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Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： ciro Caruso Luca D’Andrea Mario Troisi Michele Rinaldi Raffaele Piscopo Salvatore Troisi ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health Department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual *** therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced *** keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe *** consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks *** aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment ***,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol Dresden protocol lambert-beer law Bunsen-roscoe law

Natural Gas Power Plants in the System Security Role—The Situation and Solutions in Brazil

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Energy and Power Engineering 2024年第4期16卷 151-178页

作者： ciro Galvão Hirdan Katarina de Medeiros Costa Eduardo Guedes Pereira Edmilson Moutinho dos Santos Dorel Soares Ramos Polytechnic School (EP) University of S&#227o Paulo S&#227o Paulo Brazil Institute of Energy and Environment (IEE) University of S&#227o Paulo S&#227o Paulo Brazil

This study aims to apply a methodology to analyze the regulatory obstacles for the development of thermal power plants in a country. The study uses Brazil as an application case, although mostly of the findings can be useful to other countries. It also discusses other policies and actions by the government that may contribute to the growth of natural gas-fired power plants. Using deductive and comparative research methods, the first part of this method focuses on the stage of thermoelectric power generation in Brazil. The subsequent sections present the role of the integration of gas and electricity sectors, the main obstacles to the expansion of natural-gas power generation, how the country has deal with the expansion of natural-gas power generation, as well as how other obstacles has been faced. In raising the research question, when comparing the research results of selected countries, it should be noticed the impact that the experience and lessons elsewhere have had on policies formulation on Brazil. Our conclusions pointed out that adequate policies for the natural gas-electricity Brazilian market integration make advisable the unification of electricity and natural gas agencies. We recommended developing a mathematical model to support decision-making on natural gas and electricity integration.

关键词： Component Formatting Style Styling Insert

Neuroinflammation and glial activation in the central nervous system: a metabolic perspective

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Neural Regeneration Research 2023年第5期18卷 1025-1026页

作者： Assunta Virtuoso ciro De Luca Sohaib Ali Korai Michele Papa Giovanni Cirillo Division of Human Anatomy Laboratory of Morphology of Neuronal Networks and Systems BiologyDepartment of Mental and Physical Health and Preventive MedicineUniversity of Campania“Luigi Vanvitelli”NaplesItaly

Decades of research in glial biology have investigated mechanisms of neuro-glial interplay,demonstrating that neurons and glia intimately cooperate for energy metabolism in the central nervous system(CNS)(Magistretti ... 详细信息

关键词： metabolism inflammation system

Sources,characteristics,toxicity,and control of ultrafine particles:An overview

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Geoscience Frontiers 2022年第1期13卷 512-526页

作者： Andrea L.Moreno-Ríos Lesly P.Tejeda-Benítez ciro F.Bustillo-Lecompte Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia Research Group in Biomedical Toxicological and Environmental Sciences(Biotoxam)University of CartagenaCampus of ZaragocillaCartagenaColombia School of Occupational and Public Health Ryerson University350 Victoria StreetTorontoON M5B 2K3Canada

Air pollution by particulate matter(PM)is one of the main threats to human health,particularly in large cities where pollution levels are continually *** to their source of emission,geography,and local meteorology,the pollutant particles vary in size and *** particles are conditioned to the aerodynamic diameter and thus classified as coarse(2.5–10μm),fine(0.1–2.5μm),and ultrafine(<0.1μm),where the degree of toxicity becomes greater for smaller *** particles can get into the lungs and translocate into vital organs due to their size,causing significant human health ***,PM pollutants have been linked to respiratory conditions,genotoxic,mutagenic,and carcinogenic activity in human *** paper presents an overview of emission sources,physicochemical characteristics,collection and measurement methodologies,toxicity,and existing control mechanisms for ultrafine particles(UFPs)in the last fifteen years.

关键词： Particulate matter Ultrafine particles Air pollution Toxicity Measurement methodologies

Immunosuppressive,antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes(Hymenoptera:Braconidae)

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Insect Science 2023年第4期30卷 1105-1117页

作者： ciro P.G.Pinto Andrew A.Walker Glenn F.King Guilherme D.Rossi School of Agricultural and Veterinarian Sciences Sao Paulo State University(UNESP)JaboticabalBrazil Institute for Molecular Bioscience The University of QueenslandSt LuciaBrisbaneQueenslandAustralia Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of QueenslandQueenslandSt LuciaAustralia

Teratocytes are specialized cells released by parasitoid wasps into their *** are known for producing regulatory molecules that aid the development of imma-ture *** have recently reported the primary structures of cystine-rich peptides,including some containing inhibitor cystine knot(ICK)motifs,produced by teratocytes of the parasitoid Cotesia flavipes(Hymenoptera:Braconidae).ICKs are known for their stability and diverse biological *** this study,we produced four putative ICK peptides from the teratocytes of *** using solid-phase peptide synthesis or recom-binant expression in ***,and investigated their functions on host immune modulation as well their potential to impair the development of two lepidopterans after ingestion of the *** addition,the peptides were assayed against pathogens and human *** peptides did not influence total hemocyte count but suppressed cellular immunity,detectable as a reduction of hemocyte encapsulation(CtICK-I,CftICK-II,CtICK-I)and spread indexes(CftICK-IV)in the *** of the peptides influenced the activi-ties of prophenoloxidase and phenoloxidase in the hemolymph of larval Diatraea sacchar-alis(Lepidoptera:Crambidae).CftICK-I and CftICK-II with previously unknown function showed antifungal activity against Candida albicans but were non-toxic to human ***-I,CftICK-II,and CftICK-II increased larval mortality and reduced leaf consump-tion of ***,a permissive host for *** CftICK-III also increased larval mortality and reduced leaf consumption of Spodoptera frugiperda(Lepidoptera:Noctuidae),a non-permissive host for *** study highlights biological func-tions and biotechnological potential of ICK peptides from the teratocytes of ***.

