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Alkali/alkaline-earth metal-modified MnO_(x) supported on three-dimensionally ordered macroporous–mesoporous Ti_(x)Si+(1-x)O_(2) catalysts:Preparation and catalytic performance for soot combustion

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Journal of Environmental Sciences 2023年第3期125卷 82-94页

作者： Chao Peng Di Yu chunlei Zhang Maozhong Chen LanyiWang Xuehua Yu Xiaoqiang Fan Zhen Zhao Kai cheng Yongsheng Chen YuechangWei Jian Liu Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Energy and Catalysis Laboratory Department of Mechanical and Automation EngineeringThe Chinese University of Hong KongHong KongChina

The performance of catalysts used in after-treatment systems is the key factor for the removal of diesel soot,which is an important component of atmosphericfine particle ***,three-dimensionally ordered macroporous–mesoporous Ti_(x)Si+(1-x)O_(2)(3DOM-m Ti_(x)Si+(1-x)O_(2)) and its supported MnO_(x)catalysts doped with different alkali/alkaline-earth metals (AMnO_(x)/3 DOM-m Ti_(0.7)Si_(0.3)O_(2)(A:Li,Na,K,Ru,Cs,Mg,Ca,Sr,Ba)) were prepared by mesoporous template (P123)-assisted colloidal crystal template (CCT) and incipient wetness impregnation methods,*** characterizations of the catalysts were performed using scanning electron microscopy,X-ray diffraction,N_(2)adsorption–desorption,H_(2)temperature-programmed reduction,O_(2)temperature-programmed desorption,NO temperature-programmed oxidation,and Raman spectroscopy techniques;then,we evaluated their catalytic performances for the removal of diesel soot *** results show that the 3DOM-m Ti_(0.7)Si_(0.3)O_(2)supports exhibited a well-defined 3DOM-m nanostructure,and AMnO_(x)nanoparticles with 10–50 nm were evenly dispersed on the inner walls of the uniform *** addition,the as-prepared catalysts exhibited good catalytic performance for soot *** the prepared catalysts,CsMnO_(x)/3DOM-m Ti_(0.7)Si_(0.3)O_(2)had the highest catalytic activity for soot combustion,with T10,T50,and T90(the temperatures corresponding to soot conversion rates of 10%,50%,and 90%) values of 285,355,and 393℃,*** high catalytic activity of the CsMnO_(x)/3 DOM-m Ti_(0.7)Si_(0.3)O_(2)catalysts was attributed to their excellent low-temperature reducibility and homogeneous macroporous–mesoporous structure,as well as to the synergistic effects between Cs and Mn species and between CsMnO_(x)and the Ti_(0.7)Si_(0.3)O_(2)support.

关键词： Three-dimensionally ordered macroporous-mesoporous Ti_(0.7)Si_(0.3)O_(2) Alkali/alkaline-earth metals MnO_(x) Catalysts Preparation Soot combustion

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药品质量风险监测工作机制建设态势分析

药学研究 2022年第11期41卷 767-770页

作者：周维利赵艳霞孙铜王坤华逢彪宗凤玉程春雷山东省食品药品检验研究院山东济南250101 山东省药品监督管理局山东济南250014

目的分析山东省药品质量风险监测工作建设面临的态势,为进一步提高药品质量管理水平提供参考。方法梳理分析我省药品质量风险监测工作情况及采取的措施,参考道斯矩阵(SWOT)进行分析药品质量风险监测工作机制建设的优势、劣势、机会和挑... 详细信息

目的分析山东省药品质量风险监测工作建设面临的态势,为进一步提高药品质量管理水平提供参考。方法梳理分析我省药品质量风险监测工作情况及采取的措施,参考道斯矩阵(SWOT)进行分析药品质量风险监测工作机制建设的优势、劣势、机会和挑战。结果与结论药品质量风险监测工作,作为常规抽检的重要补充,发挥了药品监督及服务企业的作用,同时面临着内部和外部的有利与不利因素,建议充分利用网络智慧监管、优化抽检工作安排、加强业务培训、培养专家队伍、完善信息公开、注重日常监管,对药品质量风险监测工作机制不断完善,全面提升药品监管效能。

