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Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5‑HT pathway

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Journal of Animal Science and Biotechnology 2024年第2期15卷 679-698页

作者： Sheng li Xiaoqing li Kai Wang Yansen li Kentaro Nagaoka chunmei li Research Centre for livestock Environmental Control and Smart Production College of Animal Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Laboratory of Veterinary Physiology Department of Veterinary MedicineFaculty of AgricultureTokyo University of Agriculture and TechnologyTokyo 183‑8509Japan

Background Broilers have a robust metabolism and high body temperature,which make them less tolerant to hightemperature(HT)environments and more susceptible to challenges from elevated *** microbes,functioning as symbionts within the host,possess the capacity to significantly regulate the physiological functions and environmental adaptability of the *** study aims to investigate the effects of gut microbial intervention on the body temperature and thermogenesis of broilers at different ambient temperatures,as well as the underlying mechanism involving the"gut-brain"*** Broilers were subjected to gut microbiota interference with or without antibiotics(control or ABX)starting at 1 day of *** 21 day of age,they were divided into 4 groups and exposed to different environments for 7 d:The control and ABX groups at room temperature(RT,24±1℃,60%relative humidity(RH),24 h/d)and the control-HT and ABX-HT groups at high temperature(HT,32±1℃,60%RH,24 h/d).Results The results demonstrated that the antibiotic-induced gut microbiota intervention increased body weight and improved feed conversion in broiler chickens(Pliver(Plistipes was enriched in control *** contrast,antibioticinduced gut microbiota intervention resulted in a decrease in the relative abundance of Alistipes(P<0.05).Moreover,this difference was accompanied by increased hypothalamic 5-hydroxytryptamine(5-HT)content and TPH2 expression(P<0.05).Conclus

关键词： 5-HT Broiler chickens Gut microbiota Thermogenesis Thermoregulation

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A healable, mechanically robust and ultrastretchable ionic conductive elastomer for durably wearable sensor

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Nano Research 2024年第4期17卷 3369-3378页

作者： Guoxian Zhang chunmei li JiaoJun Tan Mingqi Wang Yafeng Ren Feijie Ge Qiuyu Zhang Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072China College of Bioresources Chemical and Materials Engineering National Demonstration Center for Experimental Light Chemistry Engineering EducationShaanxi University of Science&TechnologyXi’an 710021China

The ionic conductive elastomers show great promise in multifunctional wearable electronics,but they currently suffer from liquid leakage/evaporation or mechanical *** ionic conductive elastomers integrating non-volatility,mechanical robustness,superior ionic conductivity,and ultra-stretchability remains urgent and ***,we developed a healable,robust,and conductive elastomer via impregnating free ionic liquids(ILs)into the ILs-multigrafted poly(urethane-urea)(PUU)elastomer networks.A crucial strategy in the molecular design is that imidazolium cations are largely introduced by double-modification of PUU and centipede-like structures are obtained,which can lock the impregnated ILs through strong ionic *** this system,the PUU matrix contributes outstanding mechanical properties,while the hydrogen bonds and ionic interactions endow the elastomer with self-healing ability,conductivity,as well as non-volatility and *** fabricated ionic conductive elastomers show good conductivity(3.8×10^(-6) S·cm^(-1)),high mechanical properties,including tensile stress(4.64 MPa),elongation(1470%),and excellent healing ability(repairing efficiency of 90%after healing at room temperature for 12 h).Significantly,the conductive elastomers have excellent antifatigue properties,and demonstrate a highly reproducible response after 1000 uninterrupted extension-release *** work provides a promising strategy to prepare ionic conductive elastomers with excellent mechanical properties and stable sensing capacity,and further promote the development of mechanically adaptable intelligent sensors.

