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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

Photosynthesis,Metabolite Composition and Anatomical Structure of Oryza sativa and Two Wild Relatives,*** and ***

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Rice science 2017年第4期24卷 218-227页

作者： Jwakyung SUNG Suyeon LEE jong-Wook chung Gerald EDWARDS Hojin RYU Taewan KIM National Institute of Agricultural Science Rural Development Administration(RDA)WanjuJeollabu-do 55365Korea Department of Industrial Plant Science and Technology Chungbuk National UniversityCheongju 28644Korea School of Biological Science Washington State UniversityPullmanWA 99164-4236USA Department of Biology Chungbuk National UniversityCheongju 28644Korea Department of Plant Resources and Science and Institute of Ecological Phytochemistry Hankyung National UniversityAnseong 17579Korea

Photosynthesis, enzyme activities and metabolite pools associated with primary carbon metabolism in leaves were studied in O. grandiglumis and O. alta （wild relatives of rice which produce high biomass） versus O. sativa （a japonica cultivar and a indica-japonica hybrid） to assess their potential for identifying traits which might be utilized to enhance rice productivity. The wild relatives had higher rates of photosynthesis on a fresh weight basis, and higher water use efficiency than the O. sativa lines. There were no striking differences in activities of a number of key enzymes in carbon and nitrogen metabolism between the wild relatives and cultivated rice lines. Along with higher rates of photosynthesis on a fresh weight basis, the leaves of the two wild species had higher nitrate content, higher levels of starch, glucose and fructose, and higher levels of organic acids （malate, succinate and acetate）, compared to the O. sativa lines. The results suggested that O. grandiglumis and O. alta have differences in physiology and primary metabolism which might be exploited to improve growth and productivity of cultivated rice.

关键词： carbohydrate photosynthesis rate nitrogen assimilation metabolite composition leaf rice wild relative

Molecular phylogenetic status of Siberian roe deer(Capreolus pygargus) based on mitochondrial cytochrome b from Jeju Island in Korea

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Chinese Science Bulletin 2014年第32期59卷 4283-4288页

作者： Yong-Su Park Baek-Jun Kim Woo-Shin Lee jong-Taek Kim Tae-Wook Kim Hong-shik Oh Jangsu Endangered Species Restoration Team Jangsu CountyJeonbuk 176-7 Republic of Korea Department of Climate and Ecology National Institute of Ecology Seocheon 325-813 Republic of Korea Department of Forest Science Seoul National UniversitySeoul 151-192 Republic of Korea School of Veterinary Medicine Kangwon National UniversityChuncheon Gangwon 200-701 Republic of Korea Department of Science Education Jeju National UniversityJeju 690-750 Republic of Korea

In order to elucidate the genetic diversity and taxonomic status of Siberian roe deer(Capreolus pygargus)from the Korean peninsula,partial sequences of the mitochondrial cytochrome b gene were *** collected 57 roe deer samples from Mainland and Jeju Island between July 2004 and June 2009.A total of 50 sequences(1,070 bp)were obtained,and seven haplotypes were *** haplotypes were found from Mainland,and two were discovered from Jeju *** genetic diversity was lower in the Jeju Island population than in the Mainland *** addition,both the consensus neighbor-joining tree and maximum parsimony tree showed an identical topology between the Mainland and Jeju Island *** on the results,two subspecies of the Korean roe deer were *** roe deer in Jeju Island showed a distinct difference in the cytochrome b gene compared with other Siberian roe deer,being aunique native species inhabiting only Jeju Island in *** Siberian roe deer in Jeju Island can be classified at subspecies level,the new subspecies in Jeju was named Capreolus pygargus jejuensis in this *** this new subspecies,reasonable conservation and management effort is needed in the future.

