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Effect of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome： a patient-blinded pilot trial with orthogonal design

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Journal of Traditional Chinese Medicine 2017年第4期37卷 538-545页

作者： Yang Ling Lu Yuan Zhang Haifeng Ma Xiaopeng bao chunhui Wu Huangan Zhao Chen Ding Guanghong Qi Li Zhou Shuang Department of Mechanics and Engineering Science Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Fudan University Shanghai 200433 China Key Laboratory of Acupuncture-Moxibustion and Immunological Effects Shanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridians Shanghai 200030 China E-Institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Traditional Chinese Medicine Changhai Hospital Second Military Medical University Shanghai 200433 China

OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal ***: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were *** were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final ***: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and ***: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.

关键词： Irritable bowel syndrome Diarrhea Warming moxibustion Point ST25 (Tianshu), Point CV6 (Qihai) Quality of life

Acupuncture for Crohn’s disease:current status and future perspectives

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Acupuncture and Herbal Medicine 2023年第4期3卷 229-231页

作者： chunhui bao Jinrong Zhang Huangan Wu Yueyang Hospital of Integrated Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghaiChina

Crohn’s disease(CD),a type of inflammatory bowel disease,is a chronic,recurrent inflammatory disease of the intestine,with the main clinical manifestations including abdominal pain,diarrhea,and loss of body *** disease is common in Europe and the United States,and its incidence has increased in recent years in newly industrialized countries in Asia,Africa,and South America[1].

关键词： Acupuncture intestine diarrhea

Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome

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Journal of Traditional Chinese Medicine 2015年第4期35卷 402-410页

作者： Lu Zhenzhong Yin Xiaojun Teng Weijun Chen Yuehua Sun Jie Zhao Jimeng Wang Anqi bao chunhui Shi Yin Department of Physical Therapy and Acupuncture Jinhua Hospital of Zhejiang University Department of Medical Clinic Yueyang Chinese and Western Medicine Integrated Hospital affiliated to Shanghai University of Traditional Chinese Medicine Department of Gastroenterology Jinhua Hospital of Zhejiang University

OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive intestinal peptide(VIP)in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome(IBS-D and IBS-C,respectively).METHODS: Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli(ST 36)and Shangjuxu(ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions,a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases,leaving 81 participants(41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy,sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry ***: Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However,Mox was more effective at reducing diarrhea in IBS-D patients,whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa,with no significant difference shown between the two ***: Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients.

关键词： Irritable bowel syndrome Electroacu-puncture Moxibustion Substance P Vasoactive in-testinal peptide

Mild moxibustion at Tianshu (ST 25) decreases expression of prokineticin-1 and prokineticin receptor-1 in colon tissue of rats with chronic visceral hyperalgesia

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Neural Regeneration Research 2011年第33期6卷 2600-2604页

作者： Luyi Wu chunhui bao Linbao Ge Cili Zhou Huirong Liu Li Qi Tao Yi Huangan Wu Xiaomei Wang Qigong Institute Shanghai University of Traditional Chinese Medicine Shanghai 200030 China Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

Prokineticin-1 and prokineticin receptor-1 play important roles in visceral hypersensitivity and in-flammatory pain. Visceral hypersensitivity is closely associated with irritable bowel syndrome. Mild moxibustion can relieve chronic visceral hyperalgesia in rats with irritable bowel syndrome. We hypothesized that prokineticin-1 and prokineticin receptor-1 is the key target in the mechanism. This study established chronic visceral hyperalgesia rat models by colorectal distention. Protein and mRNA expression of prokineticin-1 and prokineticin receptor-1 were determined by immunohisto-chemical method and fluorescence quantitative-PCR, respectively, and were found to be signifi-cantly increased in visceral hyperalgesic rats. Mild moxibustion at Tianshu （ST 25） decreased prokineticin-1 and prokineticin receptor-1 expression in chronic visceral hyperalgesia rats and lessen the chronic visceral hyperalgesia in rats with irritable bowel syndrome at different levels of colorectal distention pressure.

关键词： mild moxibustion irritable bowel syndrome chronic visceral hyperalgesia prokineticins neural regeneration

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工程项目组织群落交错区的边缘效应

科技管理研究 2014年第23期34卷 191-194页

作者：鲍春晖冯东梅辽宁工程技术大学辽宁葫芦岛125105

对比建筑业与生态学的组织群体,划分建筑业组织层级,提出工程项目交错区及其边缘效应的概念。与生态系统中群落交错区类似,项目交错区边缘效应表现为集肤、加成、协同等作用。提出建立共生平台的建议,与项目交错区边缘效应共同作用,以... 详细信息

对比建筑业与生态学的组织群体,划分建筑业组织层级,提出工程项目交错区及其边缘效应的概念。与生态系统中群落交错区类似,项目交错区边缘效应表现为集肤、加成、协同等作用。提出建立共生平台的建议,与项目交错区边缘效应共同作用,以改善建筑群落中组织间的关系,从而促进项目顺利实施、行业健康发展。

