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肿瘤药学 2024年第3期14卷 383-386页

作者：李春梅张英赵海明赵文瑞代亚军锡林郭勒盟中心医院药学部内蒙古锡林浩特026000 锡林郭勒盟中心医院影像科内蒙古锡林浩特026000 锡林郭勒盟中心医院微创介入科内蒙古锡林浩特026000

报道1例65岁表皮生长因子受体19外显子缺失突变(E746_A750del)的右下肺腺癌患者,在服用奥希替尼100天后出现间质性肺病。停药后给予吸氧、糖皮质激素治疗后好转,尝试使用盐酸厄洛替尼片,未再发生间质性肺病。

关键词：奥希替尼表皮生长因子受体酪氨酸激酶抑制剂间质性肺病肺腺癌

Eco-friendly glucose assisted structurally simplified high-efficiency tin-lead mixed perovskite solar cells

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Journal of Energy Chemistry 2023年第10期85卷 83-90,I0004页

作者： Jiayu You Hongyu Bian Meng Wang Xinghong Cai chunmei li Guangdong Zhou Hao Lu Changxiang Fang Jia Huang Yanqing Yao Cunyun Xu Qunliang Song Institute for Clean Energy and Advanced Materials School of Materials and EnergySouthwest UniversityChongqing 400715China College of Artificial Intelligence Southwest UniversityChongqing 400715China School of Physics and Electronic Science Zunyi Normal CollegeZunyi 563002GuizhouChina College of Materials Science and Engineering Sichuan UniversityChengdu 610064SichuanChina

Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing hole transport layer(HTL). In this work, eco-friendly glucose(Gl) as an interface modifier for HTL-free narrow bandgap tin-lead(Sn-Pb) PSCs is proposed. Gl not only enhances the wettability of the indium tin oxide to promote perovskite heterogeneous nucleation on substrate, but also realizes defect passivation by interacting with uncoordinated Pb^(2+) and Sn^(2+) in perovskite films. As a result, the quality of the perovskite films has been significantly improved, accompanied by reduced defects of bottom interface and optimized energy level structure of device, leading to an efficiency increase and a less nonradiative voltage loss of 0.102 V(for a bandgap of ~1.26 eV). Consequently, the optimized PSC delivers an unprecedented efficiency over 21% with high open-circuit voltage and enhanced stability, outperforming the control device. This work demonstrates a cost-effective approach to develop simplified structure high efficiency HTL-free Sn-Pb PSC.

关键词： Efficiency Interfacial modification Passivation Narrow bandgap perovskite

2020年吉林省乙型病毒性肝炎血清流行病学调查分析

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中国生物制品学杂志 2024年第8期37卷 970-974页

作者：付思美曹凤瑞程涛李春梅李永强王爽武懿吉林省疾病预防控制中心免疫规划所吉林长春130062

目的评价2020年吉林省乙型病毒性肝炎(简称乙肝)血清流行特征。方法采用分层多阶段整群随机抽样方法,2020年抽取吉林省1~69岁人群1667人,开展现场乙肝流行病学调查,并采集血清标本,利用EliSA法检测乙型肝炎病毒(hepatitis B virus,HBV)... 详细信息

目的评价2020年吉林省乙型病毒性肝炎(简称乙肝)血清流行特征。方法采用分层多阶段整群随机抽样方法,2020年抽取吉林省1~69岁人群1667人,开展现场乙肝流行病学调查,并采集血清标本,利用EliSA法检测乙型肝炎病毒(hepatitis B virus,HBV)表面抗原(HBsAg)、HBV表面抗体(HBsAb)、HBV核心抗体(HBcAb),HBV E抗原(HBeAg)和HBV E抗体(HBeAb),应用全国流行病学动态数据采集平台,SPSS 18.0软件进行数据分析。结果2020年调查的各年龄组乙肝疫苗接种率差异有统计学意义(χ2=810.48,P<0.05)。2020年吉林省1~69岁人群HBsAg携带率为0.96%,HBsAb阳性率为59.99%,HBV感染率为15.66%,HBeAb阳性率为7.02%,HBeAg阳性率为0.18%。结论2020年吉林省HBV感染标志物各项指标良好,应继续保持人群的高接种率,同时应加强成人乙肝疫苗接种,降低成人的感染风险。

关键词：乙型病毒性肝炎乙型肝炎病毒血清学调查

Suppression of UsP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy

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Protein & Cell 2023年第3期14卷 230-234页

