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Efficacy and Safety of Iron Isomaltoside Compared with an Oral Iron Supplement in the Management of Patients with Iron Deficiency Anemia

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Open Journal of Blood Diseases 2024年第1期14卷 17-30页

作者： Zhimin Wu chunxiao zhou Chunyan Wu Qiao Song Shilyu Chen Wen Zhang Shaoling Wu Department of Medicine Qingdao University Qingdao China Department of Hematology The Affiliated Hospital of Qingdao University Qingdao China

Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.

关键词： Anemia Iron-Deficiency Drug Therapy Iron Isomaltoside 1000 Treatment Outcome

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Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity

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BIOCELL 2023年第5期47卷 1075-1083页

作者： ZHENG CAO chunxiao zhou ZHIMIN WU CHUNYAN WU WEN ZHANG SHILV CHEN XINDONG ZHAO SHAOLING WU Qingdao University Qingdao266000China Department of Hematology The Affiliated HospitalQingdao UniversityQingdao266000China

Background:Dihydroartemisinin(DHA)is reported to be a potential anticancer agent,and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still *** study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell ***:Here,the Cell Counting Kit 8 assay was conducted to study cell *** performed Annexin V-FITC/propidium iodide staining,real-time polymerase chain reaction,and western blot analysis to analyze cell apoptosis and potential molecular ***:The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis in vitro in a time-and concentration-dependent ***,STAT3 activity could be inhibited after stimulation with ***:These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling *** addition,DHA might be an effective drug for diffuse large B cell lymphoma therapy.

关键词： Diffuse large B cell lymphoma Dihydroartemisinin STAT3 Cell apoptosis

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变胞式输电线路树障清除机器人智能遥控关键技术研究

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现代工业经济和信息化 2024年第3期14卷 231-233页

作者：夏立伟周春晓李明尹洪张楚谦尹玟璇国网湖北省电力有限公司超高压公司湖北武汉430064

探索变胞式输电线路树障清除机器人智能遥控关键技术,重点研究自适应轮毂机架技术,包括设计原理与结构优化、气动式实现方案和夹紧机构的设计与优化方法,探讨转向控制算法及树枝修剪技术,包括转向控制算法的设计与优化、基于视觉感知的... 详细信息

探索变胞式输电线路树障清除机器人智能遥控关键技术,重点研究自适应轮毂机架技术,包括设计原理与结构优化、气动式实现方案和夹紧机构的设计与优化方法,探讨转向控制算法及树枝修剪技术,包括转向控制算法的设计与优化、基于视觉感知的树枝识别和修剪技术以及快拆式安装架的设计与优化,最后研究导线与修剪树干距离测量及避障技术,包括基于RTK定位的测量原理与算法、电场感应和激光雷达在避障中的应用,以及实时显示与监控系统的设计与开发.通过研究,提出了一套智能遥控变胞式输电线路树障清除机器人的关键技术实现方案.

关键词：变胞式机器人输电线路树障清除智能遥控

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Fuzzy Risk Assessment Method for Airborne Network Security Based on AHP-TOPSIS

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Computers, Materials & Continua 2024年第7期80卷 1123-1142页

作者： Kenian Wang YuanHong chunxiao Li College of Safety Science and Engineering Civil Aviation University of ChinaTianjin300300China Key Laboratory of Airworthiness Certification Technology for Civil Aviation Aircraft Civil Aviation University of ChinaTianjin300300China

With the exponential increase in information security risks,ensuring the safety of aircraft heavily relies on the accurate performance of risk ***,experts possess a limited understanding of fundamental security elements,such as assets,threats,and vulnerabilities,due to the confidentiality of airborne networks,resulting in cognitive ***,the Pythagorean fuzzy Analytic Hierarchy Process(AHP)Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)is proposed to address the expert cognitive uncertainty during information security risk assessment for airborne ***,Pythagorean fuzzy AHP is employed to construct an index system and quantify the pairwise comparison matrix for determining the index weights,which is used to solve the expert cognitive uncertainty in the process of evaluating the index system weight of airborne ***,Pythagorean fuzzy the TOPSIS to an Ideal Solution is utilized to assess the risk prioritization of airborne networks using the Pythagorean fuzzy weighted distance measure,which is used to address the cognitive uncertainty in the evaluation process of various indicators in airborne network threat ***,a comparative analysis was *** proposed method demonstrated the highest Kendall coordination coefficient of *** finding indicates superior consistency and confirms the efficacy of the method in addressing expert cognition during information security risk assessment for airborne networks.