关键词： ionic conductive elastomers poly(urethane-urea)(PUU) ionic interactions centipede-like self-healing

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Ultrasensitive detection of micro RNA-21 in human serum based on the confinement effect enhanced chemical etching of gold nanorods

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Chinese Chemical Letters 2024年第9期35卷 382-386页

作者： Min Huang Ru Cheng Shuai Wen liangtong li Jie Gao Xiaohui Zhao chunmei li Hongyan Zou Jian Wang Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Department of Biological and Chemical Engineering Chongqing University of EducationChongqing 400067China The Ninth People’s Hospital of Chongqing Chongqing 400700China

Natural enzymes,such as horseradish peroxidase(HRP),are a class of important biocatalysts with the high specificity,but their catalytic efficiency is usually ***,the higher catalytic efficiency induced by the confinement effect is promising in optical sensing *** this work,a dark-field light scattering sensing platform was fabricated by the confinement effect of HRP from hybridization chain reaction(HCR)and then released to solution by the toehold-mediated strand displacement reaction(TSDR).Then,HRP catalyzed the 3,3,5,5-tetramethylbenzidine(TMB)to TMB^(2+)with the assistance of hydrogen peroxide,which etched the gold nanorods(Au NRs)with the weakened light *** single-particle assay was established based on the decreased light scattering intensity of AuNRs under dark-field *** proposed assay revealed excellent analytical performance within a linear range from 25 pmol/L to 600 pmol/L,and a low limit of detection of 3.12 pmol/***,it also manifested satisfactory recovery of mi RNA-21 in human serum *** high sensitivity,excellent specificity,and universal applicability make this sensing platform promising for disease diagnosis.

关键词： Confinement effect Hybridization chain reaction Toehold-mediated strand displacement reaction MicroRNA-21 Gold nanorods Dark-field microscope

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Alloy as advanced catalysts for electrocatalysis:From materials design to applications

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Chinese Chemical Letters 2024年第6期35卷 104-122页

作者： Pingfan Zhang Shihuan Hong Ning Song Zhonghui Han Fei Ge Gang Dai Hongjun Dong chunmei li Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province Institute of Green Chemistry and Chemical TechnologySchool of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China Daqo Group Co.Ltd. Zhenjiang 212221China Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin Provincial Key Laboratory of Water Resource and EnvironmentCollege of New Energy and EnvironmentJilin UniversityChangchun 130021China

With the deep integration of electrochemical research with energy,environment,catalysis,and other fields,more and more new electrochemical catalytic reactions have entered our research *** catalysts have recently emerged as a new type of nanomaterial due to the rapid development of kinetic controlled synthesis *** materials offer several advantages over monometallic catalysts,including larger element combinations,complex geometries,bifunctional sites,and reduced use of precious *** paper provides a review of alloy electrocatalysts that are designed and prepared specifically for electrocatalytic *** use of alloy materials in electrocatalyst design is also discussed,highlighting their widespread application in this ***,various synthesis methods and synthesis mechanisms are systematically *** that,by correlating the properties of materials with the structure,relevant strategies toward advanced alloy electrocatalysts including composition regulation,size,morphology,surface engineering,defect engineering,interface engineering and strain engineering are *** addition,the important electrocatalytic applications and mechanisms of alloy electrocatalysts are described and ***,the current challenges and prospects regarding the development of alloy nanomaterials are *** review serves as a springboard from a fundamental understanding of alloy structural dynamics to design and various applications of electrocatalysts,particularly in energy and environmental sustainability.

关键词： Alloy Nanomaterial Electrocatalyst Materials design Electrocatalysis

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An intelligent prediction model of epidemic characters based on multi-feature

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 595-607页

作者： Xiaoying Wang chunmei li Yilei Wang lin Yin Qilin Zhou Rui Zheng Qingwu Wu Yuqi Zhou Min Dai Information Center Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina School of Computer Science Qufu Normal UniversityRizhaoChina Department of Allergy Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhou China 4Department of Otorhinolaryngology‐Head and Neck Surgery Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina Department of Pulmonary and Critical Care Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina Department of Traditional Chinese Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina

