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CD73对弓形虫侵入宿主细胞及其在细胞内繁殖过程的影响(英文)

汽车与配件 2011年第50期前插4-前插4页

作者：彭婓《产业经济报道》编辑部

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临床儿科杂志 2010年第8期28卷 701-709页

作者：汪咏梅向伟圣蒂.莫尔海南省海口市海南人民医院儿科美国康奈尔大学兽医学院感染和免疫实验室

目的探索CD73在弓形虫感染中的作用及宿主细胞缺乏CD73时是否存在更少的弓形虫感染和细胞内繁殖。方法经口饲弓形虫包囊,感染CD73缺乏和正常的小鼠。调查感染弓形虫后,两种小鼠的临床症状、生存率、小肠病理学和细胞因子产生等。用带荧... 详细信息

目的探索CD73在弓形虫感染中的作用及宿主细胞缺乏CD73时是否存在更少的弓形虫感染和细胞内繁殖。方法经口饲弓形虫包囊,感染CD73缺乏和正常的小鼠。调查感染弓形虫后,两种小鼠的临床症状、生存率、小肠病理学和细胞因子产生等。用带荧光的弓形虫子体感染CD73缺乏和正常的巨噬细胞和树突状细胞,调查两种细胞的感染率、入侵到细胞内子体的数量及其在细胞内繁殖情况。结果急性弓形虫感染时,与CD73正常小鼠相比,CD73缺乏小鼠的生存率高,临床症状轻,病理改变少。与CD73正常的巨噬细胞和树突状细胞相比,CD73缺乏的巨噬细胞和树突状细胞的弓形虫感染率低,入侵到胞内的弓形虫子体数目少,且繁殖速度慢。结论 CD73作为一种GPI细胞表面蛋白不仅可能参与了弓形虫的液泡膜形成,而且可能有利于其侵犯宿主,以及弓形虫子体在宿主细胞内的繁殖。缺乏CD73宿主可能抵抗弓形虫感染的能力更强。

关键词： CD73 弓形虫鼠

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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world Journal of Gastrointestinal surgery 2024年第3期16卷 740-750页

作者： Phillip Gu shishir Dube Norman Gellada so Yung Choi susan win Yoo Jin Lee shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav syal Andres J Yarur David Ziring shervin Rabizadeh Phillip Fleshner cindy Kallman suzanne Devkota stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTEs Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube s and Choi sY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,win s,Lee YJ and Yang s were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

基于超强拉曼增强金纳米粒子修饰的过渡金属双硫属化合物纳米片的分子检测（英文）

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分析科学学报 2019年第6期35卷 811-816页

作者： Jason D Orlando Ethan Kahn cindy Y wong Yin-ting Yeh Tej B Limbu Basant Chitara Ana L Elias Mauricio Terrones 鄢非 Department of Chemistry and Biochemistry North Carolina Central UniversityDurhamNC.27707USA Department of Materials science and Engineering The Pennsylvania State UniversityUniversity ParkPA.16802USA school for Engineering of Matter Transport and EnergyArizona State UniversityTempeAZ.85287USA Department of Physics The Pennsylvania State UniversityUniversity ParkPA.16802USA Center for Nanoscale science The Pennsylvania State UniversityUniversity ParkPA.16802USA

本文报道用不同尺寸的金纳米粒子(AuNPs)来修饰单层ws2和Mos2纳米片,通过表面增强拉曼散射(sERs)技术检测微量的罗丹明6G染料,并对比了它们在不同波长的激光激发下的等离子体特性。AuNPs在ws2和Mos2纳米片上的均匀沉积是通过种子介导的... 详细信息