关键词：药品质量风险监测工作机制建设道斯矩阵

龙胆苦苷对大鼠血管平滑肌细胞增殖、迁移的影响

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药学研究 2019年第6期38卷 326-329页

作者：董圣军李欣高天勤刘宝辉程春雷吴恩刚王玉玖滨州医学院附属医院山东滨州256603 滨州市人民医院山东滨州255610 山东省食品药品检验研究院山东济南250101

目的观察龙胆苦苷对血管平滑肌细胞(vascular smooth muscle cells,VSMC)增殖、迁移能力的影响,并探讨其可能的作用机制。方法体外分离培养大鼠血管平滑肌细胞,将血管平滑肌细胞随机分为对照组、龙胆苦苷(GPS)处理组、PF-3758309+龙胆... 详细信息

目的观察龙胆苦苷对血管平滑肌细胞(vascular smooth muscle cells,VSMC)增殖、迁移能力的影响,并探讨其可能的作用机制。方法体外分离培养大鼠血管平滑肌细胞,将血管平滑肌细胞随机分为对照组、龙胆苦苷(GPS)处理组、PF-3758309+龙胆苦苷组。采用噻唑蓝(MTT)法观察各组细胞增殖能力,计算细胞增殖抑制率;采用细胞划痕实验观察各组细胞迁移能力,计算细胞迁移率。采用Western blotting法检测各组细胞Pak4及MMP-2表达情况。结果与对照组相比,龙胆苦苷组细胞增殖率及迁移率明显降低(P<0.01),龙胆苦苷组细胞内Pak4、MMP-2表达水平明显降低(P<0.01);而与龙胆苦苷组相比,PF-3758309+龙胆苦苷组可明显增加细胞增殖率及迁移率(P<0.05),血管平滑肌细胞内MMP-2表达水平明显上调(P<0.05)。结论龙胆苦苷具有抑制血管平滑肌细胞增殖及迁移,其机制可能与抑制Pak4相关。

关键词：龙胆苦苷血管平滑肌细胞细胞增殖细胞迁移

龙胆苦苷对人上皮性卵巢癌细胞增殖、凋亡、迁移的影响及机制

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山东医药 2019年第11期59卷 22-25页

作者：高天勤李欣董圣军程春雷史荣军贾龙王健刘宝辉滨州医学院附属医院山东滨州256603 滨州市人民医院山东省食品药品检验研究院阳信县人民医院

目的观察龙胆苦苷(GPS)对人上皮性卵巢癌HO8910细胞增殖、凋亡及迁移能力的影响,并探讨其可能的作用机制。方法培养人上皮性卵巢癌HO8910细胞,随机分为对照组、GPS低剂量组、GPS中剂量组、GPS高剂量组。对照组单纯加入0. 01%DMSO培养48 ... 详细信息

目的观察龙胆苦苷(GPS)对人上皮性卵巢癌HO8910细胞增殖、凋亡及迁移能力的影响,并探讨其可能的作用机制。方法培养人上皮性卵巢癌HO8910细胞,随机分为对照组、GPS低剂量组、GPS中剂量组、GPS高剂量组。对照组单纯加入0. 01%DMSO培养48 h,GPS低、中、高剂量组分别在加入10、20与40μmol/L GPS的DMEM培养液中培养48 h。采用MTT法观察各组细胞增殖能力,计算细胞增殖抑制率;采用TUNEL实验观察各组细胞凋亡情况,计算细胞凋亡率;采用细胞划痕实验观察各组细胞迁移能力,计算细胞迁移率。采用Western blotting法检测p-P38有丝分裂原激活的蛋白激酶(MAPK)、促凋亡蛋白B细胞白血病淋巴瘤相关蛋白(Bax)、抗凋亡蛋白B淋巴细胞/白血病-2(Bcl-2)的表达。结果与对照组相比,GPS中剂量组、GPS高剂量组细胞增殖抑制率、迁移率均降低,凋亡率均升高(P <0. 05或0. 01)。与对照组相比,GPS中剂量组、GPS高剂量组细胞内Bax、p-P38MAPK表达上调,Bcl-2表达下调(P <0. 05或0. 01)。结论 GPS具有抑制人上皮性卵巢癌HO8910细胞增殖及迁移并促进其凋亡的作用,其机制可能与激活P38 MAPK信号通路相关。

