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Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： Gerie J.Glas Janneke Horn markus W.Hollmann Benedikt Preckel Kirsten colpaert manu malbrain Ary Serpa Neto Karim Asehnoune marcello Gamma de Abreu Ignacio martin-Loeches Paolo Pelosi Folke Sjoerg Jan m.Binnekade Berry cleffken Nicole P.Juffermans Paul Knape Bert G.Loef David P.mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia cachafeiro marc Jeschke Jeffrey Lipman matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss mark Kol Helen Wong Therese Starr Luc De crop Wilson de Oliveira Filho Joa manoel Silva Junior cintia m.c.grion marjorie Burnett Frederik mondrup Francois Ravat mathieu Fontaine Renan Le Floch mathieu Jeanne morgane Bacus maite chaussard marcus Lehnhardt Bassem Daniel mikhail Jochen Gille Aidan Sharkey Nicole Trommel Auke c.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting marcus J.Schultz LAmiNAR investigators Academic medical center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ JAN PALFIJN GENT Watersportlaan 5–9000 Gent–Belgium ABc medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation chirurgicale Nantes 44093France University Hospital carl Gustav carus Dresden 01307Germany St James University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden maasstad Hospital RotterdamDZ 3079The Netherlands Red cross Hospital BeverwijkLE 1942The Netherlands martini Hospital GroningenNT 9728The Netherlands University of Texas medical Branch GalvestonTX 77555USA Turin cTO Burn center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive care Research centre.monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences centre Toronto M4N 3M5Canada cHU Lyon St Luc Lyon 69007France cHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(IcUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 IcUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressurescmH_(2)***:In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： mechanical ventilation Inhalation trauma Lung-protective critical care

Seed rain and soil seed bank compensatory roles on Nassella tenuis(Phil.)Barkworth seedling recruitment in ungrazed and grazed sites

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Journal of Arid Land 2022年第5期14卷 550-560页

作者： cintia Vanesa LEDER Dianela Alejandra cALVO Guadalupe PETER Universidad Nacional de Río Negro Sede AtlánticaCentro de Estudios Ambientales desde la NorPatagonia(Center of Environmental Studies from North Patagonia(CEANPa)National University of Río Negro)Viedma 8504Argentina Universidad Nacional de Río Negro Sede AtlánticaCentro de Estudios Ambientales desde la NorPatagonia-National Council of Scientific and Technical Research(CONICET)(Center of Environmental Studies from North Patagonia(CEANPa)National University of Río Negro)Viedma 8504Argentina

In semi-arid lands,vegetation is distributed in shrub patches immersed in a less vegetated interpatch *** affects perennial grass seed bank through a decrease in seed rain and an increase in seed predation and soil ***,some species with anchorage mechanisms in their seeds might overcome this,such as Nassella tenuis(Phil.)*** is an important species in grazing paddocks because it has an intermediate palatability and its relatively tolerant to *** characteristics allow *** to increase its abundance in grazed *** objective was to assess how grazing affects the key palatable species from seeds to seedlings:i.e.,seed rain,soil seed bank,and seedling recruitment in different microsites along a windward-leeward transect across shrub *** hypothesized that:(1)the negative effects of grazing on *** fructification are reflected in its seed rain,soil seed bank,and seedling recruitment,especially in interpatches;(2)Nassella tenuis seed rain reduction,soil compaction by cattle in grazed sites,and removal of seeds by wind decrease its soil seed bank,especially in microsites exposed to the predominant wind;and(3)the decrease in *** soil seed bank and cover increase in annual species in grazed sites have negative effects on its seedling recruitment,especially in microsites exposed to predominant *** placed seed traps,collected soil samples,and monitored seedling recruitment in different locations around shrub canopy to address our ***,we established a manipulative experiment in which we sow *** seeds and followed its recruitment in different *** compared the seed rain,soil seed bank,natural seedling recruitment,and sown seeds recruitment of *** between grazed and ungrazed *** analyzed differences between microsites along a windward-leeward transect across shrubs *** rain and soil seed bank had the same density in patches and interpatches both in ungrazed a

关键词： seed rain soil seed bank seedling recruitment microsites grazing

Evolutionary importance of the relationship between cytogeography and climate:New insights on creosote bushes from North and South America

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Plant Diversity 2022年第5期44卷 492-498页