关键词： Airborne networks information security risk assessment cognitive uncertainty Pythagorean fuzzy sets

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THE SUPERCLOSENESS OF THE FINITE ELEMENT METHOD FOR A SINGULARLY PERTURBED CONVECTION-DIFFUSION PROBLEM ON A BAKHVALOV-TYPE MESH IN 2D

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Acta Mathematica Scientia 2024年第4期44卷 1572-1593页

作者： chunxiao ZHANG Jin ZHANG School of Mathematics and Statistics Shandong Normal UniversityJinan 250014China

For singularly perturbed convection-diffusion problems,supercloseness analysis of the finite element method is still open on Bakhvalov-type meshes,especially in the case of *** difficulties arise from the width of the mesh in the layer adjacent to the transition point,resulting in a suboptimal estimate for *** analysis techniques cannot handle these difficulties *** fill this gap,here a novel interpolation is designed delicately for the smooth part of the solution,bringing about the optimal supercloseness result of almost order 2 under an energy norm for the finite element *** theoretical result is uniform in the singular perturbation parameterεand is supported by the numerical experiments.

关键词： singularly perturbed convection-diffusion finite element method supercloseness Bakhvalov-type mesh

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Surface Elastic Effects on Electromechanical Responses of a Piezoelectric Semiconducting Nanobeam

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Acta Mechanica Solida Sinica 2024年第4期37卷 598-612页

作者： Aowen Bao Xiaobao Li Yuxue Pu chunxiao Zhan School of Civil Engineering Hefei University of TechnologyHefei230009China

Piezoelectric semiconductors(PSCs)find extensive applications in modern smart electronic devices because of their dual properties of being piezoelectric and *** the increasing demand for miniaturization of these devices,the performance of their components needs to be carefully designed and optimized,especially when reduced to *** has been shown that surface elastic properties play a substantial role in the mechanical performance of nanoscale materials and *** on this understanding,the surface elastic effects,encompassing surface residual stress,surface membrane stiffness,and surface bending stiffness,are comprehensively taken into account to explore the electromechanical responses of a PSC ***,the flexoelectric effect on their responses is also systematically *** results of this work reveal that surface elastic properties predominantly influence mechanical performance,while the flexoelectric effect plays a more dominant role in electric-related quantities at the ***,the significance of surface bending rigidity,which was often underestimated in the earlier literature,is ***,owing to the flexoelectric effect,the linear distribution of electric potential and charge carriers along the length transforms into a nonlinear *** distributions of electric potential and charge carriers across the cross section are also evidently ***,the size-dependent responses are *** findings may provide valuable insights for optimizing electronic devices based on nanoscale PSCs.

关键词： Surface elastic effect Flexoelectricity Size effect Piezoelectric semiconductor

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Intracavity Tunneling Introduced Transparency in Ultrastrong-coupling Regime

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Optics and Photonics Journal 2013年第2期3卷 293-297页

作者： Tao Wang Rui Zhang chunxiao zhou Xuemei Su Physics College Jilin University Changchun 130012 People’s Republic of China

Intracavity tunneling induced transparency in asymmetric double-quantum wells embedded in a microcavity in the ultrastrong-coupling regime is investigated by the input-output theory developed by Ciuti and Carusotto. In this system a narrow spectra can be realized under anti-resonant terms of the external dissipation. Fano-interference asymmetric line profile is found in the absorption spectra.