The epidemic characters of Omicron(***-scale transmission)are significantly different from the initial variants of *** data generated by large-scale transmission is important to predict the trend of epidemic ***,the re-sults of current prediction models are inaccurate since they are not closely combined with the actual situation of Omicron *** consequence,these inaccurate results have negative impacts on the process of the manufacturing and the service industry,for example,the production of masks and the recovery of the tourism *** authors have studied the epidemic characters in two ways,that is,investigation and ***,a large amount of data is collected by utilising the Baidu index and conduct questionnaire survey concerning epidemic ***,theβ-SEIDR model is established,where the population is classified as Susceptible,Exposed,Infected,Dead andβ-Recovered persons,to intelligently predict the epidemic characters of *** thatβ-Recovered persons denote that the Recovered persons may become Sus-ceptible persons with probabilityβ.The simulation results show that the model can accurately predict the epidemic characters.

关键词： artificial intelligence big data data analysis evaluation feature extraction intelligent information processing medical applications

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Origin and evolution of a new tetraploid mangrove species in an intertidal zone

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Plant Diversity 2024年第4期46卷 476-490页

作者： Hui Feng Achyut Kumar Banerjee Wuxia Guo Yang Yuan Fuyuan Duan Wei Lun Ng Xuming Zhao Yuting liu chunmei li Ying liu linfeng li Yelin Huang State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275GuangdongChina Department of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai 519041GuangdongChina China-ASEAN College of Marine Sciences Xiamen University MalaysiaSepang 43900SelangorMalaysia School of Agriculture Sun Yat-sen UniversityShenzhen 518107GuangdongChina School of Ecology Sun Yat-sen UniversityShenzhen 518107GuangdongChina

Polyploidy is a major factor in the evolution of plants,yet we know little about the origin and evolution of polyploidy in intertidal *** study aimed to identify the evolutionary transitions in three truemangrove species of the genus Acanthus distributed in the Indo-West Pacific *** this purpose,we took an integrative approach that combined data on morphology,cytology,climatic niche,phylogeny,and biogeography of 493 samples from 42 geographic *** results show that the Acanthus ilicifolius lineage distributed east of the Thai-Malay Peninsula possesses a tetraploid karyotype,which is morphologically distinct from that of the lineage on the west *** haplotype networks and phylogenetic trees for the chloroplast genome and eight nuclear genes reveal that the tetraploid species has two sub-genomes,one each from *** and ***,the paternal and maternal parents,*** structure analysis also supports the hybrid speciation history of the new tetraploid *** two sub-genomes of the tetraploid species diverged from their diploid progenitors during the *** niche models revealed that the tetraploid species not only occupied the near-entire niche space of the diploids,but also expanded into novel *** findings suggest that *** species distributed on the east side of the Thai-Malay Peninsula should be regarded as a new species,***,which originated from hybridization between *** and ***,followed by chromosome *** is the first report of a true-mangrove allopolyploid species that can reproduce sexually and clonally reproduction,which explains the long-term adaptive potential of the species.

关键词： Acanthus Allopolyploid Biogeography Evolution Hybridization Polyploidy

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肺部菌群干预对PM_(2.5)诱导肉鸡肺部炎症损伤的影响

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南京农业大学学报 2024年第2期47卷 323-333页

作者：周子琳李盛沈丹李春梅南京农业大学动物科技学院家畜环境控制与智慧生产研究中心江苏南京210095

[目的]本试验旨在研究肺部菌群对PM_(2.5)诱导肉鸡肺部炎症损伤的影响,并利用盲肠肠球菌处理肺泡上皮细胞,探究肺部盲肠肠球菌在PM_(2.5)诱发肺部炎症损伤中的作用。[方法]选取45只19日龄雄性AA肉鸡随机分为3组:对照组、PM_(2.5)组(PM)... 详细信息

