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Stroke & Vascular Neurology 2022年第2期7卷 158-165页

作者： Nawaf yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen chung y hsu Gagan Sharma Peter J Mitchell Bernard yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis Department of Medicine and Neurology Melbourne Brain Centre at The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Population Health and Immunity Division Walter and Eliza Hall Institute of Medical ResearchParkvilleVictoriaAustralia Ambulance Victoria MelbourneVictoriaAustralia Melbourne Medical School The University of MelbourneMelbourneVictoriaAustralia Stroke Division The Florey Institute of Neuroscience and Mental HealthParkvilleVictoriaAustralia Department of Neurology Christchurch HospitalChristchurchNew Zealand Department of Neurology Monash Medical CentreMonash UniversityClaytonVictoriaAustralia Department of Interventional Neuroradiology Liverpool HospitalLiverpoolNew South WalesAustralia Department of Neurology Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Neurology Princess Alexandra HospitalWoolloongabbaQueenslandAustralia Department of Neurology Box Hill HospitalEastern HealthBox HillVictoriaAustralia Stroke Centre and Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Medicine Dunedin School of MedicineUniversity of OtagoWellingtonNew Zealand Department of Neurosurgery E-Da HospitalYanchaoKaohsiungTaiwan Department of Neurology Alfred HospitalMelbourneVictoriaAustralia Department of Clinical Neuroscience Monash University Central Clinical SchoolMelbourneVictoriaAustralia Department of Medicine Sunshine Coast University HospitalNambourQueenslandAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia Department of Neurology John Hunter HospitalThe University of NewcastleNewcastleNew South WalesAustralia Department of Neurosurgery China Medical University HospitalTaichungTaiwan Department of Internal Medicine Palmerston North HospitalPalmerston NorthNew Zealand Department of Neurology St Vincent's HospitalFitzroyVictoriaAustralia Department of Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustra

Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of *** acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma *** and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical *** In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with *** size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of *** adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 *** Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching *** efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT *** We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.

关键词： placebo centre absolute

High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-Hao Wu yin-hsuan Chang Chin-Lin hsu Sheng-yi Chen Gow-Chin yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

Handheld 3D Scanner for Small Objects Using Kinect

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Journal of Electronic Science and Technology 2016年第4期14卷 377-383页

作者： Chia-Chi hsu chung-Lin Huang Taiwan Residents Army Department of M-Commerce and Multimedia Applications Asia UniversityTaichung 41354

This paper presents a handheld 3D vision-based scanner for small objects by using Kinect. It is different from the previous color-glove-based approaches which require segmenting the target object. First, we eliminate the noises and the outliers caused by holding hands. Second, we apply Kinect-fusion algorithm and truncated signed distance function （TSDF） to represent 3D surfaces. Third, we propose a modified integration strategy to eliminate the hand effect. Fourth, we take advantage of the parallel computation of GPUs for real-time operation. The major contributions of this paper are （1） the registration precision is improved, （2） the oflline amendment and loop closure operation are not required, and （3） concave 3D object reconstruction is feasible.

关键词： Handheld 3D scanning Kinect-fusion,Truncated signed distance function (TSDF).

Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Chin-Heng Lu Hung-Min Chang Kuang-Hsi Chang yen-Chuan Ou Chao-yu hsu Min-Che Tung Frank Cheau-Feng Lin Stella Chin-Shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong Hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHIymptom Scores(IPSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(py(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

Optimal design theories of tuned mass dampers with nonlinear viscous damping

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 547-560页

作者： Lap-Loi chung Lai-yun Wu hsu-Hui Huang chung-Hsin Chang Kuan-Hua Lien Center for Research on Earthquake Engineering （NCREE） Chinese Taipei Department of Civil Engineering Taiwan University. Chinese Taipei

Optimal design theory for linear tuned mass dampers （TMD） has been thoroughly investigated, but is still under development for nonlinear TMDs. In this paper, optimization procedures in the time domain are proposed for design of a TMD with nonlinear viscous damping. A dynamic analysis of a structure implemented with a nonlinear TMD is conducted first. Optimum design parameters for the nonlinear TMD are searched using an optimization method to minimize the performance index. The feasibility of the proposed optimization method is illustrated numerically by using the Taipei 101 structure implemented with TMD. The sensitivity analysis shows that the performance index is less sensitive to the damping coefficient than to the frequency ratio. Time history analysis is conducted using the Taipei 101 structure implemented with different TMDs under wind excitation. For both linear and nonlinear TMDs, the comfort requirements for building occupants are satisfied as long as the TMD is properly designed. It was found that as the damping exponent increases, the relative displacement of the TMD decreases but the damping force increases.