关键词： Ultrastrong Coupling Spectra Narrowing Anti-resonant Terms Fano-interferences

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Optimization on crystallization process of the magnetic core lysozyme

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Particuology 2024年第4期87卷 106-113页

作者： Lixia Hou chunxiao Qu Min Su Zhihan Liang Qi Hao School of Chemical Engineering Hebei University of TechnologyTianjin300130China

The continuous growth of the biomedical market highlights the significance of improvement in the ef-ficiency of batch production for protein drug ***,we investigated the effect of polymer-modified Fe_(3)O_(4) nanoparticles on lysozyme(Lys)crystallization at different conditions,using function-alized Fe_(3)O_(4) magnetic nanoparticles(Polymer C@Fe_(3)O_(4))as nucleation *** study revealed that the surface charge density of Polymer C@Fe_(3)O_(4) was highest at a modification mass ratio of Fe_(3)O_(4) to Polymer C is 8∶*** ratio facilitates the augmentation of electrostatic interaction and the promotion of *** adding 15%of the PolymerC@Fe_(3)O_(4) prepared from Fe_(3)O_(4) with an average particle size of 150 nm,the magnetic core lysozyme(M-Lys)crystals with an average particle size of 11.08μm,narrow size distribution,and regular morphology were obtained in a yield of 82.42%within 60 min.

关键词： Protein Crystallization Magnetic particle Lysozyme

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面向动态租赁的设备修复非新建模与弹性预防维护决策

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计算机集成制造系统 2017年第2期23卷 380-386页

作者：吴常洁滕春晓周晓军上海交通大学机械与动力工程学院上海200240

在同一设备先后出租给不同承租商的动态租赁模式下,为了提高相应的动态预防维护灵活性和经济性,解析了租赁设备役龄递增所致正常衰退和个性冲击下随机衰退交互共存的故障发生机制,建立了面向动态租赁的双因子修复非新模型,提出阶段租赁... 详细信息

在同一设备先后出租给不同承租商的动态租赁模式下,为了提高相应的动态预防维护灵活性和经济性,解析了租赁设备役龄递增所致正常衰退和个性冲击下随机衰退交互共存的故障发生机制,建立了面向动态租赁的双因子修复非新模型,提出阶段租赁期内基于设备状态与特定环境的弹性预防维护策略。算例分析表明,该策略能够更有效地控制设备故障、降低运营维护成本,为出租商的维护决策提供支持。

关键词：租赁设备动态环境修复非新弹性预防维护

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Crosslinked solubilizer enables nitrate-enriched carbonate polymer electrolytes for stable,high-voltage lithium metal batteries

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Science Bulletin 2024年第2期69卷 209-217页

作者： Chuyang Jing Kuan Dai Dong Liu Wenran Wang Libao Chen chunxiao Zhang Weifeng Wei State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China College of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104China

High-voltage lithium metal batteries(LMBs)have been considered promising next-generation highenergy-density ***,commercial carbonate electrolytes can scarcely be employed in LMBs owing to their poor compatibility with metallic lithium.N,N-dimethylacrylamide(DMAA)-a crosslinkable solubilizer with a high Gutmann donor number-is employed to facilitate the dissolution of insoluble lithium nitrate(LiNO3)in carbonate-based electrolytes and to form gel polymer electrolytes(GPEs)through in situ *** Lit solvation structure of the GPEs is regulated using LiNO3 and DMAA,which suppresses the decomposition of LiPFe and facilitates the formation of an inorganic-rich solid electrolyte ***,the Coulombic efficiency(CE)of the LillCu cell assembled with a GPE increases to 98.5%at room temperature,and the high-voltage LillNCM622 cell achieves a capacity retention of 80.1%with a high CE of 99.5%after 400 *** bifunctional polymer electrolytes are anticipated to pave the way for next-generation high-voltage LMBs.

关键词： Crosslinked solubilizer Lithium nitrate Carbonate electrolytes Gel polymer electrolytes Lithium metal batteries

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