[目的]本试验旨在研究肺部菌群对PM_(2.5)诱导肉鸡肺部炎症损伤的影响,并利用盲肠肠球菌处理肺泡上皮细胞,探究肺部盲肠肠球菌在PM_(2.5)诱发肺部炎症损伤中的作用。[方法]选取45只19日龄雄性AA肉鸡随机分为3组:对照组、PM_(2.5)组(PM)和肺部菌群干预组(ABX-PM)。从21日龄开始,ABX-PM组肉鸡气管滴注抗生素消减肺部菌群,每天滴注1次,连续滴注3 d,其他2组肉鸡气管滴注无菌生理盐水。在24和26日龄时,分别向PM组和ABX-PM组肉鸡气管滴注PM_(2.5)悬浮液诱导肺部炎症损伤,对照组肉鸡气管滴注无菌生理盐水。在最后一次气管滴注PM_(2.5)24 h后对肉鸡进行称重,并采集肺组织、支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)和血清样品。检测BALF和血清内炎症因子水平、肺组织内紧密连接(tight junctions,TJ)蛋白基因表达水平以及肠球菌属和盲肠肠球菌相对含量,并进行盲肠肠球菌相对含量与炎症因子水平的相关性分析。另外,体外培养A549细胞并分为2组,对照组加入不含盲肠肠球菌的DMEM/F12培养基,处理组加入含有1×10^(4) CFU·mL^(-1)盲肠肠球菌的DMEM/F12培养基。处理6 h后,检测2组细胞炎症因子、TJ及细胞凋亡相关基因表达水平。[结果]与对照组相比,PM组肉鸡BALF和血清IL-8水平显著升高,而ABX-PM组差异不显著;与对照组相比,PM组肉鸡肺组织occludin及claudin-1 mRNA表达水平显著降低,claudin-5 mRNA表达水平显著升高,而ABX-PM组差异不显著;PM组肉鸡肺部肠球菌属和盲肠肠球菌的相对含量显著高于对照组和ABX-PM组;肺部盲肠肠球菌相对含量与BALF内IL-1β、IL-6、IL-8水平和血清内IL-1β水平呈显著正相关关系。体外细胞试验结果显示,与对照组相比,处理组A549细胞tnf-α、il-1β、il-6及il-8 mRNA表达水平显著升高,il-10 mRNA表达水平显著降低;处理组A549细胞zo-1及claudin-1 mRNA表达水平显著降低;处理组A549细胞bax/bcl-2 mRNA表达水平的比值及caspase-3 mRNA表达水平显著升高,bcl-2 mRNA表达水平显著降低。[结论]肺部菌群干预降低了PM_(2.5)诱导的盲肠肠球菌增殖,减轻了肉鸡肺部炎症损伤程度,表明肺部菌群参与PM_(2.5)诱导肉鸡肺部炎症损伤的过程;另外,盲肠肠球菌能够诱导体外肺泡上皮细胞炎症反应,提示肺部菌群失衡加剧肺部炎症损伤。

关键词：肺部菌群肺部炎症肉鸡盲肠肠球菌肺泡上皮细胞

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推进酰胺质子转移加权成像临床应用助力精准诊疗

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中华放射学杂志 2024年第6期58卷 567-570页

作者：李昕阳李春媚陈敏北京医院放射科、国家老年医学中心、中国医学科学院老年医学研究院北京100730

酰胺质子转移加权(APTw)成像是一种能够检测组织中可移动蛋白质和多肽中酰胺质子的分子成像技术,广泛应用于医学领域的研究中。近年来,随着新的APTw成像数据采集方案、后处理方法等的提出及深度学习的应用,APTw成像技术走向临床成为可... 详细信息

酰胺质子转移加权(APTw)成像是一种能够检测组织中可移动蛋白质和多肽中酰胺质子的分子成像技术,广泛应用于医学领域的研究中。近年来,随着新的APTw成像数据采集方案、后处理方法等的提出及深度学习的应用,APTw成像技术走向临床成为可能。该文中对APTw成像技术的发展及其临床应用进行总结,探讨该成像技术在当今医疗背景下的机遇和挑战,以促进APTw成像的临床应用,助力疾病精准诊疗。