关键词： biocontrol encapsulation host regulation Hymenoptera parasitoid phe-noloxidase

Robot-assisted extravesical ureteral reimplantation with ureteral tailoring and dismembering for complex obstructed megaureter

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Asian Journal of Urology 2023年第1期10卷 101-102页

作者： ciro Esposito Lorenzo Masieri Giuseppe Autorino Maria Escolino Division of Pediatric Surgery Federico II University of NaplesNaplesItaly Division of Pediatric Urology Meyer Children HospitalFlorenceItaly

Dear Editor,The advantages of robotic technology including improved dexterity and visualization are particularly evident in challenging reconstructive procedures of the lower urinary tract[1,2].A recent literature review confirmed the feasibility and efficacy of robot-assisted ureteral reimplantation in case of complex anatomy or prior surgery[3].Intra-corporeal ureteral tapering and dismembering are also feasible options using robot-assisted surgery[4].

关键词： ureteral anatomy surgery

Transient infiltration tests in pyroclastic soils with double porosity

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Journal of Mountain Science 2023年第11期20卷 3327-3342页

作者： ciro SEPE Domenico CALCATERRA Emilia DAMIANO Diego DI MARTIRE Roberto GRECO Lucia PAPPALARDO Massimo RAMONDINI Enza VITALE Giacomo RUSSO Department of Civil and Mechanical Engineering University of Cassino and Southern LazioCassino 03043Italy Department of Earth Science Environment and ResourcesUniversity of Napoli Federico IINapoli 80126Italy Dipartimento di Ingegneria Universitàdegli Studi della Campania“L.Vanvitelli”Aversa 81031Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di Napoli-Osservatorio VesuvianoNapoli 80124Italy Department of Civil and Environmental Engineering University of Napoli Federico IINapoli 80125Italy

Fallout volcanic deposits of SommaVesuvius(Campania,southern Italy),characterized by the presence of layers with contrasting textural and hydraulic properties,are frequently affected by shallow landslides during rainwater *** soils of the stratigraphic sequence present intraparticle pores,originated by the gases escaped during magma decompression in the volcanic conduit,thus are characterized by double porosity(i.e.,intraparticle and interparticle pores),which is expected to affect their hydraulic behaviour,and to play a key role in rainwater infiltration through layered *** understand the effect of double porosity on the hydraulic behaviour of the involved soils,controlled experiments have been carried out in an infiltration *** experimental apparatus is provided with newly designed non-invasive Time Domain Reflectometry(TDR)probes,not buried in the investigated soil layers so as to minimize disturbance to the flow,allowing water content measurement during vertical flow ***,transient flow experiments are carried out through reconstituted specimens of black scoriae and grey pumices,both loose pyroclastic granular soils from fallout deposits of Somma-Vesuvius,featuring double porosity with different pore size distributions,that were estimated by X-ray tomography and Mercury Intrusion *** experimental results highlight the effects of the double porosity and clearly indicate the different behaviour of the two soils during wetting and drying processes,mainly related to the different dimensions of intraparticle pores.

关键词： Double porosity soil Non-invasive TDR probes Vesiculated soil particles Pyroclastic soils X-ray tomography Mercury intrusion porosimetry

SARS-CoV-2 spike protein:flexibility as a new target for fighting infection

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Signal Transduction and Targeted Therapy 2020年第1期5卷 321-323页

作者： ciro Leonardo Pierri Laboratory of Biochemistry Molecular and Structural BiologyDepartment of BiosciencesBiotechnologiesBiopharmaceuticsUniversity of BariVia E.Orabona470125 BariItaly BROWSer S.r.l.(https://***/)c/o Department of Biosciences BiotechnologiesBiopharmaceuticsUniversity“Aldo Moro”of BariVia E.Orabona470126 BariItaly

The recent study of Turoňováet al.,is the first to combine cryoelectron tomography,subtomogram averaging,and molecular dynamics simulations for analyzing the structure of the SARS-CoV-2 spike protein in situ,1 *** t... 详细信息

关键词： al infection fighting

Immunotherapy for the treatment of hepatocellular carcinoma: finally in clinical practice

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 252-255页

作者： ciro Celsa Lucia Cerrito Leonardo Stella Roberta Ciccia Giuseppe Cabibbo Francesca Romana Ponziani Section of Gastroenterology&Hepatology Department of Health PromotionMother and Child CareInternal Medicine and Medical SpecialtiesPROMISEUniversity of PalermoPalermoItaly Department of Surgical Oncological and Oral Sciences(Di.Chir.On.S.)University of PalermoPalermoItaly Digestive Disease Center-CEMAD Fondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly

Clinical guidelines for the prevention,diagnosis and management of human disease are evidence-based tools that rely on quality of clinical research,including data from randomized controlled clinical trials(RCTs)and real-world *** Society for Immunotherapy of Cancer(SITC)recently published a clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma(HCC)(1).

关键词： Hepatocellular carcinoma immunotherapy immune-checkpoint inhibitors immune-related adverse events systemic therapies