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Recent Advances in Self-assembled Nano-therapeutics

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Chinese Journal of Polymer Science 2018年第3期36卷 322-346页

作者： chun-xiong zheng Yu Zhao Yang Liu Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of Chemistryand State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin 300071China

The applications of nanotechnology in biomedicine have gained considerable attentions in recent years owing to the great enhancement of therapeutic *** of self-assembly into nanotechnology has brought tremendous convenience during the formation of *** on distinctive methods of self-assembly,nano-therapeutics have beer~developed to ar~impressive stage with the ability to perform site-specific delivery with temporal and spatial *** review focuses on the recent advances in the preparing methods for nano-therapeutics,and their applications in the treatments of diseases.

关键词： Self-assembly Nano-therapeutics Hydrophobic effect Electrostatic interaction Supramolecular host-guest interaction

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

“农业面源和重金属污染农田综合防治与修复技术研发”专项组织实施进展分析

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农业环境科学学报 2017年第7期36卷 1242-1246页

作者：徐长春熊炜郑戈林友华农业部科技发展中心北京100122

按照国家科技计划管理改革的整体部署,国家重点研发计划启动了"农业面源和重金属污染农田综合防治与修复技术研发"重点专项。按照"基础研究、共性关键技术研发、技术集成创新研究与示范"全链条设计、一体化实施,专项聚焦产业发展问题,... 详细信息

按照国家科技计划管理改革的整体部署,国家重点研发计划启动了"农业面源和重金属污染农田综合防治与修复技术研发"重点专项。按照"基础研究、共性关键技术研发、技术集成创新研究与示范"全链条设计、一体化实施,专项聚焦产业发展问题,为实现农业面源和重金属污染农田有效防治、农业生态环境健康和农产品质量安全有效提升的多重目标提供科技支撑。通过介绍农业面源专项的整体情况,分析目前专项组织实施的最新进展,总结专项管理机制方面的实践探索,以期为有关科研人员和行业部门提供参考。

关键词：国家重点研发计划农业面源和重金属污染实施进展管理机制

低黏附性正电纳米胶囊用于耐药性细菌生物被膜感染治疗

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高分子学报 2019年第3期50卷 300-310,M0006页

作者：刘晨晖曹京京赵宇郑春雄郑雅丹刘琦张展展刘阳功能高分子材料教育部重点实验室南开大学化学系天津300071

为了增强抗生素在生物被膜内部的渗透性能,并使其在生物被膜底部富集,设计了一种新颖的具有强渗透性和酸响应快速释放药物能力的纳米胶囊.这种纳米载药体系由酸响应内核和强渗透性外壳两部分组成.其中,纳米药物载体的内核由席夫碱键桥... 详细信息

为了增强抗生素在生物被膜内部的渗透性能,并使其在生物被膜底部富集,设计了一种新颖的具有强渗透性和酸响应快速释放药物能力的纳米胶囊.这种纳米载药体系由酸响应内核和强渗透性外壳两部分组成.其中,纳米药物载体的内核由席夫碱键桥联的聚己内酯(bi-PCL)共沉淀形成,外壳则通过原位聚合的方法在其表面形成一层富含2-甲基丙烯酰氧乙基磷酸胆碱(MPC)和N-(2-氨基丙基)甲基丙烯酰胺(APM)的无规交联网状聚合物.由于纳米胶囊表面由正电性的pAPM和低黏附性的pMPC共聚构成,在两者协同作用下,纳米胶囊可迅速渗透至生物被膜底部,同时由bi-PCL构成的内核在生物被膜内部酸性环境刺激下快速断键释放负载的药物.基于这一结构,该纳米胶囊可在给药后短时间内实现药物富集于生物被膜底部,从而快速有效地杀伤生物被膜内部的细菌,显著提高对生物被膜相关细菌感染的治疗效果.

