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电子级六氟丙烷的制备及纯化研究进展

低温与特气 2024年第1期42卷 5-11页

作者：黄正奇郑晨明黄军徐庆松李春胜汪晗白占旗衢州杭氧特种气体有限公司浙江衢州324012

近年来电子级六氟丙烷以其优越的安全性、高效的刻蚀速率、良好的选择性,成为了新一代等离子体刻蚀气体。对六氟丙烷HFC-236fa及其同分异构体HFC-236ea进行了概述,并介绍其制备方法、工业级及电子级纯化方法的研究进展。

关键词：六氟丙烷制备分离提纯电子级同分异构体 HFC-236fa HFC-236ea

The Applicability of SLA Research to L2 Pedagogy: Focusing on Mandarin Tones

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The Applicability of SLA Research to L2 Pedagogy: Focusing o...

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

作者： Yang chunsheng Luo han University of Connecticut Lafayette College

The relationship between SLA research and L2 pedagogy is a recurring topic. While many articles have discussed the theoretical applicability of SLA research in pedagogy, fewer attempts have been made to test the actual applicability and effectiveness of such applications. This study contributes to the discussion of this issue by applying SLA findings on the acquisition of Mandarin Tone 3 to L2 Mandarin teaching in the classroom setting. Two first-year Chinese classes in an American university participated in this study. The two classes adopted the identical curriculum except for the treatment of Tone 3（i.e., the low teaching approach versus the full teaching approach）. The comparison of Tone 3 productions in the two classes showed that the low teaching approach facilitated L2 learners’ Tone 3 acquisition and helped L2 learners reduce the production of the wrong low-dipping Tone 3 in inappropriate contexts. The low approach demonstrated advantage over the full approach in L2 tone acquisition, but also exhibited its own problems. The finding of this study supports Ellis’（2010） view that the application of SLA findings to L2 pedagogy is not straightforward. Rather, practitioners need to make adjustments specific to their own teaching contexts based on student learning outcomes and feedback. The results of this study suggest that more language instructors and practitioners should be engaged in empirical research integrating SLA research and language pedagogy.

关键词： SLA language pedagogy Mandarin Tone 3 low tone

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Bioactive Materials 2021年第2期6卷 529-542页

作者： Yang han Chunhong Gao Hao Wang Jiejie Sun Meng Liang Ye Feng Qianqian Liu Shiyao Fu Lin Cui chunsheng Gao Yi Li Yang Yang Baoshan Sun School of Traditional Chinese Medicine Shenyang Pharmaceutical UniversityShenyang110016PR China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing100850PR China School of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang10016PR China Instituto National de Investigação Agrária e Veterinária I.P.Pólo Dois PortosQuinta da AlmoinhaDois Portos2565-191Portugal

Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species(ROS)is an early event of sporadic Alzheimer's disease(AD),and considered to be a key pathologic factor in the progression of *** targeted delivery of the antioxidants to mitochondria of injured neurons in brain is a promising therapeutic strategy for AD.A safe and effective drug delivery system(DDS)which is able to cross the blood-brain barrier(BBB)and target neuronal mitochondria is ***,bioactive materials-based DDS has been widely investigated for the treatment of ***,we developed macrophage(MA)membrane-coated solid lipid nanoparticles(SLNs)by attaching rabies virus glycoprotein(RVG29)and triphenylphosphine cation(TPP)molecules to the surface of MA membrane(RVG/TPP-MASLNs)for functional antioxidant delivery to neuronal *** to the results,MA membranes camouflaged the SLNs from being eliminated by RESrich organs by inheriting the immunological characteristics of *** unique properties of the DDS after decoration with RVG29 on the surface was demonstrated by the ability to cross the BBB and the selective targeting to *** entering the neurons in CNS,TPP further lead the DDS to mitochondria driven by electric *** Genistein(GS)-encapsulated DDS(RVG/TPP-MASLNs-GS)exhibited the most favorable effects on reliveing AD symptoms in vitro and in vivo by the synergies gained from the combination of MA membranes,RVG29 and *** results demonstrated a promising therapeutic candidate for delaying the progression of AD via neuronal mitochondria-targeted delivery by the designed biomimetic nanosystems.

关键词： Macrophage-membrane coating Biomimetic nanosystems Neuronal mitochondria targeting Blood-brain barrier Alzheimer's disease Genistein

UM15 reinforces a lymphocyte-mimicking nanotrap for precise HIV-1 inhibition

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Nano Research 2023年第7期16卷 9906-9920页