关键词：线粒体细胞色素b基因济州岛系统发育地位矮鹿韩国狍遗传多样性分子

Association Analysis of the Amino Acid Contents in Rice

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Journal of Integrative Plant Biology 2009年第12期51卷 1126-1137页

作者： Weiguo Zhao Eun-Jin Park jong-Wook chung Yong-Jin Park III-Min chung Joung-Kuk Ahn Gwang-Ho Kim Department of Appfied Bioscience Konkuk University Seou1143-701 Korea Seficultural Research Institute Chinese Academy of Agricultural Sciences Jiangsu University of Science and Technology Zhenjiang 212018 China Department of Plant Resources Coflege of Industrial Science Kongju National University Yesan 340-802 Korea

The main objective of the present study was to identify simple sequence repeat （SSR） markers associated with the amino acid content of rice （Oryza sativa L.）. SSR markers were selected by prescreening for the relationship to amino acid content. Eighty-four rice landrace accessions from Korea were evaluated for 16 kinds of amino acids in brown rice and ganotyped with 25 SSR markers. Analysis of population structure revealed four subgroups in the population. Linkage disequilibrium （LD） patterns and distributions are of fundamental importance for genome-wide mapping associations. The mean r^2 value for all intrachromosomal loci pairs was 0.033. LD between linked markers decreased with distance. Marker-trait associations were investigated using the unified mixed-model approach, considering both population structure （Q） and kinship （K）. A total of 42 marker-trait associations with amino acids （P 〈 0.05） were identified using 15 different SSR markers covering three chromosomes and explaining more than 40% of the total variation. These results suggest that association analysis in rice is a viable alternative to quantitative trait loci mapping and should help rice breeders develop strategies for improving rice quality.

关键词： Amino acid content association mapping linkage disequilibrium population structure simple sequence repeats.

Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8170-8175页

作者： Miju Bae Up Huh chung Won Lee jong Won Kim Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Venous adventitial cystic disease(VACD)is a rare disease characterized by cysts,filled with a gelatinous mucous substance similar to joint fluid,in the adventitia of blood vessels adjacent to the *** is often misdiagnosed as deep vein thrombosis(DVT),femoral varices,venous tumors,or *** SUMMARY A 69-year-old woman visited our hospital with a complaint of swelling in the right lower *** patient was diagnosed with DVT and prescribed apixaban at an outpatient *** 3 wk,the patient was hospitalized again because of sudden swelling in the right lower *** diagnosed VACD and performed surgery for cyst removal as well as patch angioplasty and thrombectomy of the right common femoral *** patient received anticoagulants for 6 mo and has been doing well without recurrence for 1 year *** Recurrent VACD requires complete removal of the connections to the joint cavity to prevent recurrence.

关键词： Adventitia Cysts Edema Joints Venous thrombosis Case report

Characterizing pressure fluctuation into single-loop oscillating heat pipe

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Journal of Central South University 2012年第9期19卷 2578-2583页

作者： PARK Yong-ho Md.Riyad Tanshen Md.J.Nine chung Han-shik JEONG Hyo-min Department of Mechanical Engineering Koje CollegeJangseungpoKojeGyeongnamKorea Department of Mechanical and Precision Engineering Gyeongsang National University 445 Inpyeong-dongTongyeongGyeongnam650-160Korea Department of Energy and Mechanical Engineering Institute of Marine IndustryGyeongsang National UniversityCheondaegukchi-Gil 38TongyeongGyeongnam650-160Korea

The pressure characteristics inside single loop oscillating heat pipe （OHP） having 4.5 mm inner diameter copper tube with the loop height of 440 mm were addressed. Distilled water was used as working fluid inside the OHP with different filling ratios of 40%, 60% and 80% of total inside volume. Experimental results show that the thermal characteristics are significantly inter-related with pressure fluctuations as well as pressure frequency. And the pressure frequency also depends upon the evaporator temperature that is maintained in the range of 60-96 ℃. Piezoresistive absolute pressure sensor （Model-Kistler 4045A5） was used to take data. The investigation shows that the filling ratio of 60% gives the highest inside pressure magnitude at maximum number of pressure frequency at any of set evaporator temperature and the lowest heat flow resistance is achieved at 60% filling ratio.

