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Food Science and Human Wellness 2024年

作者： Mengya Zhao chunyu wu Jing Liu Xinian Li Zhenpeng Gao Xin Yang Di Liu Fangyu Long College of Food Science and Engineering， Northwest A&F University Institute of Animal Husbandry and Veterinary Medicine， Guizhou Academy of Agricultural Sciences College of Animal Science and Technology， Northwest A&F University

Tropomyosin (TM) is the predominant allergenic protein in shrimp， which has induced IgE-mediated food allergy reactions. In this study， Lit v 1 was purified from Penaeus vannamei muscles， which were glycosylated by pectic oligosaccharides. The results showed that Di-Galacturonic acid (DGA) and galacturonic acid (GA) induced the unfolding of the primary protein structure of TM， and changed alpha-helical structure， and IgE binding capacity. In addition， compared with TM-sensitized BALB/c mice， galacturonic acid-modified TM (GA-TM) and Di-Galacturonic acid-modified TM (DGA-TM) were insufficient to stimulate sensitization， and significantly reduced the hypersecretion of IgE， IgG1， HIS， and IL-4， up-regulated IgG2a and IFN-γ levels to improve imbalanced Th1/Th2， Treg/Th17 immunity， and promoted mRNA expression of tight junction proteins. Together， this study confirmed that glycosylation modification alleviated sensitization by altering TM structure， reducing IgE binding allergic inflammatory response， and regulating cytokine immune balance. Overall， these results indicated that glycosylation modification was a promising method for decreasing the allergenic reactivity of allergic proteins.

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Investigating the Immunogenic Cell Death‑Dependent Subtypes and Prognostic Signature of Triple‑Negative Breast Cancer

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Phenomics 2024年第1期4卷 34-45页

作者： Youyang Shi Yuanyuan wu Feifei Li Kexin Jiang Xiaofang Fang Yu Wang Xiaoyun Song Rui Wang Lixin Chen Jinzhou Zheng chunyu wu Yuenong Qin Xiaofei Liu Sheng Liu Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineWanping South Road725Shanghai 200033China First Clinical College Shandong University of Traditional Chinese MedicineNo.16369Jingshi RoadLixia DistrictJinan 250011ShandongChina

Recently,immunotherapy has emerged as a promising and efective method for treating triple-negative breast cancer(TNBC).However,challenges still *** cell death(ICD)is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead ***,the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well *** this study,we observed dysregulation of the ICD process and verifed the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction(qRT-PCR)*** investigate the potential role of the ICD process in TNBC progression,we determined the ICD-dependent subtypes,and two were *** of their distinct tumor immune microenvironment(TIME)and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune“cold”and“hot”phenotypes,*** addition,we constructed the prognostic signature ICD score of TNBC patients and demonstrated its clinical independence and *** ICD score could also serve as a potential biomarker for immune checkpoint blockade and may aid in the identifcation of targeted efective agents for individualized clinical strategies.

关键词： Immunogenic cell death Triple-negative breast cancer Tumor immune microenvironment Prognostic signature

核心素养导向的韩国特殊教育课程改革与实施困境研究——基于2015版韩国特殊教育课程方案与课程标准的分析

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中国特殊教育 2024年第3期 30-36页

作者：吴春玉泉州师范学院教育科学学院泉州362000

我国现行的特殊学校课程设置实验方案和课程标准面临诸多现实挑战,以核心素养为导向的义务教育课程改革对特殊学校课程建设指明新方向。韩国2015年特殊教育课程改革引入核心素养框架体系,凝练适宜特殊学生的学科素养,围绕学科核心概念... 详细信息