作者： Jinbang Zhang Zhengyang Li Jiaxin Li Hui Li Junwei Che Te Zhao Pengfei Zou Jingwan han Yang Yang Meiyan Yang Yuli Wang Wei Gong Haihua Xiao Zhiping Li Lin Li chunsheng Gao State key Laboratory of Toxicology and Medical Countermeasure Beijing Institute of Pharmacology and ToxicologyBeijing 100039China Pharmaceutical College Henan UniversityKaifeng 475001China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China School of Public Health and Health Management Gannan Medical UniversityGanzhou 341000China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected because these nanotraps displayed no obvious advantages compared with the infinite host ***,a glycoprotein 120(gp120)-targeting polypeptide UM15 reinforced lymphocyte-mimicking nanotrap was constructed,and its improved HIV-1 inhibiting efficacy was *** to the results,the constructed nanotraps exhibited evident escaping ability from uptake of the mononuclear phagocyte system and highly improved binding ability with gp120 *** constructed nanotraps neutralized all tested HIV-1 pseudo typed viruses with IC80 of 21.0μg/mL,and inhibited both X4-tropic and R5-tropic HIV-1 with IC80 of 34.4 and 20.6μg/mL,*** 40%of gp120 was observed to be shed from pseudo virus,and above 40%bystander T cells were prevented from gp120-induced death by the constructed *** safety of the constructed nanotraps was confirmed both in vitro and in ***,the constructed nanotraps could specifically neutralize free HIV-1,selectively bind with gp120 expressing HIV-1 infected cells,cause gp120 shedding,inhibit gp120-induced bystander T cell killing on the premise of safety,and were considered as promising therapeutic agents for precise inhibition of HIV.

关键词： nanotrap lymphocyte membrane UM15 human immunodeficiency virus-1(HIV-1) glycoprotein 120(gp120)

Cell relay-delivery improves targeting and therapeutic efficacy in tumors

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Bioactive Materials 2021年第6期6卷 1528-1540页

作者： Ye Feng Qianqian Liu Yi Li Yang han Meng Liang Hao Wang Qing Yao Yuli Wang Meiyan Yang Zhiping Li Wei Gong Yang Yang chunsheng Gao State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing100850PR China Hubei University of Science and Technology Xianning437100PR China School of Traditional Chinese Medicine Shenyang Pharmaceutical UniversityShenyang110016PR China

Cell-mediated drug delivery system(CDDS)has shown great potential for cancer ***,a single cell-mediated drug delivery mechanism has not generally been successful,particularly for systemic *** augment the antitumor therapy efficacy,herein,we propose a strategy of cell relay-delivery for the use of artificially damaging/aging erythrocytes to hitchhike on circulating monocytes/macrophages for intratumoral accumulation of anticancer *** biomimetic relay-delivery strategy was derived from the manner in which circulating monocytes/macrophages in body specifically engulf damaged/senescent erythrocytes and actively transmigrate into the tumor *** strategy elegantly combines the natural functions of both cells,which therefore provides a new perspective to challenge current obstacles in drug *** to the strategy,we developed biotinylated erythrocyte-poly(lactic-co-glycolic acid)(PLGA)nanoparticle hybrid DDSs(bE-NPs)using avidin-biotin *** such a system,biotinylated erythrocytes can mimic the natural property of damaged/senescent erythrocytes,while PLGA NPs are capable of encapsulating anticancer drugs and promoting sustained drug *** drugs can effectively target tumor sites by two ***,by using biotinylated erythrocytes as the carrier,the drug-loaded PLGA NPs could be specifically phagocytized by monocytes/***,by taking advantage of the tumor-tropic property of monocytes/macrophages,the drug-loaded PLGA NPs could be efficiently transported into the tumor *** encapsulating vincristine(VIN)as the model drug,bE-NPs exhibited the most favorable antitumor effects in vitro and in vivo by the cell relay-delivery *** results demonstrate that the cell relay-delivery provides a potential method for improving tumor treatment efficacy.

关键词： Cell relay-delivering Cell-mediated drug delivery Hitchhiking Solid tumor

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互市贸易发展进程、掣肘因素与政策思考

国际贸易 2019年第11期 67-73页

作者：安春生韩平哈尔滨商业大学经济学院

互市贸易是固边、富边和兴民的重要政策举措,对于推动边境地区经济社会发展,提高边民生活水平,具有特殊意义。我国9个省区的140个陆地边境县大都批建了互市贸易区,成为边民交易的重要载体,东兴市、瑞丽市、绥芬河市、满洲里市等地在实... 详细信息

互市贸易是固边、富边和兴民的重要政策举措,对于推动边境地区经济社会发展,提高边民生活水平,具有特殊意义。我国9个省区的140个陆地边境县大都批建了互市贸易区,成为边民交易的重要载体,东兴市、瑞丽市、绥芬河市、满洲里市等地在实践中积累了值得推广的经验。但当前还存在国家层面立法滞后、联检部门协同性弱、区域内多头对外和抬价争购、受益面窄等问题。制度设计与时代发展相契合,才能释放出最大效能。当前亟需国家、省市区、县(市)等不同层面,完善边民互市贸易,优化配套措施,让互市贸易政策红利留在边境,实现国家政策的设计初衷。

关键词：互市贸易政策红利普惠边境

Systemic delivery of microRNA for treatment of brain ischemia

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Nano Research 2021年第9期14卷 3319-3328页