关键词：龙胆苦苷卵巢癌细胞增殖细胞凋亡细胞迁移

芍药苷对人上皮性卵巢癌HO8910细胞增殖、凋亡及迁移的影响及其机制研究

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药学研究 2019年第4期38卷 198-200,204页

作者：高天勤李欣董圣军程春雷史荣军贾龙王健刘宝辉滨州医学院附属医院山东滨州256603 滨州市人民医院山东滨州255610 山东省食品药品检验研究院山东济南250101 阳信县人民医院山东阳信251800

目的观察芍药苷(paeoniflorin,PF)对人上皮性卵巢癌HO8910细胞增殖、凋亡及迁移能力的影响,并探讨其可能的作用机制。方法培养人上皮性卵巢癌HO8910细胞,随机分为对照组、芍药苷低剂量组、芍药苷中剂量组、芍药苷高剂量组。芍药苷低、... 详细信息

目的观察芍药苷(paeoniflorin,PF)对人上皮性卵巢癌HO8910细胞增殖、凋亡及迁移能力的影响,并探讨其可能的作用机制。方法培养人上皮性卵巢癌HO8910细胞,随机分为对照组、芍药苷低剂量组、芍药苷中剂量组、芍药苷高剂量组。芍药苷低、中、高剂量组分别在加入0.5、1与2 mg·mL^(-1)芍药苷的DMEM培养液中培养48 h。采用噻唑蓝(MTT)法检测HO8910细胞增殖抑制率;TUNEL染色法检测细胞凋亡率;细胞划痕实验检测HO8910细胞迁移率;免疫蛋白印迹技术(Western blot)分析核因子-κB(NF-κB) p56、Bcl-2、caspase-3蛋白的表达。结果与对照组相比,芍药苷对HO8910细胞增殖、迁移率有明显的抑制作用并促进其凋亡(P<0.05),这种作用呈现剂量依赖性;芍药苷处理组细胞内caspase-3表达水平较对照组明显升高(P<0.05),Bcl-2、核因子-κB p56表达水平较对照组明显降低(P<0.05),且呈现剂量依赖性(P<0.05)。结论芍药苷可明显抑制HO8910细胞的增殖,诱导其凋亡;其机制部分可能与阻断核因子-κB通路有关。

关键词：芍药苷细胞增殖细胞凋亡细胞迁移核因子-κB信号通路

Chemical Composition and Size Distribution of Airborne Particulate Water-Soluble Species in Xi'an,Central China during Spring 2009:Implications for Heterogeneous Reactions of Anthropogenic Pollutants with Mineral Dust

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Chemical Composition and Size Distribution of Airborne Parti...

Wheat adaptation to environmental stresses under climate change:Molecular basis and genetic improvement

第八届海峡两岸气溶胶技术研讨会暨第三届空气污染技术研讨会

作者： Gehui Wang1, Bianhong Zhou2, ianjun Li1, chunlei cheng1, Ting Zhang1, Wenting Dai1, Junji Cao1, Renjian Zhang3 1 State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China 2 Department of Geographical Science and Environment Engineering, Baoji University of Art and Science, Baoji 721013, China 3 Key Laboratory of Regional Climate-Environment for East Asia, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China

