检索结果-南通市图书馆

Updates on hepatorenal syndrome and strategies bridging to liver transplantation

在线全文

学校读者我要写书评

暂无评论

Hepatoma Research 2017年第4期3卷 67-72页

作者： chung yeung cheung Kenneth SHChok Department of Surgery Queen Mary Hospital9990777Hong KongChina Department of Surgery University of Hong Kong999077Hong KongChina State Key Laboratory for Liver Research University of Hong Kong999077Hong KongChina.

Hepatorenal syndrome is not an uncommon life-threatening complication arising from liver cirrhosis. The diagnostic criteria for this syndrome have been revised throughout the years, with recent revisions aimed at improving earlier diagnosis and treatment. Liver transplantation remains the only definitive treatment for hepatorenal syndrome. Due to the scarcity of liver grafts, many patients die waiting. This review focuses on the different strategies to bridge patients to liver transplantation and to improve the postoperative outcome.

关键词： Hepatorenal syndrome liver cirrhosis terlipressin liver transplantation portal hypertension acute kidney injury

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung cheung Wong Hoi She Siu Lun Ho Albert Chi Yan Chan chung Mau Lo Tan To cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang Wong Hoi She Simon Hing-Yin Tsang chung Mau Lo Kwan Man Tan To cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

ML(n)BiCGStab: Reformulation, Analysis and Implementation

在线全文

学校读者我要写书评

暂无评论

Numerical Mathematics(Theory,Methods and Applications) 2012年第3期5卷 447-492页

作者： Man-chung yeung Department of Mathematics University of WyomingLaramieWY 82071USA

With the aid of index functions,we re-derive the ML(n)BiCGStab algorithm in[yeung and Chan,SIAM ***.,21(1999),pp.1263-1290]*** are n ways to define the ML(n)BiCGStab residual *** definition leads to a different ML(n)BiCGStab *** demonstrate this by presenting a second algorithm which requires less *** theory,this second algorithm serves as a bridge that connects the Lanczos-based BiCGStab and the Arnoldi-based FOM while ML(n)BiCG is a bridge connecting BiCG and *** also analyze the breakdown situation from the probabilistic point of view and summarize some useful properties of ML(n)*** issues are also addressed.

关键词： CGS BiCGStab ML(n)BiCGStab multiple starting Lanczos Krylov subspace iterative methods linear systems

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

切合法在儿童语音障碍治疗中的临床应用

中国听力语言康复科学杂志 2024年第1期22卷 31-33,37页

作者：钟玉梅张显达马偕医学院听力暨语言治疗学系中国台湾25245 亚洲大学听力暨语言治疗学系中国台湾41354

切合法是基于汉语一字一音和音节高度规律性的治疗方法。在语音障碍干预过程中,切合法利用儿童已掌握的语音或音节,通过音节分切与重组,示范目标音的产生过程,使用其他辅助音消除音系历程和学习新语音,能顺畅而有效地达成语音发音错误... 详细信息

切合法是基于汉语一字一音和音节高度规律性的治疗方法。在语音障碍干预过程中,切合法利用儿童已掌握的语音或音节,通过音节分切与重组,示范目标音的产生过程,使用其他辅助音消除音系历程和学习新语音,能顺畅而有效地达成语音发音错误矫治的目标。本文分析汉语音系特征和主要分切及组合技巧、临床常见的音系历程、切合法配合应用的治疗法,并分享临床个案,以说明不同切合的细节及应用时机。

关键词：语音障碍切合法音系历程

Survival outcome of lobar or segmental transcatheter arterial embolization with ethanol-lipiodol mixture in treating hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第18期11卷 2792-2795页

作者： Yun-chung cheung Sheung-Fat Ko Shu-Hang Ng Siu-cheung Chan Department of Diagnostic Radiology Chang Gung Memorial Hospital at Keelung and at Kaohsiang 5 Fu Hsing Street Kwei Shan Tao Yuan Hsien Taiwan China