关键词： optimal design theory tuned mass damper (TMD) nonlinear performance index sensitivity analysis Taipei 101

Real-Time Human Body Motion Capturing System

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Journal of Electronic Science and Technology 2017年第2期15卷 115-122页

作者： chung-Lin Huang Chien-Wei hsu Zhi-Ren Tsai Department of M-Commerce and Multimedia Applications Asia UniversityTaichung 41354 MediaTek Inc.Hsinchu department of computer science and information engineering Asia UniversityTaichung 41354

This paper proposes a human body motion capturing system using the depth images. It consists of three processes to estimate the human pose parameters. First, we develop a pixel-based body part classifier to segment the human silhouette into different body part sub-regions and extract the primary joints. Second, we convert the distribution of the joints to the feature vector and apply the regression forest to estimate human pose parameters. Third, we apply the temporal constraints mechanism to find the best human pose parameter with the minimum estimation error. In experiments, we show that our system can operate in real-time with sufficient accuracy.

关键词： Index Terms-Motion capturing random forest classifier regression forest.

Rapid Synthesis of Piezoelectric ZnO-Nanostructures for Micro Power-Generators

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Journal of Materials Science & Technology 2013年第10期29卷 893-897页

作者： Nai-Feng hsu Tien-Kan chung Ming Chang Hong-Jun Chen Department of General Education Army Academy Department of Mechanical Engineering National Chiao Tung University Department of Mechanical Engineering Chung Yuan Christian University State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology

In this paper, we report a rapid synthesis of piezoelectric ZnO-nanostructures and fabrication of the nanostructures- based power-generators demonstrating an energy conversion from an environmental mechanical/ultrasonic energy to an electrical energy. The ZnO nanostructures are grown on a silicon wafer by a modified chemical solution method （CSD, chemical-solution-deposition） with a two-step thermal-oxidation approach. The synthesis process can be completed within 1 h. By varying the mixture-ratio of Zn micro-particles in an oxalic acid solution with 0.75 mol/l concentration in the CSD process, the growth mechanism is well-controlled to synthesize three different types of ZnO-nanostructures （i.e., dandelion-like nanostructures, columnar nanostructures, and nanowires）. Furthermore, through oxidizing at different temperatures in the thermal-oxidation process, the featured geometry of the nanostructures （e.g., the length and diameter of a nanowire） is modified. The geometry, size, morphology, crystallization, and material phase of the modified nanostructures are characterized by scanning electron microscopy and X-ray diffraction. Finally, the nanostructures are used to fabricate several micro power-generators. Through the piezoelectric effect, a maximum current density output of 0.28 μA cm-2 generated by a power-generator under an ultrasonic wave is observed.

关键词： Piezoelectric ZnO nanostructures Chemical solution method Thermal-oxidation Power-generator

A three-level authenticated conference key establishment protocol for UMTS networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第5期12卷 371-378页

作者： chung-Fu LU Tzong-Chen WU Chien-Lung hsu Department of Information Management National Taiwan University of Science and Technology Department of Computer and Communication Engineering Taipei College of Maritime Technology Department of Information Management Chang Gung University

A conference key establishment protocol allows a group of conferees to agree on a secret key shared among them for secure group *** paper proposes a three-level conference key establishment protocol based on the Universal Mobile Telecommunications System (UMTS) framework to establish a group-level key,home location register (HLR) level keys,and visitor location register (VLR) level keys simultaneously for a group of *** group-level key is used to secure the communications for all conferees,the HLR-level key is for those within the same HLR domain,and the VLR-level key is for those within the same VLR *** group-level key can be used for securing inter-domain group-oriented applications such as commercial remote conferencing *** HLRand VLR-level keys can be used for securing intra-domain subgroup applications (e.g.,location-based or context-aware services) and dynamic key *** our proposed protocol exploits existing UMTS security functions and the exclusive-or operation,it is compatible with UMTS *** means that it is fast and easy to implement on the existing UMTS ***,the proposed protocol has low computational complexities and can provide cost effectiveness,load-amortization,scalability,user authentication,key establishment,key confirmation,key updating,and lawful interception.

关键词： Universal Mobile Telecommunications System (UMTS) Three-level Conference key establishment Secure group communication Authentication

Erosion control for mudstone soil with ventilation and watertight resin

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International Journal of Sediment Research 2010年第2期25卷 194-201页

作者： chung-li hsu Shin-yi DAI Shiu-wen CHIANG Department of Soil and Water Conservation National Pingtung University of Science and Technology Graduate Institute of Disaster Prevention on Hillslopes and Water Resources Engineering National Pingtung University of Science and Technology

To accelerate the re-vegetation of exposed landslide areas, hydroseeding for soil and water conservation has been widely applied as one of the economically feasible ways. However, effect durations of different hydroseeding materials are different, the formulation density has a certain effect on plant growth and the addictives may exude. This paper presents laboratory experiments of soil erosion, exuding water quality and soil hardness by using a rainfall simulator with different conditions of slope, rainfall intensity and medication density. The results showed that soil erosion decreased significantly, suggesting a good erosion-resisting effect by the ventilation and watertight resin. No significant variation of the exuded water was observed during testing, which indicates that after gelling, the ventilation and watertight resin are unlikely to release chemical substances. It was found that high resin density will result in poor workability as well as high costs; adverse will cause the mudstone to fracture due to raindrops since cracks are common to soil surface. The weatherability after spraying and its effect on plant vegetation still need further investigation.

关键词： Ventilation and watertight resin Hydro seeding Mudstone Soil erosion Rainfall simulator