PM10 and size-resolved (9-stage) aerosol samples in the urban air of Xi’an, China were collected during the spring of 2009 including a massive dust storm occurring on April 24th and measured for inorganic ions, water-soluble organic (WSOC) and inorganic carbon (WSIC), water-soluble organic nitrogen (WSON), EC and OC. Characteristics of chemical compositions and size-distributions of those measured species in the urban samples were investigated and further compared with those simultaneously observed on the mountaintop of Mt. Hua, which is located about 150 km east to the city, to recognize the impact of dust storm on aerosol chemistry of the downwind region. PM10 in Xi’an during the non-dust storm period ranged from 58-420 g m-3 (257±79 g m-3), and sharply increased to a 3-hr maximum of 890 g m-3 (av. 589±273 g m-3) on the dust storm day (April 24th). Mass-closure study results showed that during the non-dust storm period organic matters accounted for 25% of the PM10 particle mass, followed by SO42- (13%), NO3- (10%), water-soluble carbonate (10%), EC (5%), NH4+ (4%), and other ions (7%). In contrast, water-soluble carbonate became the most abundant among the measured species during the dust storm period, accounting for 12% of the PM10 mass, followed by organic matters (11%), SO42- (3%), Ca2+(2%) and NO3- (1.5%). Such a changes in chemical compositions suggests a significant heterogeneous reaction of acidic gases (e.g., H2SO4, HNO3, SO2 and N2O5) with dust to form water-soluble mineral compounds. A bimodal size distribution of particles was observed during the non-dust time with two equivalent peaks in the fine (2.1 m) ranges, in contrast to a unimodal pattern (i.e., coarse mode) observed on the dusty day. All the measured ions except NH4+ significant shifted toward larger particles during the dust storm time. Similar size-distribution patterns of particles were found on the mountaintop of Mt. Hua, which are bimodal during the non-dust period and

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Molecular Plant 2023年第10期16卷 1564-1589页

作者： Hude Mao Cong Jiang chunlei Tang Xiaojun Nie Linying Du Yuling Liu Peng cheng Yunfeng Wu Huiquan Liu Zhensheng Kang Xiaojie Wang State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Science Northwest A&F UniversityYanglingShaanxi 712100China

Wheat(Triticum aestivum)is a staple food for about 40%of the world’s *** the global population has grown and living standards improved,high yield and improved nutritional quality have become the main targets for wheat ***,wheat production has been compromised by global warming through the more frequent occurrence of extreme temperature events,which have increased water scarcity,aggravated soil salinization,caused plants to be more vulnerable to diseases,and directly reduced plant fertility and suppressed *** promising option to address these challenges is the genetic improvement of wheat for enhanced resistance to environmental *** decades of progress in genomics and genetic engineering has tremendously advanced our understanding of the molecular and genetic mechanisms underlying abiotic and biotic stress responses in *** advances have heralded what might be considered a“golden age”of functional genomics for the genetic improvement of ***,we summarize the current knowledge on the molecular and genetic basis of wheat resistance to abiotic and biotic stresses,including the QTLs/genes involved,their functional and regulatory mechanisms,and strategies for genetic modification of wheat for improved stress *** addition,we also provide perspectives on some key challenges that need to be addressed.

关键词： wheat genomics genetic improvement abiotic stress biotic stress climate change

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成都市小学生膳食摄入对肺功能的前瞻性影响

中国学校卫生 2024年第2期45卷 183-187,192页

作者：毛泳雯刘雪婷何春雷陈梦雪李丹婷张可馨张琴汪晓语徐裕杰成果四川大学华西公共卫生学院/四川大学华西第四医院成都610041 四川大学华西第二医院西部妇幼医学研究院妇儿营养中心四川大学华西护理学院

目的探讨小学生各食物组摄入对肺功能发育的前瞻性影响,为促进中国儿童肺功能的健康发育、预防慢性呼吸系统疾病提供理论依据。方法于2021年11月,采用整群随机抽样法抽取893名成都市二至五年级小学生作为调查对象,通过食物频率法收集调... 详细信息