本文报道用不同尺寸的金纳米粒子(AuNPs)来修饰单层ws2和Mos2纳米片,通过表面增强拉曼散射(sERs)技术检测微量的罗丹明6G染料,并对比了它们在不同波长的激光激发下的等离子体特性。AuNPs在ws2和Mos2纳米片上的均匀沉积是通过种子介导的生长方法还原HAuCl4来实现的。我们进一步使用扫描电子显微镜和拉曼光谱对所制备的异质结构进行了表征。几种优化结构的拉曼增强因子接近108,几乎达到检测单分子需要的灵敏度。我们的研究结果表明,通过贵金属纳米粒子对超薄过渡金属双硫属元素化合物进行可控修饰是完全可行的。这个策略也适合于制备高效且灵活的基底,用在新一代基于表面增强拉曼散射的化学传感器和生物传感器上。Jason D Orlando 1,Ethan Kahn 2,cindy Y wong 3,Yin-ting Yeh 4,5,Tej B Limbu 1,Basant Chitara 1,Ana L Elias 4,5,Mauricio Terrones 4,5,YAN Fei(*** of Chemistry and Biochemistry,North Carolina Central University,Durham,NC.27707,UsA;*** of Materials science and Engineering,The Pennsylvania state University,University Park,PA.16802,UsA;*** for Engineering of Matter,Transport and Energy,Arizona state University,Tempe,AZ.85287,UsA;*** of Physics,The Pennsylvania state University,University Park,PA.16802,UsA;*** for Nanoscale science,The Pennsylvania state University,University Park,PA.16802,UsA)

关键词：过渡金属双硫属元素化合物表面增强拉曼散射罗丹明6G 金纳米颗粒

Implementation of a Telechemotherapy Module in the Peruvian Jungle with Adequate Quality of Life:Breaking the Access Gaps to Health with Teleoncology

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Journal of Cancer Therapy 2019年第8期10卷 677-691页

作者： Tatiana Vidaurre Jule Vásquez Fernando Valencia cindy Alcarraz Luis Más Nataly Poma Litol Becerra Gino Rodriguez socorro saldana Pepe Diaz silvia Neciosup Karina Aliaga Roxana Regalado Miriam salazar Kavita sarwal simon sutcliffe Julio Abugattas Carlos Castaneda Mónica Calderón Hugo Fuentes Henry Gómez Medical Oncologist Instituto Nacional de Enfermedades Neoplasicas(INEN)LimaPeru Hospital II-E Lamas San MartinPeru Instituto Nacional de Enfermedades Neoplasicas(INEN) LimaPeru International Cancer Control Congress Association(ICCCA) VancouverCanada

Background: Cancer is a leading cause of death worldwide as well as in Peru. The national cancer plan includes decentralization, but one of the greatest barriers is our complicated geography. san Martin is a department located in the Peruvian jungle where there are no public services for cancer care. Our aim was to implement a “distance telemedicine-enabled” outpatient chemotherapy module, monitored by oncologists. Methods: The implementation was conducted in 3 stages: 1) Planning and Organization: working teams were formed, a chemotherapy room was developed and people were trained. 2) Execution: patients from san Martín region, aged >18 years with pathological confirmation of cancer, requiring systemic chemotherapy, ECOG st course of chemotherapy received at INEN without adverse reaction were selected. 3) Evaluation: adverse events, cost-user evaluation and quality of life (QoL) were assessed. Results: By November 2015, a module with a chemotherapy room with 18 chairs, a pharmacy, a hospitalization room, 1 medical office, a training room, a nutrition area, and a nursing station was implemented. 3 physicians, 3 nurses and 1 pharmacist were trained. Through March 2018, 501 sessions of teleoncology were completed to deliver 232 cycles of chemotherapy for 56 patients aged 19 - 78 years with different solid tumors, with no serious adverse event, without negatively affecting their QoL, and with an average out-of-pocket expense saving of 500 PEN. Conclusions: Using information and communication technology, a telechemotherapy module was successfully implemented in the Peruvian jungle, without adversely affecting the QoL of patients. Neither patients nor family members needed to travel to Lima to receive chemotherapy. This first program can be replicated in other rural and remote regions through non-specialized personnel and facilities, providing chemotherapy services equivalent to a tertiary center through trained health care professionals, supported through tel

关键词： Telechemotherapy Module Cancer Treatment Urban Tertiary Center Teleoncology

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多重图形技术用光刻材料研究进展及挑战

前瞻科技 2022年第3期1卷 73-83页

作者：李冰孙嘉陈昕北京科华微电子材料有限公司北京101312

集成电路芯片在社会生活及国民经济的发展中起着越来越重要的作用,同时芯片制造能力成为衡量一个国家科技水平的重要因素。受瓦森纳协定限制,中国无法引进极紫外(EUV)光刻技术,因此氟化氩(ArF)浸没式光刻与多重图形技术成为集成电路技... 详细信息

