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基于双参数磁共振影像组学模型预测老年前列腺癌患者根治术后生化复发

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中华老年医学杂志 2024年第2期43卷 180-186页

作者：刘文王淼吕政通侯惠民王淼淼李春媚刘明北京医院泌尿外科、国家老年医学中心、中国医学科学院老年医学研究院北京100730 中国医学科学院北京协和医学院研究生院北京100730 北京医院放射科国家老年医学中心、中国医学科学院老年医学研究院北京100730

目的探讨基于双参数磁共振(bpMRI)影像组学模型对老年(≥60岁)前列腺癌患者根治术(RP)后生化复发(BCR)的预测价值。方法回顾性分析2017年8月至2021年12月北京医院收治的175例患者的资料,根据病理结果分别在术前bpMRI的T2、磁共振扩散加... 详细信息

目的探讨基于双参数磁共振(bpMRI)影像组学模型对老年(≥60岁)前列腺癌患者根治术(RP)后生化复发(BCR)的预测价值。方法回顾性分析2017年8月至2021年12月北京医院收治的175例患者的资料,根据病理结果分别在术前bpMRI的T2、磁共振扩散加权成像(DWI)和表观弥散系数(ADC)序列上进行图像分割。使用Pyradiomics提取影像组学特征,采用Cox回归、Spearman相关系数和LASSO回归对特征进行降维,构建影像组学标签。采用多因素Cox回归分析构建临床模型和影像-临床联合模型,使用一致性指数(C-index)评价模型预测BCR的效能。结果175例患者按照7∶3随机分为训练集(122例)和测试集(53例),分别有24例(19.7%、24/122)和11例(20.8%、11/53)患者发生BCR。在3个序列中提取5775个影像组学特征,最终筛选5个特征构建影像组学标签。影像组学模型在训练集和测试集的C-index分别为0.764(95%CI:0.655~0.872)和0.769(95%CI:0.632~0.906)。多因素Cox回归分析结果显示,血清前列腺特异性抗原(PSA)(HR=1.032,95%CI:1.010~1.054)、术后病理国际泌尿外科病理学学会(ISUP)分级(HR=1.682,95%CI:1.039~2.722)和切缘阳性(HR=2.513,95%CI:1.094~5.774)是BCR的独立预测因子。临床模型在训练集和测试集的C-index分别为0.751(95%CI:0.655~0.846)和0.753(95%CI:0.630~0.877)。联合临床因素和影像组学标签建模后,影像-临床联合模型的C-index最高,分别为0.782(95%CI:0.679~0.874)和0.801(95%CI:0.677~0.915)。结论基于bpMRI构建的影像组学模型可以预测老年前列腺癌患者RP术后BCR的发生,联合临床因素和影像组学标签建模可以提高预测效能。

关键词：前列腺肿瘤前列腺切除术磁共振成像预测生化复发

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不同果酒的氨基酸营养价值对比评价

中国酿造 2024年第4期43卷 211-215页

作者：沈冰易志钟璇马婷婷李春梅韩佳临广西职业技术学院农业工程学院广西南宁530226 浙江大学中原研究院大健康研究与检测中心河南郑州450000

为评价4种水果汁(百香果、水蜜桃、杨梅和甜橙)发酵成果酒后氨基酸营养价值变化,该研究对果汁和果酒的氨基酸组成进行检测,用模糊识别分析法和氨基酸比值系数法对果酒氨基酸营养价值进行分析。结果表明,4种果汁及发酵后果酒均含16种氨基... 详细信息

为评价4种水果汁(百香果、水蜜桃、杨梅和甜橙)发酵成果酒后氨基酸营养价值变化,该研究对果汁和果酒的氨基酸组成进行检测,用模糊识别分析法和氨基酸比值系数法对果酒氨基酸营养价值进行分析。结果表明,4种果汁及发酵后果酒均含16种氨基酸,果汁发酵后总氨基酸含量均有下降,百香果果酒下降幅度最小(约66%)。果汁发酵成果酒后,与联合国粮食与农业组织(FAO)/世界卫生组织(WHO)模式和全鸡蛋蛋白模式对比,百香果果酒必需氨基酸贴近度最大,分别为0.94或0.87;与FAO/WHO必需氨基酸模式对比,4种果酒必需氨基酸比值系数分(SRC)均提高,百香果果酒、蜜桃酒、杨梅酒、甜橙酒的SRC分值分别提升20.2%、8.3%、14.22%、4.1%,其中百香果果酒SRC分值最高,为82.02。百香果果酒和甜橙酒的呈味氨基酸总含量较高,分别为111.49 mg/100 mL和111.55 mg/100 mL,其中占比最大的甜味氨基酸含量分别为56.18 mg/100 mL和66.85 mg/100 mL,口感更佳。