作者： Chaoyong Liu Jing Wen Dai Li Hongzhao Qi Lina Nih Jialin Zhu Duo Xu Yu Ren Shanshan Zhang Donglin han Huanhuan Jia Junhu Zhou Meng Qin Jialing Wu Xubo Yuan Ji Liu Jin Zhao chunsheng Kang Yunfeng Lu Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China Key Laboratory of Post-Trauma Neuro-repair and Regeneration in Central Nervous System Ministry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin Neurological InstituteTianjin 300052China College of Life Science and Technology and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Medicine Tianjin Huanhu HospitalTianjin 300350China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Tianjin Research Center of Basic Medical Science Tianjin Medical UniversityTianjin 300070China Department of Neurology Tianjin Huanhu HospitalTianjin 300350China

Brain ischemia is the second leading cause of death and the third leading cause of disability in the *** delivery of microRNA,a class of molecules that regulate the expression of cellular proteins associated with angiogenesis,cell growth,proliferation and differentiation,holds great promise for the treatment of brain ***,their therapeutic efficacy has been hampered by poor delivery efficiency of *** report herein a platform technology based on microRNA nanocapsules,which enables their effective delivery to the disease sites in the *** by microRNA-21,intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume,neurological deficit and histopathological severity.

关键词： polymer nanocapsules small RNA delivery microRNA-21 brain ischemia

HPHT法合成人造金刚石用粉末触媒的发展与研究

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超硬材料工程 2024年第2期36卷 33-39页

作者：田龙谷年良毕涵蒋鑫马春生高莹王增辉魏华阳王玉宝中材人工晶体研究院(山东)有限公司山东济南250200 北京中材人工晶体研究院有限公司北京朝阳100018 中材高新材料股份有限公司山东淄博255000

研究了HPHT法合成人造金刚石用粉末触媒的制备方法,主要有雾化法、化学共沉淀法和羰基法,其中雾化法又分为气雾化法和水雾化法。水雾化法粉末触媒的合金成分均匀,工艺简单,设备要求低,推广容易,出粉率和成品率高,生产成本低,因此水雾化... 详细信息

研究了HPHT法合成人造金刚石用粉末触媒的制备方法,主要有雾化法、化学共沉淀法和羰基法,其中雾化法又分为气雾化法和水雾化法。水雾化法粉末触媒的合金成分均匀,工艺简单,设备要求低,推广容易,出粉率和成品率高,生产成本低,因此水雾化法是HPHT法合成人造金刚石用粉末触媒的普遍工艺。人工晶体研究院研发并推广了水雾化法粉末触媒,推动了中国人造金刚石行业和超硬材料行业的发展。在水雾化法制备粉末触媒的基础上,研究了收料工艺对水雾化法FeNi_(30)粉末触媒的影响。研究发现:采用沉淀放水工艺时粉末触媒氧含量、杂质含量和物料损失均远低于传统滤布收料工艺;从微观形貌分析,沉淀放水工艺粉末触媒球形度高,异形率和异形度低。沉淀放水工艺粉末触媒制备的人造金刚石TI (冲击韧性)、TTI (热冲击韧性)、晶型、透度和颜色均优于传统滤布收料工艺。

关键词： HPHT 人造金刚石粉末触媒水雾化

利用斑马鱼模型和网络药理学研究荷丹胶囊血管保护作用的主要活性成分

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沈阳药科大学学报 2024年第2期41卷 168-176页

作者：王娜王喆张杨腾皎王哲哲王松松张友刚曾英姿傅春升韩利文山东中医药大学药学院山东济南250000 山东第一医科大学药学与制药科学学院山东济南250000 山东沃华医药科技股份有限公司山东潍坊261000

目的利用斑马鱼模型和网络药理学方法研究荷丹胶囊的血管保护作用主要活性成分,为后续深入研究提供科学依据。方法采用血管转基因标记的CZ55系斑马鱼为实验动物,评价荷丹胶囊对斑马鱼血管损伤的保护作用;通过中医药整合药理学研究平台TC... 详细信息

目的利用斑马鱼模型和网络药理学方法研究荷丹胶囊的血管保护作用主要活性成分,为后续深入研究提供科学依据。方法采用血管转基因标记的CZ55系斑马鱼为实验动物,评价荷丹胶囊对斑马鱼血管损伤的保护作用;通过中医药整合药理学研究平台TCMIP、TCMSP、Gencards数据库、String平台、Cytoscape软件构建荷丹胶囊中荷叶、丹参、山楂、番泻叶、补骨脂的主要化学成分与作用靶点的相互作用网络,并筛选中药活性成分,同时利用分子对接进行成分与靶点结合能评价,然后采用斑马鱼模型对筛选的活性成分进行二次验证。结果斑马鱼实验结果显示荷丹胶囊具有显著保护血管内皮损伤的作用;网络药理学筛选和分子对接结果提示丹参酮ⅡA、荷叶碱、补骨脂异黄酮醛、槲皮素可能是荷丹胶囊发挥药效的重要物质基础;斑马鱼实验结果显示,丹参酮ⅡA、槲皮素具有明显的血管保护活性。结论荷丹胶囊中丹参酮ⅡA、槲皮素可能是发挥血管保护作用的重要物质基础,具有多靶点整合调节的作用特点。

关键词：荷丹胶囊网络药理学血管保护斑马鱼模型