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Dynamic Economic Scheduling with Self-Adaptive Uncertainty in Distribution Network Based on Deep Reinforcement Learning

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Energy Engineering 2024年第6期121卷 1671-1695页

作者： Guanfu Wang Yudie Sun Jinling li Yu Jiang chunhui li Huanan Yu He Wang Shiqiang li State Grid liaoning Electric Power Co. Ltd.Liaoyang Power Supply CompanyLiaoyang111000China Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin132012China Jilin Northeast Electric Power University Science and Technology Development Co. Ltd.Jilin132012China

Traditional optimal scheduling methods are limited to accurate physical models and parameter settings, which aredifficult to adapt to the uncertainty of source and load, and there are problems such as the inability to make dynamicdecisions continuously. This paper proposed a dynamic economic scheduling method for distribution networksbased on deep reinforcement learning. Firstly, the economic scheduling model of the new energy distributionnetwork is established considering the action characteristics of micro-gas turbines, and the dynamic schedulingmodel based on deep reinforcement learning is constructed for the new energy distribution network system with ahigh proportion of new energy, and the Markov decision process of the model is defined. Secondly, Second, for thechanging characteristics of source-load uncertainty, agents are trained interactively with the distributed networkin a data-driven manner. Then, through the proximal policy optimization algorithm, agents adaptively learn thescheduling strategy and realize the dynamic scheduling decision of the new energy distribution network ***, the feasibility and superiority of the proposed method are verified by an improved IEEE 33-node simulationsystem.

关键词： Self-adaptive the uncertainty of sources and load deep reinforcement learning dynamic economic scheduling

A general and facile calcination method to synthesize single-site catalysts for highly efficient electrochemical CO_(2) reduction

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Nano Research 2024年第5期17卷 3895-3901页

作者： Rui Sui Bingyan Wang Yongsheng Wang Jiajing Pei Wei Zhu Wenxing Chen chunhui li Ailing Sun Zhongbin Zhuang Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China College of Chemistry and Green Catalysis Center Zhengzhou UniversityZhengzhou 450001China State Key Lab of Organic-Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

The electrochemical CO_(2) reduction reaction(CO_(2)RR)has received widespread attention as a promising method for producing sustainable chemicals and mitigating the global ***,we demonstrate a general and facile synthetic route for the metal-nitrogen-carbon(M-N-C)type catalyst by simply calcinating metal acetate and urea with commercial carbon black,which have potential application in CO_(2)*** synthesized Ni-NC-600 catalyst has the structure of single Ni atom coordinated with one N atom and three C atoms(Ni-N_(1)C_(3)),which is suggested by X-ray absorption *** Ni-NC-600 catalyst exhibits high CO_(2)RR catalytic performance and a high CO Faraday efficiency above 98%in a wide potential range from-0.7 to-1.3 V(*** hydrogen electrode(RHE)),superior to most of the reported Ni-N-C *** work has developed a facile strategy to synthesize high performance CO_(2)RR catalyst.

关键词： nickel single atom catalyst CO_(2)reduction reaction CO production electrocatalyst

pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 781-794页

作者： Shuai Guo chunhui li Changrong Wang Xiaowen Cao Xinyue liu Xing-Jie liang Yuanyu Huang Yuhua Weng School of Medical Technology Advanced Research Institute of Multidisciplinary ScienceSchool of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China School of Pharmacy Shandong New Drug Loading&Release Technology and Preparation Engineering LaboratoryBinzhou Medical UniversityYantai 264003China School of Ophthalmology and Optometry School of Biomedical EngineeringThe Eye HospitalWenzhou Medical UniversityWenzhou 325027China Chinese Academy of Sciences(CAS) Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China

Small interfering RNA(siRNA)has a promising future in the treatment of ocular diseases due to its high efficiency,specificity,and low toxicity in inhibiting the expression of target genes and ***,due to the unique anatomical structure of the eye and various barriers,delivering nucleic acids to the retina remains a significant *** this study,we rationally design PACD,an A-B-C type non-viral vector copolymer composed of a hydrophilic PEG block(A),a siRNA binding block(B)and a pH-responsive block(C).PACDs can self-assemble into nanosized polymeric micelles that compact siRNAs into polyplexes through simple *** evaluating its pH-responsive activity,gene silencing efficiency in retinal cells,intraocular distribution,and anti-angiogenesis therapy in a mouse model of hypoxia-induced angiogenesis,we demonstrate the efficiency and safety of PACD in delivering siRNA in the *** are surprised to discover that,the PACD/siRNA polyplexes exhibit remarkable intracellular endosomal escape efficiency,excellent gene silencing,and inhibit retinal *** study provides design guidance for developing efficient nonviral ocular nucleic acid delivery systems.