关键词：磁共振成像化学交换饱和转移酰胺质子转移

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3.0 T脑肿瘤酰胺质子转移加权成像临床应用及检查技术规范专家共识解读

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中华放射学杂志 2024年第6期58卷 571-575页

作者：田瑶天李春媚陈敏北京医院放射科、国家老年医学中心、中国医学科学院老年医学研究院北京100730

酰胺质子转移加权(APTw)成像是通过检测距离水共振频率3.5 ppm处的酰胺基中可移动质子与水之间的交换速率,来反映组织中酰胺基浓度的技术。基于此,APTw成像可以根据组织中的内源性移动蛋白和肽生成图像对比度,从而在肿瘤性疾病中得到应... 详细信息

酰胺质子转移加权(APTw)成像是通过检测距离水共振频率3.5 ppm处的酰胺基中可移动质子与水之间的交换速率,来反映组织中酰胺基浓度的技术。基于此,APTw成像可以根据组织中的内源性移动蛋白和肽生成图像对比度,从而在肿瘤性疾病中得到应用。2022年,国际化学交换饱和转移成像工作组APTw成像小组首次发布了3.0 T脑肿瘤APTw成像临床应用的专家共识,旨在推动APTw成像在脑肿瘤中的进一步普及规范应用。本文将结合现有文献,就APTw成像目前在脑肿瘤临床应用中的现状及所面临的问题进行综述,并对共识中推荐的检查技术规范进行解读。

关键词：脑肿瘤磁共振成像酰胺质子转移加权成像临床应用规范化

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大约克公猪精液质量与粪便菌群的相关性分析

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南京农业大学学报 2024年第1期47卷 123-132页

作者：锁云鹏李晓彤李延森沈丹李春梅南京农业大学动物科技学院家畜环境控制与智慧生产研究中心江苏南京210095

[目的]本试验旨在研究不同精液质量公猪粪便的菌群组成、睾酮及内毒素水平,分析粪便菌群丰度与精液质量、睾酮及内毒素的相关性,为通过调控公猪肠道菌群改善精液质量提供依据。[方法]依据试验前3个月的所有公猪精液质量参数,挑选33头日... 详细信息

[目的]本试验旨在研究不同精液质量公猪粪便的菌群组成、睾酮及内毒素水平,分析粪便菌群丰度与精液质量、睾酮及内毒素的相关性,为通过调控公猪肠道菌群改善精液质量提供依据。[方法]依据试验前3个月的所有公猪精液质量参数,挑选33头日龄(479.33±2.85)和体况相近的大约克公猪,划分为低质量精液(LSQ)组(12头)和高质量精液(HSQ)组(21头)。采集试验公猪新鲜粪便进行睾酮和内毒素水平检测,并通过16S核糖体RNA(16S ribosomal RNA,16S rRNA)基因测序技术分析粪便的菌群组成。[结果]HSQ组公猪粪便睾酮水平显著高于LSQ组(Pligenes_group在LSQ组中显著富集(Pligenes_group和Faecalibaculum在LSQ组中显著富集(Pligenes_group丰度与精子活力及精子密度存在显著的负相关关系(P<0.01),与粪便睾酮水平呈负相关(P=0.11);Atopobiaceae丰度与精子活力、精子密度和粪便睾酮水平存在显著的正相关关系(P<0.05);Akkermansiaceae丰度与精子活力(P<0.01)及精子密度(P<0.05)存在显著的正相关关系,与粪便睾酮水平呈正相关(P=0.09)。[结论]不同精液质量的公猪粪便睾酮水平和菌群组成存在差异,公猪粪便菌群结构与精液质量、粪便睾酮水平存在不同程度的相关性,研究结果为通过调控肠道菌群来改善公猪精液质量提供新的理论支撑。

关键词：公猪精液质量睾酮内毒素粪便菌群

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