我国现行的特殊学校课程设置实验方案和课程标准面临诸多现实挑战,以核心素养为导向的义务教育课程改革对特殊学校课程建设指明新方向。韩国2015年特殊教育课程改革引入核心素养框架体系,凝练适宜特殊学生的学科素养,围绕学科核心概念重构课程内容。基于2015版韩国特殊教育课程方案和课程标准的分析发现,核心素养导向的特殊教育课程改革得到韩国特教界的普遍认可,但课程理念、课程运行、改革落地遭遇理想与现实的落差。基于此,建议我国特殊教育课程改革从普特双轨运行迈向一体化设计,着力开发核心素养导向的特殊教育课程,持续提升特殊学校和特教教师的课程建设能力。

关键词：韩国特殊教育课程改革核心素养课程标准

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韩国特殊学校职业教育框架与实施举措研究

绥化学院学报 2024年第1期44卷 140-143页

作者：吴春玉泉州师范学院特殊教育与社会融合研究中心福建泉州362000

20世纪90年代韩国特殊学校职业教育从单纯技术训练转向系统教育。法律和政策的持续推动下,韩国构建中小学一体化的特殊学校职业教育框架,加强不同学段有机衔接,通过生涯教育集中制、自由学期制、学校企业等举措,促进特殊学校职业教育专... 详细信息

20世纪90年代韩国特殊学校职业教育从单纯技术训练转向系统教育。法律和政策的持续推动下,韩国构建中小学一体化的特殊学校职业教育框架,加强不同学段有机衔接,通过生涯教育集中制、自由学期制、学校企业等举措,促进特殊学校职业教育专门化发展。我国特殊学校职业教育应持续完善法律法规、出台专项支援政策、强化学段衔接、扩大课程调整自主权,积极探索新时代特殊学校职业教育办学模式。

关键词：韩国特殊学校职业教育

Preparation and Properties of TiO2-Coated Hollow Glass Microspheres as Thermal Insulation Materials for Energy-Saving Buildings

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Transactions of Tianjin University 2020年第4期26卷 283-291页

作者： chunyu wu Weilin Wang Huiming Ji Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin 300072China

A hollow glass microsphere(HGM)/TiO2 composite hollow sphere was successfully prepared via a simple precipitation *** TiO2 coating layers grew on the surface of the HGMs that range from 20 to 50μm in diameter as nanoparticles with the formation of the SiO Ti *** growth mechanism accounting for the formation of the TiO2 nanolayers was *** morphology,composition,thermal insulation properties,and visible-near infrared(VIS-NIR)refl ectance of the HGMs/TiO2 composite hollow spheres were *** VIS-NIR reflectance of the HGMs/TiO2 composite hollow spheres increased by more than 30%compared to raw *** thermal conductivity of the particles is 0.058 W/(m K).The result indicates that the VIS-NIR reflectance of the composite hollow spheres is strongly influenced by the coating of *** composite hollow spheres were used as the main functional filler to prepare the organic-inorganic composite *** glass substrates coated by the organic-inorganic coatings had lower thermal conductivity and higher near infrared ***,the HGMs/TiO2 composite hollow spheres can reflect most of the solar energy and effectively keep out the heat as a thermal insulation coating for energy-saving constructions.

关键词： TiO2 Hollow glass microspheres Thermal insulation materials Near infrared reflectance

不同抛光方案对全瓷材料表面粗糙度影响的研究进展

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中国美容医学 2024年第7期33卷 193-197页

作者：武春雨王行康(综述) 姜涛(审校) 滨州医学院山东烟台264000 济南市口腔医院口腔医学美容中心山东济南250002 浦东新区眼病牙病防治所口腔综合二科上海201399

全瓷材料因其理想的强度和美学效果等特征成为口腔修复的一类重要材料,而当修复体制作完成之后,通常需要进行调牙合或调磨邻接,这些调磨会增加修复体表面粗糙度,临床常采用抛光来解决全瓷材料表面粗糙的问题,研究人员就不同抛光方案对... 详细信息

全瓷材料因其理想的强度和美学效果等特征成为口腔修复的一类重要材料,而当修复体制作完成之后,通常需要进行调牙合或调磨邻接,这些调磨会增加修复体表面粗糙度,临床常采用抛光来解决全瓷材料表面粗糙的问题,研究人员就不同抛光方案对全瓷材料表面效果的影响做了大量研究,本文就此作一综述。

