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Ni-catalyzed cross-electrophile alkyl-alkyl coupling reactions

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Science China Chemistry 2025年

作者： Li-Xu You lan Tian Chun-Ling Guo Shun-Xi Li yu-Cheng Liu yu-Long Li Wei Shu College of Chemistry and Environmental Engineering Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science and Engineering Guangming Advanced Research Institute Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology

Introducing saturated carbon-carbon bonds into organic molecules significantly increases the three-dimensional configuration,thus altering the physical and chemical properties as well as the functions of molecules. Transition-metal-catalyzed carboncarbon cross-couplings represent one of the most straightforward, efficient and modular alternatives to build saturation in a single step. However, the efficient construction of alkyl-alkyl bonds remains a formidable challenge due to the precise manipulation of multiple alkyl metallic intermediates as well as associated competitive side reactions and selectivity control. Over the past years, Ni-catalyzed cross-coupling under reductive conditions has gained more and more attention for alkyl-alkyl crosscoupling partially attributing to the low-valent state of metal centers under reducing conditions, which suppresses the competitive β-hydride elimination process, thus facilitating the formation of alkyl-alkyl bonds. In this review, the initiative and progress of Ni-catalyzed cross-electrophile alkyl-alkyl cross-coupling, including the efforts in racemic and enantioselective formation of alkyl-alkyl bonds, have been summarized and discussed. Moreover, the challenges and further opportunities in this area have also been discussed.

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng lan Zheng Wu Wen-Jia Chen Xin-Ning yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

基于SSR标记的澜沧江流域大理茶群体遗传多样性研究

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农业生物技术学报 2025年第1期33卷 68-78页

作者：黄利超陈洪宇罗义菊陶燕蓝蓝增全西南林业大学园林园艺学院西南林业大学古茶树研究中心

大理茶(Camellia taliensis)是茶的重要野生近缘种，是茶资源的重要组成部分，研究大理茶群体的遗传多样性和亲缘关系，对科学保护和合理利用大理茶种质资源至关重要。本研究应用SSR标记技术对澜沧江流域5个州市共45份大理茶种和5份普洱... 详细信息

大理茶(Camellia taliensis)是茶的重要野生近缘种，是茶资源的重要组成部分，研究大理茶群体的遗传多样性和亲缘关系，对科学保护和合理利用大理茶种质资源至关重要。本研究应用SSR标记技术对澜沧江流域5个州市共45份大理茶种和5份普洱茶(C. sinensis var. assamica)种的种质资源进行遗传多样性和亲缘关系分析。结果显示，15对有效引物共检测到55个多态性位点，每对引物平均扩增3.67个位点；大理茶资源的平均期望杂合度(epected heterozygosity, He)为0.346；多态信息含量(polymorphism information content, PIC)变化范围是0.024～0.661，平均值为0.381；香农指数变化范围是0.067～1.321，平均值为0.669；多态性引物比例为60.0%，多态性引物占有效引物的比例为75.0%。聚类分析结果显示，澜沧江流域大理茶树种质分类与地理区域具有相关性，地理位置较远的大理茶树居群间的遗传距离较远，但居群内遗传距离较近。以上结果表明，澜沧江流域大理茶资源具有中等遗传多样性和中等丰富度。本研究为大理茶种质资源的保护开发及遗传图谱构建提供参考。

关键词：大理茶遗传多样性 SSR

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巴西龟代谢性骨病CT诊断病例报告

动物医学进展 2025年第1期46卷 141-144页

作者：孙嘉徐甘靖宇江蓝刘波俞峰中国农业大学北京100193

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检... 详细信息

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检结果提示其肾脏、肝脏功能损害,钙磷代谢异常。CT扫查提示患龟全身组织大面积矿化、背甲凹陷,定量测量患龟背椎骨、神经骨和胸膜骨3处的骨骼密度远低于正常龟,诊断患龟有严重的MBD。治疗方案为对症治疗、改善饲养管理条件,同时对该龟补充维生素D 3。该病例报告系统陈述了龟鳖MBD的诊疗流程,同时表明了CT扫查可为龟鳖MBD精确诊断、治疗和预后提供新的参考。

关键词：龟代谢性骨病计算机断层扫描骨密度

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Composition and morphology of the thermal decomposition products of 3Mg（OH）2·MgCl2·8H2O nanowires

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Particuology 2017年第1期15卷 129-134页

作者： Bo yu lan Xiang Department of Chemical Engineering Tsinghua University Beijing 100084 China

The thermal decomposition of 3Mg（OH）2·MgCl2·8H2O （318MHCH） nanowires synthesized from agglom- erated Mg（OH）2 microspheres was investigated. The influence of heating rate and temperature on the composition and morphology of the products was investigated. Thermogravimetric-differential scan- ning calorimetry, field-emission scanning electron microscopy, high-resolution transmission electron microscopy, and X-ray diffraction showed that increasing the heating rate from I to 20 ℃/min promoted the escape of crystalline water from the 318MHCH nanowires. 318MHCH nanowires were dehydrated stepwise to 310MHCH porous nanowires from room temperature to 320℃, and then to MgO cubic nanoparticles from 420 to 700 ℃. The nanowires retained their one-dimensional morphology, until the phase changed to MgO. The immediate collapse of the one-dimensional structure was attributed to the presence of Mg-O/Cl chains.