关键词： oscillating heat pipe pressure fluctuation heat flow resistance filling ratio

Numerical assessment on improving multistage centrifugal impeller performance by changing inlet skew angle at impeller inlet

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Journal of Central South University 2012年第4期19卷 953-961页

作者： M.N.Labib Woo Ju-sik Choi Du-youl T.Utomo B.Fajar chung Han-shik Jeong Hyo-min Graduate School of Department of Mechanical and Precision Engineering Gyeongsang National UniversityTongyeong 650-160Korea Fluid and Thermal Engineering Co.Ltd. Kyungnam 621-843Korea Department of Mechanical Engineering Engineering FacultyUniversity of DiponegoroSemarang 1269Indonesia Department of Mechanical and Precision Engineering Gyeongsang National UniversityThe Institute of Marine Industr yTongyeong 650-160Korea Department of Mechanical and Precision Engineering Gyeongsang National UniversityThe Institute of Marine Industr yTongyeong 650-160Kore

Multistage centrifugal impellers with four different skew angles were investigated by using computational fluid *** purpose of this work is to investigate the influences of lean angle at the blade tip of the impeller *** variations of lean angles,that is,8°,10°,15° and 20°,were made at first stage *** Average Navier Stokes equation was used in simulation together with a shear?stress transport(SST) k-w turbulence model and mixing-plane approach,*** dimensional fluid flows were simplified using periodic model to reduce the computational cost and time required.A good performance was expected that the secondary flow can be effectively reduced in the flow passage of the impeller without excessive increase in manufacturing cost caused by the secondary *** results show that secondary flow affects the main flow intricately to form vortices or having non-uniform velocity in the flow passage,which in turn results in substantial fluid energy loss not only in the impeller but also in the guide vane downstream of *** numerical solutions were performed and allowed the optimum design and operating conditions to be obtained.

关键词： computational fluid dynamics secondary flow blade inlet skew angle multistage centrifugal compressor

Mechanical characteristics of tensile strength ratio method compared to other parameters used for moisture susceptibility evaluation of asphalt mixtures

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 621-630页

作者： Thanh chung Do Van Phuc Tran Van Phuc Le Hyun jong Lee Won Jae Kim Department of Civil and Environmental Engineering Sejong UniversitySeoul 143-747South Korea Faculty of Civil Engineering University of Transport and CommunicationsHo Chi Minh CityVietnam

In this study,mechanical characteristics of tensile strength ratio(TSR)were evaluated by comparing it to other methods in evaluating moisture sensitivity of asphalt *** types of asphalt mixtures with and without anti-stripping additives were prepared and tested in the *** compressive strength(UCS)and indirect tensile(IDT)testing were conducted to determine the mixture’s tensile strength ratio and cohesion ratio(CR).Determining TSR alone was found to be insufficient when evaluating moisture *** is a need to consider both TSR and wet IDT strength to properly evaluate moisture behavior of asphalt ***,it was found that the cohesion and the IDT strength have a good relation in which the minimum condition of the slope,must be ***,it was observed thatβvalues change depending on material type and ***,there is a need to evaluate theseβvalues for varying material and testing *** addition,it was found that the TSR and CR results are highly correlated with an average difference of 1.5%.Furthermore,other tests such as Marshall stability and dynamic immersion were also *** was found that Marshall stability ratio(MSR)and Marshall stability to flow ratio(MSFR)values are less sensitive to moisture effect when measuring moisture resistance compared to TSR ***,the 48 h testing result of the dynamic immersion test showed better correlation with TSR values.

关键词： Asphalt mixtures Moisture damage Anti-stripping additives Tensile strength ratio Cohesion strength ratio

Heat transfer characteristics of nanofluid through circular tube

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Journal of Central South University 2013年第1期20卷 142-148页

作者： WUSIMAN Ku-er-ban-jiang chung Han-shik MD.J.Nine HANDRY Afrianto EOM Yoon-sub KIM Jun-hyo JEONG Hyo-min Department of Mechanical and Precision Engineering GyeongSang National University445 Inpyeong-dongTongYoungGyeongNam 650-160Korea Department of Energy and Mechanical Engineering The Institute of Marine IndustryGyeongSang National University445 Inpyeong-dongTongYoungGyeongNam 650-160Korea Division of Marine Engineering Mokpo National Maritime UniversityHaeyangdaehang-Ro 91Mokpo-siJeollanam-do530-729Korea

Nano fluid is considered to be a class of high efficient heat transfer fluid created by dispersing some special solid nanoparticles (normally less than 100 nm) in traditional heat transfer fluid. The present experiment was conducted aiming at investigating the forced heat transfer characteristics of aqueous copper (Cu) nanofluid at varying concentration of Cu nano-particles in different flow regimes (300

关键词： nanofluid heat transfer characteristic circular tube metallic particles