关键词： SiRNA Oculardeliverysystem Block polymer Endosomalescape Retinal neovascularization Blood-retinal barrier VEGFA Safety

An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus

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Chinese Chemical Letters 2024年第8期35卷 466-470页

作者： Yuxin Tian Mengjun li Yang Yang chunhui li Yun Peng Haiyin Yang Mengyuan Zhao Pengfei Wu Shaobo Ruan Yuanyu Huang Chenguang Shen Minghui Yang Advanced Research Institute of Multidisciplinary Science School of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China BSL-3 Laboratory(Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthDepartment of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

The monkeypox virus(MPXV)outbreak,declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)in 2022,continues to pose a significant threat due to the absence of vaccines or drugs for MPXV *** this study,we developed an mRNA vaccine that expressing the A29L antigen,a specific protein of the intracellular mature *** vaccine utilizes a thermostable ionizable lipid nanoparticle(iLNP)platform and has been administered to *** find-ings demonstrate that the MPXV A29L mRNA vaccine candidate induces robust cross-neutralizing immune responses against both vaccinia virus(VACV)and MPXV live ***,immunization with the vaccine candidate provided protection against the VACV challenge in *** findings underscore the potential of mRNA-LNP vaccines as safe and effective candidates against monkeypox *** the current absence of specific interventions for MPXV infection,our study represents a significant step forward in developing a viable solution to combat this ongoing public health threat.

关键词： Monkeypox virus mRNA vaccine lipid-nano particle A29L VACV

New Quality Productive Forces:New Hope for Economic Growth

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China Report ASEAN 2024年第2期9卷 18-21页

作者： li chunhui Wang Chenxi 不详

On January 17,China announced a GDP growth rate of 5.2 percent for 2023,successfully reaching the major projected *** 2024,the Chinese economy will continue to seek progress while maintaining stability and provide great dynamism for the stability and recovery of the world *** quality productive forces will become a new driver for economic growth in China.

关键词： continue Quality forces

黄河流域农业农村氮流时空分布特征及演化规律研究

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环境科学研究 2024年第1期37卷 80-91页

作者：张弼庞爱萍李春晖中共宁夏回族自治区委员会党校(宁夏行政学院) 宁夏银川750021 中共南京市委党校江苏南京210046 北京师范大学环境学院北京100875

氮磷等营养元素过剩引发的面源污染问题,是黄河流域水质恶化的重要原因.为应对黄河流域氮素危机,从源头上降低面源污染负荷,本研究基于物质流和空间分析方法,刻画1949-2022年间黄河流域农业农村氮流时空格局演化规律,评估黄河流域面源... 详细信息

氮磷等营养元素过剩引发的面源污染问题,是黄河流域水质恶化的重要原因.为应对黄河流域氮素危机,从源头上降低面源污染负荷,本研究基于物质流和空间分析方法,刻画1949-2022年间黄河流域农业农村氮流时空格局演化规律,评估黄河流域面源污染关键氮流和高风险区.结果表明:(1)新中国成立以来,黄河流域的作物收获量整体呈现上升的趋势,2015年之后在氮输入水平持续下降的情况下,仍然能够保持年均2%的增长,黄河流域在氮素利用水平上得到了极大的提升.(2)黄河流域农业农村依然存在严重的氮流失现象,其中存贮和反硝化是氮流失的主要部分,1962年、1992年和2022年这两部分流失量分别占耕地氮输出流的51%、47%和36%.2015开始氮素流失(存储)量逐年下降,2022年比2015年减少了15.55%,但是每年仍有30.12×10^(8)kg氮素流失到大气、水体和土壤中,是当年作物收获氮量的1.64倍,氮素损失率高达62.05%.(3)降雨和地势地形是影响氮径流的决定因素,在高风险区内约有27%~45%的氮剩余流失到附近的地表水中,主要分布在甘肃省的最南部和东南角部分地区、陕西省的最南部和山东省东部地区.研究显示:黄河流域在氮素利用提升和氮污染治理方面取得一定成效,但是仍然存在严重的氮流失现象;需要持续推进化肥减量、粪便还田和农村污水治理,同时需要在高风险区采取构建缓冲带等工程措施,才能实现面源污染等氮危机的有效控制.