目的探讨小学生各食物组摄入对肺功能发育的前瞻性影响,为促进中国儿童肺功能的健康发育、预防慢性呼吸系统疾病提供理论依据。方法于2021年11月,采用整群随机抽样法抽取893名成都市二至五年级小学生作为调查对象,通过食物频率法收集调查对象过去1年各类食物摄入情况,并用三分位法将食物组摄入量从低到高分为T1、T2、T3组;2022年对调查对象进行随访获取肺活量等体检数据。采用Logistic回归模型与趋势性检验分析小学生各食物组摄入对肺功能发育的前瞻性影响。结果男生中肺活量评分优良组摄入蔬菜[118.6(50.5,188.2)g/d]和奶及奶制品[200.0(73.3,250.0)g/d]高于肺活量评分非优良组[90.0(37.1,192.9),178.6(35.7,250.0)g/d],差异均有统计学意义(Z值分别为-1.98,-2.24);女生中肺活量评分优良组食用主食[391.1(273.6,511.4)g/d]少于肺活量评分非优良组[407.4(309.5,549.3)g/d],肺活量评分优良组摄入水产品[31.2(14.6,69.8)g/d]和奶及奶制品[215.0(107.1,250.1)g/d]高于肺活量评分非优良组[19.4(10.7,58.3),114.3(35.7,250.0)g/d],差异均有统计学意义(Z值分别为-2.01,-3.33,-5.10)(P值均<0.05)。在调整能量、体质量指数Z评分(BMI-Z)、母亲文化水平、家庭平均月收入、居住环境是否有人吸烟、近1周是否参加体育活动后,男生中蔬菜摄入T3组(OR=0.48,95%CI=0.27~0.86)、豆及豆制品摄入T2组(OR=0.52,95%CI=0.27~0.96)、奶及奶制品摄入T2组与T3组[OR值(95%CI)分别为0.54(0.31~0.93),0.52(0.30~0.90)]与肺活量非优良均呈负相关;女生中水产品摄入T3组(OR=0.52,95%CI=0.28~0.97)、奶及奶制品摄入T2组与T3组[OR值(95%CI)分别为0.44(0.25~0.76),0.33(0.19~0.59)]与肺活量非优良均呈负相关,红肉摄入T2组(OR=2.51,95%CI=1.37~4.67)与肺活量非优良呈正相关(P值均<0.05)。经趋势性检验发现,在男生中随着蔬菜和奶及奶制品摄入的增加,有降低肺活量非优良的可能;在女生中随着奶及奶制品摄入的增加,有降低肺活量非优良的可能,而红肉摄入的增加会增加肺活量非优良的可能(t值分别为-1.13,-0.44;-3.03,1.95,P_(趋势)值均<0.05)。结论奶及奶制品能降低小学生肺活量非优良的风险,蔬菜能降低男生肺活量非优良的风险,红肉会增加女生肺活量非优良的风险。应帮助儿童合理选择食物,以促进儿童肺功能的健康发育。

关键词：膳食摄食行为肺前瞻性研究儿童

Optimization of operating parameters of seeding device in plot drill with seeding control system

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International Journal of Agricultural and Biological Engineering 2021年第3期14卷 83-91页

作者： Xiupei cheng Hongwen Li Jin He Qingjie Wang Caiyun Lu Yingbo Wang Chao Wang chunlei Wang Shangyi Lou College of Engineering China Agricultural UniversityBeijing 100083China China Institute for Conservation Tillage China Agricultural UniversityBeijing 100083China

Plot drill has a significant impact on field breeding by replacing manual ***,the seeding performance of plot drill needs to be further improved as the mechanical transmission method cannot work under the optimal combination of operating *** this study,a cone compartment tray of sowing device was evaluated under the laboratory conditions,using a self-designed seeding control system to adjust the operating *** them,a plot seeding control system was involved that could set operating parameters through an Android terminal,which effectively reduced the difficulty of parameters *** method of central composite experiment design was employed to conduct experiments and explore the effects of experiment factors such as lifting height of storage tube(LHST),rotation speed of cone compartment tray(RSCCT),and rotation speed seed distributor(RSSD)on the seeding uniformity coefficient of variation among rows(SUCVR)and the rate of damaged seeds(RDS).For SUCVR of wheat,the results showed that the importance order of main factors from high to low was RSSD,RSCCT and *** for SUCVR of buckwheat,RSCCT had the largest influence,followed by RSSD,and LHST had the smallest *** RDS of wheat and buckwheat,only RSSD had a very significant effect among the main *** experiments data of wheat indicated that when operated at 27.2 mm for LHST,4.5 r/min for RSCCT and 1169 r/min for RSSD,the sowing performance of wheat was optimal,with SUCVR and RDS values of 5.02%and 0.117%,*** buckwheat seeding performance was found to be optimal when the LHST,RSCCT and RSSD were 26.5 mm,3.9 r/min and 711 r/min,and SUCVR and RDS were 4.74%and 0.113%.The seeding control system realized the electromechanical control of the seeding equipment,was convenient for parameter setting and stepless adjustment,and could be operated under an optimized combination of operating *** research results could provide a reference for the perform

关键词： plot drill seeding device seeding control system seeding performance parameter optimization