关键词：生物被膜纳米胶囊响应性聚合物两性离子聚合物

Ubiquitination in diabetes and its complications:A perspective from bibliometrics

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World Journal of Diabetes 2025年第1期16卷 187-203页

作者： Li-Yuan xiong Wei Zhao Fa-Quan Hu Xue-Mei Zhou Yu-Jiao zheng College of Traditional Chinese Medicine Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel ***,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological *** hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic *** To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric *** Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core *** mapping analysis was conducted using the CiteSpace *** We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated *** articles originated from 54 countries and 386 institutions,with China as the leading *** Jiao Tong University has the highest number of publications in this *** most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited ***,The Journal of Biological Chemistry is noted as the most cited in this *** predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin *** The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research ***,these areas require further investigations.

关键词： Diabetes mellitus Ubiquitination Bibliometric analysis CiteSpace Research trends

Scapular metastasis from acinic cell carcinoma of parotid gland:A case report

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World Journal of Clinical Cases 2025年第9期13卷 41-46页

作者： Deng-Qun Sun Chang-chun Chen Duo-An zheng Hai-Yan Xing Xue Peng Department of General Surgery The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Radiology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Pathology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Acinic cell carcinoma(ACC)is a malignant epithelial neoplasm that commonly occurs in the parotid *** is known to have a high recurrence rate and the potential to metastasize to the lung or cervical lymph ***,few cases of ACC with bone metastasis have been reported in the medical *** SUMMARY The clinical significance of this case report lies in the unique site of occurrence of the metastasis:To the best of our knowledge,this report is the only literature documenting ACC arising in a shoulder *** Unusual presentations of uncommon malignancies can present diagnostic challenges for both surgeons and *** is important to be aware of these rare occurrences in order to provide the best possible treatment for patients.

关键词： Acinic cell carcinoma Shoulder mass Scapular Metastasis Case report

Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： Zhi-xiong Bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

Connection Between Screw-Instability in Black Hole Magnetosphere and Pairs of High-Frequency Quasi-Periodic Oscillations

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Chinese Physics Letters 2004年第7期21卷 1405-1408页

作者： YAOGuo-zheng WANGDing-xiong DepartmentofPhysics HuazhongUniversityofScienceandTechnologyWuhan430074

The correlation of screw-instability in black hole magnetosphere with pairs of high-frequency quasi-periodic oscillations (HFQPOs) is discussed in the coexistence of the Blandford-Znajek (BZ) and magnetic coupling (MC) processes. It turns out that screw-instability can result in HFQPOs. Such an HFQPO can be regarded as the transient process in an equivalent circuit with resistor and inductor in series (R-L circuit), and its period can be estimated by the relaxation time of this process. When the BZ process and the MC process coexist, the screw-instability can occur both in the BZ region and in the MC region, and the pairs of HFQPOs can be generated. Calculations show that such pairs of HFQPOs are likely to show frequencies in a 3:2 ratio. The frequencies of pairs of HFQPOs in our model scale inversely with the mass of central black hole, which is consistent with the observations.

关键词： Gravitation and cosmology Astrophysics and astroparticles

元宇宙下虚拟数字人信息保护的困境与解决路径

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科技与法律（中英文） 2025年第1期 26-37页

作者：熊进光张峥江西财经大学法学院南昌330013

元宇宙下虚拟数字人信息与元宇宙用户信息实时传递,具有同步性,但相较于以自然人为主体的个人信息保护,虚拟数字人信息缺少相应的监管与保护措施,泄露风险加剧。现有立法无法对虚拟数字人信息保护的适用范围、责任认定等核心内容提供精... 详细信息

元宇宙下虚拟数字人信息与元宇宙用户信息实时传递,具有同步性,但相较于以自然人为主体的个人信息保护,虚拟数字人信息缺少相应的监管与保护措施,泄露风险加剧。现有立法无法对虚拟数字人信息保护的适用范围、责任认定等核心内容提供精细指引。基于此,当前应立足民法保护、算法技术归责以及行业规范三维路径。首先,确定虚拟数字人法律主体地位、厘清虚拟数字人信息保护范围;其次,建立算法数字技术归责体系,明确责任承担方式;最后,确定元宇宙平台的准入标准、明晰企业的权利义务。

关键词：元宇宙虚拟数字人个人信息保护隐私权平台准入