关键词：全瓷材料抛光表面粗糙度上釉口腔修复

健脾祛痰化湿化瘀方联合强化生活方式干预治疗腹型肥胖患者的临床效果及对糖脂代谢的影响

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中国当代医药 2024年第11期31卷 97-100页

作者：黄伟珍彭娟吴春玉江西省新余市中医院输血科江西新余338025

目的观察健脾祛痰化湿化瘀方联合强化生活方式干预治疗腹型肥胖患者的临床效果及对糖脂代谢的影响。方法选取2021年1月至2023年6月新余市中医院体检中心收治的200例腹型肥胖患者作为研究对象,按就诊顺序分为对照组和观察组各100例。对... 详细信息

目的观察健脾祛痰化湿化瘀方联合强化生活方式干预治疗腹型肥胖患者的临床效果及对糖脂代谢的影响。方法选取2021年1月至2023年6月新余市中医院体检中心收治的200例腹型肥胖患者作为研究对象,按就诊顺序分为对照组和观察组各100例。对照组给予强化生活方式干预治疗;观察组在对照组基础上给予健脾祛痰化湿化瘀方联合治疗。对两组患者同时进行为期3个月的观察,评估两组有效率,并比较腹围(WC)、体重指数(BMI),总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及糖化血红蛋白(HbA1c)和空腹血糖的变化情况。结果治疗后,观察组总有效率(80.00%)高于对照组(64.00%),差异有统计学意义(P<0.05);治疗后,观察组WC、BMI水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组TC、TG、LDL-C、HbA1c、空腹血糖水平均低于对照组,差异有统计学意义(P<0.05)。结论健脾祛痰化湿化瘀方联合强化生活方式干预治疗腹型肥胖患者在临床上治疗效果明显,能降低患者BMI、WC水平,纠正糖脂代谢异常。

关键词：健脾祛痰化湿化瘀方强化生活方式干预腹型肥胖临床疗效糖脂代谢

从肠道菌群及色氨酸代谢角度探讨中药在三阴性乳腺癌中作用的研究进展

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中国微生态学杂志 2024年第3期36卷 363-367页

作者：王怡孙霃平秦悦农吴春宇郝炜张洋李斐斐刘胜浙江中医药大学附属第一医院浙江杭州310060 上海中医药大学附属龙华医院中西医结合乳腺科上海中医药大学附属龙华医院中医外科研究所上海中医药大学研究生院

三阴性乳腺癌属于免疫原性较强的乳腺癌亚型,由于缺乏有效的治疗靶点,仍属于难以治疗的乳腺癌类型。越来越多的研究表明,肠道菌群可通过干预宿主或微生物的色氨酸代谢,重塑肿瘤免疫微环境,从而影响三阴性乳腺癌的发生、发展及免疫治疗... 详细信息

三阴性乳腺癌属于免疫原性较强的乳腺癌亚型,由于缺乏有效的治疗靶点,仍属于难以治疗的乳腺癌类型。越来越多的研究表明,肠道菌群可通过干预宿主或微生物的色氨酸代谢,重塑肿瘤免疫微环境,从而影响三阴性乳腺癌的发生、发展及免疫治疗疗效。中药在以往的研究中已被证实可以有效调节肠道稳态,抑制炎症反应,促进肿瘤细胞的凋亡等。然而,肠道菌群及其代谢物与三阴性乳腺癌之间的中医机制尚不明确。因此,本文在中医辨证乳腺癌基础理论的基础上,回顾以往的文献,从肠道菌群和色氨酸代谢的角度出发,梳理中药对肠道菌群及其代谢物质的干预作用,探索其抗肿瘤的机制,以期能为中西医结合治疗三阴性乳腺癌提供新的思路和方法。