关键词： Magnesium hydroxide chloride hydrates Thermal decomposition Nanowires Immediate collapse Mg-O/Cl chains

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： Xing-yu Chen Xiang lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

One-step device-independent quantum secure direct communication

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Science China(Physics,Mechanics & Astronomy) 2022年第5期65卷 1-12页

作者： lan Zhou yu-Bo Sheng School of Science Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China

Device-independent quantum secure direct communication(DI-QSDC)can relax the security assumptions about the devices’internal working,and effectively enhance QSDC’s *** this paper,we put forward the first hyperentanglement-based one-step DI-QSDC *** this protocol,the communication parties adopt the nonlocal hyperentanglement-assisted complete Bell state analysis,which enables the photons to transmit in the quantum channel for only one *** one-step DI-QSDC can directly transmit 2 bits of messages by a hyperentangled photon pair,and is unconditionally secure in *** with the original DI-QSDC protocol(***.65,12(2020)),the one-step DI-QSDC protocol can simplify the experiment and reduce the message *** particular,with the help of the hyperentanglement heralded amplification and the hyperentanglement purification,the message loss and the message error caused by the channel noise can be completely eliminated,and the communication distance can be largely *** using the photon source with a repetition rate of 10 GHz,the one-step DI-QSDC’s secret message capacity under 50 km communication distance achieves about 7 bit/s with the initial fidelity in each degree of freedom of *** with the quantum repeater,it is possible for researchers to realize the one-step DI-QSDC with an arbitrarily long distance.

关键词： device-independent quantum secure direct communication hyperentanglement nonlocal Bell state analysis

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形成性评价在口腔医学理论教学中的实践与反思

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黑龙江高教研究 2025年第1期43卷 60-65页

作者：郭若兰林思宇林江首都医科大学附属北京同仁医院北京100730

目的:利用形成性评价对学生的教学评价进行改进,对口腔医学理论的教学方法进行修正,以期望提升临床教学的效果。方法:实验对象为某医科大学临床医学专业学生(包括五年制和5+3一体化两种学制),通过是否参与形成性评价教学分为对照组和实... 详细信息

目的:利用形成性评价对学生的教学评价进行改进,对口腔医学理论的教学方法进行修正,以期望提升临床教学的效果。方法:实验对象为某医科大学临床医学专业学生(包括五年制和5+3一体化两种学制),通过是否参与形成性评价教学分为对照组和实验组。对照组采用传统教学模式,主要利用教师课堂授课;实验组利用形成性评价改进教学模式,不断对学生的学习情况进行反馈和改进,最终通过期末考试定量评价对比学生的学习效果。结果:在两种学制中,实验组学生均比同学制对照组学生期末成绩有所提高,且差异具有统计学意义(P<0.05)。结论:通过形成性评价改进教学模式,能促进学生自主学习,提高学生综合学习的能力,提升学习效果。

关键词：形成性评价口腔医学教学方法

A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan's tropical environment

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 127-133页

作者： yu-Hao Wang yu-Chieh Wang Pi-Hsiung Wu lan Hsu chung-Yang Wang chung-Ren Jan Hsing-Hao Su Department of Microbiology and Immunology University of Rochester Department of Biology Wake Forest University Department of Otorhinolaryngology Head and Neck SurgeryKaohsiung Veterans General Hospital Department of Dermatology Kaohsiung Veterans General Hospital Anshing Clinic Department of Medical Education and Research Kaohsiung Veterans General Hospital

Objective:To discuss the effect of lesser-known potential risk factors,such as bedroom showers,on the prevalence of allergic ***:A cross-sectional,population-based study was performed using both survey and fungal culturing in southern *** were 998 participants enrolled in the survey,and 513 sets of fungal culture *** score for allergic rhinitis(SFAR) more than 7,the patient was defined to have allergic *** of allergic rhinitis were calculated as odds ratios for various predicted risk factors by logistic *** between predicted risk factors and fungal level were examined with linear ***:The adjusted odds ratio of frequently using bedroom shower to having allergic rhinitis was 1.572(95% confidence interval:1.090-2.265),and 0.962 for people with older age to have AR(95% confidence interval:0.949-0.976).As to the 24-hour fungal level,the standardized coefficient was 0.254 for frequent use of bedroom shower,and 0.106 for window open ***:Use of bedroom shower is a potential risk factor for allergic rhinitis development.

关键词： Allergic rhinitis Allergens Environment Fungi Indoor air quality