关键词：发酵果酒氨基酸组分分析营养价值对比评价

Intermetallic phase formation and evolution during homogenization and solution in Al-Zn-Mg-Cu alloys

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Science China(Technological Sciences) 2013年第11期56卷 2827-2838页

作者： li chunmei CHEN ZhiQian ZENG SuMin CHENG NanPu CHEN TianXiao School of Materials Science and Engineering Central South University School of Materials Science and Engineering Southwest University

The effects of major alloy element contents of Zn, Mg, Cu in Al-Zn-Mg-Cu alloys on the formation and evolution of intermetallic phases during casting, homogenization and solution treatment have been investigated through using X-ray diffraction, scanning electron microscopy and differential scanning calorimetry. Experimental results showed that a relatively higher Zn content with lower Mg and Cu contents was beneficial to the formation of MgZn2 phase instead of the A12CuMg phase, which resulted in the unicity of the intermetallics in the A1 matrix, and that the MgZn2 phase was easier for diffusion and dissolution during homogenization and solution than the Al2CuMg phase. Additionally, the results of the first-principles calculations gave support for explaining the experimental phenomena. A larger absolute value of formation enthalpy and a smaller value of binding energy of the MgZn2 phase, as compared with the Al2CuMg phase, give it priority to precipitate during casting and make it easier to re-dissolve during homogenization and solution treatment. What＇s more, higher elastic constants with severe anisotropy of Young＇s modulus make undissolved blocks of AI^CuMg phase act as crack initiation, which degrade the perfor- mance of the materials.

关键词： intermetallic phases homogenization solution first-principles Al alloys

Electrolyte and anode-electrolyte interphase in solid-state lithium metal polymer batteries:A perspective

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SusMat 2021年第1期1卷 24-37页

作者： Heng Zhang Yuhui Chen chunmei li Michel Armand Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhanP.R.China State Key Laboratory of Materials-Oriented Chemical Engineering School of EnergyNanjing Tech UniversityNanjingJiangsuP.R.China Centre for Cooperative Research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)GipuzkoaSpain

The interest for solid-state lithium metal(li◦)batteries(SSLMBs)has been growing exponentially in recent years in view of their higher energy density and eliminated safety *** polymer electrolytes(SPEs)are soft ionic conductors which can be easily processed into thin films at industrial level;these unique features confer solid-state li◦polymer batteries(SSLMPBs,i.e.,SSLMBs utilizing SPEs as electrolytes)distinct advantages compared to SSLMBs containing other *** this article,we briefly review recent progresses and achievements in SSLMPBs including the improvement of ionic conductivity of SPEs and their interfacial stability with li◦***,we outline several advanced in-situ and ex-situ characterizing techniques which could assist in-depth understanding of the anode-electrolyte interphases in *** article is hoped not only to update the state-of-the-art in the research on SSLMPBs but also to bring intriguing insights that could improve the fundamental properties(e.g.,transport,dendrite formation,and growth,etc.)and electrochemical performance of SSLMPBs.

关键词： anode-electrolyte interphase solid polymer electrolytes solid-state batteries solid-state lithium metal polymer batteries

工匠精神培育的路径实践——以成都某高职院校为例

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湖南工业职业技术学院学报 2024年第3期24卷 59-63,104页

作者：周晓美张蜀艳李春梅成都工业职业技术学院四川成都610213

2016年以来,“工匠精神”逐渐成为社会热议的高频词,工匠精神的传承与弘扬越来越受到重视,高职院校作为培养技术技能人才的摇篮,肩负着培养学生工匠精神的重任。职业教育中,需要通过打破社会文化场域的思维惯习,建立健全技术技能人才保... 详细信息