作者： Romina Vidal-Russell mariana Tadey Romana Urfusova Tomás Urfus cintia Paola Souto Laboratorio Ecotono-INIBIOmA(cONIcET-UNcomahue) Quintral1250BarilocheRío NegroArgentina Department of Botany Faculty of ScienceCharles UniversityBenátská212800PragueCzech Republic

Relationships between genome size and environmental variables suggest that DNA content might be adaptive and of evolutionary importance in *** genus Larrea provides an interesting system to test this hypothesis,since it shows both intra-and interspecific variation in genome *** has an amphitropical distribution in North and South American deserts,where it is most *** tridentata in North America shows a gradient of increasing autopolyploidy;while three of the four studied South American species are diploids,Larrea divaricata,Larrea nitida,Larrea ameghinoi,and the fourth is an allopolyploid,Larrea *** downloaded available focal species’georeferenced records from seven data *** used these records to extract biologically relevant environmental variables from Worldclim at 30 arc seconds scale,to have a broad characterization of the variable climatic conditions of both regions,and a climatic envelope for each *** estimated relative DNA content index and relative monoploid genome values,by flow cytometry,of four most abundant Larrea species throughout their respective *** we winnow the bioclimatic dataset down to uncorrelated variables and sampled locales,to analyse the degree of association between both intra-and interspecific relative DNA content and climatic variables that are functionally relevant in arid environments using Pearson correlations,general linear and mixed effects *** the genus Larrea,relative DNA content increases with rising temperature and decreases with rising *** the intraspecific level,all four species show relative DNA content variation across climatic *** is a genus that shows genome size variation correlated with *** results are also consistent with the hypothesis that extreme environmental pressures may have facilitated repeated whole genome duplication events in North America,while in South America,reticulate evolution,as allopolyploidizati

关键词： DNA content Drylands Genome size Jarilla Larrea Zygophyllaceae

microstructural evaluation of initial dissolution of aluminosilicate particles and formation of geopolymer material

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Particuology 2018年第6期16卷 101-111页

作者： Rozineide A.Antunes Boca Santa Julia cristie Kessler cintia Soares Humberto Gracher Riella Department of chemical Engineering Federal University of Santa CatannaP.O.Box 476TrindadeFlorianopolis88040-900SCBrazil

The rheological behavior of microparticulate structures of geopolymers was *** materials were developed from alternative sources of aluminosilicate and were activated in different concentrations using 5,10,and 15m sodium hydroxide,and sodium silicate,which were added in a 2:1ratio (by volume).The solid constituents used were bottom ash/metakaolin and neat metakaolin in a 2:1blend. The theological characteristics were determined after 5min of homogenization and a subsequent curing of the pastes at room temperature for 28 *** materials presented amorphous characteristics, which confirmed the formation of geopolymers.A thixotropic behavior was observed for all forrfiulations,except for bottom ash/metakaolin activated at 5m,which resulted in geopolymers with a lower intensity compared with those activated at 10 and 15m,High activator concentrations exhibited a proportional relationship for geopolymer ring growth,which resulted in a reduced structure mobility and, consequently,an increased viscosity and yield *** effects are more evident in the metakaolin samples,and are associated with the water content that is required for *** that were activated with 10m sodium hydroxide presented a favorable workability and particle packing,in terms of the theological and structural aspects.

关键词： metakaolin Bottom ash Alkaline activation Geopolymer particle microstructural Rheology

Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells

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World Journal of Stem cells 2020年第12期12卷 1640-1651页

作者： cintia DS Horinouchi maría Julia Barisón Anny W Robert crisciele Kuligovski Alessandra m Aguiar BrunoDallagiovanna Stem cells Basic Biology Laboratory Instituto Carlos ChagasCuritiba 81350010ParanáBrazil

BAcKGROUND Human adipose-derived stromal/stem cells(hAScs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of several ***,for successful clinical application,it is critical that high-quality cells can be *** factors seem to be able to influence cell quality and performance,especially factors related to donors’intrinsic characteristics,such as ***,there is no consensus regarding this characteristic,and there is conflicting information in the *** To investigate the growth kinetics and differentiation potential of adipose-derived stem cells isolated from the lipoaspirates of elderly and young *** hAScs were harvested from liposuctioned adipose tissue obtained from female donors(aged 20-70 years).cells were distributed into two groups according to age range:old hAScs(oAScs,≥55 years,n=9)and young hAScs(yAScs,≤35 years,n=9).For each group,immunophenotypic characterization was performed by flow *** doubling time was assessed over seven *** adipogenic potential evaluation,lipid deposits were assessed after 7 d,14 d and 21 d of adipogenic *** potential was verified by analyzing cell mineralization after 14 d,21 d and 28 d of osteogenic *** expression of PPARγ2,cEBPA and Runx2 were detected by quantitative reverse transcription polymerase chain *** hAScs were successfully obtained,cultured,and grouped according to their age:yAScs(26.33±4.66 years old)and oAScs(64.78±4.58 years old).After maintenance of the cells in culture,there were no differences in morphology between cells from the young and old ***,both groups showed classical immunophenotypic characteristics of mesenchymal stem/stromal *** average doubling time indicated that yAScs(4.09±0.94 d)did not significantly differ from oAScs(4.19±1.29 d).concerning differentiation pot