作者： lihong liu Birong Zheng Manhui Luo Jie Du Fang Yang Chuanxin Huang Zengyi Ma chunmei li Deyin Guo Hong Peng MOE Key Laboratory of Tropical Disease Control Centre for Infection and Immunity Study(CIIS)School of MedicineSun Yat-sen UniversityShenzhen 510275China Shanghai Institute of Immunology and Department of Immunology and Microbiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationFaculty of Basic MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200433China

Dear Editor,Ferroptosis is a newly discovered form of regulated cell death characterized by increased intracellular iron accumulation and subsequent lipid peroxidation(Dixon et al.,2012).Studies have revealed that ferroptosis plays an important role in multiple physiological and pathological processes including degenerative diseases,carcinogenesis,and cancer immunotherapy(Hassannia et al.,2019,Wang et al.,2019).

关键词： peroxidation Dixon

Teacher Expectations for Student Learning in the Classroom

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Sino-US English Teaching 2005年第4期2卷 12-19页

作者： chunmei li Wujin Duan Hebei University of Economics and Business North China Coal Medical College

This paper is a discussion of the issues about teacher expectations for students＇ learning in the classroom. The discussion mainly focuses on such topics as the types of expectation effects, the sources of teacher expectations and the communication of teacher expectations. It is concluded that teacher expectations do play an important role in classroom teaching and learning, and therefore some suggestions are made for the peer teachers.

关键词： teacher expectations Pygmalion effect classroom teaching and learning

Identification of two Major Histocompatibility(MH) Class Ⅱ A Genes and Their Association to Vibrio anguillarum Infection in Half-smooth Tongue Sole(Cynoglossus semilaevis)

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Journal of Ocean University of China 2012年第1期11卷 32-44页

作者： li chunmei WANG Xubo ZHANG Quanqi WANG Zhigang QI Jie YI Qilin liU Zhipeng WANG Yanan YU Haiyang College of Marine life Sciences Key Laboratory of Marine Genetics and BreedingMinistry of EducationOcean University of ChinaQingdao 266003P.R.China

Major histocompatibility complex class II antigens are important in vertebrate immune *** the present study,the full cDNA sequence of class II A gene was synthesized by RACE-PCR from half-smooth tongue sole(Cynoglossus semilaevis),and its open reading frame(ORF) polymorphism was *** whole cDNA sequence was 992 bp in length,including the ORF with 717 ***-five alleles were identified and clustered into two distinct groups according to the specific nucleotides/amino acids in specific *** alleles belonged to Cyse-DAA while fourteen alleles belonged to *** Cyse-DAA alleles were observed in one individual,and three to five Cyse-DBA alleles were observed in each of the three detected individuals,which indicated that at least two loci existed in each ***,in order to study the function of the alleles in resistance to infection,200 individuals were intraperitoneally injected with Vibrio anguillarum and the first 20 dead individuals and 20 surviving ones were selected for genotype ***-six alleles were identified among the 40 ***-nine alleles belonged to Cyse-DAA and the other 27 alleles belonged to *** alleles were selected for studying their function in resistance to *** Cyse-DAA*0201,Cyse-DAA*1101,Cyse-DBA*0401,Cyse-DBA*1102,Cyse-DBA*1801 and Cyse-DBA*2201 were identi-fied only in surviving individuals,while alleles Cyse-DAA*0901,Cyse-DBA*1101 and Cyse-DBA*1401 occurred more frequently in dead *** study confirmed the existence and polymorphism of two class II A genes as well as the relationship between alleles of class II A genes and disease susceptibility/resistance in half-smooth tongue sole.

关键词： major histocompatibility polymorphism Cyse-DAA Cyse-DBA allele Vibrio anguillarum

Influence and Countermeasures of Network to psychology of juvenile delinquency

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International Journal of Technology Management 2014年第12期 110-112页

作者： chunmei li li liN Mudanjiang Medical University MuDanJiangHeilongJiang Province 157011 China

With the majority of young people increasingly becoming the main force of the use of the network, the network as a new kind of social factors on the growth of young people is increasingly prominent. Network not only help young people broaden their horizons, accept avant-garde concept, concern about the world cutting-edge issues, but also spread some violence, pornographic or reactionary spare, as well as network addiction problem which will cause a serious negative impact on the healthy growth of young people and lead to increasing juvenile crime. The number of juvenile criminals has increased every year in China and has trended to lowering ages, regiment turn and malignant development, which will cause great harm to social stability. Of course, there are many causes of juvenile delinquency, but showing characteristics are also diverse.