关键词：黄河流域农业农村污染氮流路径时空分布高风险区

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang chunhui li Guoguo Ye Chenguang Shen Huiping Shi liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia liu Ge Yang Yuanyu Huang Yongxiang Zhao School of life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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基于HYCOM的西南黄海沿岸上升流分析

海洋通报 2024年第1期43卷 86-96页

作者：潘锡山李春辉王彬江苏省海涂研究中心江苏南京210036 南京信息工程大学海洋科学学院江苏南京210044 江苏科技大学船舶与海洋工程学院江苏镇江210024

沿岸上升流影响着近岸的营养物质的分布,从而对海洋生态环境的分布产生影响。本文利用经遥感SST数据检验的HYCOM模式数据,对黄海西南沿岸上升流的分布进行分析。从气候态变化、年际变化和季节内变化等三个时间尺度对西南黄海夏季的冷水... 详细信息

沿岸上升流影响着近岸的营养物质的分布,从而对海洋生态环境的分布产生影响。本文利用经遥感SST数据检验的HYCOM模式数据,对黄海西南沿岸上升流的分布进行分析。从气候态变化、年际变化和季节内变化等三个时间尺度对西南黄海夏季的冷水斑和上升流进行分析,分析表明:多年平均的海表冷水斑中心纬度在33.60°N附近;在年际变化中,沿岸上升流对表层冷水斑的面积有影响,沿岸上升流的垂向流速对海面温度有一定影响;在季节内变化中,沿岸上升流的流速与冷水斑的面积及表层海水温呈中度相关性。基于ERA5风场再分析资料,从风应力和风应力旋度对Ekman输运和Ekman抽吸的影响来分析黄海西南部的沿岸上升流机制,结果表明风应力和风应力旋度与沿岸上升流的平均流速呈中度相关。

关键词：沿岸上升流西南黄海 HYCOM 冷水斑

基于多项式混沌展开的电力系统概率可用输电能力评估

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中国电机工程学报 2024年第2期44卷 489-503,I0005页

作者：姜涛李春晖张儒峰陈厚合李国庆现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林省吉林市132012

大规模开发和利用风能有利于实现电力系统清洁低碳转型,是实现国家“碳达峰、碳中和”战略目标的重要技术手段,但风电出力的强不确定性对电力系统区域间可用输电能力(available transfer capability,ATC)评估带来了全新的挑战,传统用于... 详细信息

大规模开发和利用风能有利于实现电力系统清洁低碳转型,是实现国家“碳达峰、碳中和”战略目标的重要技术手段,但风电出力的强不确定性对电力系统区域间可用输电能力(available transfer capability,ATC)评估带来了全新的挑战,传统用于求解计及风电出力不确定性的概率ATC评估模型在计算效率和计算精度方面均存在一定的不足。为此,该文提出一种基于多项式混沌展开(polynomialchaos expansion,PCE)的电力系统概率ATC评估方法,该方法首先构建基于机会约束的电力系统概率ATC评估模型;然后,根据风电出力预测误差的概率分布特征,选择对应的正交多项式为基函数以近似风电出力预测误差及电力网络中与之相关联的其他随机变量;进一步,借助Galerkin投影和基于一阶矩、二阶矩的机会约束转化方法,将所构建的机会约束模型的概率约束转化为确定性约束,实现基于机会约束的概率ATC评估模型向易于求解的确定性优化模型的转化;进而,将概率ATC评估模型的求解问题转化为ATC的最优多项式逼近系数的求解问题,根据求得的最优多项式逼近系数和选取的基函数计算电力系统ATC的概率分布特征;最后,通过修改后的PJM-5节点测试系统、IEEE-118节点测试系统及吉林西部电网实际算例验证了所提基于多项式混沌展开的电力系统概率ATC评估方法的准确性和有效性。

关键词：可用输电能力多项式混沌展开概率模型机会约束不确定性分析

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