集成电路芯片在社会生活及国民经济的发展中起着越来越重要的作用,同时芯片制造能力成为衡量一个国家科技水平的重要因素。受瓦森纳协定限制,中国无法引进极紫外(EUV)光刻技术,因此氟化氩(ArF)浸没式光刻与多重图形技术成为集成电路技术发展的关键,这也给多重图形技术中用的光刻材料提出了更高的要求。文章在回顾光刻技术发展的基础上,总结了多重图形技术的不同路线及其涉及的光刻材料,针对ArF浸没式光刻胶、图形收缩材料及三层工艺用旋涂碳材料、旋涂硅材料等先进光刻材料的技术发展与挑战进行分析。通过对技术发展的回顾与展望可以看出,光刻材料的开发已由原先设备推动的被动模式转变为材料创新与设备工艺协同发展的模式,特别是在中国设备受限的大环境下,更需要以材料的创新为驱动力,走出有中国特色的集成电路工艺路线。

关键词：多重图形技术氟化氩浸没式化学收缩材料旋涂硅材料旋涂碳材料

Trace-Level Analysis of Hexavalent Chromium in Lake sediment samples Using Ion Chromatography Tandem Mass spectrometry

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Journal of Environmental Protection 2016年第3期7卷 422-434页

作者： stefanie Mädler Fengrong sun cindy Tat Nadya sudakova Peter Drouin Robert J. Tooley Eric J. Reiner Teresa A. switzer Richard Dyer H. M. skip Kingston Matt Pamuku Vasile I. Furdui Laboratory services Branch Ontario Ministry of the Environment and Climate Change Ontario Canada Conservation Ontario Ontario Canada Department of Chemistry University of Toronto Ontario Canada Ontario Geological survey Ontario Ministry of Northern Development and Mines Ontario Canada Department of Chemistry and Biochemistry Duquesne University Pittsburgh USA Applied Isotope Technologies Pittsburgh USA

The analysis of hexavalent chromium, Cr(VI), in soil and sediment samples has been predominantly carried out in materials containing elevated levels. Reliable analysis of trace-level of Cr(VI) in sediment samples remains challenging. Cr(VI) analyses with multipoint calibration and speciated isotope dilution (sID) adapted from U.s. EPA method 6800 were used to measure lower-level Cr(VI) on an ion chromatograph coupled with a tandem mass spectrometer (IC-Ms/Ms). Lake sediment samples were collected from various locations in Northern Ontario and Cr(VI) was extracted using both alkaline digestion and ethylene diaminetetraacetic acid (EDTA) extraction. Certified reference materials were extracted and analyzed by IC-Ms/Ms and UV-VIs detection. The sID-Ms approach allowed for the quantification of Cr(VI) in samples with concentration levels below 0.5 μg.g-1 wet weight.

关键词： Trace-Level Analysis Ion Chromatography Tandem Mass spectrometry Chromium speciation speciated Isotope Dilution

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5G商业化倒计时开始（英文）

新世纪智能 2019年第8期 16-16页

作者： cindy 不详

China’s 5G commercialization has entered a countdown stage, with certification to be issued by the end of this year at the earliest and major areas in main cities covered with 5G technology by2020, securities Daily reported on *** areas in Beijing will be covered by 5G technology with a fixed broadband network, Gigabit LTE access capability and broadband rates down 10 percent annually by 2020, said Tan Xuxiang.

关键词：商业化倒计时

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EDG获胜：中国电竞正飞速发展（英文）

新世纪智能 2022年第Z7期 14-14页

作者： cindy

Two days after eight esports games were officially announced to be included in the 19th Asian Games, China’s Edward Gaming(EDG) team earned its first League of Legends(LOL) world Championship title with a 3-2 win ove...

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5G商业化倒计时开始（英文）

新世纪智能 2019年第7期 12-12页

作者： cindy 不详

China’s 5G commercialization has entered a countdown stage,with certification to be issued by the end of this year at the earliest and major areas in main cities covered with 5G technology by2020,securities Daily reported on *** areas in Beijing will be covered by 5G technology with a fixed broadband network.

关键词：商业化倒计时