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Approaches on the Major Predictors of Blood Transfusion in Cardiovascular Surgery: A Systematic Review

Health 2019年第4期11卷 371-379页

作者： Maria Christiane Valéria Braga Braile-Sternieri Eliana Migliorini Mustafa Victor Rodrigues Ribeiro Ferreira Sofia Braile Sabino cibele olegário vianna queiroz Bethina Canaroli Sbardellini Giovanni Braile Sternieri Lúcia Angélica Buffulin de Faria Idiberto José Zotarelli Filho Domingo Marcolino Braile Domingo Braile Institute of Sao Jose do rio Preto (SP) Rua Luiz Vaz de Camoes Sao Jose do Rio Preto Sao Paulo Brazil Faceres Medical School of Sao Jose do Rio Preto Sao Jose do Rio Preto Sao Paulo Brazil

Introduction: Experimental Clinical studies have shown that loss of up to 77.0% of red cell mass can be tolerated as long as it kept the blood volume. However, the blood volume loss of about 34.0% is fatal. The initial attention in patients with bleeding should be given to maintaining blood volume and oxygen transport. Thus, transfusions of allogeneic blood products are associated with an increased risk of morbidity and mortality in cardiac surgery. Some transfusion risk scores have been proposed for cardiac surgery patients. Objective: To review and discuss literature blood transfusion (blood components gradient) in cardiovascular surgery versus polytrauma, gastrointestinal bleeding, and neoplastic diseases. Methods: The model followed for the review was PRISMA. We used the databases as Scielo, Lilacs, Google Scholar, PubMed articles and works of scientific and doctoral theses master. Results: According to the discussion in the literature, the acute bleeding of large volumes is challenging to emergency services. Accordingly, the need to support hemotherapeutics led to the development of protocols for more rational utilization of the monitored blood components. Conclusion: Hemotherapy services have adopted a very dynamic approach to the clinical condition presented by patients, the need for four or more red blood cell units.

关键词： Cardiovascular Surgery Polytrauma Transfusion Blood Components Survival Epidemiologic Data Time to Hemostasis Derivatives Volume

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Therapeutic potential of periodontal ligament stem cells

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World Journal of Stem Cells 2021年第6期13卷 605-618页

作者： Aline queiroz Emmanuel Albuquerque-Souza Leticia Miquelitto Gasparoni Bruno Nunes de França cibele Pelissari Marília Trierveiler Marinella Holzhausen Laboratory of Stem Cell Biology in Dentistry-LABITRON Department of Oral and Maxillofacial PathologySchool of DentistryUniversity of São PauloSão Paulo 05508-000Brazil Department of Stomatology Division of PeriodonticsSchool of DentistryUniversity of São PauloSão Paulo 05508-000Brazil

Inflammatory periodontal disease known as periodontitis is one of the most common conditions that affect human teeth and often leads to tooth *** to the complexity of the periodontium,which is composed of several tissues,its regeneration and subsequent return to a homeostatic state is challenging with the therapies currently *** therapy is increasingly becoming an alternative in regenerative medicine/dentistry,especially therapies using mesenchymal stem cells,as they can be isolated from a myriad of *** ligament stem cells(PDLSCs)are probably the most adequate to be used as a cell source with the aim of regenerating the *** insights have also highlighted PDLSCs as promising immunomodulator *** this review,we explore the state of knowledge regarding the properties of PDLSCs,as well as their therapeutic potential,describing current and future clinical applications based on tissue engineering techniques.

关键词： Periodontal ligament stem cell Mesenchymal stem cell Regenerative dentistry Therapeutics Immunology Cellular

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