2016年以来,“工匠精神”逐渐成为社会热议的高频词,工匠精神的传承与弘扬越来越受到重视,高职院校作为培养技术技能人才的摇篮,肩负着培养学生工匠精神的重任。职业教育中,需要通过打破社会文化场域的思维惯习,建立健全技术技能人才保障机制,将专业、职业和人文教育相结合等举措去寻回和重赋工匠精神。为此,应从博物展馆的器物鉴赏、大思政文化育人、小班化教学、双导师制、校企合作等方面加强工匠精神培育的路径实践,从而全面提升高职学生职业素养。

关键词：工匠精神职业素养培育路径实践

Controllable resistive switching of STO:Ag/SiO2-based memristor synapse for neuromorphic computing

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Journal of Materials Science & Technology 2022年第2期97卷 254-263页

作者： Nasir Ilyas Jingyong Wang chunmei li Hao Fu Dongyang li Xiangdong Jiang Deen Gu Yadong Jiang Wei li School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China

Resistive random-access memory(RRAM)is a promising technology to develop nonvolatile memory and artificial synaptic devices for brain-inspired neuromorphic ***,we have developed a STO:Ag/SiO_(2) bilayer based memristor that has exhibited a filamentary resistive switching with stable endurance and long-term data retention *** memristor also exhibits a tunable resistance modulation under positive and negative pulse trains,which could fully mimic the potentiation and depression behavior like a *** synaptic plasticity functions,including long-term potentiation(LTP)and long-term depression(LTD),paired-pulsed facilitation(PPF),spike-rate-dependent-plasticity(SRDP),and post-tetanic potentiation(PTP),are faithfully implemented with the fabricated ***,to demonstrate the feasibility of our memristor synapse for neuromorphic applications,spike-timedependent plasticity(STDP)is also *** on conductive atomic force microscopy observations and electrical transport model analyses,it can be concluded that it is the controlled formation and rupture of Ag filaments that are responsible for the resistive switching while exhibiting a switching ratio of~10;along with a good endurance and stability suitable for nonvolatile memory *** fully electroforming,the gradual conductance modulation of Ag/STO:Ag/SiO_(2)/p^(++)-Si memristor can be realized,and the working mechanism could be explained by the succeeding growth and contraction of Ag filaments promoted by a redox *** newly fabricated memristor may enable the development of nonvolatile memory and realize controllable resistance/weight modulation when applied as an artificial synapse for neuromorphic computing.

关键词： Ag/STO:Ag/SiO2/p++-Si memristor Filamentary resistive switching Resistance/weight modulation Synaptic plasticity Normomorphic computing

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变压精馏分离乙腈-乙醇共沸物的模拟与优化

山东化工 2024年第11期53卷 202-206页

作者：仲超李春梅朱雅楠南京长江江宇环保科技股份有限公司江苏南京210047

以Wilson活度系数模型为物性计算方法,使用Aspen Plus软件对变压精馏分离乙腈-乙醇常压共沸物的工艺进行模拟与优化。选择250和101.325 kPa作为加压塔和常压塔的操作压力,并在乙腈及乙醇产品纯度均为99.9%(质量分数)的约束条件下,重点... 详细信息

以Wilson活度系数模型为物性计算方法,使用Aspen Plus软件对变压精馏分离乙腈-乙醇常压共沸物的工艺进行模拟与优化。选择250和101.325 kPa作为加压塔和常压塔的操作压力,并在乙腈及乙醇产品纯度均为99.9%(质量分数)的约束条件下,重点考察了两塔理论板数对塔板温度分布以及进料板位置、回流比对两塔再沸器总热负荷的影响,得到了优化的工艺参数。优化后的工艺参数为:加压塔理论塔板数15、进料板位置5、回流比1.4;常压塔理论塔板数14、进料板位置5、回流比1.2。以此为基础,分析了常规变压精馏和热集成变压精馏的工艺能耗。结果表明:与常规变压精馏工艺相比,热集成变压精馏工艺可节能41.69%。

关键词：变压精馏乙腈乙醇分离模拟

Composition dependent elastic modulus and phase stability of Ni_2MnGa based ferromagnetic shape memory alloys

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Science China(Technological Sciences) 2012年第2期55卷 295-305页