关键词： Adipose-derived stem cells Stem cells Adipogenesis Osteogenesis cell differentiation Donor age

Hormonal modulation of reproduction and fertility signaling in polistine wasps

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current Zoology 2021年第5期67卷 519-530页

作者： cintia Akemi OI Rafael carvalho DA SILVA Ian STEVENS Helena mendes FERREIRA Fabio Santos NAScImENTO Tom WENSELEERS Laboratory of Socioecology and Social Evolution KU LeuvenLeuven 3000Belgium Faculdade de Filosofia Ciencias e Letras de Ribeirao PretoDepartamento de BiologiaUniversidade de Sao Paulo—USPRibeirao PretoSP 14040-901Brazil

In social insects,it has been suggested that reproduction and the production of particular fertilitylinked cuticular hydrocarbons(cHc)may be under shared juvenile hormone(JH)control,and this could have been key in predisposing such cues to later evolve into full-fledged queen pheromone ***,to date,only few studies have experimentally tested this“hormonal pleiotropy”***,we formally test this hypothesis using data from four species of Polistine wasps,Polistes dominula,Polistes satan,mischocyttarus metathoracicus,and mischocyttarus cassununga,and experimental treatments with JH using the JH analogue methoprene and the anti-JH *** line with reproduction being under JH control,our results show that across these four species,precocene significantly decreased ovary development when compared with both the acetone solvent-only control and the methoprene *** with the hormonal pleiotropy hypothesis,these effects on reproduction were further matched by subtle shifts in the cHc profiles,with univariate analyses showing that in *** and *** the abundance of particular linear alkanes and mono-methylated alkanes were affected by ovary development and our hormonal *** results indicate that in primitively eusocial wasps,and particularly in Polistes,reproduction and the production of some cHc cues are under joint JH *** suggest that pleiotropic links between reproduction and the production of such hydrocarbon cues have been key enablers for the origin of true fertility and queen signals in more derived,advanced eusocial insects.

关键词： Polistinae wasps fertility cues queen pheromones cuticular hydrocarbons juvenile hormone

Analysis of South Hemisphere Temperature Anomalies over the Last millennium up to the Beginning of the contemporary Age: A comparison between a Statistical model and a Global Dynamic model

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American Journal of climate change 2014年第2期3卷 205-211页

作者： Gabriela V. müller cintia R. Repinaldo centro de Investigaciones científicas y Transferencia de Tecnología a la Producción (cIcYTTP-cONIcET) Diamante Entre Ríos Argentina

We analyze the consistency of the coupled atmosphere-ocean GISS-ER climate model in reproducing South American temperature anomalies over the last millennium. For that purpose, we compare the model results with the Neukom’s temperature anomaly reconstruction provided by a statistical model that uses multiproxy data and climatological temperature anomalies. Specifically, we examine temperature anomalies for summer and winter of a 6-member ensemble of the GISS-ER model with 1× solar forcing and 2× solar forcing, calculated for the period 1000-1899. Using the Neukom’s reconstructions and the model outputs, we calculate the summer mean anomalies of the period 1001-1700 (a period that includes medieval climate Anomaly -mcA- and Little Ice Age -LIA-), and winter mean anomalies of the period 1706-1800 (a period that includes the pre-industrial period). These mean anomalies are subtracted from Neukom’s reconstructions defining the reconstructions wrt 1001-1700 (summer) and wrt 1706-1800 (summer and winter). In general, the model is not very consistent with the reconstructions, since the model’s mean and spread show very small interannual variability in contrast to what the reconstructions exhibit, and often with anomalies of opposite sign. In the period 1001-1700, the model presents, on average, negative temperature anomalies for the 1× and 2× forcing. In the period 1706-1800, the model displays positive anomalies for summer and negative anomalies for winter for the 1× and 2× forcing. In particular, the anomaly that better reproduces the sign of the reconstructions is that wrt 1001-1700 with 1× forcing and for summer. The model has an error of only 33% in reproducing the sign of the anomalies, in comparison to the Neukom’s reconstruction for the same reference period. The model’s anomaly wrt 1001-1700 with 1× forcing for summer also reproduces the mcA and LIA’s sign of the reconstruction. The mcA’s sign is reproduced in almost 75% of the comparisons, and the LIA’s sign in m