关键词：工程项目建筑群落交错区边缘效应

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气动热环境下共形整流罩热辐射特性研究

应用光学 2017年第6期38卷 999-1005页

作者：薛文慧王惠包春慧范志刚哈尔滨工业大学空间光学工程研究中心黑龙江哈尔滨150001

高温整流罩产生强烈的红外辐射,在探测器接收面上形成背景噪声,严重影响成像质量。为了评估气动热环境下高速飞行器共形整流罩热辐射对探测器性能的影响,建立了气动热环境下整流罩热流固耦合计算模型、整流罩热辐射发射以及传输模型,计... 详细信息

高温整流罩产生强烈的红外辐射,在探测器接收面上形成背景噪声,严重影响成像质量。为了评估气动热环境下高速飞行器共形整流罩热辐射对探测器性能的影响,建立了气动热环境下整流罩热流固耦合计算模型、整流罩热辐射发射以及传输模型,计算了整流罩非均匀温度场、形变场、应力以及应变场,仿真得到了共形整流罩热辐射对高速飞行器光学系统成像质量的影响。研究结果表明:随着时间的不断增长,探测器接收面的最大辐照度也逐渐增大。在第10s时,0°攻角下共形整流罩热干扰辐照度最小值为0.094 W/m^2,最大值为0.108 W/m^2。和相同工况下的共形整流罩相比,球形整流罩10s时的最大辐照度分别是椭球面和抛物面形整流罩最大辐照度的近12倍和7倍,即共形整流罩产生的干扰对探测系统的影响较小,不会对探测器的探测性能产生致命性的影响。

关键词：气动光学共形整流罩热辐射辐照度

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论美日行政改革及其对中国的启示

山东医科大学学报（社会科学版） 2000年第1期14卷 48-52页

作者：鲍春晖山东大学山东济南250100

　 1 998年的中国政府机构改革以其是建国以来规模最大、力度最大、决心最大的机构改革为世界所瞩目。纵观我国的多次行政改革 ,不难发现总也逃不出“精简———膨胀”的怪圈。从横向角度分析 ,就会发现除了我国经济体制上的根本原因之... 详细信息

　 1 998年的中国政府机构改革以其是建国以来规模最大、力度最大、决心最大的机构改革为世界所瞩目。纵观我国的多次行政改革 ,不难发现总也逃不出“精简———膨胀”的怪圈。从横向角度分析 ,就会发现除了我国经济体制上的根本原因之外 ,我国历次对行政改革的操作却是存在着问题的。通过对行政改革比较成功的美日行政改革的分析 ,我们可以得到一些有益的启示 :第一 ,加强行政立法 ,将行政改革纳入法制化轨道 ;第二 ,建立权威性的调研机构 ,以保证改革方案的科学性和可行性 ;第三 ,坚持改革的连续性、渐进性。

关键词：行政改革法制化美国日本中国

急性左心功能衰竭采用左西孟旦的临床干预评价

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中国社区医师 2016年第19期32卷 16-17页

作者：包春辉吉化集团公司总医院心内二疗区 132021

目的:评价急性左心功能衰竭采用左西孟旦的临床干预效果。方法:收治急性左心衰患者160例,随机平分为两组,并接受基线治疗。对照组给予多巴酚丁胺,研究组给予左西孟旦。对比两组疗效、主要心功能指标治疗前后变化及不良反应。结果:研究... 详细信息

目的:评价急性左心功能衰竭采用左西孟旦的临床干预效果。方法:收治急性左心衰患者160例,随机平分为两组,并接受基线治疗。对照组给予多巴酚丁胺,研究组给予左西孟旦。对比两组疗效、主要心功能指标治疗前后变化及不良反应。结果:研究组及对照组总有效率分别为91.25%及76.25%,研究组显著优于对照组。研究组治疗后左室射血分数、每搏输出量及血浆脑钠肽水平显著好于对照组(P<0.05)。结论:急性左心功能衰竭采用左西孟旦疗效确切,显著改善心功能,安全性好。

关键词：急性左心功能衰竭左西孟旦多巴酚丁胺

慢性心力衰竭应用新活素、左西孟旦和托伐普坦联合治疗的疗效分析

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中国卫生标准管理 2016年第16期7卷 102-104页

作者：包春辉吉化集团公司总医院心血管内科吉林吉林132021

目的探讨慢性心力衰竭使用新活素、左西孟旦和托伐普坦联合治疗的临床效果。方法将我院66例慢性心力衰竭患者随机分为研究组和对照组各33例,对照组应用基础治疗及硝酸甘油联合洋地黄进行治疗;研究组给予基础治疗及新活素、左西孟旦和托... 详细信息

目的探讨慢性心力衰竭使用新活素、左西孟旦和托伐普坦联合治疗的临床效果。方法将我院66例慢性心力衰竭患者随机分为研究组和对照组各33例,对照组应用基础治疗及硝酸甘油联合洋地黄进行治疗;研究组给予基础治疗及新活素、左西孟旦和托伐普坦联合治疗。观察两组疗效、心功能及不良反应。结果研究组总有效率90.9%,显著高于对照组63.6%(P<0.05),研究组心功能相关指标显著优于对照组(P<0.05)。两组均无不良反应。结论使用新活素、左西孟旦和托伐普坦联合治疗慢性心力衰竭疗效满意,安全性好。

关键词：慢性心力衰竭新活素左西孟旦托伐普坦