关键词：中药肠道菌群色氨酸代谢肿瘤微环境三阴性乳腺癌免疫治疗

Free-standing ZnO nanorod arrays modified with single-walled carbon nanotubes for betavoltaics and photovoltaics

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Journal of Materials Science & Technology 2020年第19期54卷 48-57页

作者： Changsong Chen Jiang Chen Zhen Wang Jian Zhang Haisheng San Shichao Liu chunyu wu Werner Hofmann Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China College of Energy Xiamen UniversityXiamen 361005China Shanghai Institute of Space Power-Sources Shanghai 200245China Institute of Solid State Physics Technical University of BerlinBerlin 10623Germany

A full-duplex radiant energy converter based on both betavoltaic and photovoltaic effects in an easyto-implement way is an attractive alternative for the autonomous wireless sensor ***,we report a novel beta/photovoltaic cell based on free-standing Zn O nanorod arrays(ZNRAs)modified with metallic single-walled carbon nanotubes(m-SWCNTs),using radioisotope63 Ni as beta-emitting *** ZNRAs were grown on Al-doped Zn O(AZO)conductive glass using hydrothermal *** optimum length and diameter of Zn O nanorods were determined by Monte Carlo simulation for beta energy deposition in *** m-SWCNTs were anchored into the ZNRAs to form a three-dimensional(3-D)Schottky junction structure for effectively separating the beta/photo-excited electron-hole ***,the betavoltaic and photovoltaic effects were confirmed through the I-V measurements of beta/photovoltaic cells under beta/UV/Vis irradiations,*** is suggested that the m-SWCNTs play key role for the enhancement of beta/photovoltaic performance through the formation of extensive3-D Schottky junction,the conductive network for hole transport,and the surface plasmon resonance exciton absorption for visible light.

关键词： ZnO nanorod arrays Single-walled carbon nanotube Betavoltaics Photovoltaics

Intron-retained alternatively spliced VIN3-LIKE 2 gene from Chimonanthus praecox promotes flowering in transgenic Arabidopsis

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Horticultural Plant Journal 2023年第4期9卷 789-800页

作者： Tian Xu Ning Liu chunyu wu Yi Zhang Mingkang Tian Shunzhao Sui Zhineng Li Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Chongqing Engineering Research Center for FloricultureCollege of Horticulture and Landscape ArchitectureSouthwest UniversityChongqing 400715China

Vernalization is a process of acquiring or accelerating the flowering ability by prolonged cold *** INSENSITIVE3(VIN3)is induced by chilling and is extremely important for the vernalization response in Arabidopsis ***,the issue of the induction of the VIN3-LIKE genes in wintersweet(Chimonanthus praecox)has been largely *** the present study,we explored the molecular regulation of the PHD type finger protein-encoding gene CpVIL2 in relation to the growth and development of wintersweet in *** wintersweet,quantitative real-time PCR(qRT-PCR)analysis showed that the relative expression of CpVIL2-As2i(intron-retained alternatively spliced in the second intron)was extremely higher in the pistils than in the other *** the relative CpVIL2-As2i expression in flower buds(FBs)treated at 8°C was higher than that of FBs in December,2016 under natural conditions,which was not detected in non-flowering FBs at 16°*** Arabidopsis,the expression patterns of the CpVIL2-As2i gene were detected at first in CpVIL2-As2i pro::GUS(β-glucuronidase)lines,with predominantly higher expression in flowers and ***,the hormone-induced expression profiles of the CpVIL2-As2i promoter were confirmed using exogenous induction by abscisic acid(ABA)and indole acetic acid(IAA)phytohormones,where the GUS enzyme activity obviously decreased compared with that of *** comparison with Arabidopsis/Col-0,early flowering was detected in ectopic 35S::CpVIL2-As2i ***,these results demonstrated the function of the CpVIL2-As2i gene,at the same time,provided us with new insights into the molecular mechanisms of early flowering and complex regulatory networks of vernalization in wintersweet.

关键词： Chimonanthus praecox PHD finger protein VIL2 Ectopic expression Flowering time Vernalization