作者： HU QingMiao LUO HuBin li chunmei VITOS Levente YANG Rui Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Applied Materials Physics Department of Materials Science and EngineeringRoyal Institute of TechnologyStockholm SE-10044Sweden Condensed Matter Theory Group Physics DepartmentUppsala UniversityUppsala SE-75120Sweden Research Institute for Solid State Physics and Optics P.O.Box 49Budapest H-1525Hungary

Ni2MnGa based ferromagnetic alloys are ideal candidates for applications such as actuators, magnetic refrigerators or magne-tostrictive transducers due to their attractive properties such as magnetic field induced shape memory effect and large magnetocaloric effect. The properties of these alloys （e.g., the martensitic transformation temperature TM） sensitively depend on the composition. Understanding the composition dependence of these properties so as to design the alloy as desired is one of the main research topics in this area. In recent years, we have investigated the composition dependent elastic modulus and phase stability of Ni2MnGa-based alloys by using a first-principles method, in hope of clarifying their connection to the properties of these alloys. In this article, we review the main results of our investigations. We show that the tetragonal shear modulus C＇ is a better predictor of the composition dependent TM than the number of valence electrons per atom （e/a） since the general TM-C＇ correlation works for some of the alloys for which the TM-ela correlation fails, although there exist several cases for which both the general TM-C＇ and TM-ela correlations break down. Employing the experimentally determined modulation function, the complex 5-layer modulated （5M） structure of the martensite of Ni2MnGa and the Al-doping effect on it are studied. We find that the shuffle and shear of the 5M structure are linearly coupled. The relative stability of the austenite and the marten- sites is examined by comparing their total energies. The non-modulated martensite β＇″ with the tetragonality of the unit cell c/a〉1 is shown to be globally stable whereas the 5M martensite with c/a〈1 is metastable. The critical Al atomic fraction over which the martensitic transformation between the 5M martensite and austenite cannot occur is predicted to be 0.26, in reason- able agreement with experimental findings.

关键词： NieMnGa martensitic transformation elastic modulus phase stability density functional theory

Magnetic field-induced strategy for synergistic CI/Ti_(3)C_(2)T_(x)/PVDF multilayer structured composite films with excellent electromagnetic interference shielding performance

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Journal of Materials Science & Technology 2022年第15期110卷 246-259页

作者： Qing liu Yi Zhang Yibin liu chunmei li Zongxu liu Baoliang Zhang Qiuyu Zhang MOE Key Laboratory of Materials Physics and Chemistry under Extraordinary Conditions Northwestern Polytechnical UniversityXi’an 710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

lightweight,scalable,mechanically flexible conductive polymer composite was always desirable for electromagnetic interference(EMI)shielding *** this work,we showcased a novel approach to the superior EMI shielding composite materials by orchestrating the multilayered structure and synergistic *** asymmetric structure with the carbonyl irons(CI)-rich Ti_(3)C_(2)T_(x)/poly(vinylidene fluoride)(PVDF)magneto-electric layer jointly behind the Ti_(3)C_(2)T_(x) nanosheets filled PVDF layer was designed and fabricated with the aid of a facile but efficient magnetic field-induced method and was then hotpressed into a multilayer structured ***_(3)C_(2)T_(x) nanosheets were excluded by CI agglomeration layer in the asymmetric film to form the complete 3D electrical conductive *** on this strategy,EMI shielding properties of the asymmetric multilayer structured composite was superior to the homogeneous blend and sandwiched or alternating layered *** addition,an increase in CI content in the composite referred to the thickening of CI-rich layers,making it gain the most powerful EMI SE values,i.e.42.8 d B for DCMP20–10 film(20 wt%CI,10 wt%Ti_(3)C_(2)T_(x))at a thickness of 0.4 *** importantly,the composite transformed from a reflection type to an absorption dominating EMI shielding material due to the multireflections and magneto-electric synergism in the CI-rich Ti_(3)C_(2)T_(x)/PVDF ***,the EMI SE of the composites can be adjusted by increase of either theoverall thickness,or the layer numbers of m-DCMP *** thickness specific EMI SE was calculated as 165.25 d B mm^(-1)for 4-sheet composite film,a record high value among the high efficiency polymer-based EMI shielding *** method offered an alternative protocol for preferential integration of excellent EMI shielding performance with high mechanical performance in CPC materials.

关键词： Electromagnetic interference shielding Conductive polymer composites Asymmetric/multilayer structure Magneto-electric synergism