关键词： Temperature Reconstruction climate models Solar Forcing mcA LIA

Whole body vibration and auriculotherapy improve handgrip strength in individuals with knee osteoarthritis

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Journal of Traditional chinese medicine 2019年第5期39卷 707-715页

作者： Eloa moreira-marconi carla F Dionello Danielle S morel Danubia c Sa-caputo cintia R Sousa-Goncalves Laisa L Paineiras-Domingos Ygor Teixeira-Silva mario Jose dos Santos Pereira mario Bernardo-Filho Postgraduate Program in clinical and Experimental Physiopathology University of the State of Rio de JaneiroRio de JaneiroRJBrazil Department of Biophysics and Biometrics Laboratory of Mechanical Vibrations and Integrative Practices-LAVIMPIInstitute of Biology Roberto Alcantara GomesRio de Janeiro State UniversityRio de JaneiroRJBrazil Postgraduate Program in medical Sciences Rio de Janeiro State UniversityRio de JaneiroRJBrazil Danubia c Sa-caputo Faculdade Bezerra de AraujoRio de JaneiroBrazilCentro Universitario Serra dos OrgaosTeresopolisRio de JaneiroBrasil Universidade do Estado do Rio de Janeiro Rio de JaneiroRJBrazil-Department of Biophysics and BiometricsInstitute of Biology Roberto Alcantara Gomes-Department of Physiological Sciences

OBJEcTIVE: To verify the action of non-pharmacological interventions, whole body vibration exercise (WBVE) and auriculotherapy (AT) on the management of knee osteoarthritis (KOA) analyzing the handgrip strength (HS). mETHODS: One hundred twelve participants with KOA were allocated in (a) WBVE group with peak-to-peak displacement of 2.5 to 7.5 mm, frequency from 5 up to 14 Hz, acceleration peak from 0.12 up to 2.95 g (2 d/weekly for 5 weeks),(b) AT group, points of both ears (Kidney, Knee-correspondent point and Shenmen) were stimulated with seeds,(c) WBVE + AT group and (d) respective control groups. HS was assessed in all the participants, in acute and cumulative responses. RESULTS: The intervention with WBVE alone and combined with AT improved (P cumulative response, the HS. cONcLUSION: WBVE alone or combined with AT might promote biological effects that interfere with the HS in individuals with KOA.

关键词： Osteoarthritis,knee Exercise therapy Physical and rehabilitation medicine Auriculotherapy muscle strength dynamometer

Neuroinflammation in cortical and meningeal pathology in multiple sclerosis:understanding from animal models

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Neuroimmunology and Neuroinflammation 2021年第3期8卷 174-184页

作者： Berenice Anabel Silva Esteban miglietta carina cintia Ferrari Instituto de medicina Traslacional e Ingeniería Biomédica(ImTIB)-cONIcET Buenos Aires C1181ACHArgentina Leloir Institute Foundation Institute for Biochemical InvestigationsIIBBA-CONICETPatricias Argentinas 435Buenos AiresC1405BWEArgentina.

multiple sclerosis(mS)is a neurodegenerative and inflammatory disease usually presenting with acute demyelinating events that can start as,or progress to,chronic *** development of animal experimental models,specific for each stage of mS will aid in the design of new drugs specific for the different forms of the *** models of experimental autoimmune encephalomyelitis successfully reflect the pathophysiological mechanisms of the early phases of ***,few models resemble the features of the progressive forms of mS such as cortical demyelination and meningeal ***,a few auspicious animal models recapitulating many of the characteristics of progressive mS,aimed at a better understanding of the pathology of these forms of the disease,have been *** this review,we will summarize the latest developments in animal models reflecting the cortical and meningeal pathological features of progressive mS,as well as their response to drugs specifically targeting these forms.

关键词： Progressive multiple sclerosis experimental autoimmune encephalomyelitis cortex grey matter meningeal inflammation adaptive immune response