MIR)was highest in the North(0.88)and lowest in the Southeast region(0.44).There were significant regional differences in pCa treatment rates(per new cases);the Midwest region had the highest median annual surgery rate(0.63)while the North region had the highest median annual systemic therapy rate(0.75)and the lowest radiation therapy rate(0.06).Temporal analysis of the data showed significant change in annual rate trends after the year 2018 for pCSIR(coefficient[β]=+3.66,pp=0.016),surgery([SR]β=+0.05,p=0.017)radiation therapy([RTR]β=−0.06,p=0.005)and systemic therapy([STR]β=−0.10,p=0.002).After the 2020 pandemic,annual pCSIR decreased(β=−2.15,p=0.002)but annual pCSMR,MIR,and treatment rates remained *** studies showed that the pCSIR was strongly negatively correlated with STR(ppositively correlated with RTR(p=0.004).MIR was positively correlated with STR(p<0.001)and ne

关键词： prostate cancer(pCa)epidemiology Regional disparities Temporal trends COVID-19 pandemic Screening

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： paulo Ricardo prado Nunes pamela Castro-e-Souza Anselmo Alves de oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GpEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and physical Exercise Study and Research Group(GEpCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil postgraduate program in physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in pubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to ***:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training

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physico-chemical characterization of acid base disorders in patients with COVID-19:A cohort study

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World Journal of Nephrology 2024年第2期13卷 16-23页

作者： Sergio pinto de Souza Juliana R Caldas Marcelo Barreto Lopes Marcelo Augusto Duarte Silveira Fernanda oliveira Coelho Igor oliveira Queiroz pedro Domingues Cury Rogério da Hora passos Department of Nephrology Hospital São RafaelSalvadorBA 41253190Brazil Department of Nephrology D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Faculty of Medicine Escola Bahiana de Medicina e Saúde Pública-EBMSPSalvadorBA 40290000Brazil Department of Intensive Care D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Hospital São Rafael D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Department of Intensive Care Unit Hospital Israelita Albert EinsteinSao PauloSP 05652900Brazil

BACKGROUND Acid-base imbalance has been poorly described in patients with coronavirus disease 2019(COVID-19).Study by the quantitative acid-base approach may be able to account for minor changes in ion distribution that may have been over-looked using traditional acid-base analysis *** a cohort of critically ill COVID-19 patients,we looked for an association between metabolic acidosis surrogates and worse clinical outcomes,such as mortality,renal dialysis,and length of hospital *** To describe the acid-base disorders of critically ill COVID-19 patients using Stewart’s approach,associating its variables with poor *** This study pertained to a retrospective cohort comprised of adult patients who experienced an intensive care unit stay exceeding 4 days and who were diagnosed with severe acute respiratory syndrome coronavirus 2 infection through a positive polymerase chain reaction analysis of a nasal swab and typical pulmonary involvement observed in chest computed tomography *** and clinical data were obtained from electronic *** variables were compared using Fisher’s exact *** data were presented as median and interquartile *** Mann-Whitney U test was used for *** In total,211 patients were *** mortality rate was 13.7%.Overall,149 patients(70.6%)presented with alkalosis,28 patients(13.3%)had acidosis,and the remaining 34 patients(16.2%)had a normal arterial pondus *** those presenting with acidosis,most had a low apparent strong ion difference(SID)(20 patients,9.5%).Within the group with alkalosis,128 patients(61.0%)had respiratory *** non-survivors were older,had more comorbidities,and had higher Charlson’s and simplified acute physiology score *** did not find severe acid-base imbalance in this *** analyzed Stewart’s variables(effective SID,apparent SID,and strong ion gap and the effect of albumin,lactate,phosphorus,and chloride)were not d

关键词： COVID-19 physicochemical approach Acid-base status Critically ill patients Acute respiratory syndrome

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Social determinants of gastrointestinal malformation mortality in Brazil:a national study

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World Journal of pediatric Surgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Amanda Rosendo Luiza Telles Aricia Gomes Miranda Madeleine Carroll Bruna oliveira Trindade Sarah Bueno Motter Esther Freire Gabriella Hyman Julia Ferreira Fabio Botelho Roseanne Ferreira David p Mooney Joaquim Bustorff-Silva program in Global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of Medicine and Health Sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Division of pediatric Surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of Surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação Médica(IDOMED/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of Medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da Saude de porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil Department of Health Research Methods McMaster UniversityHamiltonSouthern OntarioCanada Department of pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born with a congenital disorder,potentially fatal without *** study aims to evaluate the relationship between gastrointestinal congenital malformation(GICM)mortality,health indicators,and socioeconomic factors in *** GICM admissions(Q39-Q45)between 2012 and 2019 were collected using national *** demographics,socioeconomic factors,clinical management,outcomes,and the healthcare workforce density were also accounted *** Surgical Workforce density and the number of neonatal intensive care units in a region were extracted from national datasets and combined to create a clinical index termed'NeoSurg'.Socioeconomic variables were combined to create a socioeconomic index termed SocEcon'.Simple linear regression was used to investigate if the temporal changes of both indexes were *** correlation between mortality and the different indicators in Brazil was evaluated using pearson's correlation *** Over 8 years,Brazil recorded 12804 GICM *** Southeast led with 6147 cases,followed by the Northeast(2660),South(1727),North(1427),and Midwest(843).The North and Northeast reported the highest mortality,lowest NeoSurg,and SocEcon Index ***,mortality rates declined across regions from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and Midwest experienced the most substantial reductions,at 63%and 75%,*** significantly correlated with the indexes in nearly all regions(pclusion Our study highlights the correlation between social determinants of health and GICM mortality in Brazil,using two novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

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Structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira M.C.oliveira CQ-VR and Chemistry Department University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and physics Department University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （parallel,alcohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EpR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization NMR XpS Hydrophilic carbon paramagnetic

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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha oliveira Gustavo JS pereira claudia Bincoletto Department of pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HpLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BApTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(ppared to HEAV-exposed fibroblasts(pprimarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(pposed to HEAV alone(pppTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(pclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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