AIM: To evaluate the dinical outcome and cost-effectiveness of transcatheter arterial ethanol-lipiodoi embolotherapy on hepatocellular carcinoma (HCC). METHODS: One hundred patients with HCC who were treated only by lobar or segmental transarterial embolization (TAE) with ethanol-lipiodoi mixture were enrolled in this study. The 1st- and 2nd-year survival rates were analyzed to evaluate the feasibility of its method. These outcomes of our patients were individually correlated to the Child-Pugh classification and the computed tomographic features of HCC. RESULTS: The overall 1st- and 2nd-year survival rates were 72% and 46%, respectively. The patients were classified into three groups according to their liver function status: 68 patients as Child-Pugh class A, 26 as Child B, and 6 as Child C. Child A had better survival rate than the Child B and/or C. The 1st-year survival rates of patients with Child A-C were 84%, 50%, and 33.3% respectively and the 2nd-year survival rates were 55.5%, 28.5%, and 33.3%, respectively. According to the computed tomographic features, solitary HCC with maximum diameter less than 5 cm had the best outcome with the lst-year survival rate of 100% and the 2nd-year survival rate of 71.4%, while solitary HCC with maximum diameter over 5 cm and multiple HCC had the lst-year survival rates of 75% and 63.7%, respectively, and the 2nd-year survival rates of 33.3% and 44.4%, respectively. Only one patient was complicated with abscess formation and was cured with antibiotic therapy. No mortality resulted from the procedures performed. CONCLUSION: TAE with ethanol-lipiodoi mixture is an economic, safe and feasible method for treating HCC, especially for the patients with smaller solitary HCC or with liver function status of Child-Pugh class A.

关键词： Liver Hepatoma Transcatheter arterial embolization Treatment Survival outcome

Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1566-1575页

作者： Angela Ka Wai Lai Tsz chung Ng Victor Ka Lok Hung Ka cheung Tam Chi Wai cheung Sookja Kim chung Amy Cheuk Yin Lo Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina Department of Anesthesiology Laboratory and Clinical Research Institute for PainThe University of Hong KongHong Kong Special Administration RegionChina Macao University of Science and Technology TaipaMacao Special Administration RegionChinaSchool of Biomedical SciencesThe State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong Kong Special Administration RegionChina

Reperfusion therapy is the preferred treatment for ischemic stroke,but is hindered by its short treatment window,especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated *** mechanisms underlying exacerbated hemorrhage are not fully *** study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2Akita/+mice to mimic patients with diabetes undergoing delayed mechanical *** results showed that at as early as 2 hours after reperfusion,Ins2Akita/+mice exhibited rapid development of neurological deficits,increased infarct and hemorrhagic transformation,together with exacerbated down-regulation of tight-junction protein ZO-1 and upregulation of blood-brain barrier-disrupting matrix metallopeptidase 2 and matrix metallopeptidase 9 when compared with normoglycemic Ins2+/+*** indicated that diabetes led to the rapid compromise of vessel integrity immediately after reperfusion,and consequently earlier death and further aggravation of hemorrhagic transformation 22 hours after *** observation was associated with earlier and stronger up-regulation of pro-angiogenic vascular endothelial growth factor(VEGF)and its downstream phospho-Erk1/2 at 2 hours after reperfusion,which was suggestive of premature angiogenesis induced by early VEGF up-regulation,resulting in rapid vessel disintegration in diabetic *** reticulum stress-related pro-apoptotic C/EBP homologous protein was overexpressed in challenged Ins2Akita/+mice,which suggests that the exacerbated VEGF up-regulation may be caused by overwhelming endoplasmic reticulum stress under diabetic *** conclusion,the results mimicked complications in patients with diabetes undergoing delayed mechanical thrombectomy,and diabetes-induced accelerated VEGF up-regulation is likely to underlie exacerbated hemorrhagic transformat

关键词： blood-brain barrier brain injury diabetes mellitus hemorrhagic transformation infarct ischemia/reperfusion injury middle cerebral artery occlusion mouse model stroke vascular endothelial growth factor

Biocomposites:Their multifunctionality

在线全文

学校读者我要写书评

暂无评论

International Journal of Smart and Nano Materials 2010年第1期1卷 13-27页

作者： Kin-tak Lau Mei-po Ho Chi-ting Au-yeung Hoi-yan cheung Centre of Excellence in Engineered Fibre Composites Faculty of Engineering and SurveyingUniversity of Southern QueenslandQueenslandAustralia Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

During the last decade,tissue engineering has shown a considerable promise in providing more viable alternatives to surgical procedures for harvested tissues,implants and *** to the fast development on nano-and biomaterial technologies,it is now possible for doctors to use patients’cells to repair orthopaedic defects such as focal articular cartilage *** order to support the three-dimensional tissue formation,scaffolds made by biocompatible and bioresorbable polymers and composite materials,for providing temporary support of damaged body and cell structures,have been developed *** ceramic and metallic materials have been widely accepted for the development of implants,their non-resorbability and necessity of second surgical operation(like for bone repair),which induce extra pain for the patients,limit their wide *** development of different types of biocomposites for biomedical engineering applications is *** biocomposites include(i)basic biomaterials;(ii)natural fiber-reinforced biocomposites and(iii)nanoparticle-reinforced *** multifunctionality is discussed in terms of the control of mechanical properties,biodegradability and bioresorbability.

关键词： multifunctional materials biocomposite