关键词： Juvenile cognitive structure Network

γ-干扰素试验在结核病诊断中的临床应用价值

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云南医药 2024年第4期45卷 59-61页

作者：杨宇溪张秀琴杨宇舟李春梅李颖黄灏莹白雪晶玉溪市人民医院/昆明医科大学第六附属医院医学检验科云南玉溪653100 昆明医科大学第一附属医院核医学科云南昆明650032

目的分析CliA检测γ-干扰素试验诊断结核病的临床应用价值。方法选取2023年5月-2023年9月在本院接受检查的疑似结核病患者1616例,以临床最终诊断结果为金标准,判断全自动化学发光法检测γ-干扰素试验在结核病诊断中的诊断效能。结果临... 详细信息

目的分析CliA检测γ-干扰素试验诊断结核病的临床应用价值。方法选取2023年5月-2023年9月在本院接受检查的疑似结核病患者1616例,以临床最终诊断结果为金标准,判断全自动化学发光法检测γ-干扰素试验在结核病诊断中的诊断效能。结果临床最终诊断结果显示,阳性患者916例,阴性患者700例。γ-干扰素试验结果显示,阳性患者908例,阴性患者708例。CliA检验γ-干扰素试验在肺外结核中的阳性检出率较高,但与临床最终诊断结果比较差异有统计学意义(P0.05);在结核病中的敏感度、特异度、准确度与临床最终诊断结果比较差异无统计学意义(P>0.05)。结果采用CliA检测γ-干扰素试验可对结核病进行诊断,可明确患者为结核病或非结核疾病,并且在结核病的诊断中具有较高的敏感度、特异性。

关键词：全自动化学发光法 γ-干扰素试验结核病诊断效能

Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases

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Cellular & Molecular Immunology 2021年第10期18卷 2358-2371页

作者： Panpan Hou Yuxin lin Zibo li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang liu Cao Zhongwei Zhou chunmei li Jieruo Gu Deyin Guo MOE Key Laboratory of Tropical Disease Control Centre for Infection and Immunity Study(CIIS)School of MedicineSun Yat-sen UniversityShenzhenChina The Center for Applied Genomics Abramson Research CenterThe Children's Hospital of PhiladelphiaPhiladelphiaPAUSA Division of Rheumatology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal ***,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately *** is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA ***,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for *** of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory ***50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with ***,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune ***50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE ***50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE ***,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation.

关键词： CCDC50 STING Type I IFN HSV-1 Autophagy Autoimmune diseases

重庆地区家族性渗出性玻璃体视网膜病变患儿FZD4基因突变情况调查分析

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中国临床新医学 2024年第8期17卷 871-874页

作者：周文轲何俐莹陶雪莹岑超龚立艳黎琦李春梅刘娅重庆市妇幼保健院(重庆医科大学附属妇女儿童医院)眼耳鼻喉科重庆400000

目的调查分析重庆地区家族性渗出性玻璃体视网膜病变(FEVR)患儿FZD4基因的突变情况,并分析基因型与表型的关联性。方法招募2019年1月至2022年12月重庆市妇幼保健院经新生儿眼病筛查诊断为FEVR的患儿90个家系(300例),均来自重庆地区。... 详细信息

目的调查分析重庆地区家族性渗出性玻璃体视网膜病变(FEVR)患儿FZD4基因的突变情况,并分析基因型与表型的关联性。方法招募2019年1月至2022年12月重庆市妇幼保健院经新生儿眼病筛查诊断为FEVR的患儿90个家系(300例),均来自重庆地区。所有患儿均采用RetCamⅢ广域眼底成像系统行眼底检查,并通过RNA-seq高通量测序对白细胞基因组DNA进行FZD4、NDP、LRP5、TSPAN12、ZNF408、CFTR、ADGRG2、SLC9A3、KIF11、CAPN5等10个FEVR致病基因进行检测。分析患者基因型与表型的关联性。结果 90例先证者中,检出FZD4基因突变4例(4.44%),其中2例为自发性突变,2例为父源性突变,突变类型均为非同义突变。4例患儿均为双眼发病,根据FEVR分期,1期3眼,2A期3眼,2B期2眼;根据FEVR分区,2区2眼,3区6眼。合并CAPN5基因突变1例。该研究发现的染色体突变位置包括chr11-86662209、chr11-86663485、chr11-86665923、chr11-86662893。结论该研究拓展了FZD4基因的突变频谱,证实FEVR患者的基因型与表型可能存在不一致的情况。

关键词：家族性渗出性玻璃体视网膜病变 FZD4基因重庆

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